SE437270B - Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning - Google Patents

Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning

Info

Publication number: SE437270B
Authority: SE; Sweden
Prior art keywords: chain; atoms; agarose; gives; separation material
Prior art date: 1983-07-19

Application number

SE8304041A

Other languages

English (en)

Swedish (sv)

Other versions

SE8304041L (de

SE8304041D0 (sv

Inventor

P-A Pernemalm

M Carlsson

G Lindgren

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-19

Filing date

1983-07-19

Publication date

1985-02-18

1983-07-19 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1983-07-19 Priority to SE8304041A priority Critical patent/SE437270B/sv

1983-07-19 Publication of SE8304041D0 publication Critical patent/SE8304041D0/xx

1984-07-09 Priority to DE8484850215T priority patent/DE3461715D1/de

1984-07-09 Priority to EP84850215A priority patent/EP0132244B1/de

1984-07-10 Priority to US06/629,476 priority patent/US4665164A/en

1984-07-18 Priority to JP59147735A priority patent/JPS6039558A/ja

1985-01-20 Publication of SE8304041L publication Critical patent/SE8304041L/xx

1985-02-18 Publication of SE437270B publication Critical patent/SE437270B/sv

Links

238000000926 separation method Methods 0.000 title claims abstract description 11
239000000463 material Substances 0.000 title claims abstract description 7
238000002360 preparation method Methods 0.000 title description 4
239000003431 cross linking reagent Substances 0.000 claims abstract description 28
229920000936 Agarose Polymers 0.000 claims abstract description 15
238000004132 cross linking Methods 0.000 claims abstract description 15
230000001588 bifunctional effect Effects 0.000 claims abstract description 8
238000000034 method Methods 0.000 claims description 11
239000004971 Cross linker Substances 0.000 claims description 8
239000000010 aprotic solvent Substances 0.000 claims description 5
239000007864 aqueous solution Substances 0.000 claims description 5
229920000647 polyepoxide Polymers 0.000 claims 1
230000027455 binding Effects 0.000 abstract description 5
238000009739 binding Methods 0.000 abstract description 5
239000000499 gel Substances 0.000 description 17
239000000047 product Substances 0.000 description 15
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 14
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 14
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 12
238000006243 chemical reaction Methods 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
125000004429 atom Chemical group 0.000 description 10
239000011543 agarose gel Substances 0.000 description 9
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
239000000203 mixture Substances 0.000 description 7
150000001875 compounds Chemical class 0.000 description 6
229910000033 sodium borohydride Inorganic materials 0.000 description 6
239000012279 sodium borohydride Substances 0.000 description 6
239000007858 starting material Substances 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 3
150000004820 halides Chemical class 0.000 description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
125000004430 oxygen atom Chemical group O* 0.000 description 3
PLDLPVSQYMQDBL-UHFFFAOYSA-N 2-[[3-(oxiran-2-ylmethoxy)-2,2-bis(oxiran-2-ylmethoxymethyl)propoxy]methyl]oxirane Chemical compound C1OC1COCC(COCC1OC1)(COCC1OC1)COCC1CO1 PLDLPVSQYMQDBL-UHFFFAOYSA-N 0.000 description 2
VTPXYFSCMLIIFK-UHFFFAOYSA-N 3-(oxiran-2-ylmethoxy)-2,2-bis(oxiran-2-ylmethoxymethyl)propan-1-ol Chemical compound C1OC1COCC(COCC1OC1)(CO)COCC1CO1 VTPXYFSCMLIIFK-UHFFFAOYSA-N 0.000 description 2
239000011324 bead Substances 0.000 description 2
238000001816 cooling Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
150000002118 epoxides Chemical class 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
238000004062 sedimentation Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
QWVCIORZLNBIIC-UHFFFAOYSA-N 2,3-dibromopropan-1-ol Chemical compound OCC(Br)CBr QWVCIORZLNBIIC-UHFFFAOYSA-N 0.000 description 1
JROOCDXTPKCUIO-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butan-2-yloxymethyl]oxirane Chemical compound C1OC1COC(C)CCOCC1CO1 JROOCDXTPKCUIO-UHFFFAOYSA-N 0.000 description 1
SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
ZFIVKAOQEXOYFY-UHFFFAOYSA-N Diepoxybutane Chemical compound C1OC1C1OC1 ZFIVKAOQEXOYFY-UHFFFAOYSA-N 0.000 description 1
239000004593 Epoxy Substances 0.000 description 1
229910005948 SO2Cl Inorganic materials 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
-1 aliphatic epoxides Chemical class 0.000 description 1
125000002947 alkylene group Chemical group 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
229910052794 bromium Inorganic materials 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
239000007863 gel particle Substances 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
150000003944 halohydrins Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000011148 porous material Substances 0.000 description 1
238000005086 pumping Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
- C08B37/0039—Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Filtering Materials (AREA)

SE8304041A 1983-07-19 1983-07-19 Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning SE437270B (sv)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
SE8304041A SE437270B (sv)	1983-07-19	1983-07-19	Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning
DE8484850215T DE3461715D1 (en)	1983-07-19	1984-07-09	Separation material and its preparation
EP84850215A EP0132244B1 (de)	1983-07-19	1984-07-09	Separationsmaterial und Verfahren zu dessen Herstellung
US06/629,476 US4665164A (en)	1983-07-19	1984-07-10	Polysaccharide crosslinked separation material and its preparation
JP59147735A JPS6039558A (ja)	1983-07-19	1984-07-18	分離材料およびその製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8304041A SE437270B (sv)	1983-07-19	1983-07-19	Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning

Publications (3)

Publication Number	Publication Date
SE8304041D0 SE8304041D0 (sv)	1983-07-19
SE8304041L SE8304041L (de)	1985-01-20
SE437270B true SE437270B (sv)	1985-02-18

Family

ID=20352012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8304041A SE437270B (sv)	1983-07-19	1983-07-19	Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning

Country Status (5)

Country	Link
US (1)	US4665164A (de)
EP (1)	EP0132244B1 (de)
JP (1)	JPS6039558A (de)
DE (1)	DE3461715D1 (de)
SE (1)	SE437270B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0203049A1 (de) *	1985-05-23	1986-11-26	Pharmacia Ab	Verfahren zur Vernetzung von porösen Polysaccharid-Gelen

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE452469B (sv) *	1986-06-18	1987-11-30	Pharmacia Ab	Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
US5665216A (en) *	1986-10-21	1997-09-09	Northeastern University	Capillary column for high performance electrophoretic separation and detection of SDS proteins and system and using the same
US4997537A (en) *	1986-10-21	1991-03-05	Northeastern University	High performance microcapillary gel electrophoresis
SE9601368D0 (sv) *	1996-04-11	1996-04-11	Pharmacia Biotech Ab	Process for the production of a porous cross-linked polysaccharide gel
US5998606A (en) *	1997-11-10	1999-12-07	Grandics; Peter	Mn(IV)-mediated crosslinking and functionalization of chromatography media
EP1731175B1 (de) *	1998-11-12	2009-09-30	International Manufacturing Group, Inc.	Hämostatische vernetzte Dextranperlen verwendbar zur schnellen Blutgerinnung und Hämostase
EP1469865A4 (de) *	2001-12-31	2010-04-14	Crosslink D Inc	Hämostatische zusammensetzungen und verfahren zur kontrolle von blutungen
US20070248653A1 (en) *	2006-04-20	2007-10-25	Cochrum Kent C	Hemostatic compositions and methods for controlling bleeding
CN101293191B (zh) *	2007-04-25	2011-11-09	中国科学院过程工程研究所	一种琼脂糖凝胶微球的制备方法
WO2008136742A1 (en) *	2007-05-04	2008-11-13	Bio-Works Company Limited	Method for the manufacture of agarose gels
US8664152B2 (en) *	2007-08-31	2014-03-04	Jnc Corporation	Porous cellulose gel, method for producing the same and use thereof
CN101486799B (zh) *	2008-01-16	2012-05-23	中国科学院过程工程研究所	一种琼脂糖凝胶微球及其制备方法
AU2008221604B2 (en) *	2008-09-22	2010-04-22	Commonwealth Scientific And Industrial Research Organisation	Temperature-responsive polymer particles in protein separation applications
WO2012081616A1 (ja)	2010-12-14	2012-06-21	Jsr株式会社	高分子粒子の製造方法、及び、高分子粒子
CN103769057B (zh) *	2012-10-25	2016-07-13	中国科学院过程工程研究所	一种高强度多糖类凝胶微球、制备方法及其用途
CN102989400A (zh) *	2012-10-25	2013-03-27	江南大学	一种琼脂糖4b微球的交联方法
CN104826605B (zh) *	2015-04-24	2017-09-29	广州极泰生物科技有限公司	一种使用超声反相悬浮法制备高度交联均一粒径琼脂糖凝胶介质
CN105944686B (zh) *	2016-05-18	2018-04-20	绿麒（厦门）海洋生物科技有限公司	一种含氨基葡萄糖基的琼脂糖凝胶微球及其制备方法
CN116284886B (zh) *	2023-04-10	2024-11-29	上海其胜生物制剂有限公司	多重交联的凝胶体系及其产品、制备方法和应用
CN116813967B (zh) *	2023-07-10	2024-04-19	杭州毫厘科技有限公司	多孔琼脂糖微球制备方法及多孔琼脂糖微球

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL252506A (de) *	1959-06-12
GB1016589A (en) *	1963-07-05	1966-01-12	Scholten Chemische Fab	A process for preparing polyethers
US3402169A (en) *	1964-01-02	1968-09-17	Wyandotte Chemicals Corp	Polyhalogenous polyhydroxy ethers
US4076930A (en) *	1968-12-13	1978-02-28	James Ellingboe	Polysaccharide polyols
US3873514A (en) *	1974-05-17	1975-03-25	Bio Rad Laboratories	Preparation of gel for affinity chromatography
US4013629A (en) *	1975-02-21	1977-03-22	Krause Milling Company	Art of catalyzing the reaction between a polyol and a polyaldehyde
US4011389A (en) *	1975-03-21	1977-03-08	Basf Wyandotte Corporation	Glycoside polyethers
US4549907A (en) *	1984-12-20	1985-10-29	Celanese Corporation	Thixotropic aqueous solutions containing a crosslinked polygalactomannan gum

1983
- 1983-07-19 SE SE8304041A patent/SE437270B/sv not_active IP Right Cessation
1984
- 1984-07-09 EP EP84850215A patent/EP0132244B1/de not_active Expired
- 1984-07-09 DE DE8484850215T patent/DE3461715D1/de not_active Expired
- 1984-07-10 US US06/629,476 patent/US4665164A/en not_active Expired - Lifetime
- 1984-07-18 JP JP59147735A patent/JPS6039558A/ja active Granted

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0203049A1 (de) *	1985-05-23	1986-11-26	Pharmacia Ab	Verfahren zur Vernetzung von porösen Polysaccharid-Gelen

Also Published As

Publication number	Publication date
EP0132244A1 (de)	1985-01-23
JPS6039558A (ja)	1985-03-01
SE8304041L (de)	1985-01-20
US4665164A (en)	1987-05-12
SE8304041D0 (sv)	1983-07-19
DE3461715D1 (en)	1987-01-29
JPH0320706B2 (de)	1991-03-20
EP0132244B1 (de)	1986-12-17

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SE437270B - Separationsmaterial av tverbunden agaros och dess framstellning separationsmaterial av tverbunden agaros och dess framstellning - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (5)

Applications Claiming Priority (1)

Publications (3)

Family

ID=20352012

Family Applications (1)

Country Status (5)

Cited By (1)

Families Citing this family (20)

Family Cites Families (8)

Cited By (1)

Also Published As

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