RU2112503C1 - Композиция для ухода за кожей - Google Patents

Композиция для ухода за кожей Download PDF

Info

Publication number: RU2112503C1
Authority: RU; Russia
Prior art keywords: fer; skin; composition; analysis; concentration
Prior art date: 1993-07-05

Application number

RU94023244A

Other languages

English (en)

Russian (ru)

Other versions

RU94023244A (ru

Inventor

Рохас Константин Ингрид

Нельсон Родригес Гарсия Элиас

Мануэль Мелла Лисама Карлос

Диас Де Ла Роча Кеведо Артуро

Original Assignee

Сентро Де Инженьериа Генетика И Биотекнологиа

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-05

Filing date

1994-07-05

Publication date

1998-06-10

1994-07-05 Application filed by Сентро Де Инженьериа Генетика И Биотекнологиа filed Critical Сентро Де Инженьериа Генетика И Биотекнологиа

1996-11-10 Publication of RU94023244A publication Critical patent/RU94023244A/ru

1998-06-10 Application granted granted Critical

1998-06-10 Publication of RU2112503C1 publication Critical patent/RU2112503C1/ru

Links

239000000203 mixture Substances 0.000 title claims abstract description 10
229920002307 Dextran Polymers 0.000 claims abstract description 6
239000003381 stabilizer Substances 0.000 claims description 3
229920001282 polysaccharide Polymers 0.000 claims 1
239000005017 polysaccharide Substances 0.000 claims 1
238000000034 method Methods 0.000 abstract description 15
239000002537 cosmetic Substances 0.000 abstract description 11
239000000126 substance Substances 0.000 abstract description 6
230000032683 aging Effects 0.000 abstract description 4
229920001184 polypeptide Polymers 0.000 abstract description 4
230000008569 process Effects 0.000 abstract description 4
102000004196 processed proteins & peptides Human genes 0.000 abstract description 4
108090000765 processed proteins & peptides Proteins 0.000 abstract description 4
230000000694 effects Effects 0.000 abstract description 3
229920001353 Dextrin Polymers 0.000 abstract 1
239000004375 Dextrin Substances 0.000 abstract 1
235000019425 dextrin Nutrition 0.000 abstract 1
210000003491 skin Anatomy 0.000 description 21
238000004458 analytical method Methods 0.000 description 11
238000002965 ELISA Methods 0.000 description 9
239000006071 cream Substances 0.000 description 8
150000001413 amino acids Chemical class 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
239000000499 gel Substances 0.000 description 4
230000036512 infertility Effects 0.000 description 4
239000012071 phase Substances 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
102000005962 receptors Human genes 0.000 description 4
108020003175 receptors Proteins 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
102000008186 Collagen Human genes 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
206010040799 Skin atrophy Diseases 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000004007 reversed phase HPLC Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
208000002874 Acne Vulgaris Diseases 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
102400001368 Epidermal growth factor Human genes 0.000 description 2
101800003838 Epidermal growth factor Proteins 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
206010000496 acne Diseases 0.000 description 2
230000027455 binding Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
230000008034 disappearance Effects 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940116977 epidermal growth factor Drugs 0.000 description 2
210000002615 epidermis Anatomy 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000000835 fiber Substances 0.000 description 2
210000002950 fibroblast Anatomy 0.000 description 2
230000006870 function Effects 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
239000000178 monomer Substances 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
230000002028 premature Effects 0.000 description 2
238000003908 quality control method Methods 0.000 description 2
230000006798 recombination Effects 0.000 description 2
238000005215 recombination Methods 0.000 description 2
230000009759 skin aging Effects 0.000 description 2
241000894007 species Species 0.000 description 2
238000012360 testing method Methods 0.000 description 2
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
206010067484 Adverse reaction Diseases 0.000 description 1
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
102000016942 Elastin Human genes 0.000 description 1
108010014258 Elastin Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
101150093530 Fer gene Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 description 1
-1 Ketostearyl alcohol Chemical compound 0.000 description 1
238000013494 PH determination Methods 0.000 description 1
244000264897 Persea americana var. americana Species 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
208000000453 Skin Neoplasms Diseases 0.000 description 1
206010040844 Skin exfoliation Diseases 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
206010042496 Sunburn Diseases 0.000 description 1
206010042674 Swelling Diseases 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
VUBTYKDZOQNADH-UHFFFAOYSA-N acetyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)=O VUBTYKDZOQNADH-UHFFFAOYSA-N 0.000 description 1
230000006838 adverse reaction Effects 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
238000001574 biopsy Methods 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000003412 degenerative effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000035618 desquamation Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
229940079593 drug Drugs 0.000 description 1
229920002549 elastin Polymers 0.000 description 1
238000001493 electron microscopy Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
210000000750 endocrine system Anatomy 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
231100000321 erythema Toxicity 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
229940106582 estrogenic substances Drugs 0.000 description 1
JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
210000001061 forehead Anatomy 0.000 description 1
238000013467 fragmentation Methods 0.000 description 1
238000006062 fragmentation reaction Methods 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
210000003128 head Anatomy 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
229940116978 human epidermal growth factor Drugs 0.000 description 1
ZEDUIPIAGLVVIG-UHFFFAOYSA-N icosan-9-ol octanoic acid Chemical compound C(CCCCCCC)C(CCCCCCCCCCC)O.C(CCCCCCC)(=O)O ZEDUIPIAGLVVIG-UHFFFAOYSA-N 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000007803 itching Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000003908 liver function Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
102000006240 membrane receptors Human genes 0.000 description 1
108020004084 membrane receptors Proteins 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
230000002297 mitogenic effect Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 1
230000037311 normal skin Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000003716 rejuvenation Effects 0.000 description 1
238000007665 sagging Methods 0.000 description 1
238000003118 sandwich ELISA Methods 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
230000004215 skin function Effects 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
230000008719 thickening Effects 0.000 description 1
229940071127 thioglycolate Drugs 0.000 description 1
CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
229940042585 tocopherol acetate Drugs 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000002747 voluntary effect Effects 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1

Images

Landscapes

Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

RU94023244A 1993-07-05 1994-07-05 Композиция для ухода за кожей RU2112503C1 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CU64/93		1993-07-05
CU1993064A CU22405A1 (es)	1993-07-05	1993-07-05	Composicion cosmetica para el cuidado de la piel

Publications (2)

Publication Number	Publication Date
RU94023244A RU94023244A (ru)	1996-11-10
RU2112503C1 true RU2112503C1 (ru)	1998-06-10

Family

ID=5459284

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU94023244A RU2112503C1 (ru)	1993-07-05	1994-07-05	Композиция для ухода за кожей

Country Status (5)

Country	Link
BR (1)	BR9402638A (es)
CO (1)	CO4230067A1 (es)
CU (1)	CU22405A1 (es)
ES (1)	ES2070791B1 (es)
RU (1)	RU2112503C1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2161974C1 (ru) *	2000-01-20	2001-01-20	Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии"	Лечебно-профилактическое средство для ухода за кожей (варианты)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4717717A (en) *	1986-11-05	1988-01-05	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
NZ222413A (en) *	1986-11-05	1991-06-25	Ethicon Inc	Compositions containing a polypeptide growth factor and a water-soluble cellulose polymer stabiliser
NZ226171A (en) *	1987-09-18	1990-06-26	Ethicon Inc	Gel formulation containing polypeptide growth factor

1993
- 1993-07-05 CU CU1993064A patent/CU22405A1/es not_active IP Right Cessation
- 1993-12-31 ES ES9302740A patent/ES2070791B1/es not_active Expired - Lifetime
1994
- 1994-07-05 RU RU94023244A patent/RU2112503C1/ru not_active IP Right Cessation
- 1994-07-05 CO CO94029150A patent/CO4230067A1/es unknown
- 1994-07-05 BR BR9402638A patent/BR9402638A/pt not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2161974C1 (ru) *	2000-01-20	2001-01-20	Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии"	Лечебно-профилактическое средство для ухода за кожей (варианты)

Also Published As

Publication number	Publication date
ES2070791A1 (es)	1995-06-01
RU94023244A (ru)	1996-11-10
CU22405A1 (es)	1996-01-31
CO4230067A1 (es)	1995-10-19
ES2070791B1 (es)	1996-01-01
BR9402638A (pt)	1995-04-04

Legal Events

Date	Code	Title	Description
2007-09-20	MM4A	The patent is invalid due to non-payment of fees	Effective date: 20040706

Publication	Publication Date	Title
Saurat et al.	1994	Topical retinaldehyde on human skin: biologic effects and tolerance
US6521669B1 (en)	2003-02-18	Hydroxystilbene compounds for reducing/inhibiting protein glycation
Tsai et al.	1994	Permeability barrier disruption alters the localization and expression of TNFα/protein in the epidermis
US6414038B2 (en)	2002-07-02	Hydroxystilbenes for reducing/inhibiting protein glycation and combating skin aging
EP0899330B1 (fr)	2004-05-19	Polypeptide isolé de l'épiderme et son utilisation
US20070134183A1 (en)	2007-06-14	Aminosulfonic acid compounds for promoting desquamation of the skin
US8216618B2 (en)	2012-07-10	Cosmetic use of an Ophiopogon japonicus active principle
US20250345265A1 (en)	2025-11-13	Active principle comprising a particular extract of punica granatum and uses for preventing and/or treating acne
US5356874A (en)	1994-10-18	Angiogenic factor isolated from live yeast cell derivatives and its use in treating wounds or burns in mammals
EP2763652B1 (fr)	2017-12-06	Utilisation de glucanes obtenus a partir de prunus persica comme agent cosmetique anti-age
JP2011520768A (ja)	2011-07-21	皮膚のバリア機能を改善するための、ｆｎ３ｋおよび／またはｆｎ３ｋｒｐの発現を刺激するための有効薬剤の化粧上の使用
Sugimoto et al.	1974	Differential acceleration by hydrocortisone of the accumulation of epidermal structural proteins in the chick embryonic skin growing in a chemically defined medium
Squier et al.	1967	The ultrastructure of the melanocyte in human gingival epithelium
CN120983287A (zh)	2025-11-21	一种燕窝酸温和刷酸组合物及其应用
AU2024310292A1 (en)	2026-02-05	Modified peptides such as polypeptides la-19 and tm-19 having anti-aging and repairing effects and use thereof
CA2299171A1 (fr)	1999-02-18	Utilisation d'un 2-amino-alcane polyol pour le traitement de vieillissement cutane
KR101766393B1 (ko)	2017-08-10	블레오마이신 하이드로라제를 이용한 건조 피부 개선물질 스크리닝 방법
EP0912157B1 (fr)	2004-11-24	Heteromere isole liant l'acide arachidonique et son utilisation en cosmetique ou pharmacie
US5719126A (en)	1998-02-17	Melanogenic inhibitor, and methods of producing and using the same
JP3108358B2 (ja)	2000-11-13	抜取った毛髪に対する活性物質の試験方法
Aleporou-Marinou et al.	2001	Purification of apolipoprotein H (beta2-glycoprotein I)-like protein from human follicular fluid
JP3611675B2 (ja)	2005-01-19	皮膚外用剤
Van den Hove‐Vandenbroucke et al.	1975	Defective Thyroglobulin Endocytosis and Hydrolysis in Thyroid Cold Nodules 1
EP0967968A1 (en)	2000-01-05	Pharmaceutical or cosmetic composition containing at least one retinoid
US20090042958A1 (en)	2009-02-12	Composition and method for treating immune-mediated skin disorders

RU2112503C1 - Композиция для ухода за кожей - Google Patents

Info

Links

Images

Landscapes

Applications Claiming Priority (2)

Publications (2)

Family

ID=5459284

Family Applications (1)

Country Status (5)

Cited By (1)

Family Cites Families (3)

Cited By (1)

Also Published As

Similar Documents

Legal Events