SE8404151L - Mellanprodukter for framstellning av azolopyrimidiner - Google Patents
Mellanprodukter for framstellning av azolopyrimidinerInfo
- Publication number
- SE8404151L SE8404151L SE8404151A SE8404151A SE8404151L SE 8404151 L SE8404151 L SE 8404151L SE 8404151 A SE8404151 A SE 8404151A SE 8404151 A SE8404151 A SE 8404151A SE 8404151 L SE8404151 L SE 8404151L
- Authority
- SE
- Sweden
- Prior art keywords
- intermediates
- tetrazol
- ones
- hypersensitivity reaction
- azolopyrimidines
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 206010045240 Type I hypersensitivity Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- QLSWIGRIBOSFMV-UHFFFAOYSA-N 1h-pyrrol-2-amine Chemical class NC1=CC=CN1 QLSWIGRIBOSFMV-UHFFFAOYSA-N 0.000 abstract 1
- OEICGMPRFOJHKO-UHFFFAOYSA-N 2-(ethoxymethylidene)propanedinitrile Chemical compound CCOC=C(C#N)C#N OEICGMPRFOJHKO-UHFFFAOYSA-N 0.000 abstract 1
- ZJEIYGPBIUDZKQ-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)pyrimido[2,1-b][1,3]benzothiazol-4-one Chemical class C=1N=C2SC3=CC=CC=C3N2C(=O)C=1C1=NN=NN1 ZJEIYGPBIUDZKQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001061127 Thione Species 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/903,265 US4223031A (en) | 1978-05-05 | 1978-05-05 | Azolopyrimidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8404151L true SE8404151L (sv) | 1984-08-20 |
| SE8404151D0 SE8404151D0 (sv) | 1984-08-20 |
Family
ID=25417203
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7903927A SE445642B (sv) | 1978-05-05 | 1979-05-04 | Antiallergiskt och antiastmatiskt verksamma azolopyrimidinoner samt forfarande for deras framstellning |
| SE8404151A SE8404151D0 (sv) | 1978-05-05 | 1984-08-20 | Mellanprodukter for framstellning av azolopyrimidiner |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7903927A SE445642B (sv) | 1978-05-05 | 1979-05-04 | Antiallergiskt och antiastmatiskt verksamma azolopyrimidinoner samt forfarande for deras framstellning |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4223031A (sv) |
| JP (1) | JPS54145696A (sv) |
| AU (1) | AU528715B2 (sv) |
| BE (1) | BE876059A (sv) |
| CA (1) | CA1109870A (sv) |
| CH (2) | CH641460A5 (sv) |
| DE (1) | DE2918085A1 (sv) |
| DK (1) | DK185079A (sv) |
| FI (1) | FI65260C (sv) |
| FR (1) | FR2424924A1 (sv) |
| GB (1) | GB2020654B (sv) |
| GR (1) | GR72717B (sv) |
| IE (1) | IE47976B1 (sv) |
| LU (1) | LU81231A1 (sv) |
| NL (1) | NL7903535A (sv) |
| SE (2) | SE445642B (sv) |
| YU (1) | YU103679A (sv) |
| ZA (1) | ZA792130B (sv) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491587A (en) * | 1978-05-05 | 1985-01-01 | Mead Johnson & Company | Tetrazole derivatives |
| US4297355A (en) * | 1979-11-15 | 1981-10-27 | Schering Corporation | (1H,3H,5H)-(1)-Benzopyrano-(2,3-d)-pyrimidine-4-one-2-thiones and their use as anti-allergy agents |
| US4414388A (en) * | 1979-11-23 | 1983-11-08 | Pfizer Inc. | 1-Oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides |
| DK151811C (da) * | 1979-11-23 | 1988-06-06 | Pfizer | Analogifremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolooe3,2-aaa-pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt 1-oxo-1h-thiazolooe3,2-aaapyrimidin-2-carboxylsyrer til anvendelse som udgangsmaterialer ved fremgangsmaaden |
| JPS57165318A (en) * | 1981-04-03 | 1982-10-12 | Mochida Pharmaceut Co Ltd | Remedy for asthma |
| US4510143A (en) * | 1982-02-17 | 1985-04-09 | Roussel Uclaf | Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives |
| IL69417A (en) * | 1982-08-27 | 1987-12-20 | Roussel Uclaf | 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them |
| US4507477A (en) * | 1982-09-09 | 1985-03-26 | Riker Laboratories, Inc. | Process for tetrazolyl-pyrimidinone derivatives |
| US4474953A (en) * | 1982-09-09 | 1984-10-02 | Riker Laboratories, Inc. | Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones |
| US4476130A (en) * | 1982-09-09 | 1984-10-09 | Riker Laboratories, Inc. | 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity |
| GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| GB8334210D0 (en) * | 1983-12-22 | 1984-02-01 | Roussel Lab Ltd | Imidazo(1 2-c)pyrimidines |
| US4762840A (en) * | 1984-02-13 | 1988-08-09 | Roussel Uclaf | Pyrimido[2,1-b]benzothiazoles having antiallergic activity |
| JPS60226887A (ja) * | 1984-04-25 | 1985-11-12 | Dai Ichi Seiyaku Co Ltd | トリアゾロピリミジン誘導体 |
| GB8422918D0 (en) * | 1984-09-11 | 1984-10-17 | May & Baker Ltd | Compositions of matter |
| GB8422916D0 (en) * | 1984-09-11 | 1984-10-17 | May & Baker Ltd | Compositions of matter |
| DE3602367C2 (de) * | 1985-01-29 | 1995-04-13 | Ciba Geigy Ag | Triazolderivate und ihre Verwendung zum Stabilisieren von organischen Polymeren |
| IL78017A (en) * | 1986-03-03 | 1989-06-30 | Yissum Res Dev Co | Sustained release tablets of theophylline |
| JPS6357522A (ja) * | 1986-08-28 | 1988-03-12 | Mect Corp | ピリミド〔２，１−ｄ〕ベンゾチアゾ−ル誘導体からなる血小板凝集抑制剤 |
| IL85207A (en) * | 1987-02-06 | 1992-06-21 | Daiichi Seiyaku Co | 6-substituted thiazolo-(and 1,3,4-thiadiazolo-)(3,2-a)-(1,2,3)triazolo(4,5-d)pyrimidin-9(1h)-ones and their preparation |
| CA2724008A1 (en) * | 2008-01-11 | 2009-09-11 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidine derivatives as trpv3 modulators |
| US8119647B2 (en) | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1070243A (en) * | 1964-07-15 | 1967-06-01 | Smith Kline French Lab | S-triazolopyrimidones, their preparation and compositions containing them |
| CH491944A (de) * | 1966-11-29 | 1970-06-15 | Ciba Geigy | Verfahren zur Herstellung von benzheterocyclischen Verbindungen |
| IE33549B1 (en) * | 1968-09-13 | 1974-08-07 | Ici Ltd | S-triazolo (1,5-a) pyrimidine derivatives |
| US3888983A (en) * | 1970-08-14 | 1975-06-10 | Seperic | Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia |
| US3907799A (en) * | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
| US4033961A (en) * | 1975-10-07 | 1977-07-05 | Warner-Lambert Company | Pyrido[2-1-b]quinazolin-ones and their methods of preparation |
| DE2557425C2 (de) * | 1975-12-19 | 1987-03-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel |
| US4041163A (en) * | 1976-03-29 | 1977-08-09 | Pfizer Inc. | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents |
| US4072679A (en) * | 1976-06-15 | 1978-02-07 | E. R. Squibb & Sons, Inc. | 1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides |
| US4122274A (en) * | 1977-05-25 | 1978-10-24 | Bristol-Myers Company | 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones |
-
1978
- 1978-05-05 US US05/903,265 patent/US4223031A/en not_active Expired - Lifetime
-
1979
- 1979-05-01 GB GB7915178A patent/GB2020654B/en not_active Expired
- 1979-05-02 FI FI791411A patent/FI65260C/fi not_active IP Right Cessation
- 1979-05-02 AU AU46667/79A patent/AU528715B2/en not_active Ceased
- 1979-05-03 YU YU01036/79A patent/YU103679A/xx unknown
- 1979-05-03 ZA ZA792130A patent/ZA792130B/xx unknown
- 1979-05-04 BE BE0/195011A patent/BE876059A/xx not_active IP Right Cessation
- 1979-05-04 NL NL7903535A patent/NL7903535A/xx not_active Application Discontinuation
- 1979-05-04 DE DE19792918085 patent/DE2918085A1/de not_active Withdrawn
- 1979-05-04 FR FR7911351A patent/FR2424924A1/fr active Granted
- 1979-05-04 CA CA326,912A patent/CA1109870A/en not_active Expired
- 1979-05-04 GR GR59006A patent/GR72717B/el unknown
- 1979-05-04 DK DK185079A patent/DK185079A/da not_active Application Discontinuation
- 1979-05-04 JP JP5414279A patent/JPS54145696A/ja active Pending
- 1979-05-04 SE SE7903927A patent/SE445642B/sv unknown
- 1979-05-07 CH CH426779A patent/CH641460A5/de not_active IP Right Cessation
- 1979-05-07 CH CH597/84A patent/CH651300A5/de not_active IP Right Cessation
- 1979-05-07 LU LU81231A patent/LU81231A1/xx unknown
- 1979-08-08 IE IE912/79A patent/IE47976B1/en unknown
-
1984
- 1984-08-20 SE SE8404151A patent/SE8404151D0/sv not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI65260B (fi) | 1983-12-30 |
| ZA792130B (en) | 1980-06-25 |
| FR2424924A1 (fr) | 1979-11-30 |
| BE876059A (fr) | 1979-11-05 |
| AU528715B2 (en) | 1983-05-12 |
| FI791411A7 (fi) | 1979-11-06 |
| DE2918085A1 (de) | 1979-11-15 |
| SE7903927L (sv) | 1979-11-06 |
| JPS54145696A (en) | 1979-11-14 |
| YU103679A (en) | 1983-02-28 |
| CA1109870A (en) | 1981-09-29 |
| SE445642B (sv) | 1986-07-07 |
| LU81231A1 (fr) | 1979-12-06 |
| GB2020654B (en) | 1982-08-04 |
| FI65260C (fi) | 1984-04-10 |
| IE47976B1 (en) | 1984-08-08 |
| SE8404151D0 (sv) | 1984-08-20 |
| DK185079A (da) | 1979-11-06 |
| CH651300A5 (de) | 1985-09-13 |
| US4223031A (en) | 1980-09-16 |
| GB2020654A (en) | 1979-11-21 |
| GR72717B (sv) | 1983-12-01 |
| NL7903535A (nl) | 1979-11-07 |
| IE790912L (en) | 1979-11-05 |
| FR2424924B1 (sv) | 1983-01-14 |
| CH641460A5 (de) | 1984-02-29 |
| AU4666779A (en) | 1979-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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