SE8007397L - Forfarande och medel for bestemning av en ligand i ett verskemedium - Google Patents
Forfarande och medel for bestemning av en ligand i ett verskemediumInfo
- Publication number
- SE8007397L SE8007397L SE8007397A SE8007397A SE8007397L SE 8007397 L SE8007397 L SE 8007397L SE 8007397 A SE8007397 A SE 8007397A SE 8007397 A SE8007397 A SE 8007397A SE 8007397 L SE8007397 L SE 8007397L
- Authority
- SE
- Sweden
- Prior art keywords
- conjugate
- specific binding
- ligand
- bound
- dark
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title claims abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 230000009870 specific binding Effects 0.000 claims abstract 6
- 239000007788 liquid Substances 0.000 claims abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract 3
- 238000009739 binding Methods 0.000 claims abstract 2
- AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 claims 1
- 240000005369 Alstonia scholaris Species 0.000 claims 1
- WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 claims 1
- 239000000729 antidote Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 238000002372 labelling Methods 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 238000006911 enzymatic reaction Methods 0.000 abstract 2
- 239000000376 reactant Substances 0.000 abstract 2
- 239000005515 coenzyme Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Claims (1)
1. Pa'.ontkram 1de utnyttjande en specif)k bindninm.sreaktion fir att ) et m beotdmma en ligand vald bland Antigener nab anti- ,ropp)ar dLro.L11; hapte,er cen antAkreppar ddrtill; hormoner, vitami,er, metabol.ter eon farmakologiaka mean l saint darns recoil crop ash bindninosouh,t,noer; Vii VI Inst f)Arfanande ma, (1) bringer vdtskeme- ditA komit.akt Incd ett reagens innefattande ett mark,. konjugat till ,ildn:ng av en Aunden Corm av det mdrkta koniugatet en fri form av dct mdrkta kerjugatet, varvid propertienerna net Inn den bundna -Domes Act den fria Carmen an det mdrkta konjugatot dr en funkt ion av koncentrationen as ligand i vdtskemediet, varefter man (2) mdter mdngden mdrknrgs,,,h,tans i len bundna formes eller den fria fcrmen as dot mdr,:ta konjugateu,kdnneteck nat as Ott en kemi- ■ luminio,onA-substans anvdndes odsom markningssubstans.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57200875A | 1975-04-28 | 1975-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8007397L true SE8007397L (sv) | 1980-10-21 |
| SE451895B SE451895B (sv) | 1987-11-02 |
Family
ID=24285954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7604841A SE440280B (sv) | 1975-04-28 | 1976-04-27 | Testforfarande och reagens med koenzymmerkning |
| SE8007397A SE451895B (sv) | 1975-04-28 | 1980-10-21 | Kemiluminiscensforfarande for bestemning av en ligand i ett vetskemedium |
| SE8007396A SE447510B (sv) | 1975-04-28 | 1980-10-21 | Forfarande och reagens for bestemning av en ligand i ett vetskemedium |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7604841A SE440280B (sv) | 1975-04-28 | 1976-04-27 | Testforfarande och reagens med koenzymmerkning |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8007396A SE447510B (sv) | 1975-04-28 | 1980-10-21 | Forfarande och reagens for bestemning av en ligand i ett vetskemedium |
Country Status (23)
| Country | Link |
|---|---|
| JP (6) | JPS604939B2 (sv) |
| AT (1) | AT357685B (sv) |
| AU (2) | AU509182B2 (sv) |
| BE (1) | BE841179A (sv) |
| BR (1) | BR7602561A (sv) |
| CA (2) | CA1082577A (sv) |
| CH (1) | CH635438A5 (sv) |
| DD (1) | DD125231A5 (sv) |
| DE (3) | DE2618511C3 (sv) |
| DK (3) | DK149969C (sv) |
| ES (1) | ES447378A1 (sv) |
| FI (1) | FI68324C (sv) |
| FR (1) | FR2332533A1 (sv) |
| GB (2) | GB1552607A (sv) |
| HU (1) | HU179542B (sv) |
| IE (1) | IE42544B1 (sv) |
| IL (1) | IL49354A (sv) |
| IN (1) | IN142734B (sv) |
| IT (1) | IT1064132B (sv) |
| LU (1) | LU74834A1 (sv) |
| NL (1) | NL181281C (sv) |
| SE (3) | SE440280B (sv) |
| ZA (1) | ZA762030B (sv) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51668A (en) | 1977-03-16 | 1981-12-31 | Israel State | Analytical method for the quantitative determination of immunogens and antibodies and a kit therefor |
| SE7811630L (sv) * | 1977-11-17 | 1979-05-18 | Welsh Nat School Med | Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik |
| USRE34394E (en) * | 1978-01-23 | 1993-09-28 | Baxter Diagnostics Inc. | Method and composition for double receptor, specific binding assays |
| US4233402A (en) * | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| AU531777B2 (en) * | 1978-04-05 | 1983-09-08 | Syva Co. | Label/solid conjugate immunoassay system |
| FR2422956A1 (fr) * | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| US5605800A (en) * | 1978-04-13 | 1997-02-25 | Institut Pasteur | Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method |
| DE2924249C2 (de) * | 1978-06-22 | 1989-04-27 | Miles, Inc., Elkhart, Ind., Us | Spezifische bindungs-untersuchungsmethode zur bestimmung eines liganden in einem fluessigen medium und reagentien zur durchfuehrung dieser methode |
| DE2924332A1 (de) * | 1978-06-22 | 1980-01-03 | Miles Lab | Flavin-adenin-dinukleotid-markiertes konjugat und dessen verwendung in spezifischen bindungsversuchen |
| US4225485A (en) * | 1978-07-24 | 1980-09-30 | Miles Laboratories, Inc. | Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled polypeptides and proteins |
| US4334069A (en) * | 1978-07-24 | 1982-06-08 | Miles Laboratories, Inc. | Chemiluminescent phthalhydrazide-labeled hapten conjugates |
| US4228237A (en) * | 1978-09-21 | 1980-10-14 | Calbiochem-Behring Corp. | Methods for the detection and determination of ligands |
| US4288538A (en) | 1979-01-31 | 1981-09-08 | Baxter Travenol Laboratories, Inc. | Test method and composition therefor |
| US4273866A (en) * | 1979-02-05 | 1981-06-16 | Abbott Laboratories | Ligand analog-irreversible enzyme inhibitor conjugates and methods for use |
| US4446231A (en) * | 1979-10-03 | 1984-05-01 | Self Colin H | Immunoassay using an amplified cyclic detection system |
| GB2059421A (en) * | 1979-10-03 | 1981-04-23 | Self C H | Assay method and reagents therefor |
| US4259232A (en) * | 1979-10-23 | 1981-03-31 | Miles Laboratories, Inc. | Flavin adenine dinucleotide-labeled protein and polypeptide conjugates |
| AT367796B (de) * | 1979-10-29 | 1982-07-26 | List Hans | Verfahren zur bestimmung einer stoffkonzentration in einer loesung |
| WO1981001414A1 (en) * | 1979-11-19 | 1981-05-28 | Charles Hospital Dev | An improved method of non homogenous enzyme immunoassay |
| US4299916A (en) * | 1979-12-26 | 1981-11-10 | Syva Company | Preferential signal production on a surface in immunoassays |
| DK256581A (da) * | 1980-06-13 | 1981-12-14 | Nat Res Dev | Bindingsanalyse |
| EP0049606A1 (en) * | 1980-10-02 | 1982-04-14 | Colin Henry Self | Detection method, use and diagnostic aid |
| CA1183450A (en) * | 1980-10-30 | 1985-03-05 | Alfred C. Greenquist | Homogeneous specific binding assay device and method |
| US4404278A (en) * | 1980-11-24 | 1983-09-13 | Syva Company | Methods and compositions for assaying for the production of 1,4-dihydropyridyl |
| US4378458A (en) * | 1981-03-30 | 1983-03-29 | Baker Instruments Corporation | Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity |
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| US4366243A (en) | 1981-04-17 | 1982-12-28 | Miles Laboratories, Inc. | Stabilization of glucose oxidase apoenzyme |
| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| ATE48140T1 (de) * | 1981-04-17 | 1989-12-15 | Univ Yale | Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung. |
| JPS5818167A (ja) * | 1981-07-24 | 1983-02-02 | Fuji Photo Film Co Ltd | 分析フイルム及びこれを用いる分析方法 |
| JPS5877843U (ja) * | 1981-11-20 | 1983-05-26 | 株式会社三協精機製作所 | テ−プレコ−ダ |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| FR2519005B1 (fr) * | 1981-12-29 | 1985-10-25 | Pasteur Institut | Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn |
| FR2519004B1 (fr) * | 1981-12-29 | 1985-09-27 | Pasteur Institut | Acide adenosine 5'-triphosphorique modifie et procede de dosage de substances biologiques susceptibles de fixer des produits de degradation de l'acide adenosine 5'-triphosphorique |
| US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US5650270A (en) * | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| IL67289A (en) * | 1982-03-18 | 1985-12-31 | Miles Lab | Homogeneous immunoassay with labeled monoclonal anti-analyte |
| CA1223831A (en) * | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| US4495281A (en) * | 1982-10-21 | 1985-01-22 | Miles Laboratories, Inc. | Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| US4828979A (en) * | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
| EP0201211A1 (en) * | 1985-04-10 | 1986-11-12 | Whittaker Corporation | Method and compositions for visual solid phase immunoassays based on luminescent microspheric particles |
| JPS61271457A (ja) * | 1985-05-28 | 1986-12-01 | Olympus Optical Co Ltd | 免疫学的分析方法 |
| JPH06100599B2 (ja) * | 1985-06-27 | 1994-12-12 | 東亜医用電子株式会社 | 体液成分の測定方法 |
| JPS6321559A (ja) * | 1986-07-16 | 1988-01-29 | Matsushita Electric Ind Co Ltd | ハプテンの酵素免疫測定法 |
| DE3844954C2 (de) * | 1988-02-20 | 1998-07-16 | Hoechst Ag | Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays |
| US6002007A (en) * | 1988-02-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays |
| JP2525678B2 (ja) * | 1989-10-03 | 1996-08-21 | 富士写真フイルム株式会社 | 免疫測定装置 |
| US6380377B1 (en) | 2000-07-14 | 2002-04-30 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| CN100494399C (zh) | 2003-06-30 | 2009-06-03 | 清华大学 | 一种基于dna芯片的基因分型方法及其应用 |
| US7732153B2 (en) | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
| US7799534B2 (en) | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
| JP6214449B2 (ja) * | 2014-03-31 | 2017-10-18 | シスメックス株式会社 | キナーゼ活性の測定方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) * | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3880934A (en) * | 1972-02-10 | 1975-04-29 | Syntex Inc | Nitrophenyloxy-butanediols |
| JPS5147347A (ja) * | 1974-10-21 | 1976-04-22 | Nippon Electric Co | Johoshorisochi |
| JPS5147348A (ja) * | 1974-10-21 | 1976-04-22 | Nippon Electric Co | Johoshorisochi |
-
1975
- 1975-09-30 IN IN1874/CAL/75A patent/IN142734B/en unknown
-
1976
- 1976-04-02 IE IE696/76A patent/IE42544B1/en unknown
- 1976-04-05 IL IL49354A patent/IL49354A/xx unknown
- 1976-04-05 ZA ZA762030A patent/ZA762030B/xx unknown
- 1976-04-07 CA CA249,745A patent/CA1082577A/en not_active Expired
- 1976-04-07 CA CA249,744A patent/CA1078712A/en not_active Expired
- 1976-04-21 CH CH497976A patent/CH635438A5/de not_active IP Right Cessation
- 1976-04-23 GB GB16610/76A patent/GB1552607A/en not_active Expired
- 1976-04-23 GB GB16609/76A patent/GB1548741A/en not_active Expired
- 1976-04-26 NL NLAANVRAGE7604420,A patent/NL181281C/xx not_active IP Right Cessation
- 1976-04-26 FI FI761148A patent/FI68324C/fi not_active IP Right Cessation
- 1976-04-26 LU LU74834A patent/LU74834A1/xx unknown
- 1976-04-26 IT IT49195/76A patent/IT1064132B/it active
- 1976-04-27 AU AU13352/76A patent/AU509182B2/en not_active Expired
- 1976-04-27 DE DE2618511A patent/DE2618511C3/de not_active Expired
- 1976-04-27 DD DD192528A patent/DD125231A5/xx unknown
- 1976-04-27 DE DE2618419A patent/DE2618419C2/de not_active Expired
- 1976-04-27 ES ES447378A patent/ES447378A1/es not_active Expired
- 1976-04-27 JP JP51047347A patent/JPS604939B2/ja not_active Expired
- 1976-04-27 JP JP51047348A patent/JPS6052378B2/ja not_active Expired
- 1976-04-27 BE BE166499A patent/BE841179A/xx not_active IP Right Cessation
- 1976-04-27 HU HU76MI600A patent/HU179542B/hu unknown
- 1976-04-27 FR FR7612441A patent/FR2332533A1/fr active Granted
- 1976-04-27 BR BR2561/76A patent/BR7602561A/pt unknown
- 1976-04-27 AU AU13353/76A patent/AU502726B2/en not_active Expired
- 1976-04-27 SE SE7604841A patent/SE440280B/sv not_active IP Right Cessation
- 1976-04-27 DK DK189176A patent/DK149969C/da not_active IP Right Cessation
- 1976-04-27 AT AT309376A patent/AT357685B/de not_active IP Right Cessation
- 1976-04-27 DE DE2660548A patent/DE2660548C2/de not_active Expired
-
1980
- 1980-10-21 SE SE8007397A patent/SE451895B/sv not_active IP Right Cessation
- 1980-10-21 SE SE8007396A patent/SE447510B/sv not_active IP Right Cessation
-
1981
- 1981-12-23 DK DK576181A patent/DK158366C/da not_active IP Right Cessation
- 1981-12-23 DK DK576281A patent/DK150808C/da not_active IP Right Cessation
-
1983
- 1983-07-07 JP JP58122465A patent/JPS5951353A/ja active Granted
- 1983-07-07 JP JP58122464A patent/JPS5942454A/ja active Granted
- 1983-07-07 JP JP58122466A patent/JPS5951354A/ja active Granted
- 1983-07-07 JP JP58122463A patent/JPS5942453A/ja active Granted
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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