SE513358C2 - Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition - Google Patents

Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition

Info

Publication number
SE513358C2
SE513358C2 SE9102079A SE9102079A SE513358C2 SE 513358 C2 SE513358 C2 SE 513358C2 SE 9102079 A SE9102079 A SE 9102079A SE 9102079 A SE9102079 A SE 9102079A SE 513358 C2 SE513358 C2 SE 513358C2
Authority
SE
Sweden
Prior art keywords
cntf
dna
protein
sciatic nerve
expression
Prior art date
Application number
SE9102079A
Other languages
English (en)
Swedish (sv)
Other versions
SE9102079D0 (sv
SE9102079L (sv
Inventor
Franklin D Collins
Leu-Fen Lin
Drzislav Mismer
Christine Ko
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/293,851 external-priority patent/US5011914A/en
Priority claimed from US07/404,533 external-priority patent/US4997929A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SE9102079D0 publication Critical patent/SE9102079D0/xx
Publication of SE9102079L publication Critical patent/SE9102079L/
Publication of SE513358C2 publication Critical patent/SE513358C2/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SE9102079A 1989-01-05 1991-07-03 Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition SE513358C2 (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/293,851 US5011914A (en) 1989-01-05 1989-01-05 Purified ciliary neurotrophic factor
US07/404,533 US4997929A (en) 1989-01-05 1989-09-08 Purified ciliary neurotrophic factor
US07/458,564 US5141856A (en) 1989-01-05 1989-12-28 Expression of purified ciliary neurotrophic factor
PCT/US1990/000022 WO1990007341A1 (en) 1989-01-05 1990-01-05 Purified ciliary neurotrophic factor

Publications (3)

Publication Number Publication Date
SE9102079D0 SE9102079D0 (sv) 1991-07-03
SE9102079L SE9102079L (sv) 1991-07-03
SE513358C2 true SE513358C2 (sv) 2000-08-28

Family

ID=27404236

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9102079A SE513358C2 (sv) 1989-01-05 1991-07-03 Ciliär neurotropisk ischiasnervprotein faktor, dess framställning och använding i farmaceutisk komposition

Country Status (21)

Country Link
US (2) US5141856A (de)
EP (1) EP0385060B1 (de)
JP (2) JPH0768270B2 (de)
KR (1) KR930012105B1 (de)
AU (1) AU7032496A (de)
BR (1) BR9006996A (de)
CH (1) CH681426A5 (de)
DD (1) DD299318A5 (de)
DE (1) DE4090006C2 (de)
DK (1) DK131391A (de)
ES (1) ES2091768T3 (de)
FI (1) FI104375B (de)
GB (1) GB2246132B (de)
GR (1) GR3021705T3 (de)
HU (2) HUT58792A (de)
IE (1) IE81151B1 (de)
IL (1) IL92958A (de)
NL (1) NL9020024A (de)
NZ (1) NZ231985A (de)
SE (1) SE513358C2 (de)
WO (1) WO1990007341A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328988A (en) * 1987-10-26 1994-07-12 Immunex Corporation Interleukin-7
US5714585A (en) * 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
EP0446931A1 (de) * 1990-03-14 1991-09-18 FIDIA S.p.A. Menschlicher Wimpern-neuronotrophischer Faktor, für diesen Faktor codierende DNA-Sequenz und Herstellung des Faktors durch rekombinante Technologie
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
IT1247150B (it) * 1991-01-21 1994-12-12 Fidia Spa Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli.
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
WO1993010233A1 (en) * 1991-11-11 1993-05-27 Fidia S.P.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
US5360740A (en) * 1992-07-02 1994-11-01 Regeneron Pharmaceuticals, Inc. Assay system for degenerative muscle disease
AU6130094A (en) * 1993-01-29 1994-08-15 Regeneron Pharmaceuticals, Inc. Methods of treatment using ciliary neurotrophic factor
EP0632008B1 (de) * 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentansäurederivate
AU1847695A (en) * 1994-02-22 1995-09-04 Syntex-Synergen Neuroscience Joint Venture, The Pharmaceutical formulations of cntf
US7258983B2 (en) * 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
DK0755446T3 (da) * 1994-04-25 2007-01-29 Genentech Inc Cardiotrophin og anvendelser deraf
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
DE69732350T2 (de) 1996-03-14 2005-12-22 Washington University Persephin und verwandte wachstumsfaktoren
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US7015316B1 (en) 1996-03-14 2006-03-21 Washington University Polynucleotides encoding human persephin and related growth factors
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6689573B1 (en) * 1999-05-24 2004-02-10 New England Biolabs, Inc. Method for screening restriction endonucleases
IL152799A0 (en) 2000-04-14 2003-06-24 Uab Research Foundation Methods for delivering polypeptides to cells
WO2005014641A2 (en) * 2003-07-09 2005-02-17 Xencor, Inc. Ciliary neurotrophic factor variants
US20100143500A1 (en) * 2006-10-31 2010-06-10 The Ohio State University Research Foundation Methods and Compositions for Inhibiting GSK-3 In Glial Cell Related Disorders
EP2646007B1 (de) 2010-12-02 2016-12-21 Neurotech USA, Inc. Antiangiogene antikörpergerüste und löslichen rezeptoren sekretierende zellinien und verwendungen davon
JP6850734B2 (ja) 2015-05-27 2021-03-31 ニューロテック ユーエスエー， インコーポレイテッド 眼の障害の処置のためのカプセル化細胞療法の使用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404533A (en) * 1889-06-04 Signments
US293851A (en) * 1884-02-19 de castro
US570651A (en) * 1896-11-03 Motor-driven fan
US429517A (en) * 1890-06-03 Packing-box
US458564A (en) * 1891-09-01 Ring-gage
US408172A (en) * 1889-07-30 Steam-boiler house
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4923696A (en) * 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US4997929A (en) * 1989-01-05 1991-03-05 Synergen, Inc. Purified ciliary neurotrophic factor
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
WO1990010647A1 (en) * 1989-03-15 1990-09-20 The Regents Of The University Of California Purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
FI912358A7 (fi) * 1989-09-15 1991-05-15 Regeneron Pharma Silmäkuopan takaosan hermosolmun neurotrofinen tekijä
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors

Also Published As

Publication number Publication date
US5780600A (en) 1998-07-14
IE81151B1 (en) 2000-05-03
JPH1129598A (ja) 1999-02-02
AU4838190A (en) 1990-08-01
IE900020L (en) 1990-07-05
EP0385060A3 (de) 1991-04-03
FI913251A0 (fi) 1991-07-04
NL9020024A (nl) 1991-10-01
DK131391A (da) 1991-09-05
DD299318A5 (de) 1992-04-09
DE4090006C2 (de) 1996-09-19
EP0385060A2 (de) 1990-09-05
IL92958A (en) 1997-09-30
FI104375B (fi) 2000-01-14
HU211933A9 (en) 1996-01-29
NZ231985A (en) 1992-12-23
GB2246132A (en) 1992-01-22
CH681426A5 (de) 1993-03-31
GR3021705T3 (en) 1997-02-28
KR910700068A (ko) 1991-03-13
JPH04502916A (ja) 1992-05-28
DK131391D0 (da) 1991-07-05
WO1990007341A1 (en) 1990-07-12
SE9102079D0 (sv) 1991-07-03
GB9113704D0 (en) 1991-08-21
US5141856A (en) 1992-08-25
GB2246132B (en) 1993-09-15
JPH0768270B2 (ja) 1995-07-26
GB2246132A8 (en) 2001-05-22
AU7032496A (en) 1997-01-16
EP0385060B1 (de) 1996-08-28
IL92958A0 (en) 1990-09-17
HUT58792A (en) 1992-03-30
AU642858B2 (en) 1993-11-04
BR9006996A (pt) 1991-11-12
KR930012105B1 (ko) 1993-12-24
SE9102079L (sv) 1991-07-03
ES2091768T3 (es) 1996-11-16

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NUG Patent has lapsed