SG170020A1 - The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron - Google Patents
The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of ironInfo
- Publication number
- SG170020A1 SG170020A1 SG201101266-3A SG2011012663A SG170020A1 SG 170020 A1 SG170020 A1 SG 170020A1 SG 2011012663 A SG2011012663 A SG 2011012663A SG 170020 A1 SG170020 A1 SG 170020A1
- Authority
- SG
- Singapore
- Prior art keywords
- iron
- deferiprone
- treat
- methods
- friedreich ataxia
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 10
- 229910052742 iron Inorganic materials 0.000 title abstract 5
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 title abstract 2
- 208000024412 Friedreich ataxia Diseases 0.000 title abstract 2
- 229960003266 deferiprone Drugs 0.000 title abstract 2
- 230000003834 intracellular effect Effects 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 abstract 1
- 229960001489 deferasirox Drugs 0.000 abstract 1
- FMSOAWSKCWYLBB-VBGLAJCLSA-N deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N(N\C(N\1)=C\2C(C=CC=C/2)=O)C/1=C\1C(=O)C=CC=C/1 FMSOAWSKCWYLBB-VBGLAJCLSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003470 mitochondria Anatomy 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77532006P | 2006-02-22 | 2006-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG170020A1 true SG170020A1 (en) | 2011-04-29 |
Family
ID=38436879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG201101266-3A SG170020A1 (en) | 2006-02-22 | 2007-02-21 | The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20090023784A1 (sr) |
| EP (1) | EP1991225B1 (sr) |
| JP (1) | JP5730466B2 (sr) |
| KR (1) | KR20080104329A (sr) |
| CN (1) | CN101420954A (sr) |
| AU (1) | AU2007219009B2 (sr) |
| BR (1) | BRPI0708211A2 (sr) |
| CA (1) | CA2642778A1 (sr) |
| DK (1) | DK1991225T3 (sr) |
| ES (1) | ES2441065T3 (sr) |
| IL (1) | IL193598A (sr) |
| MA (1) | MA30266B1 (sr) |
| MX (1) | MX2008010824A (sr) |
| MY (1) | MY151412A (sr) |
| NZ (1) | NZ570730A (sr) |
| PL (1) | PL1991225T3 (sr) |
| PT (1) | PT1991225E (sr) |
| RS (1) | RS53225B (sr) |
| RU (1) | RU2008137604A (sr) |
| SG (1) | SG170020A1 (sr) |
| SI (1) | SI1991225T1 (sr) |
| TN (1) | TNSN08338A1 (sr) |
| UA (1) | UA95099C2 (sr) |
| WO (1) | WO2007095728A1 (sr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007095728A1 (en) * | 2006-02-22 | 2007-08-30 | Arnold Munnich | The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron |
| CN101679263B (zh) | 2007-03-28 | 2014-01-15 | 阿普泰克斯科技公司 | 去铁酮的氟化衍生物 |
| EP2268282B1 (en) * | 2008-04-25 | 2014-10-29 | Apotex Technologies Inc. | Liquid formulation for deferiprone with palatable taste |
| CA2750599A1 (en) * | 2009-01-26 | 2010-07-29 | Michael Spino | Use of deferiprone for treatment and prevention of iron-related eye disorders |
| GEP20146008B (en) | 2009-07-03 | 2014-01-10 | Apotex Tech Inc | Fluorinated derivatives of 3-hydroxypyridin-4-ones |
| EP2959902A1 (en) | 2009-07-23 | 2015-12-30 | Novartis AG | Use of azabicycloalkyl derivatives for the treatment or prevention of ataxia |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CA2809747C (en) * | 2010-08-30 | 2018-05-01 | Roberto Testi | Compositions and methods for treating friedreich's ataxia with interferon gamma |
| CN102861017A (zh) * | 2011-07-08 | 2013-01-09 | 辽宁省计划生育科学研究院 | 一种化合物在防治老年痴呆的应用 |
| WO2013139931A1 (en) * | 2012-03-21 | 2013-09-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Composition for use in the treatment of neurodegenerative diseases with parkinsonian syndromes |
| US10442779B2 (en) | 2014-09-22 | 2019-10-15 | Fratagene Therapeutics S.R.L. | Compositions and methods for treating Friedreich's ataxia |
| US10426775B2 (en) | 2017-09-11 | 2019-10-01 | Fratagene Therapeutics Srl | Methods for treating Friedreich's ataxia with etravirine |
| MD3684344T2 (ro) | 2017-10-25 | 2025-09-30 | Chiesi Farm Spa | Comprimate de deferipronă cu eliberare întârziată și metode de utilizare a acestora |
| US12016851B2 (en) | 2022-04-11 | 2024-06-25 | Chiesi Farmaceutici S.P.A. | Modified release pharmaceutical formulations comprising deferiprone |
| US12016850B2 (en) | 2022-04-11 | 2024-06-25 | Chiesi Farmaceutici S.P.A. | Modified release pharmaceutical formulations comprising deferiprone |
| EP4734990A1 (en) * | 2023-06-28 | 2026-05-06 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Uses of iron chelators for treating stuttering |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624807A (en) * | 1992-07-22 | 1997-04-29 | The Mclean Hospital Corporation | Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| CA2272971C (en) | 1998-10-29 | 2008-01-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
| US6933104B1 (en) * | 1999-04-23 | 2005-08-23 | Shiva Biomedical, Llc | Diagnosis and treatment of human kidney diseases |
| AUPQ262499A0 (en) | 1999-09-02 | 1999-09-23 | University Of Queensland, The | Novel iron chelators |
| CA2313270C (en) * | 2000-06-30 | 2011-09-13 | Apotex Inc. | Use of deferiprone in treating and preventing iron-induced cardiac disease |
| US20040101521A1 (en) * | 2002-07-12 | 2004-05-27 | The Buck Institute For Research On Aging | Iron sequestration or elimination to reduce neurodegeneration or Parkinsons disease progression |
| EP1565185A4 (en) * | 2002-11-07 | 2011-01-05 | Technion Res & Dev Foundation | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH |
| US9737511B2 (en) * | 2004-05-24 | 2017-08-22 | Geoffrey C. GURTNER | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
| JP2008500347A (ja) * | 2004-05-24 | 2008-01-10 | ニュー・ヨーク・ユニヴァーシティー | 高血糖症による血糖の急激な増加及び／又は急激な遊離脂肪酸流動の増加の病理学的影響の治療方法又は予防方法 |
| US7728038B2 (en) * | 2004-08-04 | 2010-06-01 | University Of Utah Research Foundation | Methods for chelation therapy |
| US20070197469A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V | Fluoroquinolone carboxylic acid salt compositions |
| WO2007095728A1 (en) * | 2006-02-22 | 2007-08-30 | Arnold Munnich | The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron |
-
2007
- 2007-02-21 WO PCT/CA2007/000252 patent/WO2007095728A1/en not_active Ceased
- 2007-02-21 JP JP2008555581A patent/JP5730466B2/ja not_active Expired - Fee Related
- 2007-02-21 US US12/279,930 patent/US20090023784A1/en not_active Abandoned
- 2007-02-21 RU RU2008137604/14A patent/RU2008137604A/ru not_active Application Discontinuation
- 2007-02-21 PT PT77018000T patent/PT1991225E/pt unknown
- 2007-02-21 UA UAA200810608A patent/UA95099C2/ru unknown
- 2007-02-21 MX MX2008010824A patent/MX2008010824A/es active IP Right Grant
- 2007-02-21 SG SG201101266-3A patent/SG170020A1/en unknown
- 2007-02-21 CA CA002642778A patent/CA2642778A1/en not_active Abandoned
- 2007-02-21 AU AU2007219009A patent/AU2007219009B2/en not_active Ceased
- 2007-02-21 RS RS20140006A patent/RS53225B/sr unknown
- 2007-02-21 DK DK07701800.0T patent/DK1991225T3/da active
- 2007-02-21 SI SI200731386T patent/SI1991225T1/sl unknown
- 2007-02-21 NZ NZ570730A patent/NZ570730A/xx not_active IP Right Cessation
- 2007-02-21 US US11/708,322 patent/US20070197649A1/en not_active Abandoned
- 2007-02-21 MY MYPI20083186 patent/MY151412A/en unknown
- 2007-02-21 BR BRPI0708211-8A patent/BRPI0708211A2/pt not_active IP Right Cessation
- 2007-02-21 PL PL07701800T patent/PL1991225T3/pl unknown
- 2007-02-21 ES ES07701800.0T patent/ES2441065T3/es active Active
- 2007-02-21 CN CNA2007800132579A patent/CN101420954A/zh active Pending
- 2007-02-21 KR KR1020087023077A patent/KR20080104329A/ko not_active Ceased
- 2007-02-21 EP EP07701800.0A patent/EP1991225B1/en active Active
-
2008
- 2008-08-21 IL IL193598A patent/IL193598A/en not_active IP Right Cessation
- 2008-08-22 TN TNP2008000338A patent/TNSN08338A1/en unknown
- 2008-09-08 MA MA31216A patent/MA30266B1/fr unknown
-
2013
- 2013-01-31 US US13/755,048 patent/US20130190365A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070197649A1 (en) | 2007-08-23 |
| AU2007219009A1 (en) | 2007-08-30 |
| MX2008010824A (es) | 2009-06-08 |
| IL193598A (en) | 2012-08-30 |
| CN101420954A (zh) | 2009-04-29 |
| AU2007219009B2 (en) | 2012-12-20 |
| KR20080104329A (ko) | 2008-12-02 |
| ES2441065T3 (es) | 2014-01-31 |
| PT1991225E (pt) | 2014-02-13 |
| RS53225B (sr) | 2014-08-29 |
| JP2009527506A (ja) | 2009-07-30 |
| IL193598A0 (en) | 2009-08-03 |
| PL1991225T3 (pl) | 2014-04-30 |
| DK1991225T3 (da) | 2013-12-16 |
| BRPI0708211A2 (pt) | 2011-05-17 |
| JP5730466B2 (ja) | 2015-06-10 |
| US20090023784A1 (en) | 2009-01-22 |
| EP1991225A1 (en) | 2008-11-19 |
| WO2007095728A1 (en) | 2007-08-30 |
| EP1991225A4 (en) | 2009-07-29 |
| MY151412A (en) | 2014-05-30 |
| TNSN08338A1 (en) | 2009-12-29 |
| US20130190365A1 (en) | 2013-07-25 |
| SI1991225T1 (sl) | 2014-02-28 |
| CA2642778A1 (en) | 2007-08-30 |
| MA30266B1 (fr) | 2009-03-02 |
| UA95099C2 (ru) | 2011-07-11 |
| EP1991225B1 (en) | 2013-11-06 |
| NZ570730A (en) | 2013-05-31 |
| RU2008137604A (ru) | 2010-03-27 |
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