SE464135B - Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov - Google Patents

Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Info

Publication number: SE464135B
Authority: SE; Sweden
Prior art keywords: protein; thrombin; coagulation; plasma; fixa
Prior art date: 1989-07-14

Application number

SE8902532A

Other languages

English (en)

Swedish (sv)

Other versions

SE8902532D0 (sv

SE8902532L (sv

Inventor

S Rosen

Original Assignee

Kabivitrum Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-14

Filing date

1989-07-14

Publication date

1991-03-11

1989-07-14 Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab

1989-07-14 Priority to SE8902532A priority Critical patent/SE464135B/sv

1989-07-14 Publication of SE8902532D0 publication Critical patent/SE8902532D0/xx

1990-07-04 Priority to DE69022425T priority patent/DE69022425T2/de

1990-07-04 Priority to IE243190A priority patent/IE902431A1/en

1990-07-04 Priority to DK90910954.8T priority patent/DK0486515T3/da

1990-07-04 Priority to US07/793,342 priority patent/US5439802A/en

1990-07-04 Priority to AU60533/90A priority patent/AU6053390A/en

1990-07-04 Priority to ES90910954T priority patent/ES2079481T3/es

1990-07-04 Priority to AT90910954T priority patent/ATE127853T1/de

1990-07-04 Priority to CA002063564A priority patent/CA2063564A1/en

1990-07-04 Priority to JP2510438A priority patent/JP2892828B2/ja

1990-07-04 Priority to EP90910954A priority patent/EP0486515B1/de

1990-07-04 Priority to PCT/SE1990/000478 priority patent/WO1991001382A1/en

1991-01-15 Publication of SE8902532L publication Critical patent/SE8902532L/

1991-03-11 Publication of SE464135B publication Critical patent/SE464135B/sv

1992-01-09 Priority to NO92920125A priority patent/NO920125L/no

Links

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Classifications

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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
- G01N2333/4613—Snake venom
- G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
- G01N2333/4626—Snake venom from Agkistrodon sp., e.g. acutase, ACTE from Agkistrodon contortrix contortrix (copperhead snake); Protac (R)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/9645—Factor IX (3.4.21.22)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
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Microbiology (AREA)
Neurosurgery (AREA)
Biotechnology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Hematology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

SE8902532A 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov SE464135B (sv)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
SE8902532A SE464135B (sv)	1989-07-14	1989-07-14	Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
PCT/SE1990/000478 WO1991001382A1 (en)	1989-07-14	1990-07-04	A method for determining the functional activity of free protein s or protein c in a plasma sample
ES90910954T ES2079481T3 (es)	1989-07-14	1990-07-04	Un procedimiento para la determinacion de la actividad funcional de la proteina s o de la proteina c libre en una muestra de plasma.
CA002063564A CA2063564A1 (en)	1989-07-14	1990-07-04	Method for determining the functional activity of free protein s or protein c in a plasma sample
DK90910954.8T DK0486515T3 (da)	1989-07-14	1990-07-04	Fremgangsmåde til bestemmelse af den funktionelle aktivitet af frit protein S eller protein C i en plasmaprøve
US07/793,342 US5439802A (en)	1989-07-14	1990-07-04	Method for determining the functional activity of free protein S or protein C in a plasma sample
AU60533/90A AU6053390A (en)	1989-07-14	1990-07-04	A method for determining the functional activity of free protein s or protein c in a plasma sample
DE69022425T DE69022425T2 (de)	1989-07-14	1990-07-04	Verfahren zur Bestimmung der funktionellen Wirkung von freiem Protein S oder Protein C in einer Plasmaprobe.
AT90910954T ATE127853T1 (de)	1989-07-14	1990-07-04	Verfahren zur bestimmung der funktionellen wirkung von freiem protein s oder protein c in einer plasmaprobe.
IE243190A IE902431A1 (en)	1989-07-14	1990-07-04	Assaying of plasma proteins
JP2510438A JP2892828B2 (ja)	1989-07-14	1990-07-04	血漿プロテインの検定方法
EP90910954A EP0486515B1 (de)	1989-07-14	1990-07-04	Verfahren zur Bestimmung der funktionellen Wirkung von freiem Protein S oder Protein C in einer Plasmaprobe
NO92920125A NO920125L (no)	1989-07-14	1992-01-09	Fremgangsmaate for aa bestemme den funksjonelle aktivitetentil fritt protein s eller protein c i en plasmaproeve

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8902532A SE464135B (sv)	1989-07-14	1989-07-14	Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Publications (3)

Publication Number	Publication Date
SE8902532D0 SE8902532D0 (sv)	1989-07-14
SE8902532L SE8902532L (sv)	1991-01-15
SE464135B true SE464135B (sv)	1991-03-11

Family

ID=20376547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8902532A SE464135B (sv)	1989-07-14	1989-07-14	Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Country Status (13)

Country	Link
US (1)	US5439802A (de)
EP (1)	EP0486515B1 (de)
JP (1)	JP2892828B2 (de)
AT (1)	ATE127853T1 (de)
AU (1)	AU6053390A (de)
CA (1)	CA2063564A1 (de)
DE (1)	DE69022425T2 (de)
DK (1)	DK0486515T3 (de)
ES (1)	ES2079481T3 (de)
IE (1)	IE902431A1 (de)
NO (1)	NO920125L (de)
SE (1)	SE464135B (de)
WO (1)	WO1991001382A1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993010261A1 (en) *	1991-11-13	1993-05-27	Dahlbaeck Bjoern	Method for the diagnosis of blood coagulation disorders
US5443960A (en) *	1991-11-13	1995-08-22	Dahlbaeck; Bjoern	Method for the diagnosis of blood coagulation disorders
WO1996014581A1 (en) *	1994-11-08	1996-05-17	Global Hemostasis Institute Mgr Ab	Method, reagent and kit for analysis of haemostatic activity
WO1998044000A1 (en) *	1997-04-03	1998-10-08	T.A.C. Thrombosis And Coagulation Aktiebolag	Recombinant protein c and protein s variants

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4006634A1 (de) *	1990-03-03	1991-09-05	Behringwerke Ag	Funktioneller test zur bestimmung der protein s-aktivitaet
AU663343B2 (en) *	1991-10-04	1995-10-05	Dade Behring Inc.	Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids
US5716795A (en) *	1991-10-04	1998-02-10	Matschiner; John T.	Thrombomodulin-based coagulometric assay of the protein C system
AU2870992A (en) *	1991-10-04	1993-05-03	Board Of Regents Of The University Of Nebraska, The	A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
US5308756A (en) *	1991-11-20	1994-05-03	Baxter Diagnostics Inc.	Protein S chromogenic assay
DE4229933A1 (de) *	1992-09-08	1994-03-10	Max Planck Gesellschaft	Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern
US7169572B1 (en) *	1993-01-29	2007-01-30	T.A.C. Thrombosis And Coagulation Ab	Assays for determining anticoagulant cofactor activity
CA2137041C (en) *	1993-12-03	2003-06-10	Katalin Varadi	Assay for determining sensitivity to activated protein c
AUPM731394A0 (en) *	1994-08-05	1994-09-01	Life Therapeutics Limited	Improved activated protein c resistance test
DE4427785A1 (de) *	1994-08-08	1996-02-15	Behringwerke Ag	Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
US5780255A (en) *	1995-06-09	1998-07-14	Instrumentation Laboratory, S.P.A.	Protein C pathway screening test
US5766869A (en) *	1995-11-30	1998-06-16	Ahs Hospital Corp.	Factor V ratio blood test for susceptibility to thromboembolism
US6379975B1 (en)	1996-11-27	2002-04-30	T.A.C. Thrombosis And Coagulation Aktiebolag	Methods and reagents for determining protein S
AUPP159698A0 (en) *	1998-02-02	1998-02-26	Life Therapeutics Limited	Improved blood coagulation test
DK0947585T3 (da) *	1998-03-19	2001-10-01	Instrumentation Lab Spa	Forbedret in vitro-fremgangsmåde, kits og reagenser til screening for blodkoagulationsdefekter
US6855509B2 (en)	2000-12-19	2005-02-15	Instrumentation Laboratory Company	Protein S functional assay and kit therefor
RU2270020C2 (ru) *	2004-04-20	2006-02-20	Государственное учреждение Кировский научно-исследовательский институт гематологии и переливания крови (ГУ Книги ПК)	Способ получения контрольной плазмы с нормальным уровнем протромбинового комплекса
JP5839256B2 (ja)	2011-03-14	2016-01-06	学校法人九州文化学園	総プロテインｓ異常症の検出方法において用いる試薬
CN106153612A (zh) *	2015-12-04	2016-11-23	上海贞元诊断用品科技有限公司	抗凝血酶活性检测试剂及其制备方法和应用
CN120761656A (zh) *	2025-09-03	2025-10-10	湖南赛新生物科技有限公司	一种高稳定性蛋白s活性测定试剂盒及其制备方法

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Publication number	Priority date	Publication date	Assignee	Title
US4657894A (en) *	1983-03-31	1987-04-14	Scripps Clinic & Research Foundation	New factor VIII coagulant polypeptides
DE3516579A1 (de) *	1984-11-19	1986-05-22	Boehringer Mannheim Gmbh, 6800 Mannheim	Gerinnungstest auf teststreifen
US4775624A (en) *	1985-02-08	1988-10-04	Eli Lilly And Company	Vectors and compounds for expression of human protein C
DE3607559A1 (de) *	1986-03-07	1987-09-10	Boehringer Mannheim Gmbh	Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US4908314A (en) *	1987-07-02	1990-03-13	American National Red Cross	Protein C activator
DE3724443A1 (de) *	1987-07-23	1989-02-02	Max Planck Gesellschaft	Funktioneller test zur bestimmung der protein s-aktivitaet
JP2739050B2 (ja) *	1988-01-28	1998-04-08	ヘキスト薬品工業株式会社	抗血液凝固剤
US5051357A (en) *	1989-07-14	1991-09-24	Board Of Trustees Operating Michigan State University	Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor

1989
- 1989-07-14 SE SE8902532A patent/SE464135B/sv not_active IP Right Cessation
1990
- 1990-07-04 IE IE243190A patent/IE902431A1/en unknown
- 1990-07-04 WO PCT/SE1990/000478 patent/WO1991001382A1/en not_active Ceased
- 1990-07-04 EP EP90910954A patent/EP0486515B1/de not_active Expired - Lifetime
- 1990-07-04 AU AU60533/90A patent/AU6053390A/en not_active Abandoned
- 1990-07-04 JP JP2510438A patent/JP2892828B2/ja not_active Expired - Fee Related
- 1990-07-04 US US07/793,342 patent/US5439802A/en not_active Expired - Fee Related
- 1990-07-04 DE DE69022425T patent/DE69022425T2/de not_active Expired - Fee Related
- 1990-07-04 DK DK90910954.8T patent/DK0486515T3/da active
- 1990-07-04 CA CA002063564A patent/CA2063564A1/en not_active Abandoned
- 1990-07-04 ES ES90910954T patent/ES2079481T3/es not_active Expired - Lifetime
- 1990-07-04 AT AT90910954T patent/ATE127853T1/de not_active IP Right Cessation
1992
- 1992-01-09 NO NO92920125A patent/NO920125L/no unknown

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993010261A1 (en) *	1991-11-13	1993-05-27	Dahlbaeck Bjoern	Method for the diagnosis of blood coagulation disorders
US5443960A (en) *	1991-11-13	1995-08-22	Dahlbaeck; Bjoern	Method for the diagnosis of blood coagulation disorders
WO1996014581A1 (en) *	1994-11-08	1996-05-17	Global Hemostasis Institute Mgr Ab	Method, reagent and kit for analysis of haemostatic activity
US6156530A (en) *	1994-11-08	2000-12-05	Global Hemostasis Institute Mgr Ab	Method for analysis of haemostatic activity
WO1998044000A1 (en) *	1997-04-03	1998-10-08	T.A.C. Thrombosis And Coagulation Aktiebolag	Recombinant protein c and protein s variants

Also Published As

Publication number	Publication date
DE69022425D1 (de)	1995-10-19
SE8902532D0 (sv)	1989-07-14
IE902431A1 (en)	1991-06-19
US5439802A (en)	1995-08-08
NO920125D0 (no)	1992-01-09
EP0486515A1 (de)	1992-05-27
ATE127853T1 (de)	1995-09-15
SE8902532L (sv)	1991-01-15
JP2892828B2 (ja)	1999-05-17
NO920125L (no)	1992-01-09
WO1991001382A1 (en)	1991-02-07
CA2063564A1 (en)	1991-01-15
JPH04506603A (ja)	1992-11-19
AU6053390A (en)	1991-02-22
DE69022425T2 (de)	1996-05-02
DK0486515T3 (da)	1996-01-29
ES2079481T3 (es)	1996-01-16
EP0486515B1 (de)	1995-09-13

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Martinoli et al.	1986	Fast functional protein C assay using protac® a novel protein C activator
EP0486515B1 (de)	1995-09-13	Verfahren zur Bestimmung der funktionellen Wirkung von freiem Protein S oder Protein C in einer Plasmaprobe
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