SG52480A1 - Immunogenic compositions against helicobacter infection polypeptides for use in the compositions and nucleic accid sequences encoding said polypeptides - Google Patents

Immunogenic compositions against helicobacter infection polypeptides for use in the compositions and nucleic accid sequences encoding said polypeptides

Info

Publication number: SG52480A1
Authority: SG; Singapore
Prior art keywords: polypeptides; fragment; compositions; helicobacter; accid
Prior art date: 1993-05-19

Application number

SG1996005085A

Other languages

English (en)

Inventor

Agnes Labigne

Sebastien Suerbaum

Richard Ferrero

Jean-Michel Thiberge

Original Assignee

Pasteur Institut

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-19

Filing date

1994-05-19

Publication date

1998-09-28

1994-05-19 Application filed by Pasteur Institut, Inst Nat Sante Rech Med filed Critical Pasteur Institut

1998-09-28 Publication of SG52480A1 publication Critical patent/SG52480A1/en

Links

239000000203 mixture Substances 0.000 title abstract 4
229920001184 polypeptide Polymers 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
230000002163 immunogen Effects 0.000 title abstract 3
206010019375 Helicobacter infections Diseases 0.000 title abstract 2
239000012634 fragment Substances 0.000 abstract 5
108010046334 Urease Proteins 0.000 abstract 4
241000590017 Helicobacter felis Species 0.000 abstract 2
241000590002 Helicobacter pylori Species 0.000 abstract 2
229940037467 helicobacter pylori Drugs 0.000 abstract 2
108050001186 Chaperonin Cpn60 Proteins 0.000 abstract 1
102000052603 Chaperonins Human genes 0.000 abstract 1
102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
241000589989 Helicobacter Species 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Diabetes (AREA)
Oncology (AREA)
Nutrition Science (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SG1996005085A 1993-05-19 1994-05-19 Immunogenic compositions against helicobacter infection polypeptides for use in the compositions and nucleic accid sequences encoding said polypeptides SG52480A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP93401309		1993-05-19
PCT/EP1993/003259 WO1995014093A1 (fr)	1993-05-19	1993-11-19	Compositions immunogenes dirigees contre les infections par helicobacter, polypeptides utilisables dans ces compositions, et sequences d'acides nucleiques codant ces polypeptides

Publications (1)

Publication Number	Publication Date
SG52480A1 true SG52480A1 (en)	1998-09-28

Family

ID=26070083

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996005085A SG52480A1 (en)	1993-05-19	1994-05-19	Immunogenic compositions against helicobacter infection polypeptides for use in the compositions and nucleic accid sequences encoding said polypeptides

Country Status (11)

Country	Link
US (1)	US6248330B1 (fr)
EP (1)	EP0703981B1 (fr)
JP (4)	JPH08509873A (fr)
AT (1)	ATE364083T1 (fr)
AU (1)	AU689779B2 (fr)
CA (1)	CA2144307C (fr)
DE (1)	DE69434985T2 (fr)
DK (1)	DK0703981T3 (fr)
ES (1)	ES2288753T3 (fr)
SG (1)	SG52480A1 (fr)
WO (2)	WO1995014093A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08509873A (ja)	1993-05-19	1996-10-22	アンスティテュ・パストゥール	ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列
US5874405A (en) *	1994-12-16	1999-02-23	Birnbaum; Gary	Heat shock protein peptides that share sequences with cyclic nucleotide phosphodiesterase and methods for modulating autoimmune central nervous system disease
NZ304756A (en) *	1995-04-21	2000-02-28	Univ New South Wales	Protective Helicobacter antigens and vaccine compositions containing them
AU723063B2 (en) *	1995-04-28	2000-08-17	Oravax, Inc	Multimeric, recombinant urease vaccine
AU5693496A (en) *	1995-05-02	1996-11-21	Institut National De La Sante Et De La Recherche Medicale	Immunogenic compositions against helicobacter infection, pol ypeptides for use in the compositions, and nucleic acid sequ ences encoding said polypeptides
ATE329031T1 (de) *	1995-11-30	2006-06-15	Agriculture Victoria Serv Pty	Therapeutische zusammensetzungen zur behandlung von lawsonia intracellularis infektionen
GB2307987A (en) *	1995-12-06	1997-06-11	Univ Manchester	Epitopes of the urease of Helicobacter pylori as dignostic agents; pharmaceuticals comprising such epitopes or the antibodies thereto
GB2324093A (en) *	1996-01-04	1998-10-14	Rican Limited	Helicobacter pylori bacterioferritin
DE19630390A1 (de) *	1996-07-26	1998-01-29	Chiron Behring Gmbh & Co	Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung
EP0835928A1 (fr) *	1996-10-11	1998-04-15	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin	Vaccin vivant d'hélicobacter pylori
US6248551B1 (en) *	1997-03-28	2001-06-19	Institut Pasteur	Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
JP3430853B2 (ja)	1997-04-11	2003-07-28	株式会社ゲン・コーポレーション	胃炎、胃潰瘍および十二指腸潰瘍の予防剤並びに治療剤
AU7537598A (en) *	1997-04-30	1998-11-24	Pasteur Merieux Serums Et Vaccins	Dna based anti-(helicobacter) vaccine composition
US5985631A (en) *	1997-09-12	1999-11-16	Oravax-Merieux Co.	Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
US20020151462A1 (en) *	1998-02-19	2002-10-17	Ling Lissolo	Helicobacter pylori membrane proteins
US6190667B1 (en)	1998-06-30	2001-02-20	Institut Pasteur	Methods of inhibiting Helicobacter pylori
CA2351110A1 (fr) *	2000-07-17	2002-01-17	Akzo Nobel N.V.	Vaccin contre les infections a helicobacter felis
GB0021757D0 (en) *	2000-09-04	2000-10-18	Colaco Camilo	Vaccine against microbial pathogens
UA81634C2 (ru)	2002-07-18	2008-01-25	Хеликс Биофарма Корп.	Фармацевтическая композиция уреазы для ингибирования роста раковых клеток и ее применение
US7264800B2 (en) *	2002-07-18	2007-09-04	Helix Biopharma Corporation	Method and composition for inhibiting cancer cell growth
WO2006133879A2 (fr) *	2005-06-16	2006-12-21	Universiteit Gent	Vaccins d'immunisation contre helicobacter
US7790143B2 (en)	2005-06-16	2010-09-07	Universiteit Gent	Vaccines for immunization against helicobacter
JP2016524459A (ja)	2013-04-08	2016-08-18	へリックスバイオファーマコーポレイション	診断および治療目的のための抗体−ウレアーゼコンジュゲートの使用
RU2689689C2 (ru)	2015-01-23	2019-05-28	Хеликс Байофарма Корпорейшн	Конъюгаты антитело-уреаза для терапевтических целей
CN118414162A (zh) *	2021-12-23	2024-07-30	英特维特国际股份有限公司	抗利什曼病的dna疫苗
CN116052799B (zh) *	2022-04-06	2026-01-23	大连理工江苏研究院有限公司	一种基于机器学习的幽门螺杆菌抗体药物制备方法及其研发用区块链应用系统

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5459041A (en) *	1988-02-18	1995-10-17	Enteric Research Laboratories, Inc.	Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
FR2637612B1 (fr) *	1988-10-06	1993-09-10	Pasteur Institut	Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) *	1989-12-19	1990-02-21	3I Res Expl Ltd	H.pylori dna probes
US5262156A (en) *	1991-08-12	1993-11-16	Hycor Biomedical, Inc.	Antigenic compositions and their use for the detection of Helicobacter pylori
FR2682122B1 (fr) *	1991-10-03	1995-06-09	Pasteur Institut	Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
CA2117490C (fr)	1992-02-26	2009-01-06	Timothy L. Cover	Toxine vacuolisante purifiee de helicobacter pylori et methodes d'utilisation
DE69333110T2 (de) *	1992-03-02	2004-05-06	Chiron S.P.A.	Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
MX9301706A (es)	1992-04-13	1994-05-31	Oravax Inc	Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
DK0661990T3 (da) *	1992-08-26	2002-06-17	Celtrix Pharma	Fremgangsmåde til systemisk behandling af kataboliske tilstande og systemisk vævsbeskadigelse
WO1994006474A1 (fr) *	1992-09-16	1994-03-31	Galagen Inc.	TRAITEMENT PAR ANTICORPS D'AFFECTIONS CAUSEES PAR $i(HELICOBACTER PYLORI)
US5972336A (en)	1992-11-03	1999-10-26	Oravax Merieux Co.	Urease-based vaccine against helicobacter infection
JPH08509873A (ja)	1993-05-19	1996-10-22	アンスティテュ・パストゥール	ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列
US5871749A (en)	1993-07-27	1999-02-16	Csl Limited	Therapeutic treatment of H. pylori associated gastroduodenal disease
AR003125A1 (es)	1995-06-01	1998-07-08	Astra Ab	Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la
SK165197A3 (en)	1995-06-07	1999-01-11	Astra Ab	Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics

1993
- 1993-11-19 JP JP7514170A patent/JPH08509873A/ja active Pending
- 1993-11-19 WO PCT/EP1993/003259 patent/WO1995014093A1/fr not_active Ceased
1994
- 1994-05-19 CA CA002144307A patent/CA2144307C/fr not_active Expired - Fee Related
- 1994-05-19 DE DE69434985T patent/DE69434985T2/de not_active Expired - Fee Related
- 1994-05-19 SG SG1996005085A patent/SG52480A1/en unknown
- 1994-05-19 ES ES94917653T patent/ES2288753T3/es not_active Expired - Lifetime
- 1994-05-19 JP JP52499794A patent/JP3955317B2/ja not_active Expired - Fee Related
- 1994-05-19 WO PCT/EP1994/001625 patent/WO1994026901A1/fr not_active Ceased
- 1994-05-19 DK DK94917653T patent/DK0703981T3/da active
- 1994-05-19 AU AU69290/94A patent/AU689779B2/en not_active Ceased
- 1994-05-19 AT AT94917653T patent/ATE364083T1/de not_active IP Right Cessation
- 1994-05-19 EP EP94917653A patent/EP0703981B1/fr not_active Expired - Lifetime
1995
- 1995-05-02 US US08/432,697 patent/US6248330B1/en not_active Expired - Fee Related
2004
- 2004-06-02 JP JP2004164306A patent/JP2004337170A/ja active Pending
2007
- 2007-09-27 JP JP2007252748A patent/JP2008086316A/ja active Pending

Also Published As

Publication number	Publication date
DK0703981T3 (da)	2007-10-08
CA2144307A1 (fr)	1994-11-24
JP3955317B2 (ja)	2007-08-08
EP0703981B1 (fr)	2007-06-06
DE69434985T2 (de)	2008-02-21
AU689779B2 (en)	1998-04-09
AU6929094A (en)	1994-12-12
JPH08510120A (ja)	1996-10-29
JP2004337170A (ja)	2004-12-02
CA2144307C (fr)	2008-09-02
EP0703981A1 (fr)	1996-04-03
WO1995014093A1 (fr)	1995-05-26
ES2288753T3 (es)	2008-01-16
DE69434985D1 (de)	2007-07-19
JPH08509873A (ja)	1996-10-22
US6248330B1 (en)	2001-06-19
WO1994026901A1 (fr)	1994-11-24
ATE364083T1 (de)	2007-06-15
JP2008086316A (ja)	2008-04-17

Publication	Publication Date	Title
SG52480A1 (en)	1998-09-28	Immunogenic compositions against helicobacter infection polypeptides for use in the compositions and nucleic accid sequences encoding said polypeptides
EA199800973A1 (ru)	1999-06-24	Полипептид белка-106 наружной мембраны moraxella catarrhalis, последовательность гена и их применение
MY119003A (en)	2005-03-31	Bacterial antigens and vaccine compositions
NZ502391A (en)	2002-12-20	Mammalian cytokine: interleukin-B30 and related reagents
CA2131729A1 (fr)	1993-09-16	Proteines de l'helicobacter pylori pouvant servir a la production de vaccins et pour le diagnostic
GB2303854B (en)	1998-10-21	Helicobacter proteins and vaccines
CY2570B1 (en)	2008-07-02	Compounds for immunotherapy and diagnosis of tuberculosis
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WO1998016646A3 (fr)	1998-10-08	Composes et methodes utilises pour l'immunotherapie et le diagnostic de la tuberculose
KR100215606B1 (en)	1999-08-16	Toxoplasma gondii antigens, the preparation thereof and the diagnostic agent containing them
GR3017019T3 (en)	1995-11-30	Pancreatic islet cell antigens obtained by molecular cloning.
MY110899A (en)	1999-06-30	Dengue virus
IL88378A (en)	2000-11-21	Human interferon-gamma binding proteins their manufacture and pharmaceutical compositions comprising them
WO2002051237A3 (fr)	2004-02-26	Proteines de helicobacter, acides nucleiques et leurs applications
NO20011263D0 (no)	2001-03-13	Moraxella Catarrhalis BASBO34-polypeptider og anvendelser derav
GR3003754T3 (fr)	1993-03-16
WO2000039301A3 (fr)	2001-05-03	Procedes d'utilisation de molecules de mycobacterium tuberculosis en tant qu'adjuvants immunologiques
SE8800981D0 (sv)	1988-03-17	A recombinant fusion protein, its use and a recombinant vector
ZA906667B (en)	1991-06-26	Antigens and polypeptides derived from babesia(12d3 antigen)
TH43863A (th)	2001-03-26	แอนติเจนแบคทีเรียและส่วนประกอบวัคซีน
MX9700215A (es)	1998-01-31	Proteinas y vacunas de helicobacter.