SG112092G - New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them - Google Patents

New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them

Info

Publication number: SG112092G
Authority: SG; Singapore
Prior art keywords: pharmaceutical compositions; production; alkyl; quinazoline derivatives; new quinazoline
Prior art date: 1985-10-07

Application number

SG1120/92A

Other languages

English (en)

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-07

Filing date

1992-10-27

Publication date

1992-12-24

1992-10-27 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1992-12-24 Publication of SG112092G publication Critical patent/SG112092G/en

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

SG1120/92A 1985-10-07 1992-10-27 New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them SG112092G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB858524663A GB8524663D0 (en)	1985-10-07	1985-10-07	Quinazoline derivatives

Publications (1)

Publication Number	Publication Date
SG112092G true SG112092G (en)	1992-12-24

Family

ID=10586291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1120/92A SG112092G (en)	1985-10-07	1992-10-27	New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them

Country Status (23)

Country	Link
US (2)	US4734419A (cs)
EP (1)	EP0218999B1 (cs)
JP (3)	JPS6296476A (cs)
KR (1)	KR940007270B1 (cs)
CN (1)	CN1017242B (cs)
AT (1)	ATE60761T1 (cs)
AU (1)	AU596611B2 (cs)
CA (1)	CA1289139C (cs)
DE (1)	DE3677452D1 (cs)
DK (1)	DK158838C (cs)
ES (1)	ES2021266B3 (cs)
FI (1)	FI90234C (cs)
GB (1)	GB8524663D0 (cs)
GR (1)	GR3001502T3 (cs)
HK (1)	HK6993A (cs)
HU (1)	HU196972B (cs)
IE (1)	IE59309B1 (cs)
IL (1)	IL80213A (cs)
NO (1)	NO171785C (cs)
SG (1)	SG112092G (cs)
SU (1)	SU1588283A3 (cs)
UA (1)	UA5562A1 (cs)
ZA (1)	ZA867043B (cs)

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GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives
PH23853A (en) *	1986-08-21	1989-11-23	Pfizer	Pyridopyrimidinediones
US4889851A (en) *	1986-11-21	1989-12-26	Fujisawa Pharmaceutical Co, Ltd.	Benzothiadiazine compounds, and pharmaceutical composition comprising the same
US4931440A (en) *	1987-07-29	1990-06-05	Fujisawa Pharmaceutical Company, Ltd.	Uricosuric composition
US4898867A (en) *	1987-09-16	1990-02-06	Taiho Pharmaceutical Company, Limited	Thienopyrimidine derivaties as aldose-reductase inhibitors
JP2621460B2 (ja) *	1988-02-29	1997-06-18	藤沢薬品工業株式会社	利尿または降圧剤
US5324747A (en) *	1992-07-15	1994-06-28	Hoffmann-La Roche Inc.	N-substituted anilines, inhibitors of phospholipases A2
WO1994007867A1 (en) *	1992-09-28	1994-04-14	Pfizer Inc.	Substituted pyrimidines for control of diabetic complications
DE19532052C2 (de) *	1995-08-31	1998-11-19	Clariant Gmbh	Verfahren zur Herstellung von Chinazolinderivaten
EP0847382B1 (de) *	1995-08-31	2000-12-20	Clariant GmbH	Monoester der carboxymethylenanthranilsäuren und verfahren zu ihrer herstellung
CA2193932C (en) *	1995-12-26	2001-08-21	Shinji Nishii	Process for producing isatoic anhydrides
EP0896961A4 (en)	1995-12-28	1999-04-07	Fuji Chem Ind Co Ltd	PROCESS FOR THE MANUFACTURE OF 3-DIHALOBENZYL-2,4-QUINAZOLINEDIONE DERIVATIVES
US5780628A (en) *	1996-02-01	1998-07-14	Sumitomo Chemical Company, Limited	Process for producing dioxoquinazolines
DE19650975A1 (de) *	1996-12-09	1998-06-10	Basf Ag	Neue heterocyclisch substituierte Benzamide und deren Anwendung
AP2003002729A0 (en) *	1997-04-15	2003-06-30	Csir	Pharmaceutical compositions having appetite suppressant activity
US6444816B1 (en)	1997-10-27	2002-09-03	Dr. Reddy's Research Foundation	Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
TR200002209T2 (tr) *	1998-01-30	2000-11-21	R-Tech Ueno, Ltd.	Oftalmik bileşim.
WO2000043015A1 (fr) *	1999-01-25	2000-07-27	Fujisawa Pharmaceutical Co., Ltd.	Gouttes ophtalmologiques
BR0005010A (pt)	1999-02-18	2002-03-19	R Tech Ueno Ltd	Composição para tratamento de distúrbios de secreção externa exceto a hipolacrimação e seu uso
CA2366597A1 (en) *	1999-03-09	2000-09-14	Fujisawa Pharmaceutical Co., Ltd.	Process for producing quinazoline derivative or salt thereof
GB2355657B (en) *	1999-10-27	2004-07-28	Phytopharm Plc	Inhibitors Of Gastric Acid Secretion
US6545004B1 (en) *	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6380200B1 (en)	1999-12-07	2002-04-30	Pfizer, Inc.	Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
CA2430309A1 (en)	2000-11-30	2002-06-06	Pfizer Products Inc.	Combination of gaba agonists and aldose reductase inhibitors
JP4273406B2 (ja) *	2001-06-01	2009-06-03	小野薬品工業株式会社	アルドース還元酵素阻害剤を有効成分とする脱髄性疾患または脱髄を伴う疾患治療剤
WO2003070701A2 (en) *	2002-02-15	2003-08-28	Cytokinetics, Inc.	Syntheses of quinazolinones
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
AU2003270015A1 (en)	2002-05-09	2003-12-02	Cytokinetics, Inc.	Compounds, compositions, and methods
WO2003094839A2 (en) *	2002-05-09	2003-11-20	Cytokinetics, Inc.	Pyrimidinone compounds, compositions and methods
WO2004026226A2 (en) *	2002-05-10	2004-04-01	Cytokinetics, Inc.	Compounds, compositions and methods
JP2005536475A (ja) *	2002-05-23	2005-12-02	サイトキネティクス・インコーポレーテッド	化合物、組成物、および方法
EP1556357A4 (en) *	2002-06-14	2006-09-13	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
EP1537089A4 (en) *	2002-07-23	2008-04-16	Cytokinetics Inc	CONNECTIONS, COMPOSITIONS AND PROCEDURES
AU2003262747A1 (en) *	2002-08-21	2004-03-11	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1558083A4 (en) *	2002-09-30	2008-04-16	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
WO2005041888A2 (en) *	2003-11-03	2005-05-12	Cytokinetics, Inc.	Pyrimidin-4-one compounds, compositions and methods
US20050148593A1 (en) *	2003-11-07	2005-07-07	Gustave Bergnes	Compounds, compositions, and methods
JP2007513154A (ja) *	2003-12-08	2007-05-24	サイトキネティクス・インコーポレーテッド	化合物、組成物及び方法
US20070010537A1 (en) *	2004-08-20	2007-01-11	Kazumasa Hamamura	Fused pyramidine derivative and use thereof
US20110092566A1 (en) *	2004-11-19	2011-04-21	Srivastava Satish K	Treatment of cancer with aldose reductase inhibitors
ES2470566T3 (es) *	2006-07-19	2014-06-24	E.I. Du Pont De Nemours And Company	Procedimiento para preparar 2-amino-5-halobenzamidas sustituidas en 3
JP2010520913A (ja)	2007-03-12	2010-06-17	サズセアーペーエス	ルイボスの抗糖尿病性抽出物
EP2848252A3 (en)	2007-03-23	2015-06-17	The Board of Regents of the University of Texas System	Aldose reductase inhibitors for use in treating uveitis
BRPI0814758A2 (pt) *	2007-08-03	2015-03-03	Hoffmann La Roche	Piridinacarboxamida e derivados de benzamida como ligantes taar1
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition
CN102219759B (zh) *	2010-04-16	2013-07-24	中国科学院上海药物研究所	芳基甲酰胺类化合物及其制备方法、药物组合物和用途
US8785483B2 (en)	2010-12-23	2014-07-22	The Board Of Regents Of The University Of Texas System	Methods for treating COPD
MX2015015422A (es)	2013-05-10	2016-06-21	Nimbus Apollo Inc	Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
CN105358152A (zh)	2013-05-10	2016-02-24	尼普斯阿波罗有限公司	Acc抑制剂和其用途
HK1221662A1 (zh)	2013-05-10	2017-06-09	Gilead Apollo, Llc	Acc抑制剂和其用途
TW201623257A (zh)	2014-05-09	2016-07-01	奧利安公司	藥理活性之喹唑啉二酮衍生物
WO2019165195A1 (en)	2018-02-22	2019-08-29	Srivastava Satish	Combination therapy for the treatment of cancer
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US4016166A (en) *	1973-12-14	1977-04-05	Hisamitsu Pharmaceutical Co., Inc.	1-Nitrophenylquinazoline-2,4(1H,3H)-diones
DE2652144A1 (de) *	1976-11-16	1978-05-18	Merck Patent Gmbh	Neue chinazolindione
CA1161036A (en) *	1980-05-15	1984-01-24	Masayuki Ishikawa	Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
EP0040793B1 (en) *	1980-05-22	1985-08-28	Masayuki Ishikawa	Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
JPS58159480A (ja) *	1982-03-17	1983-09-21	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
DD232702A1 (de) *	1982-09-20	1986-02-05	Adw Ddr	Verfahren zur herstellung von 1,2,3,4-tetrahydrochinazolin-2,4-dion-essigsaeuren, deren salzen und estern
US4490374A (en) *	1982-09-30	1984-12-25	Ortho Pharmaceutical Corporation	5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
JPS59186963A (ja) *	1983-04-08	1984-10-23	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives

1985
- 1985-10-07 GB GB858524663A patent/GB8524663D0/en active Pending
1986
- 1986-09-16 US US06/908,005 patent/US4734419A/en not_active Expired - Lifetime
- 1986-09-16 ZA ZA867043A patent/ZA867043B/xx unknown
- 1986-09-23 IE IE252086A patent/IE59309B1/en not_active IP Right Cessation
- 1986-09-25 DK DK459086A patent/DK158838C/da not_active IP Right Cessation
- 1986-09-29 FI FI863917A patent/FI90234C/fi not_active IP Right Cessation
- 1986-10-02 EP EP86113559A patent/EP0218999B1/en not_active Expired - Lifetime
- 1986-10-02 AT AT86113559T patent/ATE60761T1/de not_active IP Right Cessation
- 1986-10-02 DE DE8686113559T patent/DE3677452D1/de not_active Expired - Fee Related
- 1986-10-02 ES ES86113559T patent/ES2021266B3/es not_active Expired - Lifetime
- 1986-10-02 IL IL80213A patent/IL80213A/xx not_active IP Right Cessation
- 1986-10-03 SU SU864028362A patent/SU1588283A3/ru active
- 1986-10-03 CA CA000519759A patent/CA1289139C/en not_active Expired - Fee Related
- 1986-10-03 UA UA4028362A patent/UA5562A1/uk unknown
- 1986-10-06 JP JP61237605A patent/JPS6296476A/ja active Granted
- 1986-10-06 NO NO863980A patent/NO171785C/no not_active IP Right Cessation
- 1986-10-06 AU AU63589/86A patent/AU596611B2/en not_active Ceased
- 1986-10-06 HU HU864192A patent/HU196972B/hu not_active IP Right Cessation
- 1986-10-07 CN CN86106984A patent/CN1017242B/zh not_active Expired
- 1986-10-07 KR KR86008374A patent/KR940007270B1/ko not_active Expired - Fee Related
1987
- 1987-12-08 US US07/130,297 patent/US4883800A/en not_active Expired - Lifetime
1988
- 1988-08-22 JP JP63207570A patent/JPH0794447B2/ja not_active Expired - Lifetime
- 1988-08-22 JP JP63207571A patent/JPH01125322A/ja active Granted
1991
- 1991-02-25 GR GR90401160T patent/GR3001502T3/el unknown
1992
- 1992-10-27 SG SG1120/92A patent/SG112092G/en unknown
1993
- 1993-01-28 HK HK69/93A patent/HK6993A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0218999A2 (en)	1987-04-22
AU6358986A (en)	1987-04-09
ES2021266B3 (es)	1991-11-01
UA5562A1 (uk)	1994-12-28
EP0218999B1 (en)	1991-02-06
FI863917A0 (fi)	1986-09-29
NO171785C (no)	1993-05-05
JPH0482148B2 (cs)	1992-12-25
GR3001502T3 (en)	1992-11-23
HK6993A (en)	1993-02-05
JPH01125322A (ja)	1989-05-17
FI863917L (fi)	1987-04-08
ATE60761T1 (de)	1991-02-15
NO863980D0 (no)	1986-10-06
CA1289139C (en)	1991-09-17
NO863980L (no)	1987-04-08
IE862520L (en)	1987-04-07
JPH0794447B2 (ja)	1995-10-11
JPH05366B2 (cs)	1993-01-05
DK158838B (da)	1990-07-23
US4734419A (en)	1988-03-29
CN1017242B (zh)	1992-07-01
JPS6296476A (ja)	1987-05-02
AU596611B2 (en)	1990-05-10
NO171785B (no)	1993-01-25
DK459086A (da)	1987-04-08
KR870003998A (ko)	1987-05-06
IL80213A0 (en)	1987-01-30
DE3677452D1 (de)	1991-03-14
US4883800A (en)	1989-11-28
SU1588283A3 (ru)	1990-08-23
KR940007270B1 (en)	1994-08-12
IE59309B1 (en)	1994-02-09
JPH01131164A (ja)	1989-05-24
HUT41747A (en)	1987-05-28
FI90234B (fi)	1993-09-30
FI90234C (fi)	1994-01-10
EP0218999A3 (en)	1988-01-13
HU196972B (en)	1989-02-28
IL80213A (en)	1991-06-30
GB8524663D0 (en)	1985-11-13
DK459086D0 (da)	1986-09-25
ZA867043B (en)	1987-07-29
CN86106984A (zh)	1987-05-20
DK158838C (da)	1991-01-14

Publication	Publication Date	Title
GR3001502T3 (en)	1992-11-23	New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them
IL107426A0 (en)	1994-01-25	Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same
HUT37128A (en)	1985-11-28	Process for the production of dihydropyridazinone-derivatives, as well as of pharmaceutical preparations containing these derivatives as agent
AU589427B2 (en)	1989-10-12	Pyridonecarboxylic acid derivatives and process for their preparation
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
HUT56089A (en)	1991-07-29	Process for producing quinazoline derivatives and pharmaceutical compositions containing them
DE3477380D1 (en)	1989-04-27	Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
HUT52044A (en)	1990-06-28	Process for producing pyrrolidine derivatives
HUT40658A (en)	1987-01-28	Process for producing benzo/c/-1,5-naphtiridin derivatives and pharmaceutical compositions containing them as active agents
ZA872925B (en)	1987-11-25	Heterocyclic compounds