SE462779B - Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat - Google Patents

Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat

Info

Publication number: SE462779B
Authority: SE; Sweden
Prior art keywords: acetylcysteine; coated; pharmaceutical composition; composition containing; amount
Prior art date: 1988-10-10

Application number

SE8803583A

Other languages

English (en)

Swedish (sv)

Other versions

SE8803583L (sv

SE8803583D0 (sv

Inventor

C H Appelgren

E C Eskilsson

U G Smith

Original Assignee

Lejus Medical Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-10

Filing date

1988-10-10

Publication date

1990-09-03

1988-10-10 Application filed by Lejus Medical Ab filed Critical Lejus Medical Ab

1988-10-10 Priority to SE8803583A priority Critical patent/SE462779B/sv

1988-10-10 Publication of SE8803583D0 publication Critical patent/SE8803583D0/xx

1988-10-14 Priority to US07/258,255 priority patent/US4968506A/en

1990-04-06 Priority to EP90850133A priority patent/EP0451431A1/fr

1990-04-11 Publication of SE8803583L publication Critical patent/SE8803583L/

1990-09-03 Publication of SE462779B publication Critical patent/SE462779B/sv

Links

PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title claims description 45
239000008194 pharmaceutical composition Substances 0.000 title claims 2
229920002678 cellulose Polymers 0.000 title 1
229960004308 acetylcysteine Drugs 0.000 claims description 37
239000000203 mixture Substances 0.000 claims description 26
239000008363 phosphate buffer Substances 0.000 claims description 5
210000004051 gastric juice Anatomy 0.000 claims description 3
235000011389 fruit/vegetable juice Nutrition 0.000 claims description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
229960000541 cetyl alcohol Drugs 0.000 description 13
239000008187 granular material Substances 0.000 description 13
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 13
239000011248 coating agent Substances 0.000 description 9
238000000576 coating method Methods 0.000 description 9
239000003826 tablet Substances 0.000 description 7
229920006318 anionic polymer Polymers 0.000 description 5
239000013563 matrix tablet Substances 0.000 description 5
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 4
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
235000021355 Stearic acid Nutrition 0.000 description 3
239000007938 effervescent tablet Substances 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
239000006187 pill Substances 0.000 description 3
239000008117 stearic acid Substances 0.000 description 3
210000002784 stomach Anatomy 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
210000004211 gastric acid Anatomy 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
241000509579 Draco Species 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229910052626 biotite Inorganic materials 0.000 description 1
230000037058 blood plasma level Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000007931 coated granule Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
210000001156 gastric mucosa Anatomy 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
-1 methyl methacrylate methyl esters Chemical class 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940071138 stearyl fumarate Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
150000005691 triesters Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

SE8803583A 1988-10-10 1988-10-10 Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat SE462779B (sv)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
SE8803583A SE462779B (sv)	1988-10-10	1988-10-10	Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat
US07/258,255 US4968506A (en)	1988-10-10	1988-10-14	Pharmaceutical dosage with core of N-acetyl cystein
EP90850133A EP0451431A1 (fr)	1988-10-10	1990-04-06	Composition pharmaceutique

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8803583A SE462779B (sv)	1988-10-10	1988-10-10	Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat

Publications (3)

Publication Number	Publication Date
SE8803583D0 SE8803583D0 (sv)	1988-10-10
SE8803583L SE8803583L (sv)	1990-04-11
SE462779B true SE462779B (sv)	1990-09-03

Family

ID=20373568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8803583A SE462779B (sv)	1988-10-10	1988-10-10	Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat

Country Status (3)

Country	Link
US (1)	US4968506A (fr)
EP (1)	EP0451431A1 (fr)
SE (1)	SE462779B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5350741A (en) *	1988-07-30	1994-09-27	Kanji Takada	Enteric formulations of physiologically active peptides and proteins
US5580577A (en) *	1990-01-11	1996-12-03	Herzenberg; Leonard A.	Method of treating the symptoms of human rhinovirus infection
DK0481294T4 (da) *	1990-10-19	2001-06-18	Spirig Ag	Fast, hurtigt-opløseligt lægemiddelpræparat indeholdende N-acetylcystein
EP1609468A3 (fr) *	2000-11-22	2006-01-25	Rxkinetix, Inc.	Une composition sur la base d'un antioxydant contenant du soufre et son utilisation pour la production d'un médicament pour le traitement de la mucosite
US6623754B2 (en) *	2001-05-21	2003-09-23	Noveon Ip Holdings Corp.	Dosage form of N-acetyl cysteine
US20050118261A1 (en) *	2003-06-12	2005-06-02	Oien Hal J.	Compositions and methods of administering doxepin to mucosal tissue
US20050089502A1 (en) *	2003-08-21	2005-04-28	Todd Schansberg	Effervescent delivery system
CA2635603C (fr) *	2005-11-30	2016-01-19	Endo Pharmaceuticals Inc.	Traitement de la xerostomie
FI20060501A7 (fi) *	2006-05-22	2007-11-23	Biohit Oyj	Koostumus ja menetelmä asetaldehydin sitomiseksi mahalaukussa
US20100120776A1 (en) *	2008-11-12	2010-05-13	Hall Bioscience Corporation	Carbocysteine medical foods
CN110292569B (zh) *	2019-07-15	2021-11-02	广东人人康药业有限公司	一种乙酰半胱氨酸胶囊及其制备方法
CN113750052B (zh) *	2021-10-19	2022-11-18	桂林华信制药有限公司	一种乙酰半胱氨酸颗粒及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4499103A (en) *	1983-03-17	1985-02-12	Merck & Co., Inc.	Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure
AU574360B2 (en) *	1983-05-13	1988-07-07	Reichert, D.	Antisnoring agent
JPS6064912A (ja) *	1983-09-20	1985-04-13	Shiseido Co Ltd	パ−マネントウェ−ブ用剤第２剤
IT1170268B (it) *	1983-12-21	1987-06-03	Zambon Spa	Uso dell'acetilcisteina per ridurre l'incremento della prolieferazione delle cellule basali dell'epitelio respiratoriotracheo-bronchiale indotto dal fumo di tabacco nei mammiferi
US4767627A (en) *	1985-05-29	1988-08-30	Merck & Co., Inc.	Drug delivery device which can be retained in the stomach for a controlled period of time
CH667590A5 (it) *	1986-07-24	1988-10-31	Inpharzam Int Sa	Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. .
SE463674B (sv) *	1987-01-15	1991-01-07	Lejus Medical Ab	Foerfarande foer behandling i fluidiserad baedd av amfotaera aminosyror och amfotaera derivat av aminosyror

1988
- 1988-10-10 SE SE8803583A patent/SE462779B/sv not_active IP Right Cessation
- 1988-10-14 US US07/258,255 patent/US4968506A/en not_active Expired - Fee Related
1990
- 1990-04-06 EP EP90850133A patent/EP0451431A1/fr not_active Withdrawn

Also Published As

Publication number	Publication date
SE8803583L (sv)	1990-04-11
EP0451431A1 (fr)	1991-10-16
SE8803583D0 (sv)	1988-10-10
US4968506A (en)	1990-11-06

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

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Effective date: 19920510

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