SG47773A1 - Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors - Google Patents

Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors

Info

Publication number: SG47773A1
Authority: SG; Singapore
Prior art keywords: carbon atoms; aryl; lower alkyl; pyrrolidines; isoquinoline
Prior art date: 1990-05-21

Application number

SG1996004319A

Other languages

English (en)

Inventor

Michael Sotirios Malamas

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-21

Filing date

1991-05-17

Publication date

1998-04-17

1991-05-17 Application filed by American Home Prod filed Critical American Home Prod

1998-04-17 Publication of SG47773A1 publication Critical patent/SG47773A1/en

Links

239000003288 aldose reductase inhibitor Substances 0.000 title 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
230000009286 beneficial effect Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG1996004319A 1990-05-21 1991-05-17 Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors SG47773A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/526,356 US5037831A (en)	1990-05-21	1990-05-21	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors

Publications (1)

Publication Number	Publication Date
SG47773A1 true SG47773A1 (en)	1998-04-17

Family

ID=24097007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996004319A SG47773A1 (en)	1990-05-21	1991-05-17	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors

Country Status (10)

Country	Link
US (1)	US5037831A (de)
EP (1)	EP0458551B1 (de)
JP (1)	JP3244283B2 (de)
AT (1)	ATE160780T1 (de)
CA (1)	CA2042113C (de)
DE (1)	DE69128302T2 (de)
DK (1)	DK0458551T3 (de)
ES (1)	ES2110977T3 (de)
GR (1)	GR3026186T3 (de)
SG (1)	SG47773A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5106978A (en) *	1991-05-22	1992-04-21	American Home Products Corporation	Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5189167A (en) *	1991-11-25	1993-02-23	American Home Products Corporation	Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5189168A (en) *	1991-11-25	1993-02-23	American Home Products Corporation	1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
ES2101291T3 (es) *	1991-11-25	1997-07-01	American Home Prod	1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa.
US5189044A (en) *	1992-03-20	1993-02-23	American Home Products Corporation	Isoquinoline-1,3-dione acetyl carbamates useful as aldose reductase inhibitors
ATE422359T1 (de) *	1997-04-15	2009-02-15	Csir	Verbindungen und pharmazeutische zusammensetzungen mit appetitunterdrückender aktivität
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
HRP20030419A2 (en)	2000-11-30	2004-08-31	Pfizer Prod Inc	Combination of gaba agonists and aldose reductase inhibitors
US20110092566A1 (en) *	2004-11-19	2011-04-21	Srivastava Satish K	Treatment of cancer with aldose reductase inhibitors
ATE518544T1 (de)	2007-03-12	2011-08-15	Zadec Aps	Rotbusch-extrakt gegen diabetes
CA2685202C (en)	2007-03-23	2017-11-28	The Board Of Regents Of The University Of Texas System	Methods for treating allergic asthma
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition
CA2822672C (en)	2010-12-23	2018-06-05	The Board Of Regents Of The University Of Texas System	Methods for treating copd
CN107286092B (zh) *	2017-05-24	2020-02-21	浙江大学	甲氧基苯甲酰胺和重氮酸酯经碳-氢官能化制备异喹啉二酮的方法
US12090142B2 (en)	2018-02-22	2024-09-17	Board Of Regents, The University Of Texas System	Combination therapy for the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
ES2032749T3 (es) *	1985-11-07	1993-03-01	Pfizer Inc.	Acidos oxoftalazinil-aceticos heterociclicos.
DE3769066D1 (de) *	1986-08-28	1991-05-08	Sanwa Kagaku Kenkyusho Co	Hydantoin-derivate zur behandlung von komplikationen bei diabetes.
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) *	1988-10-20	1990-05-22	American Home Products	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

1990
- 1990-05-21 US US07/526,356 patent/US5037831A/en not_active Expired - Lifetime
1991
- 1991-05-08 CA CA002042113A patent/CA2042113C/en not_active Expired - Fee Related
- 1991-05-17 SG SG1996004319A patent/SG47773A1/en unknown
- 1991-05-17 DK DK91304487T patent/DK0458551T3/da active
- 1991-05-17 EP EP91304487A patent/EP0458551B1/de not_active Expired - Lifetime
- 1991-05-17 AT AT91304487T patent/ATE160780T1/de not_active IP Right Cessation
- 1991-05-17 ES ES91304487T patent/ES2110977T3/es not_active Expired - Lifetime
- 1991-05-17 DE DE69128302T patent/DE69128302T2/de not_active Expired - Fee Related
- 1991-05-20 JP JP11447991A patent/JP3244283B2/ja not_active Expired - Fee Related
1998
- 1998-02-20 GR GR980400364T patent/GR3026186T3/el unknown

Also Published As

Publication number	Publication date
JPH04226984A (ja)	1992-08-17
DE69128302T2 (de)	1998-03-26
ES2110977T3 (es)	1998-03-01
DE69128302D1 (de)	1998-01-15
US5037831A (en)	1991-08-06
CA2042113A1 (en)	1991-11-22
GR3026186T3 (en)	1998-05-29
EP0458551A1 (de)	1991-11-27
DK0458551T3 (da)	1998-08-10
HK1004067A1 (en)	1998-11-13
ATE160780T1 (de)	1997-12-15
EP0458551B1 (de)	1997-12-03
JP3244283B2 (ja)	2002-01-07
CA2042113C (en)	2001-08-28

Publication	Publication Date	Title
GR3026186T3 (en)	1998-05-29	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
HUT59081A (en)	1992-04-28	Process for producing aryl- and heteroaryl-ethylene derivatives and pharmaceutical compositions containing them
YU208687A (en)	1988-10-31	Process for obtaining analog of rebecamicine
IL103825A0 (en)	1993-04-04	Aromatic amino-alcohol derivatives,a method for the preparation thereof and pharmaceutical compositions containing the same
ZA924425B (en)	1993-03-31	Tetrahydropyrrolo(1,2-a)pyrazine-4-spiro-3'-pyrrolidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU1039688A (en)	1988-07-21	3(2h)pyridazinone, process for its preparation and antagonistic agent against srs-a containing it
DK0430201T3 (de)	1997-06-16
IL86080A0 (en)	1988-09-30	Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same
NO172939C (no)	1993-09-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive estere av estramustin
HUT50337A (en)	1990-01-29	Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
CA2042112A1 (en)	1991-11-22	N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
SG47809A1 (en)	1998-04-17	1'-Aminospiro(isoqunoline-4(1H) ,3'-pyrrolidine)-1, 2',3,'5' (2H9-tetrones and analogs thereof useful as aldose reductase inhibitors
GR70356B (de)	1982-09-27
DE3879650D1 (en)	1993-04-29	N-acyl-n-naphthoylglycine als aldose-reductase-inhibitoren.
GR3023563T3 (en)	1997-08-29	1'-amino-2- (benzothiazolyl)methyl)spiro isoquinoline-4(1h),3'-pyrrolidine)-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors.
ES2032413T3 (es)	1993-02-16	Procedimiento para preparar pirimidoquinoxalinas sustituidas. (reserva del art. 167.2 cpe).