SE9900519D0 - A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof - Google Patents

A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof

Info

Publication number
SE9900519D0
SE9900519D0 SE9900519A SE9900519A SE9900519D0 SE 9900519 D0 SE9900519 D0 SE 9900519D0 SE 9900519 A SE9900519 A SE 9900519A SE 9900519 A SE9900519 A SE 9900519A SE 9900519 D0 SE9900519 D0 SE 9900519D0
Authority
SE
Sweden
Prior art keywords
antioxidant
preparation
implant made
uhmwpe doped
uhmwpe
Prior art date
Application number
SE9900519A
Other languages
English (en)
Swedish (sv)
Inventor
Peter Bengtsson
Peter Sjoevall
Bengt Wesslen
Lars Lidgren
Original Assignee
Lars Lidgren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lars Lidgren filed Critical Lars Lidgren
Priority to SE9900519A priority Critical patent/SE9900519D0/xx
Publication of SE9900519D0 publication Critical patent/SE9900519D0/xx
Priority to US09/890,077 priority patent/US6448315B1/en
Priority to EP00909859A priority patent/EP1161489B1/de
Priority to DE60011243T priority patent/DE60011243T2/de
Priority to AT00909859T priority patent/ATE268353T1/de
Priority to PCT/SE2000/000314 priority patent/WO2000049079A1/en
Priority to AU32038/00A priority patent/AU3203800A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
SE9900519A 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof SE9900519D0 (sv)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SE9900519A SE9900519D0 (sv) 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
US09/890,077 US6448315B1 (en) 1999-02-17 2000-02-17 Method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
EP00909859A EP1161489B1 (de) 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
DE60011243T DE60011243T2 (de) 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
AT00909859T ATE268353T1 (de) 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
PCT/SE2000/000314 WO2000049079A1 (en) 1999-02-17 2000-02-17 A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof
AU32038/00A AU3203800A (en) 1999-02-17 2000-02-17 A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9900519A SE9900519D0 (sv) 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof

Publications (1)

Publication Number Publication Date
SE9900519D0 true SE9900519D0 (sv) 1999-02-17

Family

ID=20414490

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9900519A SE9900519D0 (sv) 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof

Country Status (7)

Country Link
US (1) US6448315B1 (de)
EP (1) EP1161489B1 (de)
AT (1) ATE268353T1 (de)
AU (1) AU3203800A (de)
DE (1) DE60011243T2 (de)
SE (1) SE9900519D0 (de)
WO (1) WO2000049079A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275052A1 (de) 2000-04-27 2011-01-19 Orthopaedic Hospital Oxidationsbeständige und abnutzungsbeständige Polyethylene für den Ersatz menschlicher Gelenke und Herstellungsverfahren dafür
WO2002026464A1 (en) * 2000-09-29 2002-04-04 Depuy Orthopaedics, Inc. Supercritical fluid treatment of irradiated polyethylene
WO2003000751A1 (en) * 2001-05-10 2003-01-03 Bittner George D Endocrine disruptive chemical free additives and method
WO2003049930A1 (en) * 2001-12-12 2003-06-19 Depuy Products, Inc. Orthopaedic device and method for making same
US7819925B2 (en) * 2002-01-28 2010-10-26 Depuy Products, Inc. Composite prosthetic bearing having a crosslinked articulating surface and method for making the same
US20050146070A1 (en) * 2002-06-21 2005-07-07 Massachusetts General Hospital Meta lback or mesh crosslinking
EP2671538A1 (de) * 2003-01-16 2013-12-11 Massachusetts General Hospital Verfahren zur Herstellung von oxidationsbeständigem Polymermaterial
AT412969B (de) * 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) * 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
EP3111895B1 (de) 2004-02-03 2019-09-04 The General Hospital Corporation Hochkristallines vernetztes oxidationsresistentes polyethylen
JP5248107B2 (ja) * 2004-05-11 2013-07-31 ザ、ジェネラル、ホスピタル、コーポレイション 耐酸化性重合体状材料の製造方法
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7335697B2 (en) 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
JP2008540809A (ja) * 2005-05-18 2008-11-20 ザ ジェネラル ホスピタル コーポレイション ディー ビー エイ マサチューセッツ ジェネラル ホスピタル ヒドロゲルおよびヒドロゲル粒子
AU2006259555B2 (en) * 2005-06-14 2011-03-03 Omni Life Science, Inc. Crosslinked polyethylene article
US20090062909A1 (en) * 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
KR101406415B1 (ko) 2005-07-15 2014-06-19 미셀 테크놀로지즈, 인코포레이티드 제어된 형태의 약물 분말을 함유하는 중합체 코팅
AU2012203503B2 (en) * 2005-08-18 2014-01-30 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
ES2441608T3 (es) * 2005-08-18 2014-02-05 Zimmer Gmbh Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ulra-alto
ATE529464T1 (de) 2005-08-22 2011-11-15 Gen Hospital Corp Dba Massachusetts General Hospital Oxidationsbeständiges homogenisiertes polymermaterial
WO2007024684A2 (en) 2005-08-22 2007-03-01 The General Hospital Corporation Dba Massachusetts General Hospital Highly crystalline polyethylene
US8343230B2 (en) 2005-09-22 2013-01-01 Depuy Products, Inc. Orthopaedic bearing material
US20070077268A1 (en) * 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
WO2007106582A2 (en) * 2006-03-15 2007-09-20 Promethean Lifesciences, Inc. Preparation and storage of stable, biologically active materials
US8425614B2 (en) * 2006-03-20 2013-04-23 Biomet Manufacturing Corp. Modular center pegged glenoid
US7812098B2 (en) 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
EP1891987B1 (de) * 2006-08-25 2010-09-22 DePuy Products, Inc. Material zum Tragen eines medizinischen Implantats
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
EP2456283B1 (de) * 2007-01-25 2015-12-16 The General Hospital Corporation Verfahren zur herstellung von oxidationsbeständigem vernetztem polymermaterial
DE102007006086B4 (de) 2007-02-07 2009-12-03 Kisielinski, Kajetan Stefan, Dr. med. Vorrichtung und Verfahren zum Erfassen des Verschleißes eines Implantatwerkstoffes und ein entsprechend hergestelltes Implantat
WO2008109515A1 (en) 2007-03-02 2008-09-12 The General Hospital Corporation Cross-linking of antioxidant-containing polymers
US20100144930A1 (en) * 2007-03-20 2010-06-10 Smith & Nephew Orthopaedics Ag Oxidation resistant highly-crosslinked uhmwpe
EP2486948B1 (de) * 2007-04-10 2018-02-21 Zimmer, Inc. Durch ein antioxidationsmittel stabilisiertes, vernetztes polyethylen mit ultrahohem molekulargewicht für verwendungen in einer medizinischen vorrichtung
AU2014274546B2 (en) * 2007-04-10 2016-06-02 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US8664290B2 (en) * 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
WO2008148013A1 (en) 2007-05-25 2008-12-04 Micell Technologies, Inc. Polymer films for medical device coating
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
US8546460B2 (en) * 2007-09-04 2013-10-01 Smith & Nephew, Inc. Ultra high molecular weight polyethylene for bearing surfaces
WO2009048456A1 (en) * 2007-10-12 2009-04-16 Peak Plastic & Metal Products (International) Limited Wafer container with staggered wall structure
EP2249887B1 (de) * 2008-01-30 2017-06-21 Zimmer, Inc. Orthopädischer bestandteil geringer steifheit
JP5608160B2 (ja) 2008-04-17 2014-10-15 ミセル テクノロジーズ、インコーポレイテッド 生体吸収性の層を有するステント
ES2439586T3 (es) * 2008-05-13 2014-01-23 Smith & Nephew Orthopaedics Ag UHMWPE altamente reticulado resistente a la oxidación
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
DE102008047009B4 (de) 2008-07-11 2020-08-06 Mathys Ag Bettlach Gelenkpfanne mit physiologischer Lastübertragung
EP2313122B1 (de) 2008-07-17 2019-03-06 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
US20100022678A1 (en) * 2008-07-24 2010-01-28 Zimmer, Inc. Reduction of free radicals in crosslinked polyethylene by infrared heating
US8133436B2 (en) 2008-08-05 2012-03-13 Howmedica Osteonics Corp. Polyethylene cross-linked with an anthocyanin
DE102008053793A1 (de) 2008-10-21 2010-04-22 Aesculap Ag Antioxidativ wirksames, synthetisches Polymermaterial
CN102307945B (zh) * 2008-11-20 2015-07-01 捷迈有限责任公司 聚乙烯材料
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
WO2010117752A1 (en) * 2009-03-31 2010-10-14 Zimmer, Inc. Surface modification of ultrahigh molecular weight polyethylene
JP2012522589A (ja) 2009-04-01 2012-09-27 ミシェル テクノロジーズ，インコーポレイテッド 被覆ステント
DE102009023651B4 (de) 2009-05-26 2021-07-01 Aesculap Ag Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens
EP2453834A4 (de) 2009-07-16 2014-04-16 Micell Technologies Inc Medizinische wirkstofffreisetzungsvorrichtung
GB0922339D0 (en) * 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
EP2531140B1 (de) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
EP2593039B1 (de) 2010-07-16 2022-11-30 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
US8858979B1 (en) 2011-01-28 2014-10-14 Clemson University Service induced byproducts for localized drug delivery in orthopaedic implants
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US20130018476A1 (en) 2011-07-13 2013-01-17 Biomet Manufacturing Corp. Shoulder prosthesis
US8506638B2 (en) 2011-07-13 2013-08-13 Biomets Manufacturing, LLC Shoulder prosthesis
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
WO2014025636A1 (en) * 2012-08-06 2014-02-13 The General Hospital Corporation Spatial control of additives by high temperature
EP2967803B1 (de) 2013-03-12 2023-12-27 Micell Technologies, Inc. Bioabsorbierbare biomedizinische implantate
EP2996629B1 (de) 2013-05-15 2021-09-22 Micell Technologies, Inc. Bioabsorbierbare biomedizinische implantate
US9586370B2 (en) 2013-08-15 2017-03-07 Biomet Manufacturing, Llc Method for making ultra high molecular weight polyethylene
US9708467B2 (en) 2013-10-01 2017-07-18 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
WO2015057943A2 (en) 2013-10-17 2015-04-23 The General Hospital Corporation Peroxide cross-linking and high temperature melting
CA2942565A1 (en) * 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US9707314B2 (en) * 2014-03-26 2017-07-18 DePuy Synthes Products, Inc. Acrylic bone cement having a delayed release polymerization inhibitor such as an anti-oxidant for increased working time
US10265891B2 (en) 2014-12-03 2019-04-23 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
CZ2015267A3 (cs) 2015-04-21 2016-11-09 Ústav makromolekulární chemie AV ČR, v. v. i. Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
AU2016352992A1 (en) 2015-11-12 2018-05-24 The General Hospital Corporation Methods of making therapeutic polymeric material
US12115289B2 (en) 2016-02-05 2024-10-15 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
US10953136B2 (en) 2016-04-15 2021-03-23 The General Hospital Corporation Systems and methods of radioprotection of allografts
US11667762B2 (en) 2017-08-29 2023-06-06 The General Hospital Corporation UV-initiated reactions in polymeric materials
CN110448723B (zh) * 2019-07-12 2022-04-05 四川大学 协同抗氧型高交联超高分子量聚乙烯人工关节材料及其制备方法
AU2021200854A1 (en) 2020-03-03 2021-09-16 Howmedica Osteonics Corp. Glenoid implant with additively manufactured fixation posts
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS221404B1 (cs) * 1981-12-23 1983-04-29 Bretislav Dolezel Způsob stabilizace polyolefinů pro dosažení zvýšené odolnosti proti biologické degradaci v organismu
US4439420A (en) 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
GB8724897D0 (en) 1987-10-23 1987-11-25 Downes S Material
SE464912B (sv) 1989-10-25 1991-07-01 Bioapatite Ab Implantationsmaterial foer aaterstaellning av benvaevnad samt saett foer dess tillverkning
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
DE4306593A1 (de) * 1993-03-03 1994-09-08 Hoechst Ag Stabilisierte Formmasse aus Polyethylen, ein Verfahren zur Herstellung und Verwendung
DE4433201A1 (de) 1994-09-17 1996-03-21 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
US5844027A (en) 1996-05-03 1998-12-01 Ciba Specialty Chemicals Corporation Stabilizer composition for thermoplastic materials
US5827904A (en) * 1996-09-27 1998-10-27 Hahn; David Medical implant composition
IT1289935B1 (it) 1997-02-20 1998-10-19 Great Lakes Chemical Italia Forma solida di uno stabilizzante per polimeri organici
SE9802528D0 (sv) 1998-07-13 1998-07-13 Gs Dev Ab Bone tissue restoring composition
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
EP0995449A1 (de) * 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate

Also Published As

Publication number Publication date
ATE268353T1 (de) 2004-06-15
DE60011243D1 (de) 2004-07-08
DE60011243T2 (de) 2005-06-23
WO2000049079A1 (en) 2000-08-24
AU3203800A (en) 2000-09-04
US6448315B1 (en) 2002-09-10
EP1161489B1 (de) 2004-06-02
EP1161489A1 (de) 2001-12-12

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