SE8301794D0 - Plasminogenaktivatorkomplex - Google Patents

Plasminogenaktivatorkomplex

Info

Publication number: SE8301794D0
Authority: SE; Sweden
Prior art keywords: plasmin; plasminogen; complex; streptokinase; activity
Prior art date: 1976-09-24

Application number

SE8301794A

Other languages

English (en)

Other versions

SE454047B (sv

Inventor

K C Robbins

L Summaria

Original Assignee

Reese Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-24

Filing date

1983-03-30

Publication date

1983-03-30

1983-03-30 Application filed by Reese Res Found filed Critical Reese Res Found

1983-03-30 Publication of SE8301794D0 publication Critical patent/SE8301794D0/sv

1988-03-28 Publication of SE454047B publication Critical patent/SE454047B/sv

Links

102000001938 Plasminogen Activators Human genes 0.000 title abstract 2
229940127126 plasminogen activator Drugs 0.000 title abstract 2
108010001014 Plasminogen Activators Proteins 0.000 title 1
229940012957 plasmin Drugs 0.000 abstract 4
108010023197 Streptokinase Proteins 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 3
229960005202 streptokinase Drugs 0.000 abstract 3
102000013566 Plasminogen Human genes 0.000 abstract 2
108010051456 Plasminogen Proteins 0.000 abstract 2
108010022999 Serine Proteases Proteins 0.000 abstract 2
102000012479 Serine Proteases Human genes 0.000 abstract 2
101001067249 Bos taurus Plasminogen Proteins 0.000 abstract 1
101000605403 Homo sapiens Plasminogen Proteins 0.000 abstract 1
101710145796 Staphylokinase Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
239000005018 casein Substances 0.000 abstract 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
235000021240 caseins Nutrition 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002504 physiological saline solution Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SE8301794A 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum SE454047B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/726,142 US4082612A (en)	1976-09-24	1976-09-24	Plasminogen activator complex

Publications (2)

Publication Number	Publication Date
SE8301794D0 true SE8301794D0 (sv)	1983-03-30
SE454047B SE454047B (sv)	1988-03-28

Family

ID=24917422

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SE7710653A SE442304B (sv)	1976-09-24	1977-09-22	Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum
SE8301795A SE454048B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum
SE8301794A SE454047B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
SE7710653A SE442304B (sv)	1976-09-24	1977-09-22	Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum
SE8301795A SE454048B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Country Status (10)

Country	Link
US (1)	US4082612A (sv)
JP (1)	JPS5352606A (sv)
CA (1)	CA1094449A (sv)
CH (2)	CH637991A5 (sv)
DE (1)	DE2742529C2 (sv)
DK (1)	DK421577A (sv)
FR (1)	FR2365583A1 (sv)
GB (1)	GB1533205A (sv)
NL (1)	NL7710451A (sv)
SE (3)	SE442304B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0028489B1 (en) *	1979-11-05	1983-10-05	Beecham Group Plc	Enzyme derivatives, and their preparation
JPS58189122A (ja) *	1982-04-30	1983-11-04	Kaken Pharmaceut Co Ltd	高脂血症予防治療剤
US4536391A (en) *	1982-11-17	1985-08-20	Otsuka Pharmaceutical Co.	Process for preparing urokinase complex
JPS60136520A (ja) *	1983-12-23	1985-07-20	Otsuka Pharmaceut Co Ltd	フイブリン吸着性ウロキナ−ゼ複合体
US4880776A (en) *	1983-12-24	1989-11-14	Beecham Group P.L.C.	Plasmin A-chain urokinase B-chain hybrid protein
GB8334498D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Compounds
GB8334499D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Derivatives
GB8400653D0 (en) *	1984-01-11	1984-02-15	Beecham Group Plc	Conjugates
DE3584902D1 (de) *	1984-02-29	1992-01-30	Asahi Chemical Ind	Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
US4774087A (en) *	1987-08-14	1988-09-27	Northwestern University	Micro-size fibrinolytic plasmin
DE3833936C1 (sv) *	1988-10-05	1989-09-21	Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US6964764B2 (en) *	1999-11-13	2005-11-15	Talecris Biotherapeutics, Inc.	Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) *	1999-11-13	2002-03-12	Bayer Corporation	Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) *	1999-11-13	2009-06-09	Talecris Biotherapeutics, Inc.	Process for the production of a reversibly inactive acidified plasmin composition
US6969515B2 (en)	1999-11-13	2005-11-29	Talecris Biotherapeutics, Inc.	Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
WO2009149199A2 (en) *	2008-06-04	2009-12-10	Talecris Biotherapeutics, Inc.	Composition, method and kit for preparing plasmin
PT2403865E (pt)	2009-03-03	2015-11-18	Grifols Therapeutics Inc	Métodos de preparação de plasminogénio

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3865692A (en) *	1974-01-11	1975-02-11	Abbott Lab	Method for making highly potent plasminogen

1976
- 1976-09-24 US US05/726,142 patent/US4082612A/en not_active Expired - Lifetime
1977
- 1977-08-16 CA CA284,760A patent/CA1094449A/en not_active Expired
- 1977-09-19 GB GB38933/77A patent/GB1533205A/en not_active Expired
- 1977-09-21 DE DE2742529A patent/DE2742529C2/de not_active Expired
- 1977-09-21 JP JP11276977A patent/JPS5352606A/ja active Pending
- 1977-09-22 SE SE7710653A patent/SE442304B/sv not_active IP Right Cessation
- 1977-09-22 FR FR7728611A patent/FR2365583A1/fr active Granted
- 1977-09-23 NL NL7710451A patent/NL7710451A/xx not_active Application Discontinuation
- 1977-09-23 CH CH1165677A patent/CH637991A5/de not_active IP Right Cessation
- 1977-09-23 DK DK421577A patent/DK421577A/da not_active Application Discontinuation
1982
- 1982-08-27 CH CH511282A patent/CH637992A5/de not_active IP Right Cessation
1983
- 1983-03-30 SE SE8301795A patent/SE454048B/sv not_active IP Right Cessation
- 1983-03-30 SE SE8301794A patent/SE454047B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK421577A (da)	1978-03-25
SE8301795D0 (sv)	1983-03-30
DE2742529C2 (de)	1984-01-05
SE442304B (sv)	1985-12-16
CH637992A5 (de)	1983-08-31
JPS5352606A (en)	1978-05-13
NL7710451A (nl)	1978-03-29
US4082612A (en)	1978-04-04
FR2365583B1 (sv)	1981-07-10
SE7710653L (sv)	1978-03-25
SE8301795L (sv)	1983-03-30
CA1094449A (en)	1981-01-27
DE2742529A1 (de)	1978-03-30
GB1533205A (en)	1978-11-22
SE454048B (sv)	1988-03-28
FR2365583A1 (fr)	1978-04-21
CH637991A5 (de)	1983-08-31
SE454047B (sv)	1988-03-28

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 8301794-7

Effective date: 19900703

Format of ref document f/p: F

Publication	Publication Date	Title
SE8301794D0 (sv)	1983-03-30	Plasminogenaktivatorkomplex
Silverstein et al.	1985	Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation.
Hajjar et al.	1988	Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface.
ES2262264T3 (es)	2006-11-16	Proteasa para activar el factor de coagulacion vii.
Adelman et al.	1986	Proteolysis of platelet glycoprotein lb by plasmin is facilitated by plasmin lysine-binding regions
Tran-Thang et al.	1984	Tissue-type plasminogen activator increases the binding of glu-plasminogen to clots.
NO922237D0 (no)	1992-06-05	Proteiner og nukleinsyrer
Silverstein et al.	1986	Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin.
DK0477274T3 (da)	1994-03-28	Faktor Xa baserede antikoaguleringspræparater
JPS6236502B2 (sv)	1987-08-07
ATE108206T1 (de)	1994-07-15	Gewebe-plasminogenaktivator.
CA2101614A1 (en)	1994-01-31	Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
Røjkjær et al.	1999	Activation of the plasma kallikrein/kinin system on endothelial cell membranes
Shih et al.	1993	Plasminogen and plasminogen activator assembly on the human endothelial cell
ATE129525T1 (de)	1995-11-15	Verfahren zur bestimmung der aktivität von serinproteasen oder serinproteaseninhibitoren.
Higazi et al.	1992	Stimulation of plasmin activity by oleic acid
KR870010186A (ko)	1987-11-30	가수분해효소 활성 축진제
Kolev et al.	1995	Dual effect of synthetic plasmin substrates on plasminogen activation
Davidson et al.	1979	Synthetic fibrinolytic agents
Rijken et al.	2000	Molecular transport during fibrin clot lysis
NO872875L (no)	1988-01-12	Modifisert vevsplasminaktivator, samt fremgangsmte for fremstilling av en slik.
HUT59610A (en)	1992-06-29	Process for producing pharmaceutical compositions for solving blood clot containing t-pa without glycosilyzing
GB1531654A (en)	1978-11-08	Purification of antiserum for detecting activation of fibrinolysis and/or blood coagulation
Young et al.	1968	Sustained lymphatic delivery of fibrinogen after induced afibrinogenemia
Prentice et al.	1973	Evaluation of a new preparation of urokinase