SE503876C2 - Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen - Google Patents

Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen

Info

Publication number: SE503876C2
Authority: SE; Sweden
Prior art keywords: intestinal; lumen; patients; sample; levels
Prior art date: 1994-11-30

Application number

SE9404161A

Other languages

English (en)

Swedish (sv)

Other versions

SE9404161D0 (sv

SE9404161L (sv

Inventor

Kjell Alving

Edward Weitzberg

Jan Lundberg

Jon Lundberg

Original Assignee

Kjell Alving

Edward Weitzberg

Jan Lundberg

Jon Lundberg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-30

Filing date

1994-11-30

Publication date

1996-09-23

1994-11-30 Application filed by Kjell Alving, Edward Weitzberg, Jan Lundberg, Jon Lundberg filed Critical Kjell Alving

1994-11-30 Priority to SE9404161A priority Critical patent/SE503876C2/sv

1994-11-30 Publication of SE9404161D0 publication Critical patent/SE9404161D0/xx

1995-11-29 Priority to DE69516172T priority patent/DE69516172T2/de

1995-11-29 Priority to EP95939469A priority patent/EP0795130B1/de

1995-11-29 Priority to ES95939469T priority patent/ES2147308T3/es

1995-11-29 Priority to PCT/SE1995/001429 priority patent/WO1996017244A1/en

1995-11-29 Priority to US08/849,282 priority patent/US6063027A/en

1995-11-29 Priority to AU41273/96A priority patent/AU4127396A/en

1995-11-29 Priority to AT95939469T priority patent/ATE191563T1/de

1995-11-29 Priority to DK95939469T priority patent/DK0795130T3/da

1995-11-29 Priority to JP51867796A priority patent/JP3377005B2/ja

1996-05-31 Publication of SE9404161L publication Critical patent/SE9404161L/

1996-09-23 Publication of SE503876C2 publication Critical patent/SE503876C2/sv

1999-03-22 Priority to US09/273,514 priority patent/US6183416B1/en

2000-06-27 Priority to GR20000401484T priority patent/GR3033785T3/el

Links

230000000968 intestinal effect Effects 0.000 title claims abstract description 22
230000004968 inflammatory condition Effects 0.000 title claims abstract description 7
210000001035 gastrointestinal tract Anatomy 0.000 title claims 2
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title description 5
238000001514 detection method Methods 0.000 title description 2
238000000034 method Methods 0.000 claims abstract description 22
210000000936 intestine Anatomy 0.000 claims abstract description 11
206010009900 Colitis ulcerative Diseases 0.000 claims description 17
201000006704 Ulcerative Colitis Diseases 0.000 claims description 14
210000001072 colon Anatomy 0.000 claims description 14
208000011231 Crohn disease Diseases 0.000 claims description 6
238000003745 diagnosis Methods 0.000 abstract 1
239000007789 gas Substances 0.000 description 20
238000004519 manufacturing process Methods 0.000 description 15
210000000664 rectum Anatomy 0.000 description 10
210000004347 intestinal mucosa Anatomy 0.000 description 8
238000005259 measurement Methods 0.000 description 7
238000002052 colonoscopy Methods 0.000 description 6
150000003873 salicylate salts Chemical class 0.000 description 6
238000005070 sampling Methods 0.000 description 6
208000022559 Inflammatory bowel disease Diseases 0.000 description 5
102000008299 Nitric Oxide Synthase Human genes 0.000 description 5
108010021487 Nitric Oxide Synthase Proteins 0.000 description 5
201000010099 disease Diseases 0.000 description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 4
210000004877 mucosa Anatomy 0.000 description 4
229910002651 NO3 Inorganic materials 0.000 description 3
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 3
102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 3
101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 3
230000001154 acute effect Effects 0.000 description 3
239000003570 air Substances 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
238000001574 biopsy Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
210000001815 ascending colon Anatomy 0.000 description 2
239000003246 corticosteroid Substances 0.000 description 2
229960001334 corticosteroids Drugs 0.000 description 2
210000001731 descending colon Anatomy 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
241000283707 Capra Species 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
238000000585 Mann–Whitney U test Methods 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
230000009798 acute exacerbation Effects 0.000 description 1
239000012080 ambient air Substances 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
235000013305 food Nutrition 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
238000002991 immunohistochemical analysis Methods 0.000 description 1
238000012151 immunohistochemical method Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000028774 intestinal disease Diseases 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000002547 new drug Substances 0.000 description 1
229940124624 oral corticosteroid Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
210000003384 transverse colon Anatomy 0.000 description 1
238000012800 visualization Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B2010/0083—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements for taking gas samples
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173076—Nitrite or nitrate

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Surgery (AREA)
Engineering & Computer Science (AREA)
Pathology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Control Of Stepping Motors (AREA)
Electrotherapy Devices (AREA)
Apparatus For Radiation Diagnosis (AREA)
Measuring And Recording Apparatus For Diagnosis (AREA)

SE9404161A 1994-11-30 1994-11-30 Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen SE503876C2 (sv)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
SE9404161A SE503876C2 (sv)	1994-11-30	1994-11-30	Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen
JP51867796A JP3377005B2 (ja)	1994-11-30	1995-11-29	腸の炎症状態を診断する方法
AU41273/96A AU4127396A (en)	1994-11-30	1995-11-29	Diagnostic method for inflammatory conditions in the intestines
EP95939469A EP0795130B1 (de)	1994-11-30	1995-11-29	Diagnostisches verfahren für darmentzündungszustände
ES95939469T ES2147308T3 (es)	1994-11-30	1995-11-29	Metodo para diagnosticar los trastornos inflamatorios del intestino.
PCT/SE1995/001429 WO1996017244A1 (en)	1994-11-30	1995-11-29	Diagnostic method for inflammatory conditions in the intestines
US08/849,282 US6063027A (en)	1994-11-30	1995-11-29	Diagnostic method for inflammatory conditions in the intestines
DE69516172T DE69516172T2 (de)	1994-11-30	1995-11-29	Diagnostisches verfahren für darmentzündungszustände
AT95939469T ATE191563T1 (de)	1994-11-30	1995-11-29	Diagnostisches verfahren für darmentzündungszustände
DK95939469T DK0795130T3 (da)	1994-11-30	1995-11-29	Diagnostisk metode ved inflammatoriske tilstande i tarmene
US09/273,514 US6183416B1 (en)	1994-11-30	1999-03-22	Diagnostic method for inflammatory conditions in the intestines
GR20000401484T GR3033785T3 (en)	1994-11-30	2000-06-27	Diagnostic method for inflammatory conditions in the intestines

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9404161A SE503876C2 (sv)	1994-11-30	1994-11-30	Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen

Publications (3)

Publication Number	Publication Date
SE9404161D0 SE9404161D0 (sv)	1994-11-30
SE9404161L SE9404161L (sv)	1996-05-31
SE503876C2 true SE503876C2 (sv)	1996-09-23

Family

ID=20396176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9404161A SE503876C2 (sv)	1994-11-30	1994-11-30	Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen

Country Status (11)

Country	Link
US (2)	US6063027A (de)
EP (1)	EP0795130B1 (de)
JP (1)	JP3377005B2 (de)
AT (1)	ATE191563T1 (de)
AU (1)	AU4127396A (de)
DE (1)	DE69516172T2 (de)
DK (1)	DK0795130T3 (de)
ES (1)	ES2147308T3 (de)
GR (1)	GR3033785T3 (de)
SE (1)	SE503876C2 (de)
WO (1)	WO1996017244A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9701009D0 (sv) *	1997-03-16	1997-03-16	Anders Pettersson	Method and technique to obtain regionally representative gaseous samples from the human gastrointestinal tract used in the diagnosis of gastrointestinal disease
US6511425B1 (en)	1997-05-30	2003-01-28	Aerocrine Ab	Method for the diagnosis of food intolerance
US6612306B1 (en)	1999-10-13	2003-09-02	Healthetech, Inc.	Respiratory nitric oxide meter
SE9903885D0 (sv)	1999-10-26	1999-10-26	Diabact Ab	Förfarande och medel för påvisning av inflammatoriska processer
AU1907201A (en) *	1999-11-16	2001-05-30	Aerocrine Ab	Method for use in the diagnosis of food allergies and/or food intolerances
WO2002020005A1 (en) *	2000-09-06	2002-03-14	Norgine Europe B.V.	Use of arginine in endoscopy and other medical procedures
AU2001296456A1 (en)	2000-09-29	2002-04-08	Healthetech, Inc.	Indirect calorimetry system
DE10065081A1 (de) *	2000-12-23	2002-07-11	It Dr Gambert Gmbh	Vorrichtung zur Bestimmung der Konzentration von Stickstoffmonoxid im Intestinaltrakt von Mensch oder Tier
IL140949A0 (en) *	2001-01-17	2002-02-10	Yeda Res & Dev	Nitric oxide (no) detector
US20060036138A1 (en) *	2004-08-06	2006-02-16	Adam Heller	Devices and methods of screening for neoplastic and inflammatory disease
JP2009533682A (ja) *	2006-04-14	2009-09-17	セラマテック・インク	呼気中の窒素酸化物を測定する装置および方法
EP2514473A1 (de) *	2006-11-07	2012-10-24	The General Hospital Corporation	Vorrichtung zur Zuführung von Stickoxid
JP6389125B2 (ja)	2011-11-07	2018-09-12	ザジェネラルホスピタルコーポレイション	赤血球の処理法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4412006A (en) *	1980-08-01	1983-10-25	University Of Iowa Research Foundation	Method for determination of nitrate and/or nitrite
SE455368B (sv) *	1986-11-11	1988-07-11	Roger Hellgren	Anordning for nedleggning i tunntarmen i och for intestinal aspiration/perfusion
SE465017B (sv) *	1989-11-24	1991-07-15	Lars Knutson	Anordning foer segmentell perfusion/aspiration av grovtarmen
SE9102812L (sv) *	1991-09-27	1993-01-18	Lars Erik Gustafsson	Saett att faststaella aktuell lungfunktion samt anordning foer att indikera naemnda lungfunktion
US5459076A (en) *	1992-04-22	1995-10-17	Brigham And Women's Hospital	Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems
JP3248533B2 (ja) *	1993-07-06	2002-01-21	アエロクライン・アクチボラゲット	呼気中のｎｏレベルの測定に使用されるシステムおよび異常ｎｏレベルに関連する疾患の診断方法
US5437292A (en) *	1993-11-19	1995-08-01	Bioseal, Llc	Method for sealing blood vessel puncture sites
US5767103A (en) *	1994-05-17	1998-06-16	Research Corporation Tech., Inc.	Nitric oxide sequestrant
US5756540A (en) *	1995-06-02	1998-05-26	Mcw Research Foundation, Inc.	Methods for in vivo reduction of nitric oxide levels and compositions useful therefor

1994
- 1994-11-30 SE SE9404161A patent/SE503876C2/sv not_active IP Right Cessation
1995
- 1995-11-29 AT AT95939469T patent/ATE191563T1/de not_active IP Right Cessation
- 1995-11-29 AU AU41273/96A patent/AU4127396A/en not_active Abandoned
- 1995-11-29 ES ES95939469T patent/ES2147308T3/es not_active Expired - Lifetime
- 1995-11-29 DE DE69516172T patent/DE69516172T2/de not_active Expired - Lifetime
- 1995-11-29 WO PCT/SE1995/001429 patent/WO1996017244A1/en not_active Ceased
- 1995-11-29 EP EP95939469A patent/EP0795130B1/de not_active Expired - Lifetime
- 1995-11-29 JP JP51867796A patent/JP3377005B2/ja not_active Expired - Fee Related
- 1995-11-29 US US08/849,282 patent/US6063027A/en not_active Expired - Fee Related
- 1995-11-29 DK DK95939469T patent/DK0795130T3/da active
1999
- 1999-03-22 US US09/273,514 patent/US6183416B1/en not_active Expired - Lifetime
2000
- 2000-06-27 GR GR20000401484T patent/GR3033785T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2147308T3 (es)	2000-09-01
GR3033785T3 (en)	2000-10-31
EP0795130B1 (de)	2000-04-05
ATE191563T1 (de)	2000-04-15
WO1996017244A1 (en)	1996-06-06
SE9404161D0 (sv)	1994-11-30
JPH10510052A (ja)	1998-09-29
DE69516172T2 (de)	2000-11-16
AU4127396A (en)	1996-06-19
US6063027A (en)	2000-05-16
EP0795130A1 (de)	1997-09-17
DK0795130T3 (da)	2000-07-24
JP3377005B2 (ja)	2003-02-17
DE69516172D1 (de)	2000-05-11
SE9404161L (sv)	1996-05-31
US6183416B1 (en)	2001-02-06

Legal Events

Date	Code	Title	Description
2003-07-29	NUG	Patent has lapsed

Publication	Publication Date	Title
Nehra et al.	1999	Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity
Kharitonov et al.	1997	Exhaled and nasal nitric oxide measurements: recommendations. The European respiratory society task force
Garay et al.	1979	A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients
SE503876C2 (sv)	1996-09-23	Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen
Nussbaum et al.	1987	Association of lipid-laden alveolar macrophages and gastroesophageal reflux in children
DuBois et al.	2005	Breath ammonia testing for diagnosis of hepatic encephalopathy
Kharitonov et al.	2002	Biomarkers of some pulmonary diseases in exhaled breath
Piqué et al.	1984	Methane production and colon cancer
EP4293358B1 (de)	2026-04-08	Flüchtige organische verbindungen als krebs biomarker
Bonetto et al.	2006	Longitudinal monitoring of lung injury in children after acute chlorine exposure in a swimming pool
Peters et al.	2017	Constipation-predominant irritable bowel syndrome females have normal colonic barrier and secretory function
Moloney et al.	2004	Exhaled breath condensate detects markers of pulmonary inflammation after cardiothoracic surgery
US6509169B2 (en)	2003-01-21	Detection of Helicobacter pylori
WO2002082977A2 (en)	2002-10-24	Breath test for assessing diseases, particularly asthma
Steerenberg et al.	1999	Increased exhaled nitric oxide on days with high outdoor air pollution is of endogenous origin
Jones	1995	Measuring ethanol in saliva with the QED® enzymatic test device: comparison of results with blood-and breath-alcohol concentrations
Olesen et al.	2003	Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis
Al-Bahrani et al.	2010	Gut barrier dysfunction in critically ill surgical patients with abdominal compartment syndrome
Yuan et al.	1999	Helicobacter pylori infection and risk of gastric cancer in Shanghai, China: updated results based upon a locally developed and validated assay and further follow-up of the cohort
Perkins et al.	2006	Role of nonbronchoscopic lavage for investigating alveolar inflammation and permeability in acute respiratory distress syndrome
WO2002006822A1 (en)	2002-01-24	Method for detection of helicobacter pylori and apparatus therefor
Tiankanon et al.	2024	Identification of breath volatile organic compounds to distinguish pancreatic adenocarcinoma, pancreatic cystic neoplasm, and patients without pancreatic lesions
US20080275355A1 (en)	2008-11-06	Method For Diagnosing An Infectioin Condition
Kochhar et al.	2017	Utility of biomarkers in the management of inflammatory bowel disease
Zagórska et al.	2014	Nitric oxide, IL‐6 and IL‐13 are increased in the exhaled breath condensates of children with allergic rhinitis