SE8403375L - Ny plasminogenaktivator, framstellningsprocess for denna samt ett trombolytiskt medel innehallande densamma - Google Patents

Ny plasminogenaktivator, framstellningsprocess for denna samt ett trombolytiskt medel innehallande densamma

Info

Publication number: SE8403375L
Authority: SE; Sweden
Prior art keywords: column; plasminogen activator; manufacturing process; agent containing; thrombolytic agent
Prior art date: 1982-10-29

Application number

SE8403375A

Other languages

Unknown language ( )

English (en)

Swedish (sv)

Other versions

SE8403375D0 (sv

Inventor

Seishi Takahashi

Kazushi Morimoto

Yoshikazu Fujisawa

Fumiaki Ikeda

Original Assignee

Mitsui Toatsu Chemicals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-29

Filing date

1984-06-25

Publication date

1984-06-25

1982-10-29 Priority claimed from JP57189065A external-priority patent/JPH0637398B2/ja

1982-10-29 Priority claimed from JP57189067A external-priority patent/JPS5980613A/ja

1984-06-25 Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals

1984-06-25 Publication of SE8403375D0 publication Critical patent/SE8403375D0/xx

1984-06-25 Publication of SE8403375L publication Critical patent/SE8403375L/

Links

102000001938 Plasminogen Activators Human genes 0.000 title abstract 2
108010001014 Plasminogen Activators Proteins 0.000 title abstract 2
229940127126 plasminogen activator Drugs 0.000 title abstract 2
239000003527 fibrinolytic agent Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229960000103 thrombolytic agent Drugs 0.000 title 1
SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 abstract 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
101710154606 Hemagglutinin Proteins 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
229930064664 L-arginine Natural products 0.000 abstract 1
235000014852 L-arginine Nutrition 0.000 abstract 1
101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
101710176177 Protein A56 Proteins 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
235000009697 arginine Nutrition 0.000 abstract 1
210000004204 blood vessel Anatomy 0.000 abstract 1
239000013522 chelant Substances 0.000 abstract 1
239000000185 hemagglutinin Substances 0.000 abstract 1
238000005342 ion exchange Methods 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000002808 molecular sieve Substances 0.000 abstract 1
238000007670 refining Methods 0.000 abstract 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SE8403375A 1982-10-29 1984-06-25 Ny plasminogenaktivator, framstellningsprocess for denna samt ett trombolytiskt medel innehallande densamma SE8403375L (sv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP57189065A JPH0637398B2 (ja)	1982-10-29	1982-10-29	血栓溶解剤
JP57189067A JPS5980613A (ja)	1982-10-29	1982-10-29	新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
PCT/JP1983/000386 WO1984001714A1 (fr)	1982-10-29	1983-10-27	Nouvel activateur de plasminogene, son procede de preparation et medicament thrombolytique le contenant

Publications (2)

Publication Number	Publication Date
SE8403375D0 SE8403375D0 (sv)	1984-06-25
SE8403375L true SE8403375L (sv)	1984-06-25

Family

ID=26505289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8403375A SE8403375L (sv)	1982-10-29	1984-06-25	Ny plasminogenaktivator, framstellningsprocess for denna samt ett trombolytiskt medel innehallande densamma

Country Status (12)

Country	Link
EP (1)	EP0124613B1 (da)
CA (1)	CA1221029A (da)
CH (1)	CH660742A5 (da)
DE (1)	DE3390272C2 (da)
DK (1)	DK169686B1 (da)
FI (1)	FI80597C (da)
GB (1)	GB2138824B (da)
IT (1)	IT1169910B (da)
NL (1)	NL191755C (da)
NO (1)	NO166314C (da)
SE (1)	SE8403375L (da)
WO (1)	WO1984001714A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3582338D1 (de) *	1984-01-30	1991-05-08	Asahi Chemical Ind	Verfahren zur herstellung eines doppelkettigen plasminogenaktivators.
AU569429B2 (en) *	1985-05-28	1988-01-28	Wellcome Foundation Limited, The	Aqueous acidic tissue plasminogen activator parenternal formulation
US4929444A (en) *	1985-05-28	1990-05-29	Burroughs Wellcome Co.	Low pH pharmaceutical formulation containing t-PA
AU7709287A (en) *	1986-07-16	1988-02-10	Celltech Limited	Process for purifying a plasminogen activator
JPS6379591A (ja) *	1986-09-22	1988-04-09	Mitsui Toatsu Chem Inc	ｔＰＡの精製方法
AU1668988A (en) *	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
DE3726019A1 (de) *	1987-08-05	1989-02-16	Boehringer Mannheim Gmbh	Verfahren zur abtrennung und reinigung von t-pa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8003402A (nl) *	1980-06-11	1982-01-04	Leuven Res & Dev Vzw	Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5913732A (ja) *	1982-07-16	1984-01-24	Mitsui Toatsu Chem Inc	血栓溶解剤

1983
- 1983-10-27 NL NL8320346A patent/NL191755C/xx not_active IP Right Cessation
- 1983-10-27 DE DE19833390272 patent/DE3390272C2/de not_active Expired
- 1983-10-27 CH CH3063/84A patent/CH660742A5/de not_active IP Right Cessation
- 1983-10-27 EP EP83903315A patent/EP0124613B1/en not_active Expired - Lifetime
- 1983-10-27 GB GB08414992A patent/GB2138824B/en not_active Expired
- 1983-10-27 WO PCT/JP1983/000386 patent/WO1984001714A1/ja not_active Ceased
- 1983-10-28 CA CA000439941A patent/CA1221029A/en not_active Expired
- 1983-10-28 IT IT23533/83A patent/IT1169910B/it active
1984
- 1984-06-19 NO NO84842468A patent/NO166314C/no unknown
- 1984-06-22 DK DK307384A patent/DK169686B1/da active
- 1984-06-25 SE SE8403375A patent/SE8403375L/ unknown
- 1984-06-29 FI FI842627A patent/FI80597C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE8403375D0 (sv)	1984-06-25
NO166314C (no)	1991-07-03
FI80597B (fi)	1990-03-30
CH660742A5 (de)	1987-06-15
NO842468L (no)	1984-06-19
NL191755B (nl)	1996-03-01
EP0124613B1 (en)	1992-12-30
GB2138824A (en)	1984-10-31
IT1169910B (it)	1987-06-03
DE3390272C2 (de)	1987-09-17
NL8320346A (nl)	1984-09-03
WO1984001714A1 (fr)	1984-05-10
DE3390272T1 (de)	1984-11-29
EP0124613A1 (en)	1984-11-14
NL191755C (nl)	1996-07-02
IT8323533A0 (it)	1983-10-28
NO166314B (no)	1991-03-25
FI842627L (fi)	1984-06-29
GB8414992D0 (en)	1984-07-18
CA1221029A (en)	1987-04-28
FI842627A0 (fi)	1984-06-29
FI80597C (fi)	1990-07-10
GB2138824B (en)	1986-12-31
DK169686B1 (da)	1995-01-09
DK307384D0 (da)	1984-06-22
DK307384A (da)	1984-06-22
EP0124613A4 (en)	1986-07-29

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