SE8004873L - Forfarande for framstellning av oleandomycinderivat - Google Patents
Forfarande for framstellning av oleandomycinderivatInfo
- Publication number
- SE8004873L SE8004873L SE8004873A SE8004873A SE8004873L SE 8004873 L SE8004873 L SE 8004873L SE 8004873 A SE8004873 A SE 8004873A SE 8004873 A SE8004873 A SE 8004873A SE 8004873 L SE8004873 L SE 8004873L
- Authority
- SE
- Sweden
- Prior art keywords
- preparation
- procedure
- alkanoyl
- reed
- carbon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical class O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 title claims 2
- 235000014676 Phragmites communis Nutrition 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- DKWOHBPRFZIUQL-UHFFFAOYSA-N dimethyl-methylidene-oxo-$l^{6}-sulfane Chemical compound C[S+](C)([CH2-])=O DKWOHBPRFZIUQL-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (2)
1. POrfarande for framstallning av en forening, son: her formeln:. 2 N(CH3)2 CH3 och de icke-toxiska syraadditionssalterna darav, van i X hetecknar gruppen R2CC112; R Sr vdte eller alkanoyl reed
2-3 kolatomer; Ri Sr vate eller alkanoyl med 2-3 kolatomer: och R2 5r vdte, tri-(15gre alkyl) -silyl rued 1-6 kolatomer vane alkylgrupp.eller alkanoyl reed 2-3 kolatomer, k anneteckn-t darav, att forening, som har formeln III ___ 0_„_..„.,, 0 OCH3 van i R, Ri och R2 tar oVan angiVen betydelse, bringas att reagera i ett reaktionsinert losningsmedel under kylning Oct i ett isvattenbad med fran 1 till 1,5 mol per mol oleandomycinderivat reed dimetylsulfoxoniummetylid, varefter blandningen f5r anta rumstemperatur under uppratthallande av kontakten mellan de reagerande substanserna tills reaktionen Sr VOsentligen fullstandig och, ndr s5 onskas, framstallning av syraadditicnssaltet. N(CR3)2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66346776A | 1976-03-03 | 1976-03-03 | |
| US70346476A | 1976-07-08 | 1976-07-08 | |
| US05/709,703 US4069379A (en) | 1976-07-08 | 1976-07-29 | Semi-synthetic oleandomycins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8004873L true SE8004873L (sv) | 1980-07-01 |
| SE436284B SE436284B (sv) | 1984-11-26 |
Family
ID=27418084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7700786A SE436283B (sv) | 1976-03-03 | 1977-01-25 | Forfarande for framstellning av halvsyntetiska oleandomycin-derivat och icke-toxiska syraadditionssalter derav |
| SE8004873A SE436284B (sv) | 1976-03-03 | 1980-07-01 | Forfarande for framstellning av cyklopropyloleandomyciner och icke-toxiska syraadditionssalter derav |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7700786A SE436283B (sv) | 1976-03-03 | 1977-01-25 | Forfarande for framstellning av halvsyntetiska oleandomycin-derivat och icke-toxiska syraadditionssalter derav |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS52106880A (sv) |
| AR (1) | AR212524A1 (sv) |
| AT (1) | AT347586B (sv) |
| BG (2) | BG27913A3 (sv) |
| CA (1) | CA1069503A (sv) |
| DD (1) | DD129789A5 (sv) |
| DE (2) | DE2660089C2 (sv) |
| DK (1) | DK146778C (sv) |
| ES (1) | ES455805A1 (sv) |
| FI (1) | FI770440A7 (sv) |
| FR (1) | FR2342989A1 (sv) |
| GB (1) | GB1567390A (sv) |
| IE (1) | IE44509B1 (sv) |
| IL (1) | IL51361A (sv) |
| LU (1) | LU76764A1 (sv) |
| NL (1) | NL170151C (sv) |
| NZ (1) | NZ183235A (sv) |
| PH (1) | PH13171A (sv) |
| PT (1) | PT66157B (sv) |
| RO (2) | RO72560A (sv) |
| SE (2) | SE436283B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166901A (en) * | 1978-01-03 | 1979-09-04 | Pfizer Inc. | 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters |
| US4180654A (en) * | 1978-01-03 | 1979-12-25 | Pfizer Inc. | 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate |
-
1976
- 1976-11-23 IE IE2578/76A patent/IE44509B1/en unknown
- 1976-12-02 DE DE2660089A patent/DE2660089C2/de not_active Expired
- 1976-12-02 DE DE2654627A patent/DE2654627C3/de not_active Expired
-
1977
- 1977-01-25 SE SE7700786A patent/SE436283B/sv unknown
- 1977-01-31 IL IL51361A patent/IL51361A/xx unknown
- 1977-02-01 AT AT62777A patent/AT347586B/de not_active IP Right Cessation
- 1977-02-02 NZ NZ183235A patent/NZ183235A/xx unknown
- 1977-02-02 PH PH19411A patent/PH13171A/en unknown
- 1977-02-04 PT PT66157A patent/PT66157B/pt unknown
- 1977-02-09 CA CA271,457A patent/CA1069503A/en not_active Expired
- 1977-02-09 FR FR7703604A patent/FR2342989A1/fr active Granted
- 1977-02-10 JP JP1403577A patent/JPS52106880A/ja active Granted
- 1977-02-10 FI FI770440A patent/FI770440A7/fi not_active Application Discontinuation
- 1977-02-10 ES ES455805A patent/ES455805A1/es not_active Expired
- 1977-02-10 DK DK57177A patent/DK146778C/da not_active IP Right Cessation
- 1977-02-10 NL NLAANVRAGE7701401,A patent/NL170151C/xx not_active IP Right Cessation
- 1977-02-11 GB GB5755/77A patent/GB1567390A/en not_active Expired
- 1977-02-11 AR AR266519A patent/AR212524A1/es active
- 1977-02-11 LU LU76764A patent/LU76764A1/xx unknown
- 1977-02-23 RO RO7789496A patent/RO72560A/ro unknown
- 1977-02-23 RO RO7797127A patent/RO76882A/ro unknown
- 1977-02-25 BG BG035526A patent/BG27913A3/xx unknown
- 1977-02-25 BG BG036454A patent/BG27914A4/xx unknown
- 1977-02-28 DD DD7700197598A patent/DD129789A5/xx unknown
-
1980
- 1980-07-01 SE SE8004873A patent/SE436284B/sv unknown
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