SG145782A1 - Process for the purification of terbinafine - Google Patents

Process for the purification of terbinafine

Info

Publication number: SG145782A1
Authority: SG; Singapore
Prior art keywords: terbinafine; acid addition; addition salt; purification process; free base
Prior art date: 2003-08-29

Application number

SG200806418-0A

Other languages

English (en)

Inventor

Ulrich Beutler

Gerhard Penn

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-29

Filing date

2004-08-27

Publication date

2008-09-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28686596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG145782(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-08-27 Application filed by Novartis Ag filed Critical Novartis Ag

2008-09-29 Publication of SG145782A1 publication Critical patent/SG145782A1/en

Links

238000000746 purification Methods 0.000 title abstract 3
DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 title abstract 3
229960002722 terbinafine Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title 1
VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
239000012458 free base Substances 0.000 abstract 2
150000003839 salts Chemical group 0.000 abstract 2
239000002585 base Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000012264 purified product Substances 0.000 abstract 1
238000000526 short-path distillation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/84—Purification
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SG200806418-0A 2003-08-29 2004-08-27 Process for the purification of terbinafine SG145782A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0320312.2A GB0320312D0 (en)	2003-08-29	2003-08-29	Purification process

Publications (1)

Publication Number	Publication Date
SG145782A1 true SG145782A1 (en)	2008-09-29

Family

ID=28686596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200806418-0A SG145782A1 (en)	2003-08-29	2004-08-27	Process for the purification of terbinafine

Country Status (25)

Country	Link
US (2)	US20060076227A1 (fr)
EP (1)	EP1694631A2 (fr)
JP (1)	JP5208416B2 (fr)
KR (2)	KR101233024B1 (fr)
CN (1)	CN100491334C (fr)
AR (1)	AR045506A1 (fr)
AU (1)	AU2004268051B2 (fr)
BR (1)	BRPI0413896A (fr)
CA (1)	CA2536498C (fr)
EC (1)	ECSP066382A (fr)
GB (1)	GB0320312D0 (fr)
IL (1)	IL173709A (fr)
IS (1)	IS8369A (fr)
MA (1)	MA28030A1 (fr)
MX (1)	MXPA06002348A (fr)
MY (1)	MY149357A (fr)
NO (1)	NO20061404L (fr)
NZ (1)	NZ545445A (fr)
PE (1)	PE20050873A1 (fr)
RU (1)	RU2367649C2 (fr)
SG (1)	SG145782A1 (fr)
TN (1)	TNSN06066A1 (fr)
TW (1)	TWI350829B (fr)
WO (1)	WO2005021483A2 (fr)
ZA (1)	ZA200601264B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0503942D0 (en) *	2005-02-25	2005-04-06	Novartis Ag	Purification process
EP1900378A1 (fr) *	2006-08-31	2008-03-19	Novartis AG	Compositions pharmaceutiques pour le traitment d'infections fongiques
AU2009288680B2 (en)	2008-09-05	2013-07-04	Teikoku Pharma Usa, Inc.	Iontophoretic drug delivery packaging

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0000896B1 (fr) *	1977-08-19	1982-10-13	Sandoz Ag	Propényl-amines, procédés pour leur préparation et les compositions pharmaceutiques les contenant
CY1410A (en) *	1979-08-22	1988-04-22	Sandoz Ag	Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US5132459A (en) *	1979-08-22	1992-07-21	Sandoz Ltd.	Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
CS232849B1 (cs) *	1983-05-04	1985-02-14	Ladislav Kalvoda	Způsob přípravy honjugavaných eninů
RU2005717C1 (ru) *	1989-02-17	1994-01-15	Такеда кемикал-индастриз Лтд	Способ получения производных аралкиламинов или их кислотно-аддитивных солей
CH678527A5 (en)	1989-06-22	1991-09-30	Sandoz Ag	Trans(E)-N-(1-naphthyl:methyl)-heptenyl-amine prepn. - by simultaneously converting crude mixt. contg. cis and trans isomers to salt and precipitating trans isomer
JP3116364B2 (ja) *	1989-10-02	2000-12-11	萬有製薬株式会社	エンイン誘導体の製造法
NZ280065A (en) *	1995-09-20	1998-04-27	Apotex Inc	Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
US6248363B1 (en)	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2001028976A1 (fr)	1999-10-22	2001-04-26	Richter Gedeon Vegyészeti Gyár Rt.	Procede de preparation d'un derive d'allylamine substituee et de ses sels
GB2357762B (en)	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
ITMI20010421A1 (it)	2001-03-01	2002-09-02	Ausimont Spa	Membrane porose semipermeabili di fluoropolimeri semicristallini
ITMI20010430A1 (it) *	2001-03-02	2002-09-02	Dinamite Dipharma S P A In For	Metodo per la sintesi di terbinafina
KR100459275B1 (ko)	2001-12-28	2004-12-03	주식회사유한양행	터비나핀 또는 그의 염산염의 제조방법
ITMI20022534A1 (it) *	2002-11-29	2004-05-30	Dinamite Dipharma S P A	Procedimento per la preparazione di terbinafina mediante l'uso di platino come catalizzatore.
US20060004230A1 (en) *	2004-06-30	2006-01-05	Joseph Kaspi	Process for the preparation of terbinafine and salts thereof

2003
- 2003-08-29 GB GBGB0320312.2A patent/GB0320312D0/en not_active Ceased
2004
- 2004-08-26 AR ARP040103068A patent/AR045506A1/es not_active Application Discontinuation
- 2004-08-27 PE PE2004000823A patent/PE20050873A1/es not_active Application Discontinuation
- 2004-08-27 US US10/522,828 patent/US20060076227A1/en not_active Abandoned
- 2004-08-27 SG SG200806418-0A patent/SG145782A1/en unknown
- 2004-08-27 NZ NZ545445A patent/NZ545445A/en not_active IP Right Cessation
- 2004-08-27 CN CNB2004800249663A patent/CN100491334C/zh not_active Expired - Fee Related
- 2004-08-27 BR BRPI0413896-1A patent/BRPI0413896A/pt not_active IP Right Cessation
- 2004-08-27 AU AU2004268051A patent/AU2004268051B2/en not_active Ceased
- 2004-08-27 CA CA2536498A patent/CA2536498C/fr not_active Expired - Fee Related
- 2004-08-27 WO PCT/EP2004/009587 patent/WO2005021483A2/fr not_active Ceased
- 2004-08-27 JP JP2006524338A patent/JP5208416B2/ja not_active Expired - Fee Related
- 2004-08-27 KR KR1020067003979A patent/KR101233024B1/ko not_active Expired - Fee Related
- 2004-08-27 RU RU2006109640/04A patent/RU2367649C2/ru not_active IP Right Cessation
- 2004-08-27 EP EP04764561A patent/EP1694631A2/fr not_active Withdrawn
- 2004-08-27 MY MYPI20043511A patent/MY149357A/en unknown
- 2004-08-27 TW TW093125943A patent/TWI350829B/zh not_active IP Right Cessation
- 2004-08-27 KR KR1020127012618A patent/KR20120054109A/ko not_active Withdrawn
- 2004-08-27 MX MXPA06002348A patent/MXPA06002348A/es active IP Right Grant
2006
- 2006-02-13 ZA ZA200601264A patent/ZA200601264B/en unknown
- 2006-02-13 IL IL173709A patent/IL173709A/en not_active IP Right Cessation
- 2006-02-17 EC EC2006006382A patent/ECSP066382A/es unknown
- 2006-02-27 TN TNP2006000066A patent/TNSN06066A1/en unknown
- 2006-03-08 MA MA28862A patent/MA28030A1/fr unknown
- 2006-03-23 IS IS8369A patent/IS8369A/is unknown
- 2006-03-28 NO NO20061404A patent/NO20061404L/no not_active Application Discontinuation
2008
- 2008-11-14 US US12/291,863 patent/US7985323B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2536498C (fr)	2012-10-09
WO2005021483A3 (fr)	2005-05-12
EP1694631A2 (fr)	2006-08-30
AU2004268051A1 (en)	2005-03-10
IL173709A0 (en)	2006-07-05
JP5208416B2 (ja)	2013-06-12
NO20061404L (no)	2006-08-25
WO2005021483A2 (fr)	2005-03-10
PE20050873A1 (es)	2005-11-21
CA2536498A1 (fr)	2005-03-10
US7985323B2 (en)	2011-07-26
US20090216047A1 (en)	2009-08-27
ZA200601264B (en)	2007-06-27
IL173709A (en)	2012-02-29
TNSN06066A1 (en)	2007-10-03
TWI350829B (en)	2011-10-21
NZ545445A (en)	2010-03-26
MY149357A (en)	2013-08-30
RU2006109640A (ru)	2007-10-10
IS8369A (is)	2006-03-23
MXPA06002348A (es)	2006-05-22
CN1845895A (zh)	2006-10-11
JP2007504110A (ja)	2007-03-01
AU2004268051B2 (en)	2009-03-05
TW200523231A (en)	2005-07-16
BRPI0413896A (pt)	2006-10-24
CN100491334C (zh)	2009-05-27
US20060076227A1 (en)	2006-04-13
AR045506A1 (es)	2005-11-02
KR20120054109A (ko)	2012-05-29
ECSP066382A (es)	2006-09-18
KR20060119892A (ko)	2006-11-24
KR101233024B1 (ko)	2013-02-13
MA28030A1 (fr)	2006-07-03
RU2367649C2 (ru)	2009-09-20
GB0320312D0 (en)	2003-10-01

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