SE8001424L - Antibakteriella medel och beta-laktamashemmare och forfarande for deras framstellning - Google Patents

Antibakteriella medel och beta-laktamashemmare och forfarande for deras framstellning

Info

Publication number: SE8001424L
Authority: SE; Sweden
Prior art keywords: lower alkyl; procedures; production; bacterial agents; beta lactam
Prior art date: 1979-02-24

Application number

SE8001424A

Other languages

English (en)

Other versions

SE449489B (sv

Inventor

M Foglio

G Franceschi

C Scarafile

F Arcamone

A Sanfilippo

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-24

Filing date

1980-02-22

Publication date

1980-08-25

1980-02-22 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-08-25 Publication of SE8001424L publication Critical patent/SE8001424L/sv

1987-05-04 Publication of SE449489B publication Critical patent/SE449489B/sv

Links

239000003242 anti bacterial agent Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
150000003952 β-lactams Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
-1 p.methoxybenzyl Chemical group 0.000 abstract 2
230000004913 activation Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
125000006502 nitrobenzyl group Chemical group 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

SE8001424A 1979-02-24 1980-02-22 Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet SE449489B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7906634		1979-02-24
GB7932591		1979-09-20

Publications (2)

Publication Number	Publication Date
SE8001424L true SE8001424L (sv)	1980-08-25
SE449489B SE449489B (sv)	1987-05-04

Family

ID=26270697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8001424A SE449489B (sv)	1979-02-24	1980-02-22	Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet

Country Status (24)

Country	Link
AT (1)	AT368506B (sv)
AU (1)	AU535080B2 (sv)
CA (2)	CA1154010A (sv)
CH (2)	CH654831A5 (sv)
CS (1)	CS226010B2 (sv)
DE (1)	DE3006273A1 (sv)
DK (1)	DK159448C (sv)
ES (2)	ES8200685A1 (sv)
FI (1)	FI75163C (sv)
FR (1)	FR2449690B1 (sv)
GB (1)	GB2043639B (sv)
GR (1)	GR73623B (sv)
HK (1)	HK74487A (sv)
HU (1)	HU182664B (sv)
IE (1)	IE49407B1 (sv)
IT (1)	IT1193922B (sv)
LU (1)	LU82192A1 (sv)
NL (1)	NL192265C (sv)
NO (1)	NO161000C (sv)
NZ (1)	NZ192949A (sv)
PT (1)	PT70849A (sv)
SE (1)	SE449489B (sv)
UA (1)	UA6041A1 (sv)
YU (1)	YU42964B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
DE3121510A1 (de) *	1980-07-04	1982-06-16	Farmitalia Carlo Erba S.p.A., 20159 Milano	6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) *	1981-07-08	1983-01-18	Takeda Chem Ind Ltd	（６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
DE3277696D1 (en) *	1981-07-15	1987-12-23	Sumitomo Pharma	Carboxylic beta-lactam compounds and the preparation thereof
US4508649A (en) *	1981-12-11	1985-04-02	Farmitalia Carlo Erba	Process for preparing optically active penems
NO831160L (no) *	1982-04-08	1983-10-10	Erba Farmitalia	Fremstilling av substituerte penem-derivater
PH21930A (en) *	1982-11-16	1988-04-08	Ciba Geigy Ag	6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (de) *	1982-11-16	1987-08-12	Ciba-Geigy Ag	Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
GB8300295D0 (en) *	1983-01-06	1983-02-09	Erba Farmitalia	Penem esters
JPS59152387A (ja) *	1983-02-10	1984-08-31	Shionogi & Co Ltd	新規ペネム化合物
GB8321677D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	Preparation of penems
US4656165A (en) *	1983-09-02	1987-04-07	Ciba-Geigy Corporation	Aminomethyl penem compounds
US4711886A (en) *	1984-07-02	1987-12-08	Merck & Co., Inc.	β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) *	1984-11-02	1988-08-02	Ciba-Geigy Corporation	Crystalline aminomethyl compound
EP0278911B1 (de) *	1987-02-11	1993-08-04	Ciba-Geigy Ag	Bicyclische beta-Lactam-carbonsäuren
GB2206578B (en) *	1987-07-07	1991-07-03	Erba Carlo Spa	Process for the preparation of penems
US5364768A (en) *	1987-07-07	1994-11-15	Farmitalia Carlo Erba S.R.L.	Process for the preparation of penems
IT1286558B1 (it) *	1996-02-27	1998-07-15	Menarini Farma Ind	Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
US6156745A (en)	1997-12-29	2000-12-05	Research Corporation Technologies, Inc.	2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
US6407091B1 (en)	1999-04-15	2002-06-18	Research Corporation Technologies, Inc.	β-lactamase inhibiting compounds
US6720445B2 (en) *	2000-12-21	2004-04-13	Beacon Laboratories, Inc.	Acetyloxymethyl esters and methods for using the same
ATE339424T1 (de)	2001-07-24	2006-10-15	Univ Southern Methodist	3-substituierte 7-alkylidene-3-cephem-4- carbonsäuren als beta-lactamase inhibitoren
AU2003224874A1 (en)	2002-04-04	2003-10-27	Alamx, L.L.C.	INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (sv) *	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) *	1977-12-14	1979-05-22	Bristol-Myers Company	2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) *	1978-01-20	1979-09-12	Glaxo Group Ltd	Novel lactam compound
EP0003960B1 (de) *	1978-02-02	1983-06-29	Ciba-Geigy Ag	6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
JPS5559193A (en) *	1978-09-20	1980-05-02	Glaxo Group Ltd	Bblactam compound
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
EP0013067A1 (en) *	1978-12-22	1980-07-09	Beecham Group Plc	Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

1980
- 1980-02-19 NL NL8001012A patent/NL192265C/nl not_active IP Right Cessation
- 1980-02-19 AT AT0091980A patent/AT368506B/de not_active IP Right Cessation
- 1980-02-19 AU AU55670/80A patent/AU535080B2/en not_active Ceased
- 1980-02-19 FI FI800493A patent/FI75163C/sv not_active IP Right Cessation
- 1980-02-19 IT IT20021/80A patent/IT1193922B/it active
- 1980-02-19 GR GR61228A patent/GR73623B/el unknown
- 1980-02-19 GB GB8005476A patent/GB2043639B/en not_active Expired
- 1980-02-20 IE IE338/80A patent/IE49407B1/en not_active IP Right Cessation
- 1980-02-20 YU YU461/80A patent/YU42964B/xx unknown
- 1980-02-20 CA CA000346011A patent/CA1154010A/en not_active Expired
- 1980-02-20 PT PT70849A patent/PT70849A/pt not_active IP Right Cessation
- 1980-02-20 DE DE19803006273 patent/DE3006273A1/de active Granted
- 1980-02-21 CH CH2794/84A patent/CH654831A5/de not_active IP Right Cessation
- 1980-02-21 CH CH1400/80A patent/CH651570A5/de not_active IP Right Cessation
- 1980-02-22 NZ NZ192949A patent/NZ192949A/en unknown
- 1980-02-22 NO NO800501A patent/NO161000C/no unknown
- 1980-02-22 CS CS801241A patent/CS226010B2/cs unknown
- 1980-02-22 HU HU80420A patent/HU182664B/hu not_active IP Right Cessation
- 1980-02-22 UA UA2886007A patent/UA6041A1/uk unknown
- 1980-02-22 SE SE8001424A patent/SE449489B/sv not_active IP Right Cessation
- 1980-02-22 LU LU82192A patent/LU82192A1/fr unknown
- 1980-02-22 FR FR8003938A patent/FR2449690B1/fr not_active Expired
- 1980-02-22 DK DK077580A patent/DK159448C/da not_active IP Right Cessation
- 1980-02-23 ES ES488886A patent/ES8200685A1/es not_active Expired
- 1980-10-16 ES ES495977A patent/ES495977A0/es active Granted
1986
- 1986-01-14 CA CA000499579A patent/CA1212665B/en not_active Expired
1987
- 1987-10-15 HK HK744/87A patent/HK74487A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI800493A7 (fi)	1980-08-25
NL192265B (nl)	1996-12-02
FI75163B (fi)	1988-01-29
IT1193922B (it)	1988-08-31
DE3006273A1 (de)	1980-09-04
NO161000B (no)	1989-03-13
IE800338L (en)	1980-08-24
GB2043639A (en)	1980-10-08
NL8001012A (nl)	1980-08-26
UA6041A1 (uk)	1994-12-29
DK159448B (da)	1990-10-15
HK74487A (en)	1987-10-23
GB2043639B (en)	1983-07-20
SE449489B (sv)	1987-05-04
FR2449690B1 (fr)	1986-06-13
CH654831A5 (de)	1986-03-14
LU82192A1 (fr)	1980-06-06
NZ192949A (en)	1984-03-16
FR2449690A1 (fr)	1980-09-19
AT368506B (de)	1982-10-25
NL192265C (nl)	1997-04-03
NO161000C (no)	1989-06-21
HU182664B (en)	1984-02-28
ES488886A0 (es)	1981-11-16
CH651570A5 (de)	1985-09-30
NO800501L (no)	1980-08-25
YU42964B (en)	1989-02-28
AU535080B2 (en)	1984-03-01
CA1154010A (en)	1983-09-20
AU5567080A (en)	1980-09-11
PT70849A (en)	1980-03-01
DK159448C (da)	1991-03-04
FI75163C (sv)	1988-05-09
ES8107224A1 (es)	1981-10-01
DK77580A (da)	1980-08-25
GR73623B (sv)	1984-03-26
ES495977A0 (es)	1981-10-01
IE49407B1 (en)	1985-10-02
ES8200685A1 (es)	1981-11-16
CA1212665B (en)	1986-10-14
CS226010B2 (en)	1984-03-19
YU46180A (en)	1983-02-28
IT8020021A0 (it)	1980-02-19
ATA91980A (de)	1982-02-15
IT8020021A1 (it)	1981-08-19

Legal Events

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8001424-4

Format of ref document f/p: F

2000-05-02

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