SE513358C2 - Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition - Google Patents

Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition

Info

Publication number
SE513358C2
SE513358C2 SE9102079A SE9102079A SE513358C2 SE 513358 C2 SE513358 C2 SE 513358C2 SE 9102079 A SE9102079 A SE 9102079A SE 9102079 A SE9102079 A SE 9102079A SE 513358 C2 SE513358 C2 SE 513358C2
Authority
SE
Sweden
Prior art keywords
cntf
dna
protein
sciatic nerve
expression
Prior art date
Application number
SE9102079A
Other languages
English (en)
Swedish (sv)
Other versions
SE9102079D0 (sv
SE9102079L (sv
Inventor
Franklin D Collins
Leu-Fen Lin
Drzislav Mismer
Christine Ko
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/293,851 external-priority patent/US5011914A/en
Priority claimed from US07/404,533 external-priority patent/US4997929A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SE9102079D0 publication Critical patent/SE9102079D0/xx
Publication of SE9102079L publication Critical patent/SE9102079L/
Publication of SE513358C2 publication Critical patent/SE513358C2/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SE9102079A 1989-01-05 1991-07-03 Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition SE513358C2 (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/293,851 US5011914A (en) 1989-01-05 1989-01-05 Purified ciliary neurotrophic factor
US07/404,533 US4997929A (en) 1989-01-05 1989-09-08 Purified ciliary neurotrophic factor
US07/458,564 US5141856A (en) 1989-01-05 1989-12-28 Expression of purified ciliary neurotrophic factor
PCT/US1990/000022 WO1990007341A1 (en) 1989-01-05 1990-01-05 Purified ciliary neurotrophic factor

Publications (3)

Publication Number Publication Date
SE9102079D0 SE9102079D0 (sv) 1991-07-03
SE9102079L SE9102079L (sv) 1991-07-03
SE513358C2 true SE513358C2 (sv) 2000-08-28

Family

ID=27404236

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9102079A SE513358C2 (sv) 1989-01-05 1991-07-03 Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition

Country Status (21)

Country Link
US (2) US5141856A (de)
EP (1) EP0385060B1 (de)
JP (2) JPH0768270B2 (de)
KR (1) KR930012105B1 (de)
AU (1) AU7032496A (de)
BR (1) BR9006996A (de)
CH (1) CH681426A5 (de)
DD (1) DD299318A5 (de)
DE (1) DE4090006C2 (de)
DK (1) DK131391A (de)
ES (1) ES2091768T3 (de)
FI (1) FI104375B (de)
GB (1) GB2246132B (de)
GR (1) GR3021705T3 (de)
HU (2) HUT58792A (de)
IE (1) IE81151B1 (de)
IL (1) IL92958A (de)
NL (1) NL9020024A (de)
NZ (1) NZ231985A (de)
SE (1) SE513358C2 (de)
WO (1) WO1990007341A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328988A (en) * 1987-10-26 1994-07-12 Immunex Corporation Interleukin-7
US5714585A (en) * 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
HUT62033A (en) * 1990-03-14 1993-03-29 Fidia Spa Process for producing human ciliary body neuronotropic factor
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
IT1247150B (it) * 1991-01-21 1994-12-12 Fidia Spa Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli.
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
EP0668911A1 (de) * 1991-11-11 1995-08-30 FIDIA S.p.A. Synthese und reinigung von unvollständigen und mutierten formen des humanen ciliaren neurotrophen faktors
US5360740A (en) * 1992-07-02 1994-11-01 Regeneron Pharmaceuticals, Inc. Assay system for degenerative muscle disease
AU6130094A (en) * 1993-01-29 1994-08-15 Regeneron Pharmaceuticals, Inc. Methods of treatment using ciliary neurotrophic factor
EP0632008B1 (de) * 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentansäurederivate
WO1995022560A1 (en) * 1994-02-22 1995-08-24 The Syntex-Synergen Neuroscience Joint Venture Pharmaceutical formulations of cntf
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
ES2276393T3 (es) * 1994-04-25 2007-06-16 Genentech, Inc. Cardiotrofina y sus usos.
US7258983B2 (en) * 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
DE69732350T2 (de) 1996-03-14 2005-12-22 Washington University Persephin und verwandte wachstumsfaktoren
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6689573B1 (en) * 1999-05-24 2004-02-10 New England Biolabs, Inc. Method for screening restriction endonucleases
CA2409190A1 (en) 2000-04-14 2001-10-25 The Uab Research Foundation Poliovirus replicons encoding therapeutic agents and uses thereof
US20050064555A1 (en) * 2003-07-09 2005-03-24 Xencor, Inc. Ciliary neurotrophic factor variants
WO2008054786A2 (en) * 2006-10-31 2008-05-08 The Ohio State University Research Foundation Methods and compositions for inhibiting gsk-3 in glial cell related disorders
JP2014506119A (ja) 2010-12-02 2014-03-13 ニューロテック ユーエスエー， インコーポレイテッド 抗血管新生抗体足場および可溶性受容体を分泌する細胞株およびその使用
CA2986769A1 (en) 2015-05-27 2016-12-01 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404533A (en) * 1889-06-04 Signments
US293851A (en) * 1884-02-19 de castro
US408172A (en) * 1889-07-30 Steam-boiler house
US429517A (en) * 1890-06-03 Packing-box
US570651A (en) * 1896-11-03 Motor-driven fan
US458564A (en) * 1891-09-01 Ring-gage
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4923696A (en) * 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US4997929A (en) * 1989-01-05 1991-03-05 Synergen, Inc. Purified ciliary neurotrophic factor
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
EP0463082A1 (de) * 1989-03-15 1992-01-02 The Regents Of The University Of California Reinigung von cntf
FI912358A0 (fi) * 1989-09-15 1991-05-15 Max Planck Gesellschaft Neurotrofisk faktor av ciliar ganglion.
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors

Also Published As

Publication number Publication date
IL92958A (en) 1997-09-30
IE900020L (en) 1990-07-05
JPH0768270B2 (ja) 1995-07-26
DD299318A5 (de) 1992-04-09
EP0385060A2 (de) 1990-09-05
GB2246132A8 (en) 2001-05-22
AU4838190A (en) 1990-08-01
HU211933A9 (en) 1996-01-29
NZ231985A (en) 1992-12-23
EP0385060B1 (de) 1996-08-28
GB2246132B (en) 1993-09-15
KR930012105B1 (ko) 1993-12-24
SE9102079D0 (sv) 1991-07-03
GB9113704D0 (en) 1991-08-21
JPH1129598A (ja) 1999-02-02
DK131391A (da) 1991-09-05
EP0385060A3 (de) 1991-04-03
CH681426A5 (de) 1993-03-31
IL92958A0 (en) 1990-09-17
AU642858B2 (en) 1993-11-04
HUT58792A (en) 1992-03-30
JPH04502916A (ja) 1992-05-28
DE4090006C2 (de) 1996-09-19
ES2091768T3 (es) 1996-11-16
BR9006996A (pt) 1991-11-12
FI104375B (fi) 2000-01-14
SE9102079L (sv) 1991-07-03
NL9020024A (nl) 1991-10-01
IE81151B1 (en) 2000-05-03
GR3021705T3 (en) 1997-02-28
DK131391D0 (da) 1991-07-05
WO1990007341A1 (en) 1990-07-12
GB2246132A (en) 1992-01-22
US5141856A (en) 1992-08-25
KR910700068A (ko) 1991-03-13
AU7032496A (en) 1997-01-16
FI913251A0 (fi) 1991-07-04
US5780600A (en) 1998-07-14

Similar Documents

Publication Publication Date Title
SE513358C2 (sv) Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition
US5235043A (en) Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
AU647397B2 (en) Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
EP0541920B1 (de) Interleukin-1-Inhibitoren
DK172763B1 (da) Isoleret interleukin-1 (IL-1) inhibitor eller forstadiepolypeptid dertil, isoleret DNA-molekyle, som koder derfor, vektor o
KR0132425B1 (ko) 신규 폴리펩타이드 및 그 제조방법
US6143866A (en) Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
US5986070A (en) Production of biologically active NGF proteins
EP0421059B1 (de) Gereinigter ciliärer neurotropher Faktor
AU642858C (en) Purified ciliary neurotrophic factor
CA2006813C (en) Purified ciliary neurotrophic factor
PL164726B1 (pl) Sposób wytwarzania czynnika neurotroflcznego CNTF metoda rekombinowanego DNA PL
AT405835B (de) Aufgereinigter ziliärer neurotropher faktor
HU217102B (hu) Tisztított neurotróf faktor és eljárás előállítására

Legal Events

Date Code Title Description
NUG Patent has lapsed