DK307384A - Ny plasminogen-aktivator og fremgangsmaade til fremstilling heraf samt thrombolytisk middel indeholdende samme - Google Patents

Ny plasminogen-aktivator og fremgangsmaade til fremstilling heraf samt thrombolytisk middel indeholdende samme Download PDF

Info

Publication number: DK307384A
Authority: DK; Denmark
Prior art keywords: plasminogen activator; column containing; preparing; agents containing; containing same
Prior art date: 1982-10-29

Application number

DK307384A

Other languages

English (en)

Other versions

DK169686B1 (da

DK307384D0 (da

Inventor

Seishi Takahashi

Kazushi Morimoto

Yoshikazu Fujisawa

Fumiaki Ikeda

Original Assignee

Mitsui Toatsu Chemicals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-29

Filing date

1984-06-22

Publication date

1984-06-22

1982-10-29 Priority claimed from JP57189067A external-priority patent/JPS5980613A/ja

1982-10-29 Priority claimed from JP57189065A external-priority patent/JPH0637398B2/ja

1984-06-22 Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals

1984-06-22 Publication of DK307384D0 publication Critical patent/DK307384D0/da

1984-06-22 Publication of DK307384A publication Critical patent/DK307384A/da

1995-01-09 Application granted granted Critical

1995-01-09 Publication of DK169686B1 publication Critical patent/DK169686B1/da

Links

102000001938 Plasminogen Activators Human genes 0.000 title abstract 5
108010001014 Plasminogen Activators Proteins 0.000 title abstract 5
229940127126 plasminogen activator Drugs 0.000 title abstract 5
239000003527 fibrinolytic agent Substances 0.000 title abstract 2
229960000103 thrombolytic agent Drugs 0.000 title abstract 2
239000000463 material Substances 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 2
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
229930064664 L-arginine Natural products 0.000 abstract 1
235000014852 L-arginine Nutrition 0.000 abstract 1
SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 abstract 1
150000001483 arginine derivatives Chemical class 0.000 abstract 1
210000004204 blood vessel Anatomy 0.000 abstract 1
239000013522 chelant Substances 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
238000005342 ion exchange Methods 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000002808 molecular sieve Substances 0.000 abstract 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
230000002537 thrombolytic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK307384A 1982-10-29 1984-06-22 Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre DK169686B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP18906782		1982-10-29
JP18906582		1982-10-29
JP57189067A JPS5980613A (ja)	1982-10-29	1982-10-29	新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
JP57189065A JPH0637398B2 (ja)	1982-10-29	1982-10-29	血栓溶解剤
JP8300386		1983-10-27
PCT/JP1983/000386 WO1984001714A1 (fr)	1982-10-29	1983-10-27	Nouvel activateur de plasminogene, son procede de preparation et medicament thrombolytique le contenant

Publications (3)

Publication Number	Publication Date
DK307384D0 DK307384D0 (da)	1984-06-22
DK307384A true DK307384A (da)	1984-06-22
DK169686B1 DK169686B1 (da)	1995-01-09

Family

ID=26505289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK307384A DK169686B1 (da)	1982-10-29	1984-06-22	Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre

Country Status (12)

Country	Link
EP (1)	EP0124613B1 (da)
CA (1)	CA1221029A (da)
CH (1)	CH660742A5 (da)
DE (1)	DE3390272C2 (da)
DK (1)	DK169686B1 (da)
FI (1)	FI80597C (da)
GB (1)	GB2138824B (da)
IT (1)	IT1169910B (da)
NL (1)	NL191755C (da)
NO (1)	NO166314C (da)
SE (1)	SE8403375L (da)
WO (1)	WO1984001714A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0151996B1 (en) *	1984-01-30	1991-04-03	Asahi Kasei Kogyo Kabushiki Kaisha	Process for the preparation of a double-chain plasminogen activator
SE462893B (sv) *	1985-05-28	1990-09-17	Wellcome Found	Vattenhaltig parenteral loesning av vaevnadsplasminogenaktivator och saett foer framstaellning av den
US4929444A (en) *	1985-05-28	1990-05-29	Burroughs Wellcome Co.	Low pH pharmaceutical formulation containing t-PA
WO1988000615A1 (en) *	1986-07-16	1988-01-28	Celltech Limited	Process for purifying a plasminogen activator
JPS6379591A (ja) *	1986-09-22	1988-04-09	Mitsui Toatsu Chem Inc	ｔＰＡの精製方法
AU1668988A (en) *	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
DE3726019A1 (de) *	1987-08-05	1989-02-16	Boehringer Mannheim Gmbh	Verfahren zur abtrennung und reinigung von t-pa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8003402A (nl) *	1980-06-11	1982-01-04	Leuven Res & Dev Vzw	Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5913732A (ja) *	1982-07-16	1984-01-24	Mitsui Toatsu Chem Inc	血栓溶解剤

1983
- 1983-10-27 NL NL8320346A patent/NL191755C/xx not_active IP Right Cessation
- 1983-10-27 DE DE19833390272 patent/DE3390272C2/de not_active Expired
- 1983-10-27 WO PCT/JP1983/000386 patent/WO1984001714A1/ja not_active Ceased
- 1983-10-27 EP EP83903315A patent/EP0124613B1/en not_active Expired - Lifetime
- 1983-10-27 GB GB08414992A patent/GB2138824B/en not_active Expired
- 1983-10-27 CH CH3063/84A patent/CH660742A5/de not_active IP Right Cessation
- 1983-10-28 CA CA000439941A patent/CA1221029A/en not_active Expired
- 1983-10-28 IT IT23533/83A patent/IT1169910B/it active
1984
- 1984-06-19 NO NO84842468A patent/NO166314C/no unknown
- 1984-06-22 DK DK307384A patent/DK169686B1/da active
- 1984-06-25 SE SE8403375A patent/SE8403375L/ unknown
- 1984-06-29 FI FI842627A patent/FI80597C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0124613A1 (en)	1984-11-14
DK169686B1 (da)	1995-01-09
CA1221029A (en)	1987-04-28
FI842627L (fi)	1984-06-29
EP0124613B1 (en)	1992-12-30
WO1984001714A1 (fr)	1984-05-10
NO166314B (no)	1991-03-25
FI842627A0 (fi)	1984-06-29
EP0124613A4 (en)	1986-07-29
GB8414992D0 (en)	1984-07-18
NL8320346A (nl)	1984-09-03
FI80597B (fi)	1990-03-30
SE8403375D0 (sv)	1984-06-25
GB2138824A (en)	1984-10-31
CH660742A5 (de)	1987-06-15
FI80597C (fi)	1990-07-10
DE3390272T1 (de)	1984-11-29
SE8403375L (sv)	1984-06-25
NL191755B (nl)	1996-03-01
NO842468L (no)	1984-06-19
IT1169910B (it)	1987-06-03
IT8323533A0 (it)	1983-10-28
NL191755C (nl)	1996-07-02
DE3390272C2 (de)	1987-09-17
DK307384D0 (da)	1984-06-22
NO166314C (no)	1991-07-03
GB2138824B (en)	1986-12-31

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