SE8500462L - Sett att framstella prednisolonderivat och mellanprodukter av detta forfarande - Google Patents

Sett att framstella prednisolonderivat och mellanprodukter av detta forfarande

Info

Publication number: SE8500462L
Authority: SE; Sweden
Prior art keywords: formula; image; compound; reacting; agent
Prior art date: 1984-02-03

Application number

SE8500462A

Other languages

Unknown language ( )

English (en)

Swedish (sv)

Other versions

SE8500462D0 (sv

Inventor

J Buendia

M Vivat

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-03

Filing date

1985-02-01

Publication date

1985-08-04

1985-02-01 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1985-02-01 Publication of SE8500462D0 publication Critical patent/SE8500462D0/xx

1985-08-04 Publication of SE8500462L publication Critical patent/SE8500462L/

Links

238000000034 method Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical class O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 9
239000003795 chemical substances by application Substances 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
239000003638 chemical reducing agent Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000004215 Carbon black (E152) Chemical group 0.000 abstract 1
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229910001431 copper ion Inorganic materials 0.000 abstract 1
239000012024 dehydrating agents‎ Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229930195733 hydrocarbon Chemical group 0.000 abstract 1
150000002430 hydrocarbons Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003118 prednisones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE8500462A 1984-02-03 1985-02-01 Sett att framstella prednisolonderivat och mellanprodukter av detta forfarande SE8500462L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR848401684A FR2559156B1 (fr)	1984-02-03	1984-02-03	Procede de preparation de derives de la prednisone et produits intermediaires de ce procede

Publications (2)

Publication Number	Publication Date
SE8500462D0 SE8500462D0 (sv)	1985-02-01
SE8500462L true SE8500462L (sv)	1985-08-04

Family

ID=9300741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8500462A SE8500462L (sv)	1984-02-03	1985-02-01	Sett att framstella prednisolonderivat och mellanprodukter av detta forfarande

Country Status (14)

Country	Link
US (1)	US4601854A (fr)
JP (1)	JPS60237096A (fr)
AT (1)	AT393683B (fr)
BE (1)	BE901627A (fr)
CA (1)	CA1225635A (fr)
CH (1)	CH662571A5 (fr)
DE (1)	DE3503704C2 (fr)
FR (1)	FR2559156B1 (fr)
GB (1)	GB2153357B (fr)
HU (1)	HU191771B (fr)
IT (1)	IT1182168B (fr)
LU (1)	LU85755A1 (fr)
NL (1)	NL194613C (fr)
SE (1)	SE8500462L (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04316593A (ja) *	1991-02-21	1992-11-06	Japan Tobacco Inc	Ｄ−アロサンの製造方法
CN108014117A (zh) *	2017-05-19	2018-05-11	南开大学	糖皮质激素受体的小分子拮抗剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1159490A (en) *	1966-02-09	1969-07-23	Boots Pure Drug Co Ltd	Improvements in Acylated Steroids
CH490362A (de) *	1967-04-03	1970-05-15	Upjohn Co	Verfahren zur Herstellung von 20-Ketosteroidverbindungen
YU41412B (en) *	1978-08-15	1987-04-30	Gist Brocades Nv	Process for obtaining 17 beta-hydroxy -3-dxo-17 alpha-pregn-4-en-21-carboxylic acid
HU179980B (en) *	1979-12-28	1983-01-28	Gyogyszerkutato Intezet	Process for preparing substituted steroid-spiro-oxazolidinone derivatives
FR2493324B1 (fr) *	1980-11-05	1983-01-21	Roussel Uclaf
JPS5788198A (en) *	1980-11-21	1982-06-01	Mitsubishi Chem Ind Ltd	Synthetic intermediate of corticoids

1984
- 1984-02-03 FR FR848401684A patent/FR2559156B1/fr not_active Expired
1985
- 1985-01-28 US US06/695,485 patent/US4601854A/en not_active Expired - Lifetime
- 1985-02-01 LU LU85755A patent/LU85755A1/fr unknown
- 1985-02-01 CH CH474/85A patent/CH662571A5/fr not_active IP Right Cessation
- 1985-02-01 HU HU85399A patent/HU191771B/hu not_active IP Right Cessation
- 1985-02-01 CA CA000473406A patent/CA1225635A/fr not_active Expired
- 1985-02-01 JP JP60016711A patent/JPS60237096A/ja not_active Withdrawn
- 1985-02-01 SE SE8500462A patent/SE8500462L/ not_active Application Discontinuation
- 1985-02-01 IT IT47630/85A patent/IT1182168B/it active
- 1985-02-01 BE BE0/214432A patent/BE901627A/fr not_active IP Right Cessation
- 1985-02-04 DE DE3503704A patent/DE3503704C2/de not_active Expired - Fee Related
- 1985-02-04 AT AT0031885A patent/AT393683B/de not_active IP Right Cessation
- 1985-02-04 NL NL8500297A patent/NL194613C/nl not_active IP Right Cessation
- 1985-02-04 GB GB08502765A patent/GB2153357B/en not_active Expired

Also Published As

Publication number	Publication date
FR2559156B1 (fr)	1989-03-24
GB2153357A (en)	1985-08-21
LU85755A1 (fr)	1985-10-22
AT393683B (de)	1991-11-25
NL8500297A (nl)	1985-09-02
HU191771B (en)	1987-04-28
GB2153357B (en)	1988-04-07
HUT37630A (en)	1986-01-23
US4601854A (en)	1986-07-22
CA1225635A (fr)	1987-08-18
IT1182168B (it)	1987-09-30
JPS60237096A (ja)	1985-11-25
DE3503704C2 (de)	1994-06-30
SE8500462D0 (sv)	1985-02-01
NL194613C (nl)	2002-09-03
GB8502765D0 (en)	1985-03-06
IT8547630A1 (it)	1986-08-01
ATA31885A (de)	1991-05-15
DE3503704A1 (de)	1985-08-08
IT8547630A0 (it)	1985-02-01
CH662571A5 (fr)	1987-10-15
BE901627A (fr)	1985-08-01
NL194613B (nl)	2002-05-01
FR2559156A1 (fr)	1985-08-09

Legal Events

Date

Code

Title

Description

1995-02-28

NAV

Patent application has lapsed

Ref document number: 8500462-0

Effective date: 19920918

Format of ref document f/p: F

Publication	Publication Date	Title
ATE21245T1 (de)	1986-08-15	Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole.
HUT57722A (en)	1991-12-30	Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds
CA1262357A (fr)	1989-10-17	Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones
HUT35649A (en)	1985-07-29	Process for preparing substituted 2-mercapto-imidazoles
FI871655A7 (fi)	1987-11-16	Foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
DK211283A (da)	1983-05-11	Benzothiazolinforbindelser
SE8500462D0 (sv)	1985-02-01	Sett att framstella prednisolonderivat och mellanprodukter av detta forfarande
FI873443A7 (fi)	1987-08-07	Norfloxacinmellanprodukt.
ES8500910A1 (es)	1984-11-01	Un procedimiento para la preparacion de 6-(fenil sustituido)-3(2h)-piridazinonas.
DE3260408D1 (en)	1984-08-30	Process for the preparation of 17-alpha-hydroxy-17-beta-hydroxyacetyl steroids, and corresponding intermediates obtained
DE3465737D1 (en)	1987-10-08	Process for the preparation of 4-quinolinones
SE8004622L (sv)	1980-12-26	Acylaminobensoesyraderivat
DE3462035D1 (en)	1987-02-19	Process for the preparation of 4-quinolinones
ES8601917A1 (es)	1985-11-16	Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas
SE7811761L (sv)	1980-02-08	4,5,6,7-tetrahydroimidazo-(4,5-c),pyridinderivat och forfarande for deras framstellning
ES508992A0 (es)	1982-12-01	Procedimiento para la obtencion de nuevos compuestos de poliglicidilurazol n.substituidos.
MX173415B (es)	1994-03-03	Procedimiento de preparacion de nuevos derivados de 1-estireno sulfonil-2-oxo 5-hidroxi pirrolidina y producto obtenido
HUT50833A (en)	1990-03-28	Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
EP0546875A3 (en)	1994-05-18	New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof
JPS51133243A (en)	1976-11-18	Process for preparing phthalamic acid ester derivatives
JPS54163569A (en)	1979-12-26	Carbazole derivative
ES297480A1 (es)	1964-09-01	Procedimiento para la obtenciën de amida de acidos fenilalcoilcarboxilicos