SE8306714L - Forfarande for framstellning av l-karnitin och herfor anvenda kemiska mellanprodukter - Google Patents

Forfarande for framstellning av l-karnitin och herfor anvenda kemiska mellanprodukter

Info

Publication number: SE8306714L
Authority: SE; Sweden
Prior art keywords: hydroxybutyrate; converting; carnitine; salt; chemical intermediates
Prior art date: 1982-12-06

Application number

SE8306714A

Other languages

Unknown language ( )

English (en)

Other versions

SE8306714D0 (sv

SE455501B (sv

Inventor

C J Sih

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-06

Filing date

1983-12-05

Publication date

1984-06-07

1982-12-06 Priority claimed from US06/447,171 external-priority patent/US4642290A/en

1983-12-05 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1983-12-05 Publication of SE8306714D0 publication Critical patent/SE8306714D0/sv

1984-06-07 Publication of SE8306714L publication Critical patent/SE8306714L/sv

1988-07-18 Publication of SE455501B publication Critical patent/SE455501B/sv

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000126 substance Substances 0.000 title abstract 2
FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 abstract 3
WGNSGQNASYNCBU-GSVOUGTGSA-N (3r)-4-bromo-3-hydroxybutanoic acid Chemical compound BrC[C@H](O)CC(O)=O WGNSGQNASYNCBU-GSVOUGTGSA-N 0.000 abstract 2
AKDAXGMVRMXFOO-GSVOUGTGSA-N (3r)-4-chloro-3-hydroxybutanoic acid Chemical compound ClC[C@H](O)CC(O)=O AKDAXGMVRMXFOO-GSVOUGTGSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
101710088194 Dehydrogenase Proteins 0.000 abstract 1
WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical class CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Inorganic materials [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 abstract 1
235000009518 sodium iodide Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SE8306714A 1982-12-06 1983-12-05 Optiskt aktiva gamma-substituerade beta-hydroxismorsyraderivat samt forfarande for framstellning av dessa genom fermentativ enzymatisk verkan av en mikroorganism SE455501B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/447,171 US4642290A (en)	1982-12-06	1982-12-06	Process for preparing a compound for use in the production of L-carnitine
US54495783A	1983-10-24	1983-10-24

Publications (3)

Publication Number	Publication Date
SE8306714D0 SE8306714D0 (sv)	1983-12-05
SE8306714L true SE8306714L (sv)	1984-06-07
SE455501B SE455501B (sv)	1988-07-18

Family

ID=27034888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8306714A SE455501B (sv)	1982-12-06	1983-12-05	Optiskt aktiva gamma-substituerade beta-hydroxismorsyraderivat samt forfarande for framstellning av dessa genom fermentativ enzymatisk verkan av en mikroorganism

Country Status (23)

Country	Link
JP (1)	JPH0767674A (sv)
KR (1)	KR840008165A (sv)
AT (1)	AT393136B (sv)
AU (1)	AU566906B2 (sv)
CA (1)	CA1225956A (sv)
CH (1)	CH661498A5 (sv)
DE (1)	DE3344085C2 (sv)
DK (1)	DK163917C (sv)
ES (1)	ES8601305A1 (sv)
FI (1)	FI81115C (sv)
FR (1)	FR2537130B1 (sv)
GB (1)	GB2132614B (sv)
GR (1)	GR78767B (sv)
IE (1)	IE56322B1 (sv)
IL (1)	IL70352A (sv)
IT (1)	IT1167289B (sv)
LU (1)	LU85115A1 (sv)
NL (1)	NL8304190A (sv)
NO (1)	NO159291C (sv)
PH (1)	PH20456A (sv)
PT (1)	PT77780B (sv)
SE (1)	SE455501B (sv)
TR (1)	TR23136A (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK544284A (da) *	1983-12-06	1985-06-07	Hoffmann La Roche	Fremgangsmaade til fremstilling af optisk aktive propionsyrederivater
IT1181908B (it) *	1984-07-12	1987-09-30	Debi Derivati Biologici	Procedimento per la preparazione di l-carnitina
IT1181812B (it) *	1984-07-27	1987-09-30	Sigma Tau Ind Farmaceuti	Procedimento per la preparazione dell'acido gamma-dimetilammino l-beta-idrossibutirrico
IT1190358B (it) *	1985-05-24	1988-02-16	Sclavo Spa	Procedimento per la preparazione di l-carnitina
JPS62126997A (ja) *	1985-11-28	1987-06-09	Nippon Synthetic Chem Ind Co Ltd:The	光学活性のγ−ハロ−βヒドロキシ酪酸エステルの製造法
IT1189070B (it) *	1986-03-14	1988-01-28	Donegani Guido Ist	Processo per la preparazione della l(-)-carnitina cloruro a partire da esteri 3,4-epossibutirrici
JPH0678277B2 (ja) *	1988-02-19	1994-10-05	高砂香料工業株式会社	光学活性アルコールおよびその誘導体の製造方法
JP2939646B2 (ja) *	1990-07-17	1999-08-25	チッソ株式会社	４―置換―２―ヒドロキシブタン酸エステルおよび製造法
US5215919A (en) *	1991-02-25	1993-06-01	Takeda Chemical Industries, Ltd.	Process for producing optically active 2-hydroxycycloalkanecarboxylic acid esters using microbially derived reductase
US5324662A (en)	1992-05-15	1994-06-28	E. R. Squibb & Sons, Inc.	Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JP3155107B2 (ja) *	1993-01-12	2001-04-09	ダイセル化学工業株式会社	光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JP2000189170A (ja) *	1998-05-08	2000-07-11	Daicel Chem Ind Ltd	光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法
CN1162422C (zh)	1998-08-05	2004-08-18	钟渊化学工业株式会社	制备光学活性的2－[6－(羟甲基)－1,3－二噁烷－4－基]乙酸衍生物的方法
JP4578240B2 (ja) *	2002-08-09	2010-11-10	コデクシス，インコーポレイテッド	４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
DE10315760A1 (de) *	2003-04-07	2004-10-21	Basf Ag	L-Carnitin Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von substituierten (S)-Alkanolen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3931410A (en) *	1974-02-28	1976-01-06	The Upjohn Company	Composition and method of use
CH589604A5 (sv) *	1974-04-26	1977-07-15	Lonza Ag
JPS5139634A (en) *	1974-09-27	1976-04-02	Ono Pharmaceutical Co	Ganma amino beeta hidorokishibutansananirido no seizoho
JPS6017776B2 (ja) *	1979-11-07	1985-05-07	電気化学工業株式会社	γ−クロロ−β−ヒドロキシ酪酸アルキルエステルの製法
JPS5950661B2 (ja) *	1980-07-28	1984-12-10	電気化学工業株式会社	γ−アミノ−β−ヒドロキシ酪酸の製造法
JPS5950663B2 (ja) *	1981-04-28	1984-12-10	電気化学工業株式会社	γ−アミノ−β−ヒドロキシ酪酸の製造法

1983
- 1983-11-22 IE IE2732/83A patent/IE56322B1/en not_active IP Right Cessation
- 1983-11-28 AU AU21758/83A patent/AU566906B2/en not_active Ceased
- 1983-11-29 CA CA000442170A patent/CA1225956A/en not_active Expired
- 1983-11-30 IL IL8370352A patent/IL70352A/xx not_active IP Right Cessation
- 1983-12-01 GR GR73128A patent/GR78767B/el unknown
- 1983-12-02 FI FI834419A patent/FI81115C/sv not_active IP Right Cessation
- 1983-12-02 CH CH6448/83A patent/CH661498A5/it not_active IP Right Cessation
- 1983-12-05 AT AT4237/83A patent/AT393136B/de not_active IP Right Cessation
- 1983-12-05 SE SE8306714A patent/SE455501B/sv not_active IP Right Cessation
- 1983-12-05 NO NO834461A patent/NO159291C/no unknown
- 1983-12-05 DK DK559283A patent/DK163917C/da not_active IP Right Cessation
- 1983-12-05 GB GB08332359A patent/GB2132614B/en not_active Expired
- 1983-12-05 PH PH29928A patent/PH20456A/en unknown
- 1983-12-05 LU LU85115A patent/LU85115A1/fr unknown
- 1983-12-05 IT IT8324018A patent/IT1167289B/it active
- 1983-12-05 ES ES83527807A patent/ES8601305A1/es not_active Expired
- 1983-12-06 FR FR8319505A patent/FR2537130B1/fr not_active Expired
- 1983-12-06 DE DE3344085A patent/DE3344085C2/de not_active Expired - Fee Related
- 1983-12-06 PT PT77780A patent/PT77780B/pt not_active IP Right Cessation
- 1983-12-06 NL NL8304190A patent/NL8304190A/nl not_active Application Discontinuation
- 1983-12-06 TR TR10354/83A patent/TR23136A/xx unknown
- 1983-12-06 KR KR1019830005765A patent/KR840008165A/ko not_active Ceased
1993
- 1993-09-01 JP JP21771093A patent/JPH0767674A/ja active Pending

Also Published As

Publication number	Publication date
ES527807A0 (es)	1985-11-01
NO159291C (no)	1988-12-14
JPH0767674A (ja)	1995-03-14
IT8324018A0 (it)	1983-12-05
IE832732L (en)	1984-06-06
DE3344085C2 (de)	1993-10-14
FI81115B (fi)	1990-05-31
FR2537130A1 (fr)	1984-06-08
NO834461L (no)	1984-06-07
GB8332359D0 (en)	1984-01-11
DK163917C (da)	1992-09-14
PT77780B (en)	1986-04-17
FI834419L (fi)	1984-06-07
SE8306714D0 (sv)	1983-12-05
GR78767B (sv)	1984-10-02
PH20456A (en)	1987-01-14
TR23136A (tr)	1989-04-11
GB2132614B (en)	1986-03-26
AU566906B2 (en)	1987-11-05
NL8304190A (nl)	1984-07-02
CH661498A5 (it)	1987-07-31
IL70352A (en)	1987-10-20
KR840008165A (ko)	1984-12-13
NO159291B (no)	1988-09-05
AU2175883A (en)	1984-06-14
FI81115C (sv)	1990-09-10
IT1167289B (it)	1987-05-13
ES8601305A1 (es)	1985-11-01
DK163917B (da)	1992-04-21
FR2537130B1 (fr)	1988-10-14
SE455501B (sv)	1988-07-18
GB2132614A (en)	1984-07-11
DE3344085A1 (de)	1984-06-07
DK559283D0 (da)	1983-12-05
PT77780A (en)	1984-01-01
IE56322B1 (en)	1991-06-19
LU85115A1 (fr)	1984-04-02
CA1225956A (en)	1987-08-25
DK559283A (da)	1984-06-07
IL70352A0 (en)	1984-02-29
AT393136B (de)	1991-08-26
ATA423783A (de)	1991-01-15
FI834419A0 (fi)	1983-12-02

Legal Events

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

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1995-09-04

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