SG25792G - Improvements in or relating to a process for purifying proteins - Google Patents

Improvements in or relating to a process for purifying proteins

Info

Publication number
SG25792G
SG25792G SG257/92A SG25792A SG25792G SG 25792 G SG25792 G SG 25792G SG 257/92 A SG257/92 A SG 257/92A SG 25792 A SG25792 A SG 25792A SG 25792 G SG25792 G SG 25792G
Authority
SG
Singapore
Prior art keywords
relating
purifying proteins
purifying
proteins
Prior art date
Application number
SG257/92A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SG25792G publication Critical patent/SG25792G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/223—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material containing metals, e.g. organo-metallic compounds, coordination complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3265—Non-macromolecular compounds with an organic functional group containing a metal, e.g. a metal affinity ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/49—Materials comprising an indicator, e.g. colour indicator, pH-indicator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG257/92A 1984-12-05 1992-03-06 Improvements in or relating to a process for purifying proteins SG25792G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/678,602 US4569794A (en) 1984-12-05 1984-12-05 Process for purifying proteins and compounds useful in such process

Publications (1)

Publication Number Publication Date
SG25792G true SG25792G (en) 1992-05-15

Family

ID=24723484

Family Applications (1)

Application Number Title Priority Date Filing Date
SG257/92A SG25792G (en) 1984-12-05 1992-03-06 Improvements in or relating to a process for purifying proteins

Country Status (12)

Country Link
US (1) US4569794A (fr)
EP (1) EP0184355B1 (fr)
JP (1) JPH0788400B2 (fr)
AU (1) AU588840B2 (fr)
CA (1) CA1252948A (fr)
DE (1) DE3585147D1 (fr)
DK (1) DK171917B1 (fr)
HK (1) HK39192A (fr)
HU (1) HU208025B (fr)
IE (1) IE58501B1 (fr)
IL (1) IL77104A (fr)
SG (1) SG25792G (fr)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1340522C (fr) * 1987-03-10 1999-05-04 Heinz Dobeli Proteins hybrides renfermant des histidines voisines pour une purification amelioree
GB8706599D0 (en) * 1987-03-19 1987-04-23 Hoffmann La Roche Plasmodium falciparum merozoite antigen peptides
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
EP0316695B1 (fr) * 1987-11-16 1993-03-31 F. Hoffmann-La Roche Ag Polypeptides recombinants de HIV-2
JPH084519B2 (ja) * 1987-12-25 1996-01-24 エフ・ホフマン―ラ ロシュ アーゲー ハイブリッド形成用担体およびその調整方法
US4931498A (en) * 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4927879A (en) * 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US4952321A (en) * 1988-10-07 1990-08-28 Brigham Young University Process of removing and concentrating desired ions from solutions
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5115102A (en) * 1989-07-21 1992-05-19 Monsanto Company Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices
US5780597A (en) * 1989-12-22 1998-07-14 Hoffmann-La Roche Inc. Monoclonal antibodies to cytotoxic lymphocyte maturation factor
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
ATE139572T1 (de) * 1990-04-09 1996-07-15 Upjohn Co Verfahren zur reinigung von rekombinanten proteinen und dafür nützliche produkte
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
WO1992010576A1 (fr) * 1990-12-13 1992-06-25 The Upjohn Company Polypeptides de fusion
AU1332992A (en) * 1991-01-25 1992-08-27 Sloan-Kettering Institute For Cancer Research Antigen recognized by patients with antibody associated cerebellar degeneration, dna encoding same and uses thereof
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
CA2063316A1 (fr) * 1991-03-19 1992-09-20 Larry C. Blaszczak Sequence d'adn et d'acides amines de la proteine 2a fixant la penicilline de la souche 27r de staphylococcus aureus et derives utilises pour leur purification et dosage pour
US6602861B1 (en) 1992-04-16 2003-08-05 Research Corporation Technologies, Inc. Acylated phospholipid drugs
EP0583894A3 (en) * 1992-07-29 1995-09-06 Hybritech Inc Method of immobilizing and orienting molecules by use of metal chelating moieties to facilitate atomic force microscopy of proteins and molecular scale manipulation
US7105159B1 (en) 1992-11-05 2006-09-12 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US7070782B1 (en) * 1992-11-05 2006-07-04 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US6569432B1 (en) * 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
SE9303822D0 (sv) * 1993-11-18 1993-11-18 Kabi Pharmacia Ab Method for purification
US5449758A (en) * 1993-12-02 1995-09-12 Life Technologies, Inc. Protein size marker ladder
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US20040253246A1 (en) * 1996-02-23 2004-12-16 Israeli Ron S. Prostate-specific membrane antigen and uses thereof
ES2108652B1 (es) * 1996-04-19 1998-07-16 Antibioticos Sa Un procedimiento para modificar la enzima 7/3-(4-carboxibutanamido) cefalosporinacilasa y purificarla en un solo paso cromatografico.
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
US6544769B1 (en) * 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
US6074847A (en) * 1996-12-13 2000-06-13 Eli Lilly And Company Streptococcus pneumoniae gene sequence HI1146
US20080261289A1 (en) * 1996-12-13 2008-10-23 Schering-Plough Corporation Compositions comprising viruses and methods for concentrating virus preparations
JP2001512306A (ja) * 1997-01-08 2001-08-21 ライフ テクノロジーズ，インコーポレイテッド タンパク質の産生方法
US5932102A (en) * 1998-01-12 1999-08-03 Schering Corporation Immobilized metal, affinity chromatography
US7026456B1 (en) 1998-01-23 2006-04-11 Hoffman-La Roche, Inc. Antibodies against human IL-12
US6008329A (en) * 1998-03-06 1999-12-28 The United States Of America As Represented By The Secretary Of The Army Method for purifying cholera toxin
WO1999057992A1 (fr) * 1998-05-14 1999-11-18 Clontech Laboratories, Inc. Compositions et procedes destines a la purification de proteines sur la base d'une site d'affinite a ions metalliques
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
US7176298B2 (en) 1998-09-25 2007-02-13 Clontech Laboratories, Inc. Polynucleotides encoding metal ion affinity peptides and related products
US7282369B2 (en) * 1998-10-02 2007-10-16 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20050142613A1 (en) * 1998-10-02 2005-06-30 David Bar-Or Test for the rapid evaluation of ischemic states and kits
US7449338B2 (en) * 1998-10-02 2008-11-11 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US7070937B1 (en) 1998-10-02 2006-07-04 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US20030215359A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US6479300B1 (en) 1999-03-15 2002-11-12 Millipore Corporation Metal loaded ligand bound membranes for metal ion affinity chromatography
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
EP1223947A4 (fr) 1999-10-15 2004-12-08 Canji Inc Vecteurs cibles
US6521111B1 (en) * 2000-04-10 2003-02-18 Invitrogen Corporation Methods and articles for labeling polymer gels
US6623655B1 (en) 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
DE50112379D1 (de) * 2000-08-11 2007-05-31 Univ Ruprecht Karls Heidelberg Fv-konstrukte mit beeinflussbarer affinitat zu einer zu bindenden substanz
DE10040179A1 (de) * 2000-08-17 2002-02-28 Ipk Inst Fuer Pflanzengenetik Beeinflussung der Verteilung von Metallen in transgenen Pflanzen
US20040180415A1 (en) * 2001-05-15 2004-09-16 Tchaga Grigoriy S. Methods and compositions for protein purification
CA2447594A1 (fr) 2001-06-21 2003-01-03 Clontech Laboratories, Inc. Compositions a affinite d'ions metalliques polymeres hydrosolubles et procedes d'utilisation afferents
US6902914B2 (en) * 2001-09-28 2005-06-07 Sigma-Aldrich, Co. Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
SG159387A1 (en) * 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
ITMI20030755A1 (it) * 2003-04-11 2004-10-12 Bottega Verde S R L Peptidi e loro derivati quali inibitori di fenomeni degradativi e composizioni contenenti gli stessi.
JP4078247B2 (ja) * 2003-05-02 2008-04-23 キヤノン株式会社 磁性体−生体物質複合体型構造体、磁性体に対して結合能を有するアミノ酸配列を有するペプチド断片及びその遺伝子、ならびに磁性体−生体物質複合体型構造体の製造方法
AU2004236740A1 (en) * 2003-05-02 2004-11-18 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
US20040224425A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
WO2006026248A1 (fr) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions et procedes faisant appel a des combinaisons de detergents zwitterioniques
US7294614B2 (en) * 2004-10-12 2007-11-13 Clontech Laboratories, Inc. Phosphoprotein affinity resins and methods for making and using the same
US20100029911A1 (en) * 2004-11-24 2010-02-04 Aplagen Gmbh Method For Solid-Phase Peptide Synthesis And Purification
EP2290088A1 (fr) 2004-12-22 2011-03-02 Genentech, Inc. Méthode de production de protéines multi-membranaires
WO2006076471A2 (fr) * 2005-01-12 2006-07-20 Nobex Corporation Conjugues bnp et procedes d'utilisation
JP2006239661A (ja) * 2005-03-07 2006-09-14 Pentax Corp 吸着剤、吸着剤の製造方法、吸着装置および吸着装置の製造方法
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
US7265213B2 (en) * 2005-07-28 2007-09-04 Kpl, Inc. Methodology of conjugating chelators to biomolecules
EP1948802A4 (fr) * 2005-10-13 2009-01-14 Virexx Medical Corp Antigène chimère contenant un polypeptide du virus de l'hépatite c et un fragment fc destiné à provoquer une réponse immunitaire
WO2007096899A2 (fr) * 2006-02-08 2007-08-30 Usv Limited Polypeptide d'affinité pour la purification de protéines recombinantes
GB0604187D0 (en) * 2006-03-02 2006-04-12 Fusion Antibodies Ltd Peptide and uses thereof
WO2007120999A2 (fr) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chélation de monomères et de polymères
EP1878739A1 (fr) * 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. Purification de protéines en une étape par IMAC (MCAC)
WO2009093962A1 (fr) * 2008-01-24 2009-07-30 Ge Healthcare Bio-Sciences Ab Marqueurs polyfonctionnels
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
EP2456786B2 (fr) 2009-07-24 2017-04-19 Immune Design Corp Vecteurs lentiviraux pseudotypés avec une glycoprotéine d'enveloppe de virus sindbis
AU2012217723A1 (en) 2011-02-15 2013-08-29 Immune Design Corp. Methods for enhancing immunogen specific immune responses by vectored vaccines
NZ616304A (en) 2011-04-08 2016-01-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
WO2013067448A2 (fr) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions et procédés de détection de divers organismes infectieux
AU2013237900B2 (en) 2012-03-30 2017-07-27 Immune Design Corp. Lentiviral vector particles having improved transduction efficiency for cells expressing DC- SIGN
HU230585B1 (hu) 2012-05-30 2017-01-30 Budapesti Műszaki és Gazdaságtudományi Egyetem Fehérjék megkötésére és elválasztására alkalmas lantanida fémionokkal komplexált hordozók
WO2013181461A2 (fr) 2012-06-01 2013-12-05 University Of Kansas Peptide de capture de métal avec une activité superoxyde dismutase
EA035259B1 (ru) 2014-02-14 2020-05-21 Иммьюн Дизайн Корп. Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции
MX2017000630A (es) 2014-07-15 2017-04-27 Immune Design Corp Regimenes de sensibilización-refuerzo con un adyuvante de agonista tlr4 y un vector lentiviral.
KR20180074699A (ko) 2015-11-09 2018-07-03 이뮨 디자인 코포레이션 이종 핵산을 발현하는 rna 레플리콘의 발현 및 투여를 위한 레트로바이러스 벡터
EA201890861A1 (ru) 2015-11-09 2018-10-31 Иммьюн Дизайн Корп. Композиции, содержащие лентивирусные векторы, экспрессирующие il-12, и способы их применения
SG11202007070VA (en) 2018-01-30 2020-08-28 Life Technologies Corp Instruments, devices and consumables for use in a workflow of a smart molecular analysis system
WO2020254540A1 (fr) 2019-06-18 2020-12-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Conjugaison spécifique à un site et cinétiquement inerte de marqueurs et/ou supports à des molécules cibles, telles que des protéines marquées par his, par l'intermédiaire de réactifs de type complexes métalliques
MX2022008770A (es) 2020-01-14 2022-10-07 Synthekine Inc Muteinas de la il2.
CN115362168A (zh) 2020-01-14 2022-11-18 辛德凯因股份有限公司 偏向化il2突变蛋白方法和组合物
CN115315273A (zh) 2020-01-14 2022-11-08 辛德凯因股份有限公司 Il-2直向同源物及其使用方法
JP7743500B2 (ja) 2020-08-05 2025-09-24 シンセカイン インコーポレイテッド Ｉｌ１０受容体結合性分子および使用方法
EP4192489A4 (fr) 2020-08-05 2024-12-11 Synthekine, Inc. Molécules de liaison à l'il2rb et leurs procédés d'utilisation
WO2022032005A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison à l'il10rb et leurs procédés d'utilisation
KR102846963B1 (ko) 2020-08-05 2025-08-18 신테카인, 인크. IL27Rα 결합 분자 및 사용 방법
KR20230061392A (ko) 2020-08-05 2023-05-08 신테카인, 인크. 수용체 쌍형성과 관련된 조성물 및 방법
WO2022031885A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison à l'il10ra et procédés d'utilisation
WO2022031884A2 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Molécules de liaison à il2rg et procédés d'utilisation
CA3190415A1 (fr) 2020-08-05 2022-02-10 Synthekine, Inc. Cytokines synthetiques il2rb/il2rg
MX2023001491A (es) 2020-08-05 2023-03-08 Synthekine Inc Moleculas de union a gp130 y metodos de uso.
US20250163162A1 (en) 2021-01-11 2025-05-22 Synthekine, Inc. Compositions and methods related to receptor pairing
EP4370139A4 (fr) 2021-07-14 2025-10-15 Synthekine Inc Méthodes et compositions destinées à être utilisées dans la thérapie cellulaire contre la maladie néoplasique
WO2024086739A1 (fr) 2022-10-20 2024-04-25 Synthekine, Inc. Procédés et compositions de mutéines il12 et de mutéines il2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1048150B (it) * 1973-10-31 1980-11-20 O T I Officina Terapeutica Ita Metodo per l isolamento delle transferine da materiali biologici
US4216144A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
US4216143A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble non-ferrous metal proteinates
US4172072A (en) * 1977-10-20 1979-10-23 Ashmead H H Buffered enzymatically produced metal proteinates
JPS5562902A (en) * 1978-11-07 1980-05-12 Toray Ind Inc Separation of endotoxin
JPS55148098A (en) * 1979-05-10 1980-11-18 Toray Ind Inc Concentration and purification of interferon
JPS5835157A (ja) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd ヒトリムホブラストイドインターフェロンのｎ末端ペプチド
GB2097279B (en) * 1981-04-27 1984-08-01 Health Lab Service Board Affinity chromatography in presence of metal ions
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
JPS59130254A (ja) * 1982-10-18 1984-07-26 Mitsubishi Chem Ind Ltd ポリペプチド
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
GB8311136D0 (en) * 1983-04-25 1983-06-02 Lepetit Spa Immobilised oligopeptides
JPS59206342A (ja) * 1983-05-10 1984-11-22 Mitsubishi Chem Ind Ltd ペプチド類

Also Published As

Publication number Publication date
JPS61148197A (ja) 1986-07-05
EP0184355B1 (fr) 1992-01-08
IE852913L (en) 1986-06-05
EP0184355A3 (en) 1987-04-08
DE3585147D1 (de) 1992-02-20
AU588840B2 (en) 1989-09-28
US4569794A (en) 1986-02-11
EP0184355A2 (fr) 1986-06-11
IL77104A0 (en) 1986-04-29
CA1252948A (fr) 1989-04-18
HK39192A (en) 1992-06-04
IL77104A (en) 1990-03-19
HU208025B (en) 1993-07-28
JPH0788400B2 (ja) 1995-09-27
DK535285D0 (da) 1985-11-20
DK171917B1 (da) 1997-08-11
IE58501B1 (en) 1993-10-06
HUT39462A (en) 1986-09-29
AU5024085A (en) 1986-06-12
DK535285A (da) 1986-06-06

Similar Documents

Publication Publication Date Title
AU588840B2 (en) Improvements in or relating to a process for purifying proteins
EP0169997A3 (en) Process for purifying smoke
EP0201983A3 (en) Improvements relating to microtomes
GB8521744D0 (en) Purifying process
DE3563308D1 (en) Improvements in or relating to wrist supports
GB2162217B (en) Improvements in or relating to walls
IL75615A0 (en) Improvements in or relating to a crystallization process for ceftazidime
GB2176420B (en) Improvements relating to filters
ZA868274B (en) Purification method for proteins
GB2166453B (en) Purification process
GB2181368B (en) Improvements in or relating to crease setting apparatus
GB8510109D0 (en) Purification process
PT85956A (en) Process for protein purification
GB2160167B (en) Improvements in or relating to tractors
YU186587A (en) Process for purifying aluminium-trioxide
GB2167643B (en) Improvements in or relating to a clamp
GB8815715D0 (en) Improvements in & relating to vehicles
GB2119278B (en) Improvements in or relating to a chemical method
ZA84628B (en) Improvements in or relating to hydro-cyclones
GB8427744D0 (en) Improvements in or relating to hydrophones
GB2168026B (en) Improvements relating to containers
GB2166424B (en) Improvements in or relating to materials
GB2160494B (en) Improvements in or relating to pallets
DE3565978D1 (en) Process for hydroxymethylation
GB2156708B (en) Improvements in or relating to separation