SE0302599L - Bioartificellt implantat och dess användning samt förfarande för reducering av risken för bildning av bindväv efter implantering - Google Patents
Bioartificellt implantat och dess användning samt förfarande för reducering av risken för bildning av bindväv efter implanteringInfo
- Publication number
- SE0302599L SE0302599L SE0302599A SE0302599A SE0302599L SE 0302599 L SE0302599 L SE 0302599L SE 0302599 A SE0302599 A SE 0302599A SE 0302599 A SE0302599 A SE 0302599A SE 0302599 L SE0302599 L SE 0302599L
- Authority
- SE
- Sweden
- Prior art keywords
- risk
- implant
- reducing
- barrier
- connective tissue
- Prior art date
Links
- 239000007943 implant Substances 0.000 title abstract 4
- 210000002808 connective tissue Anatomy 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002513 implantation Methods 0.000 title 1
- 230000009772 tissue formation Effects 0.000 title 1
- 230000004888 barrier function Effects 0.000 abstract 5
- 238000009792 diffusion process Methods 0.000 abstract 5
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 230000000975 bioactive effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
- 229910052719 titanium Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302599A SE526959C2 (sv) | 2003-10-02 | 2003-10-02 | Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall |
| UAA200604785A UA81982C2 (uk) | 2003-10-02 | 2004-04-10 | Біосинтетичний імплантат з металевим покриттям, його застосування і спосіб зменшення ризику формування сполучної тканини після імплантації |
| ZA200602759A ZA200602759B (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| HK07100590.7A HK1095542B (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| YUP-2006/0235A RS20060235A (sr) | 2003-10-02 | 2004-10-04 | Bioveštački implanti i njihova upotreba i postupak smanjivanja rizika od formiranja vezivnog tkiva posle implantacije |
| JP2006532233A JP4837563B2 (ja) | 2003-10-02 | 2004-10-04 | 生体人工インプラントおよびインスリンポンプ |
| AU2004275685A AU2004275685B2 (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| KR1020067008504A KR101181535B1 (ko) | 2003-10-02 | 2004-10-04 | 생체인공 임플란트 및 이의 용도 및 이식 후 결합 조직의형성 위험을 감소시키는 방법 |
| EP04775510A EP1667746B1 (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| NZ546775A NZ546775A (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| MXPA06003665A MXPA06003665A (es) | 2003-10-02 | 2004-10-04 | Implante bioartificial y su uso y metodo de reducir el riesgo de formacion de tejido conjuntivo despues de la implantacion. |
| DK04775510T DK1667746T3 (da) | 2003-10-02 | 2004-10-04 | Biosyntetisk omplantat og dets anvendelse og fremgangsmåde til reduktion af risikoen for dannelse af bindevæv efter implantation |
| BRPI0415004-0A BRPI0415004A (pt) | 2003-10-02 | 2004-10-04 | implante bioartificial e seu uso e método de redução do risco de formação de tecido conjuntivo após o implante |
| ES04775510T ES2313072T3 (es) | 2003-10-02 | 2004-10-04 | Implante bioartificial y su uso y metodo para reducir el riesgo de formacion de tejido conjuntivo tras el implante. |
| CNB200480028566XA CN100536937C (zh) | 2003-10-02 | 2004-10-04 | 生物人工植入物及其用途和降低植入后结缔组织形成的危险的方法 |
| US10/574,114 US7955613B2 (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| PCT/SE2004/001418 WO2005030283A1 (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| CA2539150A CA2539150C (en) | 2003-10-02 | 2004-10-04 | Bioartificial implant and its use and method of reducing the risk of formation of connective tissue after implantation |
| PL04775510T PL1667746T3 (pl) | 2003-10-02 | 2004-10-04 | Biosyntetyczny wszczep i jego zastosowanie oraz sposób zmniejszania ryzyka tworzenia się tkanki łącznej po jego wszczepieniu |
| SI200430926T SI1667746T1 (sl) | 2003-10-02 | 2004-10-04 | Biološki umetni implantat in njegova uporaba terpostopek za zmanjšanje tveganja za tvorbo vezivnega tkiva po implantaciji |
| PT04775510T PT1667746E (pt) | 2003-10-02 | 2004-10-04 | Implante bioartificial e seu uso e processo para reduzir o risco de formação de tecido conjuntivo após implantação |
| AT04775510T ATE405301T1 (de) | 2003-10-02 | 2004-10-04 | Biosynthetisches implantat und seine verwendung und verfahren zur reduzierung des risikos der bildung von bindegewebe nach der implantation |
| DE602004016008T DE602004016008D1 (de) | 2003-10-02 | 2004-10-04 | Biosynthetisches implantat und seine verwendung und verfahren zur reduzierung des risikos der bildung von bindegewebe nach der implantation |
| RU2006114350/15A RU2349349C2 (ru) | 2003-10-02 | 2004-10-04 | Биосинтетический имплантат, его применение и способ уменьшения риска формирования соединительной ткани после имплантации |
| IL174488A IL174488A0 (en) | 2003-10-02 | 2006-03-22 | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation |
| NO20061899A NO328180B1 (no) | 2003-10-02 | 2006-04-28 | Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302599A SE526959C2 (sv) | 2003-10-02 | 2003-10-02 | Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE0302599D0 SE0302599D0 (sv) | 2003-10-02 |
| SE0302599L true SE0302599L (sv) | 2005-04-03 |
| SE526959C2 SE526959C2 (sv) | 2005-11-29 |
Family
ID=29247003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0302599A SE526959C2 (sv) | 2003-10-02 | 2003-10-02 | Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7955613B2 (sv) |
| EP (1) | EP1667746B1 (sv) |
| JP (1) | JP4837563B2 (sv) |
| KR (1) | KR101181535B1 (sv) |
| CN (1) | CN100536937C (sv) |
| AT (1) | ATE405301T1 (sv) |
| AU (1) | AU2004275685B2 (sv) |
| BR (1) | BRPI0415004A (sv) |
| CA (1) | CA2539150C (sv) |
| DE (1) | DE602004016008D1 (sv) |
| DK (1) | DK1667746T3 (sv) |
| ES (1) | ES2313072T3 (sv) |
| IL (1) | IL174488A0 (sv) |
| MX (1) | MXPA06003665A (sv) |
| NO (1) | NO328180B1 (sv) |
| NZ (1) | NZ546775A (sv) |
| PL (1) | PL1667746T3 (sv) |
| PT (1) | PT1667746E (sv) |
| RS (1) | RS20060235A (sv) |
| RU (1) | RU2349349C2 (sv) |
| SE (1) | SE526959C2 (sv) |
| SI (1) | SI1667746T1 (sv) |
| UA (1) | UA81982C2 (sv) |
| WO (1) | WO2005030283A1 (sv) |
| ZA (1) | ZA200602759B (sv) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE515227C2 (sv) | 1999-04-28 | 2001-07-02 | Bruce Medical Ab | Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen |
| JP4543152B2 (ja) * | 2004-08-20 | 2010-09-15 | 独立行政法人産業技術総合研究所 | 透明チタン被覆生体適合化材料 |
| WO2008103101A1 (en) * | 2007-02-19 | 2008-08-28 | Ticapex Ab | Implant assembly |
| WO2008112190A1 (en) * | 2007-03-09 | 2008-09-18 | The University Of Akron | Bio-artificial pancreas and a procedure for preparation of same |
| CA2698212A1 (en) | 2007-08-23 | 2009-02-26 | Intrexon Corporation | Methods and compositions for diagnosing disease |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| RU2525737C1 (ru) * | 2013-05-22 | 2014-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Способ изготовления внутрикостного стоматологического имплантата |
| RU2526252C1 (ru) * | 2013-05-30 | 2014-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Способ изготовления внутрикостных имплантатов с многослойным покрытием |
| CA3042495A1 (en) | 2016-11-10 | 2018-05-17 | Viacyte, Inc. | Pdx1 pancreatic endoderm cells in cell delivery devices and methods thereof |
| JP7084566B2 (ja) * | 2017-05-29 | 2022-06-15 | 創生ライフサイエンス株式会社 | 生体適合性高分子材料のマーキング方法 |
| WO2021061940A1 (en) | 2019-09-27 | 2021-04-01 | Isla Technologies, Inc. | Bioartificial pancreas |
| US12485274B2 (en) | 2021-03-08 | 2025-12-02 | Samsung Electronics Co., Ltd. | Apparatus and method with electrical stimulus |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752292A (en) * | 1983-01-24 | 1988-06-21 | Icu Medical, Inc. | Medical connector |
| SE450623B (sv) * | 1984-11-07 | 1987-07-13 | Dan Lundgren | Element for kontrollerad vevnadsinvext i kirurgiskt intervenerade omraden |
| US5611347A (en) * | 1989-07-25 | 1997-03-18 | Smith & Nephew, Inc. | Zirconium oxide and zirconium nitride coated percutaneous devices |
| FI923023A7 (sv) * | 1990-10-31 | 1992-06-29 | Baxter Int | Implantationsmaterial åstadkommande närvaskularisation |
| ATE156344T1 (de) | 1991-04-25 | 1997-08-15 | Univ Brown Res Found | Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte |
| ES2087337T3 (es) * | 1991-06-24 | 1996-07-16 | American Cyanamid Co | Composiciones de implantes que contienen una proteina, peptido o polipeptido biologicamente activos. |
| US5429821A (en) | 1992-05-29 | 1995-07-04 | The Regents Of The University Of California | Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use |
| US5387327A (en) * | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
| RU2040277C1 (ru) | 1992-12-27 | 1995-07-25 | Товарищество с ограниченной ответственностью "МиТ" (Медицина и Технология) | Способ изготовления материала для имплантата с электретными свойствами для остеосинтеза |
| US5876742A (en) * | 1994-01-24 | 1999-03-02 | The Regents Of The University Of California | Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof |
| AUPM425294A0 (en) * | 1994-03-04 | 1994-03-31 | Australian National University, The | In-vitro angiogenesis assay |
| WO1996039993A1 (en) | 1995-06-07 | 1996-12-19 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
| US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
| RU2113830C1 (ru) | 1996-04-02 | 1998-06-27 | Самарский государственный аэрокосмический университет им.С.П.Королева | Зубной имплантат |
| RU2109495C1 (ru) | 1996-07-19 | 1998-04-27 | Наум Абрамович Иофис | Искусственный клапан сердца и способ его изготовления |
| RU2117456C1 (ru) | 1996-11-18 | 1998-08-20 | Жусев Андрей Иванович | Пластиночный эндооссальный имплантант |
| RU2162715C2 (ru) * | 1997-08-20 | 2001-02-10 | Трофимов Виктор Венедиктович | Состав для покрытия пористых имплантатов |
| RU2142867C1 (ru) | 1998-02-23 | 1999-12-20 | Суслов Анатолий Григорьевич | Комбинированный (режуще-деформирующий) метчик |
| RU2157245C1 (ru) | 1999-03-05 | 2000-10-10 | Антонив Василий Федорович | Способ изготовления имплантатов |
| AU3724900A (en) * | 1999-03-05 | 2000-09-21 | Louis R. Matson | Surface-modified bioactive surgical implants suppressing tissue growth |
| RU2185127C2 (ru) | 1999-07-19 | 2002-07-20 | Нижегородская государственная медицинская академия | Винтовой зубной имплантат |
| DE19950386A1 (de) * | 1999-10-19 | 2001-05-10 | Miladin Lazarov | Biokompatibler Gegenstand |
| WO2001070379A1 (en) * | 2000-03-17 | 2001-09-27 | Koch Membrane Systems, Inc. | Filtration element for severe service applications |
| EP1280613A4 (en) | 2000-04-14 | 2003-08-27 | Virginia Tech Intell Prop | SELF-BUILDING THIN FILM COATING TO IMPROVE THE BIO-COMPATIBILITY OF MATERIALS |
| RU2191607C2 (ru) | 2000-06-23 | 2002-10-27 | Гюнтер Виктор Эдуардович | Носитель клеточных культур искусственных внутренних органов |
| AU2001273234A1 (en) | 2000-07-05 | 2002-01-14 | Islet Technology, Inc. | Method and system for consistent and effective encapsulation of biological material |
| DK1381402T3 (da) | 2001-04-27 | 2010-03-08 | Vivoxid Oy | Fremgangsmåde til forbedring af blødvævsmodtagelse og implantater der gør brug af denne fremgangsmåde |
| US7163688B2 (en) * | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| SE0200269D0 (sv) | 2002-01-31 | 2002-01-31 | Ellem Bioteknik Ab | Material for implantation |
| US7458991B2 (en) * | 2002-02-08 | 2008-12-02 | Howmedica Osteonics Corp. | Porous metallic scaffold for tissue ingrowth |
-
2003
- 2003-10-02 SE SE0302599A patent/SE526959C2/sv not_active IP Right Cessation
-
2004
- 2004-04-10 UA UAA200604785A patent/UA81982C2/uk unknown
- 2004-10-04 MX MXPA06003665A patent/MXPA06003665A/es active IP Right Grant
- 2004-10-04 KR KR1020067008504A patent/KR101181535B1/ko not_active Expired - Fee Related
- 2004-10-04 US US10/574,114 patent/US7955613B2/en not_active Expired - Fee Related
- 2004-10-04 SI SI200430926T patent/SI1667746T1/sl unknown
- 2004-10-04 DE DE602004016008T patent/DE602004016008D1/de not_active Expired - Lifetime
- 2004-10-04 BR BRPI0415004-0A patent/BRPI0415004A/pt not_active IP Right Cessation
- 2004-10-04 ES ES04775510T patent/ES2313072T3/es not_active Expired - Lifetime
- 2004-10-04 AU AU2004275685A patent/AU2004275685B2/en not_active Ceased
- 2004-10-04 EP EP04775510A patent/EP1667746B1/en not_active Expired - Lifetime
- 2004-10-04 PL PL04775510T patent/PL1667746T3/pl unknown
- 2004-10-04 DK DK04775510T patent/DK1667746T3/da active
- 2004-10-04 ZA ZA200602759A patent/ZA200602759B/en unknown
- 2004-10-04 RS YUP-2006/0235A patent/RS20060235A/sr unknown
- 2004-10-04 JP JP2006532233A patent/JP4837563B2/ja not_active Expired - Fee Related
- 2004-10-04 PT PT04775510T patent/PT1667746E/pt unknown
- 2004-10-04 AT AT04775510T patent/ATE405301T1/de active
- 2004-10-04 CN CNB200480028566XA patent/CN100536937C/zh not_active Expired - Fee Related
- 2004-10-04 WO PCT/SE2004/001418 patent/WO2005030283A1/en not_active Ceased
- 2004-10-04 CA CA2539150A patent/CA2539150C/en not_active Expired - Fee Related
- 2004-10-04 NZ NZ546775A patent/NZ546775A/en not_active IP Right Cessation
- 2004-10-04 RU RU2006114350/15A patent/RU2349349C2/ru not_active IP Right Cessation
-
2006
- 2006-03-22 IL IL174488A patent/IL174488A0/en not_active IP Right Cessation
- 2006-04-28 NO NO20061899A patent/NO328180B1/no not_active IP Right Cessation
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| NUG | Patent has lapsed |