DK189983A - Fremgangsmaade til fremstilling af ergolinderivater - Google Patents

Fremgangsmaade til fremstilling af ergolinderivater Download PDF

Info

Publication number: DK189983A
Authority: DK; Denmark
Prior art keywords: procedure; preparation; ergoline derivatives; derivatives; ergoline
Prior art date: 1982-04-30

Application number

DK189983A

Other languages

English (en)

Other versions

DK164058C (da

DK164058B (da

DK189983D0 (da

Inventor

Luigi Bernardi

Aldemio Temperilli

Sergio Mantegani

Gabriella Traquandi

Patricia Salvati

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-30

Filing date

1983-04-28

Publication date

1983-10-31

1983-04-28 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1983-04-28 Publication of DK189983D0 publication Critical patent/DK189983D0/da

1983-10-31 Publication of DK189983A publication Critical patent/DK189983A/da

1992-05-04 Publication of DK164058B publication Critical patent/DK164058B/da

1992-10-12 Application granted granted Critical

1992-10-12 Publication of DK164058C publication Critical patent/DK164058C/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
238000006000 Knoevenagel condensation reaction Methods 0.000 description 1
125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 description 1
-1 amino, methyl Chemical group 0.000 description 1
230000003276 anti-hypertensive effect Effects 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001728 carbonyl compounds Chemical class 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
230000005494 condensation Effects 0.000 description 1
238000009833 condensation Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

N=C-Rg, hvor C-atomet er anbragt mellem ringens nitrogenatomer, og Rg er eventuelt substitueret amino, methyl, phenyl, thiomethyl eller mercapto, fremstilles ved kondensation af Ø-dicarbonylergolinderivater

med (III) hvori R^ til R^, n og X er som ovenfor.

forbindelserne II fremstilles ved en Knoevenagel-omsætning mellem en β-dicarbonylforbindelse og en 6-alkyl-8p-formylergolin til dannelse af en β, -umættet carbonylforbindelse, hvorefter denne reduceres med hydrogen i nærværelse af en tungmetalkatalysator.

Forbindelserne med formel II er mellemprodukter.

Forbindelserne med formel I er lægemidler med anti-hypertensiv virkning.

DK189983A 1982-04-30 1983-04-28 Analogifremgangsmaade til fremstilling af ergolinderivater DK164058C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8212653		1982-04-30
GB8212653		1982-04-30

Publications (4)

Publication Number	Publication Date
DK189983D0 DK189983D0 (da)	1983-04-28
DK189983A true DK189983A (da)	1983-10-31
DK164058B DK164058B (da)	1992-05-04
DK164058C DK164058C (da)	1992-10-12

Family

ID=10530108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK189983A DK164058C (da)	1982-04-30	1983-04-28	Analogifremgangsmaade til fremstilling af ergolinderivater

Country Status (21)

Country	Link
US (1)	US4657914A (da)
JP (1)	JPS58194884A (da)
AT (1)	AT385035B (da)
AU (1)	AU553851B2 (da)
BE (1)	BE896609A (da)
CA (1)	CA1210389A (da)
CH (1)	CH654305A5 (da)
CS (1)	CS236874B2 (da)
DE (1)	DE3314878A1 (da)
DK (1)	DK164058C (da)
FI (1)	FI73996C (da)
FR (1)	FR2526022B1 (da)
GB (1)	GB2120242A (da)
GR (1)	GR78842B (da)
HU (1)	HU193527B (da)
IE (1)	IE53950B1 (da)
IL (1)	IL68496A (da)
IT (1)	IT1215630B (da)
NL (1)	NL191709C (da)
SE (1)	SE460967B (da)
ZA (1)	ZA833008B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
GB2173189B (en) *	1985-02-21	1988-04-27	Maruko Pharmaceutical Co	Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
EP2566333A4 (en) *	2010-05-07	2014-04-02	Univ Leland Stanford Junior	IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS
US20160045609A1 (en)	2014-08-14	2016-02-18	Mamoun M. Alhamadsheh	Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
EP3582773A4 (en)	2017-02-17	2021-03-10	Eidos Therapeutics, Inc.	PROCESS FOR THE MANUFACTURING OF AG-10, ITS INTERMEDIATES AND SALTS THEREOF
WO2019183463A1 (en)	2018-03-23	2019-09-26	Eidos Therapeutics, Inc.	Methods of treating ttr amyloidosis using ag10
LT3836920T (lt)	2018-08-17	2026-01-26	Eidos Therapeutics, Inc.	Ag10 farmacinės formos

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3238211A (en) *		1966-03-01		Derhvatives of g-methyl and i,g-dimethyl ergolhne
US3296071A (en) *	1963-05-31	1967-01-03	Upjohn Co	Reducing blood sugar with 3-alkyl-5-alkoxymethylisoxazole
CH507248A (de) *	1967-03-16	1971-05-15	Spofa Vereinigte Pharma Werke	Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
US3957785A (en) *	1971-12-02	1976-05-18	Societa' Farmaceutici Italia S.P.A.	Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
CH563376A5 (da) *	1972-06-29	1975-06-30	Lonza Ag
US3996228A (en) *	1973-12-21	1976-12-07	Societa' Farmaceutici Italia S.P.A.	Pyrimidinoaminoethyl ergoline derivatives
NL7416120A (nl) *	1973-12-21	1975-06-24	Farmaceutici Italia	Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
IE41533B1 (en) *	1974-03-14	1980-01-30	Sandoz Ltd	Thiomethyl ergolene derivatives
US4147789A (en) *	1974-03-14	1979-04-03	Sandoz Ltd.	6-Methyl-8-thiomethyl-ergolene derivatives
CS171480B1 (da) *	1974-03-19	1976-10-29
CS177530B1 (en) *	1974-07-19	1977-07-29	Miroslav Semonsky	New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof
CH617452A5 (da) *	1974-10-25	1980-05-30	Hoffmann La Roche
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
AU526764B2 (en) *	1978-09-08	1983-01-27	Farmitalia Carlo Erba S.P.A.	Ergoline derivatives
GB2056437A (en) *	1979-08-07	1981-03-18	Erba Farmitalia	Secoergoline derivatives
US4382940A (en) *	1979-12-06	1983-05-10	Farmitalia Carlo Erba S.P.A.	Ercoline derivatives and therapeutic compositions having CNS affecting activity

1983
- 1983-04-21 GB GB08310843A patent/GB2120242A/en not_active Withdrawn
- 1983-04-25 CS CS832921A patent/CS236874B2/cs unknown
- 1983-04-25 US US06/488,168 patent/US4657914A/en not_active Expired - Fee Related
- 1983-04-25 FI FI831406A patent/FI73996C/fi not_active IP Right Cessation
- 1983-04-25 DE DE19833314878 patent/DE3314878A1/de active Granted
- 1983-04-25 GR GR71190A patent/GR78842B/el unknown
- 1983-04-25 IE IE932/83A patent/IE53950B1/en not_active IP Right Cessation
- 1983-04-26 JP JP58072295A patent/JPS58194884A/ja active Granted
- 1983-04-26 IL IL68496A patent/IL68496A/xx not_active IP Right Cessation
- 1983-04-26 CH CH2256/83A patent/CH654305A5/it not_active IP Right Cessation
- 1983-04-27 SE SE8302379A patent/SE460967B/sv not_active IP Right Cessation
- 1983-04-27 CA CA000426874A patent/CA1210389A/en not_active Expired
- 1983-04-27 IT IT8320807A patent/IT1215630B/it active
- 1983-04-27 HU HU851631A patent/HU193527B/hu not_active IP Right Cessation
- 1983-04-27 FR FR8306926A patent/FR2526022B1/fr not_active Expired
- 1983-04-28 DK DK189983A patent/DK164058C/da not_active IP Right Cessation
- 1983-04-28 ZA ZA833008A patent/ZA833008B/xx unknown
- 1983-04-28 AU AU14029/83A patent/AU553851B2/en not_active Ceased
- 1983-04-29 AT AT0156783A patent/AT385035B/de not_active IP Right Cessation
- 1983-04-29 NL NL8301529A patent/NL191709C/xx not_active IP Right Cessation
- 1983-04-29 BE BE0/210660A patent/BE896609A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE460967B (sv)	1989-12-11
US4657914A (en)	1987-04-14
IT1215630B (it)	1990-02-22
GB8310843D0 (en)	1983-05-25
IL68496A (en)	1985-06-30
IE53950B1 (en)	1989-04-26
FR2526022B1 (fr)	1985-06-14
DK164058C (da)	1992-10-12
DK164058B (da)	1992-05-04
GB2120242A (en)	1983-11-30
IT8320807A0 (it)	1983-04-27
DE3314878C2 (da)	1993-09-23
SE8302379D0 (sv)	1983-04-27
FI73996C (fi)	1987-12-10
CH654305A5 (it)	1986-02-14
DK189983D0 (da)	1983-04-28
FI831406L (fi)	1983-10-31
IL68496A0 (en)	1983-07-31
GR78842B (da)	1984-10-02
ATA156783A (de)	1987-07-15
FI831406A0 (fi)	1983-04-25
SE8302379L (sv)	1983-10-31
DE3314878A1 (de)	1983-11-03
IE830932L (en)	1983-10-30
NL191709B (nl)	1995-12-01
NL8301529A (nl)	1983-11-16
BE896609A (fr)	1983-08-16
NL191709C (nl)	1996-04-02
FR2526022A1 (fr)	1983-11-04
JPS58194884A (ja)	1983-11-12
CA1210389A (en)	1986-08-26
AU1402983A (en)	1983-11-03
CS236874B2 (en)	1985-05-15
ZA833008B (en)	1984-01-25
AU553851B2 (en)	1986-07-31
HU193527B (en)	1987-10-28
AT385035B (de)	1988-02-10
JPH0354668B2 (da)	1991-08-20
FI73996B (fi)	1987-08-31

Legal Events

Date	Code	Title	Description
1999-03-15	PBP	Patent lapsed

Publication	Publication Date	Title
KR860004918A (ko)	1986-07-16	트리사이클로 화합물의 제조방법
MX9206114A (es)	1993-08-01	Derivados de urea y proceso para su preparacion
DK0554708T3 (da)	2005-07-18	Thioetherkonjugater
GB957797A (en)	1964-05-13	Method for making 2,4-diamino-5-arylmethylpyrimidines and intermediates therefor
EP0895991A3 (en)	2001-09-05	Halogenating agent
FR2405921A1 (fr)	1979-05-11	Procede de preparation d'une amine
EA200200970A1 (ru)	2003-02-27	Способ получения циталопрама
EP0357404A3 (en)	1991-06-12	Process for the preparation of cyclopentane derivatives
KR840008323A (ko)	1984-12-14	5-아실-2-(1h)-피리디논의 제조방법
KR830009085A (ko)	1983-12-17	(피리딘일)-y-벤즈이미다졸
DE3773066D1 (de)	1991-10-24	Pristinamycin-verfahren.
JPS5223145A (en)	1977-02-21	Process for preparing a modified polyolefin composition
DK159457C (da)	1991-03-18	Analogifremgangsmaade til fremstilling af 7alfa-acylthio-15,16-methylen-3-oxo-17alfa-pregna-1,4-dien-21,17-carbolactoner
KR830007510A (ko)	1983-10-21	심장질환 치료제의 제조방법
DK133285D0 (da)	1985-03-25	Fremgangsmaade og udgangsmateriale til fremstilling af bestatinderivater
DK197586A (da)	1986-11-11	Fremgangsmaade til fremstilling af 17alfa-ethynyl-17beta-hydroxy-18-methyl-4,15-oestradien-3-on og udgangsforbindelser til denne fremgangsmaade
EP0258030A3 (en)	1988-09-21	A fungicidal composition containing an iodopropargyl carbamate
KR870002065A (ko)	1987-03-28	설페닐화 아실히드라존의 제조 방법
KR930700458A (ko)	1993-03-15	선충류 박멸제 피리미딘 유도체
GB1436519A (en)	1976-05-19	N-sulphenylated n-methyl-carbamates process for their preparation and their use as insecticides or acaricides
DK59488A (da)	1988-08-07	Fremgangsmaade til fremstilling af beta-lactamer med hjaelp af en metalforbindelse
EP0094612A3 (en)	1985-01-23	Novel alkyloxazolylacetic acid derivative, processes for preparation and pharmaceutical compositions containing same
KR840003642A (ko)	1984-09-15	에르고트 5's-(2r-부틸)펩티드 알카로이드의 제조방법
EP0273432A3 (en)	1989-03-01	2-nitro-5-(substituted phenoxy) benzohydroximate derivatives and their use as herbicide
EP0254049A3 (en)	1989-04-12	Herbicidal compositions