SE439647B - Kontinuerligt forfarande for framstellning av dextran - Google Patents

Kontinuerligt forfarande for framstellning av dextran

Info

Publication number: SE439647B
Authority: SE; Sweden
Prior art keywords: dextran; molecular weight; process according; carried out; sucrose
Prior art date: 1982-02-18

Application number

SE8201021A

Other languages

English (en)

Swedish (sv)

Other versions

SE8201021L (sv

Inventor

K Jarl

C Engblom

Original Assignee

Sorigona Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-18

Filing date

1982-02-18

Publication date

1985-06-24

1982-02-18 Application filed by Sorigona Ab filed Critical Sorigona Ab

1982-02-18 Priority to SE8201021A priority Critical patent/SE439647B/sv

1983-02-16 Priority to EP83850040A priority patent/EP0087404A3/fr

1983-02-17 Priority to JP2389483A priority patent/JPS58155097A/ja

1983-08-19 Publication of SE8201021L publication Critical patent/SE8201021L/

1985-06-24 Publication of SE439647B publication Critical patent/SE439647B/sv

Links

229920002307 Dextran Polymers 0.000 title claims description 45
238000000034 method Methods 0.000 title claims description 19
238000002360 preparation method Methods 0.000 title description 3
239000000758 substrate Substances 0.000 claims description 16
229930006000 Sucrose Natural products 0.000 claims description 15
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 15
239000005720 sucrose Substances 0.000 claims description 15
108090000790 Enzymes Proteins 0.000 claims description 14
102000004190 Enzymes Human genes 0.000 claims description 14
238000004519 manufacturing process Methods 0.000 claims description 9
239000011541 reaction mixture Substances 0.000 claims description 9
238000000926 separation method Methods 0.000 claims description 6
241000192132 Leuconostoc Species 0.000 claims description 5
238000001556 precipitation Methods 0.000 claims description 5
238000000855 fermentation Methods 0.000 claims description 4
230000004151 fermentation Effects 0.000 claims description 4
244000005700 microbiome Species 0.000 claims description 4
241000894007 species Species 0.000 claims 2
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 36
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
238000006243 chemical reaction Methods 0.000 description 9
239000000243 solution Substances 0.000 description 8
239000007788 liquid Substances 0.000 description 6
239000000203 mixture Substances 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 4
238000004113 cell culture Methods 0.000 description 4
238000009826 distribution Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
229940041514 candida albicans extract Drugs 0.000 description 3
239000000470 constituent Substances 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
239000012138 yeast extract Substances 0.000 description 3
239000005715 Fructose Substances 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
241000192130 Leuconostoc mesenteroides Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000005273 aeration Methods 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
238000012365 batch cultivation Methods 0.000 description 2
238000010923 batch production Methods 0.000 description 2
238000010586 diagram Methods 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
238000000746 purification Methods 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000002902 bimodal effect Effects 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000010367 cloning Methods 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229940119744 dextran 40 Drugs 0.000 description 1
229940119743 dextran 70 Drugs 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000029219 regulation of pH Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
229910001868 water Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- C12P19/08—Dextran

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SE8201021A 1982-02-18 1982-02-18 Kontinuerligt forfarande for framstellning av dextran SE439647B (sv)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
SE8201021A SE439647B (sv)	1982-02-18	1982-02-18	Kontinuerligt forfarande for framstellning av dextran
EP83850040A EP0087404A3 (fr)	1982-02-18	1983-02-16	Procédé pour la fabrication de dextrane
JP2389483A JPS58155097A (ja)	1982-02-18	1983-02-17	デキストランの製法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8201021A SE439647B (sv)	1982-02-18	1982-02-18	Kontinuerligt forfarande for framstellning av dextran

Publications (2)

Publication Number	Publication Date
SE8201021L SE8201021L (sv)	1983-08-19
SE439647B true SE439647B (sv)	1985-06-24

Family

ID=20346053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8201021A SE439647B (sv)	1982-02-18	1982-02-18	Kontinuerligt forfarande for framstellning av dextran

Country Status (3)

Country	Link
EP (1)	EP0087404A3 (fr)
JP (1)	JPS58155097A (fr)
SE (1)	SE439647B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3422246C1 (de) *	1984-06-15	1986-03-27	Pfeifer & Langen, 5000 Köln	Verfahren zur Herstellung monovalenter Haptene
CA2009194A1 (fr) *	1989-02-08	1990-08-08	Hideo Kado	Methode de production d'une substance polysaccharidique ron active
JPH0740953B2 (ja) *	1989-02-08	1995-05-10	サッポロビール株式会社	生理活性多糖ｒｏｎの生産法
US5332667A (en) *	1989-02-08	1994-07-26	Sapporo Breweries Limited	Method for producing biologically active polysaccharide RON substance
FR2765888B1 (fr)	1997-07-09	1999-10-15	Serobiologiques Lab Sa	Procede de synthese enzymatique de sucroesters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD35367A (fr) *
US2724679A (en) *	1953-05-12	1955-11-22	Henry M Tsuchiya	Synthesis of dextran and dextran analogues of predetermined molecular weight
US2717853A (en) *	1954-07-07	1955-09-13	Commercial Solvents Corp	Continuous dialysis process for the production of clinical dextran
US3044940A (en) *	1957-04-30	1962-07-17	Bernburg Serum Werk Veb	Process for enzymatic synthesis of dextran

1982
- 1982-02-18 SE SE8201021A patent/SE439647B/sv not_active IP Right Cessation
1983
- 1983-02-16 EP EP83850040A patent/EP0087404A3/fr not_active Withdrawn
- 1983-02-17 JP JP2389483A patent/JPS58155097A/ja active Pending

Also Published As

Publication number	Publication date
EP0087404A3 (fr)	1985-05-15
JPS58155097A (ja)	1983-09-14
SE8201021L (sv)	1983-08-19
EP0087404A2 (fr)	1983-08-31

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 8201021-6

Effective date: 19910117

Format of ref document f/p: F

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