SE441009B - Sett att immobilisera levande biomaterial i perlformiga polymerer - Google Patents
Sett att immobilisera levande biomaterial i perlformiga polymererInfo
- Publication number
- SE441009B SE441009B SE8201401A SE8201401A SE441009B SE 441009 B SE441009 B SE 441009B SE 8201401 A SE8201401 A SE 8201401A SE 8201401 A SE8201401 A SE 8201401A SE 441009 B SE441009 B SE 441009B
- Authority
- SE
- Sweden
- Prior art keywords
- cells
- polymer
- aqueous solution
- pct
- agarose
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 19
- 239000012620 biological material Substances 0.000 title abstract description 5
- 210000004027 cell Anatomy 0.000 claims abstract description 26
- 229920000936 Agarose Polymers 0.000 claims abstract description 12
- 210000004102 animal cell Anatomy 0.000 claims abstract description 10
- 239000011324 bead Substances 0.000 claims abstract description 8
- 102000008186 Collagen Human genes 0.000 claims abstract description 7
- 108010035532 Collagen Proteins 0.000 claims abstract description 7
- 239000005662 Paraffin oil Substances 0.000 claims abstract description 7
- 229920001436 collagen Polymers 0.000 claims abstract description 7
- 229960005188 collagen Drugs 0.000 claims abstract description 7
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 5
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 5
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 5
- 229920001817 Agar Polymers 0.000 claims abstract description 4
- 241000894006 Bacteria Species 0.000 claims abstract description 4
- 241000195493 Cryptophyta Species 0.000 claims abstract description 4
- 239000008272 agar Substances 0.000 claims abstract description 4
- 239000000679 carrageenan Substances 0.000 claims abstract description 4
- 229920001525 carrageenan Polymers 0.000 claims abstract description 4
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 4
- 229940113118 carrageenan Drugs 0.000 claims abstract description 4
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims abstract description 3
- 230000000717 retained effect Effects 0.000 claims abstract description 3
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000007864 aqueous solution Substances 0.000 claims abstract 4
- 241000233866 Fungi Species 0.000 claims abstract 3
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 9
- 241000196324 Embryophyta Species 0.000 abstract description 5
- 239000002612 dispersion medium Substances 0.000 abstract description 4
- 235000012424 soybean oil Nutrition 0.000 abstract description 4
- 239000003549 soybean oil Substances 0.000 abstract description 4
- 108010010803 Gelatin Proteins 0.000 abstract description 3
- 239000008273 gelatin Substances 0.000 abstract description 3
- 229920000159 gelatin Polymers 0.000 abstract description 3
- 229940014259 gelatin Drugs 0.000 abstract description 3
- 235000019322 gelatine Nutrition 0.000 abstract description 3
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 3
- 238000005538 encapsulation Methods 0.000 abstract 2
- 229920001661 Chitosan Polymers 0.000 abstract 1
- 229940045110 chitosan Drugs 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 230000001419 dependent effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003855 balanced salt solution Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/07—Microporous membranes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Artificial Fish Reefs (AREA)
- Medicinal Preparation (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8201401A SE441009B (sv) | 1982-03-08 | 1982-03-08 | Sett att immobilisera levande biomaterial i perlformiga polymerer |
| DE8383900856T DE3375581D1 (en) | 1982-03-08 | 1983-03-08 | A method of immobilizing bio material in bead polymers |
| PCT/SE1983/000074 WO1983003102A1 (en) | 1982-03-08 | 1983-03-08 | A method of encapsulating bio material in bead polymers |
| EP83900856A EP0102985B1 (de) | 1982-03-08 | 1983-03-08 | Verfahren zum immobilisieren von biomaterial in kugelpolymeren |
| US06/552,044 US4647536A (en) | 1982-03-08 | 1983-03-08 | Method of encapsulating biomaterial in bead polymers |
| JP58500933A JPS59500350A (ja) | 1982-03-08 | 1983-03-08 | ビ−ドポリマ−による生物学的物質のカプセル化法 |
| AT83900856T ATE32348T1 (de) | 1982-03-08 | 1983-03-08 | Verfahren zum immobilisieren von biomaterial in kugelpolymeren. |
| DK5094/83A DK509483D0 (da) | 1982-03-08 | 1983-11-07 | Fremgangsmade til inkorporering af biomateriale i perleformige polymerer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8201401A SE441009B (sv) | 1982-03-08 | 1982-03-08 | Sett att immobilisera levande biomaterial i perlformiga polymerer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8201401L SE8201401L (sv) | 1983-09-09 |
| SE441009B true SE441009B (sv) | 1985-09-02 |
Family
ID=20346185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8201401A SE441009B (sv) | 1982-03-08 | 1982-03-08 | Sett att immobilisera levande biomaterial i perlformiga polymerer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4647536A (de) |
| EP (1) | EP0102985B1 (de) |
| JP (1) | JPS59500350A (de) |
| AT (1) | ATE32348T1 (de) |
| DE (1) | DE3375581D1 (de) |
| DK (1) | DK509483D0 (de) |
| SE (1) | SE441009B (de) |
| WO (1) | WO1983003102A1 (de) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4643968A (en) * | 1981-01-29 | 1987-02-17 | Massachusetts Institute Of Technology | Process for determining metabolism and growth of cells under various conditions |
| EP0129619B1 (de) * | 1983-06-22 | 1988-05-18 | The Stolle Research And Development Corporation | Eingekapselte Zellen, Verfahren zu deren Herstellung und ihre Verwendung |
| ATE69263T1 (de) * | 1984-09-21 | 1991-11-15 | Cernitin Sa | Lebende mikroorganismen enthaltendes fluessiges praeparat, verfahren zu dessen herstellung, lebende mikroorganismen enthaltendes pelletiertes produkt und verfahren zu dessen herstellung. |
| US5629191A (en) * | 1985-01-03 | 1997-05-13 | Integra Lifesciences Corporation | Method of making a porous matrix particle |
| US4871671A (en) * | 1985-04-29 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Immobilization of biological cells in polytetrafluoroethylene matrix |
| US4997443A (en) * | 1985-08-26 | 1991-03-05 | Hana Biologics, Inc. | Transplantable artificial tissue and process |
| GB8523327D0 (en) * | 1985-09-20 | 1985-10-23 | Atomic Energy Authority Uk | Cells |
| SE464816B (sv) * | 1985-10-15 | 1991-06-17 | Nilsson Kjell | Makroporoesa partiklar, foerfarande foer dess framstaellning och dess anvaendning |
| PT83746B (pt) * | 1985-11-15 | 1988-08-17 | Gist Brocades Nv | Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao |
| US5314814A (en) * | 1985-11-15 | 1994-05-24 | Gist-Brocades | Preparation of novel immobilized biocatalysts |
| EP0258441A4 (de) * | 1986-01-25 | 1988-06-27 | Nitta Gelatin Kk | Zuchtverfahren tierischer zellen in grossem umfang. |
| US4789545A (en) * | 1986-03-31 | 1988-12-06 | New York Blood Center, Inc. | Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof |
| US5560909A (en) * | 1986-06-03 | 1996-10-01 | Dowelanco | Insecticidal compositions and process for preparation thereof |
| JPH06104606B2 (ja) * | 1986-06-24 | 1994-12-21 | 森下仁丹株式会社 | 寒天皮膜カプセルを含有する化粧用組成物 |
| US5293838A (en) * | 1987-07-10 | 1994-03-15 | Joergensen Leif | Method and apparatus for incubating eggs and larvae of fish crustaceans and similar organisms |
| US5427935A (en) * | 1987-07-24 | 1995-06-27 | The Regents Of The University Of Michigan | Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| IL89243A (en) * | 1988-02-12 | 1993-05-13 | Harvard College | Polymer encapsulated bacterium containing insect toxin |
| DE68913890T2 (de) * | 1988-04-18 | 1994-08-04 | Nitta Gelatin Kk | Verfahren zur züchtung tierischer zellen in grossem massstab und verfahren zur herstellung von trägermaterial dafür. |
| US4959301A (en) * | 1988-04-22 | 1990-09-25 | Massachusetts Institute Of Technology | Process for rapidly enumerating viable entities |
| US5055390A (en) * | 1988-04-22 | 1991-10-08 | Massachusetts Institute Of Technology | Process for chemical manipulation of non-aqueous surrounded microdroplets |
| US5129877A (en) * | 1988-04-29 | 1992-07-14 | University Of Georgia Research Foundation, Inc. | Receptor-mediated delivery system |
| US5605835A (en) * | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
| HU202579B (en) * | 1988-07-27 | 1991-03-28 | Reanal Finomvegyszergyar | Process for closing in gel microorganisma or parts of microorganisma utilizable in fermentations |
| WO1990010063A1 (en) * | 1989-02-21 | 1990-09-07 | Biosys | Method and medium for packaging entomogenous nematodes |
| US5053332A (en) * | 1989-07-24 | 1991-10-01 | Cook Richard B | Agarose beads, preferably incorporating biological materials |
| WO1991001720A1 (en) * | 1989-08-07 | 1991-02-21 | Herman Wade Schlameus | Composition and method of promoting hard tissue healing |
| ZA907737B (en) * | 1989-09-29 | 1991-07-31 | Nisshin Oil Mills Ltd | Stable immunogen composition for oral administration |
| CA2083496A1 (en) * | 1990-06-13 | 1991-12-14 | Richard B. Provonchee | Fractionated agaroid compositions, their preparation, and use |
| US5178882A (en) * | 1990-06-22 | 1993-01-12 | The Regents Of The University Of California | Viral decoy vaccine |
| EP0546075A4 (en) * | 1990-08-29 | 1993-07-28 | Sterling Chaykin | Method and product for eliminating undesirable side effects of eating vegetables such as onion or garlic |
| US6007809A (en) * | 1990-08-29 | 1999-12-28 | Chaykin; Sterling | Method and product for eliminating undesirable side effects of eating vegetables such as onion or garlic |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
| FR2680005B1 (fr) * | 1991-08-01 | 1994-09-02 | Coletica | Utilisation de collagene comme support solide de fixation d'un capteur capable de reagir specifiquement avec un element a detecter dans un milieu biologique, reactif et procede de mise en óoeuvre. |
| US5648208A (en) * | 1991-08-01 | 1997-07-15 | Coletica | Use of a collagen as solid binding substrate for a ligand capable of reacting specifically with an element to be detected in a biological medium, reactant and implementation |
| IL100096A (en) * | 1991-11-20 | 1996-03-31 | Univ Ramot | Method for entrapment of active materials in chitosan |
| US5170744A (en) * | 1991-12-13 | 1992-12-15 | Biosys Corporation | Long-term storage of infective juvenile nematodes in pseudoplastic layers |
| US5496728A (en) * | 1991-12-13 | 1996-03-05 | The Procter & Gamble Company | Encapsulation of liquids in micro-organisms |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| AU4402793A (en) * | 1992-05-29 | 1993-12-30 | Regents Of The University Of California, The | Coated transplant and method for making same |
| AU4693093A (en) * | 1992-07-27 | 1994-02-14 | Haemacure Biotech Inc. | Biocompatible surgical implant |
| US5871985A (en) * | 1992-09-28 | 1999-02-16 | Brown University Research Foundation | Particulate non cross-linked chitosan core matrices for encapsulated cells |
| GB9310557D0 (en) * | 1993-05-21 | 1993-07-07 | Smithkline Beecham Plc | Novel process and apparatus |
| US5965149A (en) * | 1993-08-13 | 1999-10-12 | Thermo Trilogy Corporation | Granular formulation of biological entities with improved storage stability |
| US5718969A (en) * | 1993-08-25 | 1998-02-17 | Fmc Corporation | Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation |
| US5453368A (en) * | 1993-08-27 | 1995-09-26 | Brown University Research Foundation | Method of encapsulating biological substances in microspheres |
| SG47996A1 (en) * | 1993-12-30 | 1998-04-17 | Nitta Gelatin Kk | Method for culturing animal cells under embedded conditions |
| RU2208636C2 (ru) * | 1994-01-13 | 2003-07-20 | Дзе Рогозин Институт | Макрогранула с секреторными клетками, способ ее получения и способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток |
| USRE39542E1 (en) * | 1994-01-13 | 2007-04-03 | The Rogosin Institute | Preparation of agarose coated, solid agarose-collagen beads containing secretory cells |
| CA2133789A1 (en) * | 1994-10-06 | 1996-04-07 | Ronald James Neufeld | Immobilized-cell carrageenan bead production and a brewing process utilizing carrageenan bead immobilized yeast cells |
| US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
| US5658588A (en) * | 1995-03-31 | 1997-08-19 | University Of Cincinnati | Fibrinogen-coated liposomes |
| US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| US5744337A (en) * | 1995-12-26 | 1998-04-28 | The United States Of America As Represented By The Secretary Of The Navy | Internal gelation method for forming multilayer microspheres and product thereof |
| JPH11508477A (ja) * | 1996-02-23 | 1999-07-27 | サーシ・バイオメディカル・インコーポレーテッド | 新規の人工膵臓 |
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| US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
| PT914043E (pt) * | 1996-04-03 | 2004-02-27 | Rogosin Inst | Perolas de agarose-colagenio implantaveis contendo celulas que produzem um produto biologico difusivel e suas utilizacoes |
| US6224912B1 (en) | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
| US7297331B2 (en) * | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
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| US20030054543A1 (en) * | 1997-06-16 | 2003-03-20 | Lafferty William Michael | Device for moving a selected station of a holding plate to a predetermined location for interaction with a probe |
| US20020102598A1 (en) * | 1997-06-16 | 2002-08-01 | Lafferty William Michael | Positioning system for moving a selected station of a holding plate to a predetermined location for interaction with a probe |
| US20050070005A1 (en) * | 1997-06-16 | 2005-03-31 | Martin Keller | High throughput or capillary-based screening for a bioactivity or biomolecule |
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| US6248321B1 (en) * | 1999-01-14 | 2001-06-19 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service | Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size |
| US6333194B1 (en) | 1999-01-19 | 2001-12-25 | The Children's Hospital Of Philadelphia | Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof |
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| AU1375301A (en) * | 1999-11-15 | 2001-05-30 | Bio Syntech Canada Inc | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789195A (fr) * | 1971-09-24 | 1973-03-22 | Gist Brocades Nv | Compositions d'enzymes |
| SE393115B (sv) * | 1972-04-07 | 1977-05-02 | K Mosbach | Sett att immobilisera enzymer genom inneslutning i polymernetverk med hjelp av perlpolymerisationsprocessen |
| JPS5312994B2 (de) * | 1974-06-15 | 1978-05-06 | ||
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| US4169804A (en) * | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
| DE2805607C3 (de) * | 1978-02-10 | 1980-08-28 | 3300 Braunschweig | Herstellung von Bio-Katalysatoren durch Polymereinschluß von Mikroorganismen |
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| US4353888A (en) * | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4518693A (en) * | 1982-11-01 | 1985-05-21 | Research Corporation | Immobilized biocatalysts |
-
1982
- 1982-03-08 SE SE8201401A patent/SE441009B/sv not_active IP Right Cessation
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1983
- 1983-03-08 EP EP83900856A patent/EP0102985B1/de not_active Expired
- 1983-03-08 AT AT83900856T patent/ATE32348T1/de not_active IP Right Cessation
- 1983-03-08 WO PCT/SE1983/000074 patent/WO1983003102A1/en not_active Ceased
- 1983-03-08 DE DE8383900856T patent/DE3375581D1/de not_active Expired
- 1983-03-08 JP JP58500933A patent/JPS59500350A/ja active Pending
- 1983-03-08 US US06/552,044 patent/US4647536A/en not_active Expired - Lifetime
- 1983-11-07 DK DK5094/83A patent/DK509483D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0102985B1 (de) | 1988-02-03 |
| DK509483A (da) | 1983-11-07 |
| WO1983003102A1 (en) | 1983-09-15 |
| JPS59500350A (ja) | 1984-03-08 |
| DK509483D0 (da) | 1983-11-07 |
| SE8201401L (sv) | 1983-09-09 |
| EP0102985A1 (de) | 1984-03-21 |
| US4647536A (en) | 1987-03-03 |
| DE3375581D1 (en) | 1988-03-10 |
| ATE32348T1 (de) | 1988-02-15 |
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