SE0301009D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE0301009D0
SE0301009D0 SE0301009A SE0301009A SE0301009D0 SE 0301009 D0 SE0301009 D0 SE 0301009D0 SE 0301009 A SE0301009 A SE 0301009A SE 0301009 A SE0301009 A SE 0301009A SE 0301009 D0 SE0301009 D0 SE 0301009D0
Authority
SE
Sweden
Prior art keywords
novel compounds
processes
preparation
compositions containing
relates
Prior art date
Application number
SE0301009A
Other languages
English (en)
Swedish (sv)
Inventor
Garry Pairaudeau
Stephen Thom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0301009A priority Critical patent/SE0301009D0/xx
Publication of SE0301009D0 publication Critical patent/SE0301009D0/xx
Priority to JP2006508006A priority patent/JP4588018B2/ja
Priority to AT04726045T priority patent/ATE411280T1/de
Priority to EP04726045A priority patent/EP1636175B1/de
Priority to ES04726045T priority patent/ES2314389T3/es
Priority to PCT/SE2004/000534 priority patent/WO2004089884A1/en
Priority to DE602004017174T priority patent/DE602004017174D1/de
Priority to US10/552,082 priority patent/US20060211765A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
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AT04726045T ATE411280T1 (de) 2003-04-07 2004-04-06 Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
EP04726045A EP1636175B1 (de) 2003-04-07 2004-04-06 Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
ES04726045T ES2314389T3 (es) 2003-04-07 2004-04-06 Derivados de acido fenoxiacetico para tratar trastornos respiratorios.
PCT/SE2004/000534 WO2004089884A1 (en) 2003-04-07 2004-04-06 Novel compounds
DE602004017174T DE602004017174D1 (de) 2003-04-07 2004-04-06 Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
JP4051398B2 (ja) 2004-03-11 2008-02-20 アクテリオン ファマシューティカルズ リミテッド テトラヒドロピリドインドール誘導体
WO2005102338A1 (en) * 2004-04-20 2005-11-03 Pfizer Limited Method of treating neuropathic pain using a crth2 receptor antagonist
GB0409921D0 (en) * 2004-05-04 2004-06-09 Novartis Ag Organic compounds
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
EP1817282B1 (de) 2004-11-23 2011-07-20 AstraZeneca AB Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate
RU2405770C2 (ru) 2005-09-27 2010-12-10 Сионоги Энд Ко., Лтд. Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2
EP1937632A1 (de) * 2005-10-06 2008-07-02 Astra Zeneca AB Neue verbindungen
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
GB0520324D0 (en) * 2005-10-06 2005-11-16 Astrazeneca Ab Novel compounds
RU2424229C2 (ru) * 2005-10-06 2011-07-20 Астразенека Аб Производные бифенилоксиуксусной кислоты, их применение для изготовления лекарственного средства и промежуточные соединения
US20080255150A1 (en) * 2005-11-05 2008-10-16 Astrazeneca Ab Novel Compounds
WO2007062678A1 (en) * 2005-11-29 2007-06-07 7Tm Pharma A/S Phenoxyacetic acid derivatives as crth2 receptor ligands
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
UA100983C2 (ru) * 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
JP5327762B2 (ja) 2007-12-14 2013-10-30 プルマジェン セラピューティクス（アズマ）リミテッド インドールおよびその治療的使用
US20110136877A1 (en) * 2008-01-07 2011-06-09 Ligand Pharmaceuticals Inc. 2-phenyl phenoxyacetic acids useful for treating inflammatory disorders
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
WO2010102154A2 (en) * 2009-03-05 2010-09-10 Ligand Pharmaceuticals Incorporated Biaryl oxyacetic acid compounds
CA2805452C (en) 2010-07-05 2018-07-31 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
EP2526945A1 (de) 2011-05-25 2012-11-28 Almirall, S.A. Neue CRTH2-Antagonisten
EP2548863A1 (de) 2011-07-18 2013-01-23 Almirall, S.A. Neue CRTH2-Antagonisten
EP2548876A1 (de) 2011-07-18 2013-01-23 Almirall, S.A. Neue CRTH2-Antagonisten
CN104114169A (zh) 2011-12-16 2014-10-22 阿托佩斯治疗有限公司 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物
TW201331179A (zh) 2011-12-21 2013-08-01 Actelion Pharmaceuticals Ltd 雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途
EP2885307A1 (de) 2012-07-05 2015-06-24 Actelion Pharmaceuticals Ltd. 1-phenyl-substituierte heterocyclyl-derivate und ihre verwendung als prostaglandin-d2-rezeptormodulatoren
ES2732310T3 (es) * 2013-12-10 2019-11-21 Univ California Diagnóstico diferencial de enfermedad hepática
KR102722949B1 (ko) 2015-06-15 2024-10-28 엔엠디 파마 에이/에스 신경근 장애의 치료에 사용하기 위한 화합물
US10385028B2 (en) 2017-12-14 2019-08-20 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
TWI780281B (zh) 2017-12-14 2022-10-11 丹麥商Ｎｍｄ藥品公司 用於治療神經肌肉病症的化合物
US11730714B2 (en) 2017-12-14 2023-08-22 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
TWI794369B (zh) 2017-12-14 2023-03-01 丹麥商Ｎｍｄ藥品公司 用於治療神經肌肉病症的化合物
US11147788B2 (en) 2017-12-14 2021-10-19 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
TW201927738A (zh) 2017-12-14 2019-07-16 丹麥商Ｎｍｄ藥品公司 用於治療神經肌肉病症的化合物
US11591284B2 (en) 2017-12-14 2023-02-28 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US12415771B2 (en) 2019-06-19 2025-09-16 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278524A (en) * 1962-03-13 1966-10-11 Beecham Group Ltd Penicillins and their production
BE790679A (fr) * 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
JPS5239888B2 (de) * 1973-05-28 1977-10-07
US4670566A (en) * 1979-07-12 1987-06-02 A. H. Robins Company, Incorporated 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5145790A (en) * 1990-05-04 1992-09-08 Abbott Laboratories Reagents and method for detecting polychlorinated biphenyls
CA2090283A1 (en) * 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
JPH06313995A (ja) * 1993-04-28 1994-11-08 Hodogaya Chem Co Ltd 静電荷像現像用トナー
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
CA2304713C (en) * 1997-10-14 2003-06-10 Asahi Kasei Kogyo Kabushiki Kaisha Biphenyl-5-alkanoic acid derivatives and use thereof
JP2002516305A (ja) * 1998-05-12 2002-06-04 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
WO2001016120A1 (en) * 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
JP2003523336A (ja) * 2000-02-18 2003-08-05 メルク エンド カムパニー インコーポレーテッド 糖尿病及び脂質障害のためのアリールオキシ酢酸
CA2413702A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
US6878522B2 (en) * 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
US20040097555A1 (en) * 2000-12-26 2004-05-20 Shinegori Ohkawa Concomitant drugs
EP1395257A1 (de) * 2001-06-12 2004-03-10 Elan Pharmaceuticals, Inc. Makrocyclische verbindungen zur behandlung der alzheimer-krankheit
MXPA04009040A (es) * 2002-03-20 2005-01-25 Metabolex Inc Acidos fenilaceticos sustituidos.
ES2401079T3 (es) * 2002-12-20 2013-04-16 Amgen Inc. Moduladores del asma y de la inflamación alérgica
BRPI0408353A (pt) * 2003-03-28 2006-03-21 Lilly Co Eli composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) * 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) * 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
EP1817282B1 (de) * 2004-11-23 2011-07-20 AstraZeneca AB Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate
EP1937632A1 (de) * 2005-10-06 2008-07-02 Astra Zeneca AB Neue verbindungen
TW200745003A (en) * 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
US20080255150A1 (en) * 2005-11-05 2008-10-16 Astrazeneca Ab Novel Compounds
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
UA100983C2 (ru) * 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты

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JP2006522117A (ja) 2006-09-28
ATE411280T1 (de) 2008-10-15
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JP4588018B2 (ja) 2010-11-24

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