SE8007540L - Aminocyklitoler - Google Patents
AminocyklitolerInfo
- Publication number
- SE8007540L SE8007540L SE8007540A SE8007540A SE8007540L SE 8007540 L SE8007540 L SE 8007540L SE 8007540 A SE8007540 A SE 8007540A SE 8007540 A SE8007540 A SE 8007540A SE 8007540 L SE8007540 L SE 8007540L
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- resulting
- prepared
- hydroxy
- dideoxy
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 239000001257 hydrogen Substances 0.000 claims abstract 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 6
- 241000187722 Micromonospora echinospora Species 0.000 claims abstract 4
- 239000002253 acid Substances 0.000 claims abstract 4
- 235000014633 carbohydrates Nutrition 0.000 claims abstract 4
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 235000015097 nutrients Nutrition 0.000 claims abstract 4
- 239000003054 catalyst Substances 0.000 claims abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 238000012258 culturing Methods 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 241000589232 Gluconobacter oxydans Species 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000003999 cyclitols Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
- C07C49/497—Saturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (1)
1. Forfarande for framstallning av en aminocyklitol med formeln I: 6 5 - 112' HO van i R2 och vardera betecknar vAte eller hydroxi; och i nSrvaro av Micromonospora purpurea ATCC 31 164, att om sA 5nskas en erhAllen fOrening fAr reagera med en N-hydroxisuccinimidester med formeln IV: 0 CH2O-C-NRCH2(CH2)nCH0HCO-0-0 vari R1, R3 och R8 vardera betecknar :rate och R2 och R5 vardera betecknar vate eller hydroxi, R6 och R7 vardera betecknar vate eller metyl, kanntecknat darav, att ett naringsmedium innehallande kolhydrater, en kalla far assimilerbart kvave, esscntiella salter och en aminocyklitol med formeln Ha eller IIb: van i n betecknar noll eller 1, och att bensyloxikarbonylgruppen i den erhallna produkten underkastas hydrogenolys med vate aver en katalysator for framstallning av en farening, van i en av R1. R3 och 128 betecknar en ta-amino-0C-hydroxi-lagre-alkanoylgrupp, och att om sa beckon en erhallen-fri bas overfares till ett syraadditionssalt darav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/550,273 US3972930A (en) | 1975-02-18 | 1975-02-18 | Aminocyclitol antibiotics |
| US05/615,593 US3982996A (en) | 1975-09-22 | 1975-09-22 | Process for preparing aminocyclitol antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8007540L true SE8007540L (sv) | 1980-10-27 |
Family
ID=27069389
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7601810A SE7601810L (sv) | 1975-02-18 | 1976-02-17 | Aminocyklitolantibiotika och forfarande for framstellning derav |
| SE8007540A SE8007540L (sv) | 1975-02-18 | 1980-10-27 | Aminocyklitoler |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7601810A SE7601810L (sv) | 1975-02-18 | 1976-02-17 | Aminocyklitolantibiotika och forfarande for framstellning derav |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS51108041A (sv) |
| AR (3) | AR221027A1 (sv) |
| AU (1) | AU503105B2 (sv) |
| CA (1) | CA1061731A (sv) |
| CH (3) | CH617964A5 (sv) |
| DE (1) | DE2606517A1 (sv) |
| DK (1) | DK143111C (sv) |
| EG (1) | EG12994A (sv) |
| ES (1) | ES445274A1 (sv) |
| FI (1) | FI56026C (sv) |
| FR (1) | FR2301265A1 (sv) |
| GB (1) | GB1529376A (sv) |
| GR (1) | GR60050B (sv) |
| IE (1) | IE42807B1 (sv) |
| IL (1) | IL49053A (sv) |
| IN (2) | IN147046B (sv) |
| NL (1) | NL7601655A (sv) |
| NO (3) | NO147308C (sv) |
| NZ (1) | NZ180036A (sv) |
| PT (1) | PT64816B (sv) |
| SE (2) | SE7601810L (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR955564A (sv) * | 1946-10-24 | 1950-01-17 | ||
| RU2458931C2 (ru) | 2006-06-02 | 2012-08-20 | Мейдзи Сейка Фарма Ко., Лтд. | Новые аминогликозидные антибиотики |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH606434A5 (sv) * | 1973-08-06 | 1978-10-31 | Scherico Ltd |
-
1976
- 1976-02-09 GB GB4973/76A patent/GB1529376A/en not_active Expired
- 1976-02-13 NO NO760472A patent/NO147308C/no unknown
- 1976-02-17 FI FI760387A patent/FI56026C/fi not_active IP Right Cessation
- 1976-02-17 IE IE311/76A patent/IE42807B1/en unknown
- 1976-02-17 GR GR50077A patent/GR60050B/el unknown
- 1976-02-17 CH CH193476A patent/CH617964A5/fr not_active IP Right Cessation
- 1976-02-17 FR FR7604291A patent/FR2301265A1/fr active Granted
- 1976-02-17 NZ NZ180036A patent/NZ180036A/xx unknown
- 1976-02-17 DK DK63176A patent/DK143111C/da not_active IP Right Cessation
- 1976-02-17 CA CA245,916A patent/CA1061731A/en not_active Expired
- 1976-02-17 AU AU11177/76A patent/AU503105B2/en not_active Ceased
- 1976-02-17 IL IL49053A patent/IL49053A/xx unknown
- 1976-02-17 SE SE7601810A patent/SE7601810L/sv not_active Application Discontinuation
- 1976-02-18 JP JP51016876A patent/JPS51108041A/ja active Pending
- 1976-02-18 EG EG100/76A patent/EG12994A/xx active
- 1976-02-18 ES ES445274A patent/ES445274A1/es not_active Expired
- 1976-02-18 NL NL7601655A patent/NL7601655A/xx not_active Application Discontinuation
- 1976-02-18 PT PT64816A patent/PT64816B/pt unknown
- 1976-02-18 DE DE19762606517 patent/DE2606517A1/de not_active Ceased
- 1976-02-18 AR AR262294A patent/AR221027A1/es active
-
1977
- 1977-02-10 AR AR266507A patent/AR227266A1/es active
- 1977-02-10 AR AR266506A patent/AR217417A1/es active
- 1977-09-20 IN IN1416/CAL/77A patent/IN147046B/en unknown
-
1978
- 1978-11-01 CH CH1126778A patent/CH618215A5/fr not_active IP Right Cessation
- 1978-11-01 CH CH1126678A patent/CH618214A5/fr not_active IP Right Cessation
-
1979
- 1979-07-20 IN IN525/DEL/79A patent/IN149240B/en unknown
-
1980
- 1980-10-24 NO NO803185A patent/NO146811C/no unknown
- 1980-10-27 SE SE8007540A patent/SE8007540L/sv not_active Application Discontinuation
-
1982
- 1982-02-24 NO NO820574A patent/NO148298C/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8007540-1 |