SE8201181L - Forfarande for framstellning av nya derivat av 1,2,3,3a-tetra-hydro-indolo-(3,2,1-de) (1,5)naftyridin - Google Patents
Forfarande for framstellning av nya derivat av 1,2,3,3a-tetra-hydro-indolo-(3,2,1-de) (1,5)naftyridinInfo
- Publication number
- SE8201181L SE8201181L SE8201181A SE8201181A SE8201181L SE 8201181 L SE8201181 L SE 8201181L SE 8201181 A SE8201181 A SE 8201181A SE 8201181 A SE8201181 A SE 8201181A SE 8201181 L SE8201181 L SE 8201181L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- compounds
- methyl
- indolo
- naftyridine
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000002253 acid Substances 0.000 claims abstract 2
- 150000007513 acids Chemical class 0.000 claims abstract 2
- -1 3-hydroxybutyl Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000004803 chlorobenzyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000006277 halobenzyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 150000005054 naphthyridines Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- FTNWXGFYRHWUKG-UHFFFAOYSA-N triflupromazine hydrochloride Chemical compound [H+].[Cl-].C1=C(C(F)(F)F)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 FTNWXGFYRHWUKG-UHFFFAOYSA-N 0.000 claims 1
- VYQRBKCKQCRYEE-UHFFFAOYSA-N ctk1a7239 Chemical class C12=CC=CC=C2N2CC=CC3=NC=CC1=C32 VYQRBKCKQCRYEE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Naftyridinderivat i form av racemat eller optiska isomerer med formeln: R2 RI (I) R4 R_ b van i R, betecknar %rate eller en av grupperna alkyl med 1-4 kolatomer, 2-oxopropyl, 2-hydroxipropyl, 3-oxobutyl, 3-hydroxibutyl, cyklopropylmetyl, bensyl, halogenbensyl, f8retradesvis fluor- eller klorbensyl, acetyl, cyklopropyl arbonyl, bensoyl och -(CH2)6-R,, varvid n beteck- nar 1 eller 2 och etecknar en :ikarbonyl-, etoxikarbonyl- eller cyanogrupp, R2 beteoknar vate, halogen, metyl eller metoxi, R6 betecknar vate eller en grupp COR7, varvid R7 betecknar hydroxi, alkoxi med 1-4 kolatomer, amino, metylamino, dimetylamino eller cyklopropylamino och vari R3 betecknar en metyl- eller etylgrupp, R4 betecknar vate eller en hydroxigrupp och 116 betecknar vate eller vani R3 och 114 tillsammans betecknar syre och R6 betecknar vate eller R3 betecknar metyl eller etyl och R4 och 126 tillsammans betecknar en ytterligare kol-kolbindning, med undantag ay foreningar i vilka R3 och R4 = 0 och antingen R1 = H, R
2 . CH30 i 10-stallning och R6 H eller R1 = H, R2 = H och R6 H, samt stereoisomerer av foreningar, I vilka R6 betecknar en alkoxikarbonylgrupp, och additionssalter av f5reningarna I med organiska eller oorganiska, farmaceutiskt godtagbare syrcr.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7610773A FR2358146A1 (fr) | 1976-04-13 | 1976-04-13 | Derives de la tetrahydro-1,2,3,3a indolo(3,2,1-de) (1,5)naphtyridine |
| FR7616445A FR2353550A2 (fr) | 1976-06-01 | 1976-06-01 | Procede de preparation de derives de naphtyridine |
| FR7632319A FR2368955A2 (fr) | 1976-10-27 | 1976-10-27 | Derives de la tetrahydro-1,2,3,3a indolo (3,2,1-de) (1,5) naphtyridine |
| FR7639035A FR2374905A2 (fr) | 1976-12-24 | 1976-12-24 | Derives de naphtyridine |
| FR7707248A FR2383181A2 (fr) | 1977-03-11 | 1977-03-11 | Derives de naphtyridine |
| FR7707249A FR2383182A2 (fr) | 1977-03-11 | 1977-03-11 | Nouveaux derives de naphtyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8201181L true SE8201181L (sv) | 1982-05-25 |
Family
ID=27546337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7704172A SE432932B (sv) | 1976-04-13 | 1977-04-12 | Analogiforfarande for framstellning av derivat av 1,2,3,3a-tetrahydro-indolo/3,2,1-de/ /1,5/ naftyridin |
| SE8201181A SE8201181L (sv) | 1976-04-13 | 1982-02-25 | Forfarande for framstellning av nya derivat av 1,2,3,3a-tetra-hydro-indolo-(3,2,1-de) (1,5)naftyridin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7704172A SE432932B (sv) | 1976-04-13 | 1977-04-12 | Analogiforfarande for framstellning av derivat av 1,2,3,3a-tetrahydro-indolo/3,2,1-de/ /1,5/ naftyridin |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4190657A (sv) |
| JP (1) | JPS5823877B2 (sv) |
| AR (1) | AR214519A1 (sv) |
| AU (1) | AU506031B2 (sv) |
| CA (1) | CA1072960A (sv) |
| CH (1) | CH622795A5 (sv) |
| DD (1) | DD129791A5 (sv) |
| DE (1) | DE2716190A1 (sv) |
| DK (1) | DK143703C (sv) |
| FI (2) | FI63404C (sv) |
| GB (1) | GB1543283A (sv) |
| GR (1) | GR63658B (sv) |
| IE (1) | IE44989B1 (sv) |
| IL (1) | IL51853A (sv) |
| LU (1) | LU77100A1 (sv) |
| MT (1) | MTP811B (sv) |
| MX (1) | MX5340E (sv) |
| NO (1) | NO146777C (sv) |
| NZ (1) | NZ183846A (sv) |
| PL (1) | PL197373A1 (sv) |
| PT (1) | PT66428B (sv) |
| SE (2) | SE432932B (sv) |
| SU (1) | SU655314A3 (sv) |
| YU (1) | YU94877A (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5337696A (en) * | 1976-08-26 | 1978-04-06 | Omnium Chimique Sa | Hexahydrocantinonee6 derivative |
| US4228168A (en) * | 1978-11-22 | 1980-10-14 | Tanabe Seiyaku Co., Ltd. | Azepino [1,2,3-lm]-β-carboline compounds and pharmaceutical composition thereof |
| US4367230A (en) * | 1980-01-04 | 1983-01-04 | Tanabe Seiyaku Co., Ltd. | Novel triazafluoranthene compound and processes for preparing the same |
| FR2494693A1 (fr) * | 1980-11-21 | 1982-05-28 | Synthelabo | Derives de l'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de)(naphtyridine-1,5), leur preparation et leur application en therapeutique |
| FR2517679A1 (fr) * | 1981-12-03 | 1983-06-10 | Synthelabo | Derives de diaza-3,7a cyclohepta (j,k) fluorenes, leur preparation et leur application en therapeutique |
| LU84664A1 (fr) * | 1983-02-25 | 1984-11-08 | Onmichem S A | Alkyl-4-indolonaphtyridines et leur application therapeutique |
| EP0347980A1 (en) * | 1988-06-20 | 1989-12-27 | Duphar International Research B.V | 8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines |
| CN103193776A (zh) * | 2013-04-16 | 2013-07-10 | 苏州维泰生物技术有限公司 | 一种具有抗肿瘤疗效的新型萘啶衍生物的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299078A (en) * | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
| US3555018A (en) * | 1968-12-03 | 1971-01-12 | Ayerst Mckenna & Harrison | Thiazinopyridoindolone derivatives |
-
1977
- 1977-04-07 DD DD7700198314A patent/DD129791A5/xx unknown
- 1977-04-11 MT MT811A patent/MTP811B/xx unknown
- 1977-04-11 US US05/786,557 patent/US4190657A/en not_active Expired - Lifetime
- 1977-04-11 JP JP52041904A patent/JPS5823877B2/ja not_active Expired
- 1977-04-11 IL IL51853A patent/IL51853A/xx unknown
- 1977-04-11 YU YU00948/77A patent/YU94877A/xx unknown
- 1977-04-12 GB GB15165/77A patent/GB1543283A/en not_active Expired
- 1977-04-12 NO NO77771263A patent/NO146777C/no unknown
- 1977-04-12 DK DK161377A patent/DK143703C/da not_active IP Right Cessation
- 1977-04-12 CH CH450777A patent/CH622795A5/fr not_active IP Right Cessation
- 1977-04-12 AU AU24189/77A patent/AU506031B2/en not_active Expired
- 1977-04-12 CA CA275,948A patent/CA1072960A/en not_active Expired
- 1977-04-12 SE SE7704172A patent/SE432932B/sv unknown
- 1977-04-12 DE DE19772716190 patent/DE2716190A1/de not_active Withdrawn
- 1977-04-12 AR AR267179A patent/AR214519A1/es active
- 1977-04-12 MX MX775626U patent/MX5340E/es unknown
- 1977-04-12 PT PT66428A patent/PT66428B/pt unknown
- 1977-04-12 LU LU77100A patent/LU77100A1/xx unknown
- 1977-04-13 SU SU772470258A patent/SU655314A3/ru active
- 1977-04-13 IE IE758/77A patent/IE44989B1/en unknown
- 1977-04-13 PL PL19737377A patent/PL197373A1/xx unknown
- 1977-04-13 GR GR53198A patent/GR63658B/el unknown
- 1977-04-13 FI FI771159A patent/FI63404C/fi not_active IP Right Cessation
- 1977-04-13 FI FI803790A patent/FI803790A7/sv not_active Application Discontinuation
- 1977-04-13 NZ NZ183846A patent/NZ183846A/xx unknown
-
1982
- 1982-02-25 SE SE8201181A patent/SE8201181L/sv not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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