SE9403831L - Lagringsstabil vattenlösning för infusion av trombininhibitorer - Google Patents

Lagringsstabil vattenlösning för infusion av trombininhibitorer

Info

Publication number
SE9403831L
SE9403831L SE9403831A SE9403831A SE9403831L SE 9403831 L SE9403831 L SE 9403831L SE 9403831 A SE9403831 A SE 9403831A SE 9403831 A SE9403831 A SE 9403831A SE 9403831 L SE9403831 L SE 9403831L
Authority
SE
Sweden
Prior art keywords
pct
infusion
storage
aqueous solution
stable aqueous
Prior art date
Application number
SE9403831A
Other languages
English (en)
Other versions
SE504185C2 (sv
SE9403831D0 (sv
Inventor
Ulla Stjaernfelt
Mats Sundgren
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9403831A priority Critical patent/SE504185C2/sv
Publication of SE9403831D0 publication Critical patent/SE9403831D0/sv
Priority to TW084110363A priority patent/TW407057B/zh
Priority to FI971949A priority patent/FI971949L/sv
Priority to EP95938085A priority patent/EP0789585B1/en
Priority to DE69522702T priority patent/DE69522702T2/de
Priority to DK95938085T priority patent/DK0789585T3/da
Priority to BR9509634A priority patent/BR9509634A/pt
Priority to CZ19971294A priority patent/CZ287256B6/cs
Priority to SK535-97A priority patent/SK53597A3/sk
Priority to PCT/SE1995/001228 priority patent/WO1996014084A1/en
Priority to ES95938085T priority patent/ES2163528T3/es
Priority to AT95938085T priority patent/ATE205399T1/de
Priority to NZ295492A priority patent/NZ295492A/en
Priority to RU97108965/14A priority patent/RU2164803C2/ru
Priority to PL95320342A priority patent/PL320342A1/xx
Priority to HU9800400A priority patent/HU217073B/hu
Priority to US08/557,189 priority patent/US5830865A/en
Priority to AU38846/95A priority patent/AU695719B2/en
Priority to CA002203396A priority patent/CA2203396A1/en
Priority to JP8515235A priority patent/JPH10508598A/ja
Priority to MX9703339A priority patent/MX9703339A/es
Priority to CN95196108A priority patent/CN1090508C/zh
Priority to PT95938085T priority patent/PT789585E/pt
Priority to KR1019970703043A priority patent/KR100416677B1/ko
Priority to EE9700218A priority patent/EE9700218A/xx
Priority to MYPI95003226A priority patent/MY112593A/en
Priority to IL11587995A priority patent/IL115879A/en
Priority to ZA959377A priority patent/ZA959377B/xx
Priority to TR95/01391A priority patent/TR199501391A2/xx
Publication of SE9403831L publication Critical patent/SE9403831L/sv
Publication of SE504185C2 publication Critical patent/SE504185C2/sv
Priority to IS4468A priority patent/IS4468A/is
Priority to NO19972065A priority patent/NO322048B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9403831A 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer SE504185C2 (sv)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer
TW084110363A TW407057B (en) 1994-11-08 1995-10-04 A storage stable water solution for infusion containing a thrombin inhibitor
EE9700218A EE9700218A (et) 1994-11-08 1995-10-19 Trombiini inhibiitorit sisaldav säilituskindel vesilahus süstimiseks
PL95320342A PL320342A1 (en) 1994-11-08 1995-10-19 Thrombin inhibitor containing infusion solution, stable during storage
AU38846/95A AU695719B2 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
DE69522702T DE69522702T2 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
DK95938085T DK0789585T3 (da) 1994-11-08 1995-10-19 Opbevaringsstabil vandopløsning til infusion indeholdende en trombinhæmmer
BR9509634A BR9509634A (pt) 1994-11-08 1995-10-19 Solução aquosa concentrada estável ao armazenamento para infusao uso da mesma e processos de preparação da mesma de tratamento de um paciente necessitando de um inibidor de trombina e de estabilização de um inibidor de trombina ativo
CZ19971294A CZ287256B6 (en) 1994-11-08 1995-10-19 Concentrated aqueous solution for infusion being stable when stored and process for preparing thereof
SK535-97A SK53597A3 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
PCT/SE1995/001228 WO1996014084A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
ES95938085T ES2163528T3 (es) 1994-11-08 1995-10-19 Una solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina.
AT95938085T ATE205399T1 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
NZ295492A NZ295492A (en) 1994-11-08 1995-10-19 Storage stable aqueous infusion for iv administration comprising a thrombin inhibitor
RU97108965/14A RU2164803C2 (ru) 1994-11-08 1995-10-19 Содержащий ингибитор тромбина водный раствор для внутривенного введения, стабильный при хранении
FI971949A FI971949L (sv) 1994-11-08 1995-10-19 Lagringsstabil vattenlösning för infusion inehållande en trombininhibitor
HU9800400A HU217073B (hu) 1994-11-08 1995-10-19 Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására
US08/557,189 US5830865A (en) 1994-11-08 1995-10-19 Storage stable water solution for infusion containing a thrombin inhibitor
EP95938085A EP0789585B1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
CA002203396A CA2203396A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
JP8515235A JPH10508598A (ja) 1994-11-08 1995-10-19 トロンビン阻害剤を含有する貯蔵安定な輸液用水溶液
MX9703339A MX9703339A (es) 1994-11-08 1995-10-19 Solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina.
CN95196108A CN1090508C (zh) 1994-11-08 1995-10-19 输注用含凝血酶抑制剂的贮存稳定的水溶液
PT95938085T PT789585E (pt) 1994-11-08 1995-10-19 Solucao aquosa para infusao estavel a armazenagem contendo um inibidor de trombina
KR1019970703043A KR100416677B1 (ko) 1994-11-08 1995-10-19 트롬빈억제제를함유하는주입용저장안정성수용액
MYPI95003226A MY112593A (en) 1994-11-08 1995-10-26 A storage stable water solution for infusion containing a thrombin inhibitor
IL11587995A IL115879A (en) 1994-11-08 1995-11-06 Storage stable water solution for infusion containing a thrombin inhibitor
ZA959377A ZA959377B (en) 1994-11-08 1995-11-06 A storage stable water solution for infusion containing a thrombin inhibitor
TR95/01391A TR199501391A2 (tr) 1994-11-08 1995-11-08 Bir trombin inhibitör ihtiva eden infüzyon icin bir depolama icin dayanikli su mahlulu.
IS4468A IS4468A (is) 1994-11-08 1997-04-21 Vatnslausn til inndælingar sem er stöðug við geymslu og inniheldur þrombín-hemil
NO19972065A NO322048B1 (no) 1994-11-08 1997-05-05 Lagringsstabil vannopplosning for infusjon inneholdende en trombininhibitor, fremgangsmate for fremstilling av slik vannopplosning og anvendelse derav.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Publications (3)

Publication Number Publication Date
SE9403831D0 SE9403831D0 (sv) 1994-11-08
SE9403831L true SE9403831L (sv) 1996-05-09
SE504185C2 SE504185C2 (sv) 1996-12-02

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Country Status (31)

Country Link
US (1) US5830865A (sv)
EP (1) EP0789585B1 (sv)
JP (1) JPH10508598A (sv)
KR (1) KR100416677B1 (sv)
CN (1) CN1090508C (sv)
AT (1) ATE205399T1 (sv)
AU (1) AU695719B2 (sv)
BR (1) BR9509634A (sv)
CA (1) CA2203396A1 (sv)
CZ (1) CZ287256B6 (sv)
DE (1) DE69522702T2 (sv)
DK (1) DK0789585T3 (sv)
EE (1) EE9700218A (sv)
ES (1) ES2163528T3 (sv)
FI (1) FI971949L (sv)
HU (1) HU217073B (sv)
IL (1) IL115879A (sv)
IS (1) IS4468A (sv)
MX (1) MX9703339A (sv)
MY (1) MY112593A (sv)
NO (1) NO322048B1 (sv)
NZ (1) NZ295492A (sv)
PL (1) PL320342A1 (sv)
PT (1) PT789585E (sv)
RU (1) RU2164803C2 (sv)
SE (1) SE504185C2 (sv)
SK (1) SK53597A3 (sv)
TR (1) TR199501391A2 (sv)
TW (1) TW407057B (sv)
WO (1) WO1996014084A1 (sv)
ZA (1) ZA959377B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
CA2781529C (en) * 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
MX2021008557A (es) * 2021-01-13 2021-11-17 Grupo Ion Biotech S A P I De C V Sistema de suministro de ionoforos quimicos de membrana celular sintetica que comprende composiciones de ligandos hexa-acuaticos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2096415C1 (ru) * 1991-09-30 1997-11-20 Дзе Дюпон Мерк Фармасьютикал Компани Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
DE69522702D1 (de) 2001-10-18
BR9509634A (pt) 1998-01-06
FI971949A7 (sv) 1997-05-07
RU2164803C2 (ru) 2001-04-10
IS4468A (is) 1997-04-21
HU217073B (hu) 1999-11-29
MX9703339A (es) 1997-07-31
US5830865A (en) 1998-11-03
PL320342A1 (en) 1997-09-29
CN1090508C (zh) 2002-09-11
KR100416677B1 (ko) 2004-06-16
TW407057B (en) 2000-10-01
DK0789585T3 (da) 2001-11-12
EP0789585A1 (en) 1997-08-20
IL115879A (en) 2001-08-08
NO322048B1 (no) 2006-08-07
FI971949A0 (sv) 1997-05-07
AU695719B2 (en) 1998-08-20
JPH10508598A (ja) 1998-08-25
NO972065D0 (no) 1997-05-05
CZ129497A3 (cs) 1998-02-18
FI971949L (sv) 1997-05-07
NZ295492A (en) 1998-06-26
EE9700218A (et) 1998-02-16
CA2203396A1 (en) 1996-05-17
CN1162921A (zh) 1997-10-22
PT789585E (pt) 2002-01-30
CZ287256B6 (en) 2000-10-11
WO1996014084A1 (en) 1996-05-17
MY112593A (en) 2001-07-31
ES2163528T3 (es) 2002-02-01
SE504185C2 (sv) 1996-12-02
HUT77560A (hu) 1998-06-29
NO972065L (no) 1997-05-05
IL115879A0 (en) 1996-01-31
DE69522702T2 (de) 2002-07-11
SE9403831D0 (sv) 1994-11-08
AU3884695A (en) 1996-05-31
TR199501391A2 (tr) 1996-06-21
ATE205399T1 (de) 2001-09-15
ZA959377B (en) 1996-05-08
KR970706844A (ko) 1997-12-01
SK53597A3 (en) 1998-07-08
EP0789585B1 (en) 2001-09-12

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