SG78091G - Intermediates and process for antibiotics - Google Patents

Intermediates and process for antibiotics

Info

Publication number
SG78091G
SG78091G SG780/91A SG78091A SG78091G SG 78091 G SG78091 G SG 78091G SG 780/91 A SG780/91 A SG 780/91A SG 78091 A SG78091 A SG 78091A SG 78091 G SG78091 G SG 78091G
Authority
SG
Singapore
Prior art keywords
carbacephalosporins
trifluoromethylsulfonyloxy
amino
antibiotics
intermediates
Prior art date
Application number
SG780/91A
Other languages
English (en)
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of SG78091G publication Critical patent/SG78091G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG780/91A 1985-08-02 1991-09-19 Intermediates and process for antibiotics SG78091G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/761,647 US4673737A (en) 1985-08-02 1985-08-02 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Publications (1)

Publication Number Publication Date
SG78091G true SG78091G (en) 1991-11-15

Family

ID=25062866

Family Applications (1)

Application Number Title Priority Date Filing Date
SG780/91A SG78091G (en) 1985-08-02 1991-09-19 Intermediates and process for antibiotics

Country Status (22)

Country Link
US (1) US4673737A (fr)
EP (1) EP0211540B1 (fr)
JP (2) JPH0762016B2 (fr)
KR (1) KR900001883B1 (fr)
CN (1) CN1015103B (fr)
AT (1) ATE52779T1 (fr)
AU (1) AU586694B2 (fr)
CA (2) CA1262356A (fr)
DE (1) DE3671225D1 (fr)
DK (1) DK335786A (fr)
ES (1) ES2000589A6 (fr)
GR (1) GR861858B (fr)
HK (1) HK3392A (fr)
HU (1) HU201932B (fr)
IE (1) IE58998B1 (fr)
IL (1) IL79421A (fr)
NZ (1) NZ216872A (fr)
PH (1) PH22722A (fr)
PT (1) PT82990B (fr)
SG (1) SG78091G (fr)
SU (1) SU1547709A3 (fr)
ZA (1) ZA865275B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665171A (en) 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4820816A (en) * 1985-08-02 1989-04-11 President And Fellows Of Harvard College 3-trifuoromethylsulfonyloxy-substituted 1-carbacephalosporins as intermediates for antibiotics
EP0266896B1 (fr) * 1986-10-03 1992-08-05 Eli Lilly And Company 7-(Phénylglycine(substituée sur la position meta))-1-carba-1-déthiacéphalosporines
EP0299728A3 (fr) * 1987-07-17 1989-08-23 Eli Lilly And Company Procédé de carbonylation pour des antibiotiques bêta-lactames
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
US4885291A (en) * 1988-01-14 1989-12-05 Eli Lilly And Company 1-carba(dethia)-3-cephem derivatives
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
US4855418A (en) * 1988-03-23 1989-08-08 Eli Lilly And Company Process for production of ceophalosporins
US4820832A (en) * 1988-03-23 1989-04-11 Eli Lilly And Company Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins
US5191075A (en) * 1988-10-19 1993-03-02 Pfizer Inc Process for the preparation of penems
US4895940A (en) * 1988-10-19 1990-01-23 Pfizer Inc. Process for the preparation of penems
US4992543A (en) * 1988-10-19 1991-02-12 Pfizer Inc. Penem derivatives
US5159073A (en) * 1990-09-13 1992-10-27 Eli Lilly And Company Intermediates to 1-carbacephalosporins and process for preparation thereof
US5225553A (en) * 1990-09-13 1993-07-06 Eli Lilly And Company Intermediates to 1-carbacephalosporins and process for preparation thereof
US5169843A (en) * 1990-10-22 1992-12-08 Bristol-Myers Squibb Company Antibiotic C-3 cyclobutenedione substituted (1-carba) cephalosporin compounds, cmpositions, and methods of use thereof
US5206360A (en) * 1990-10-22 1993-04-27 Bristol-Myers Squibb Company Intermediates for cyclobutenedione substituted (1-carba)cephalosporin compounds
US5106842A (en) * 1990-10-22 1992-04-21 Bristol-Myers Squibb Co. Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
US5099015A (en) * 1991-01-10 1992-03-24 Eli Lilly And Company Trifluoromethyl 1-carba(1-dethia)cephems
US5084447A (en) * 1991-04-25 1992-01-28 Eli Lilly And Company C-3 phosphine oxide substituted carbacephalosporins
WO1997030707A1 (fr) 1996-02-23 1997-08-28 Eli Lilly And Company ANTAGONISTES DU RECEPTEUR DE LA VASOPRESSINE V1a NON PEPTIDYLIQUES
CN107556212B (zh) * 2017-09-14 2020-03-24 台州昌霖化工科技有限公司 一种制备2-重氮乙酰乙酸对硝基苄酯的方法
CN112500361B (zh) * 2020-12-27 2023-05-12 甘肃瀚聚药业有限公司 一种(s)-4-苯基-2-恶唑烷酮的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US4275207A (en) * 1978-08-14 1981-06-23 Merck & Co., Inc. Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
JPS6058920B2 (ja) * 1978-12-26 1985-12-23 協和醗酵工業株式会社 セフアロスポリン類縁体
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd ３位置換カルバセフエム化合物
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
IE862850L (en) * 1985-11-21 1987-05-21 Inst Animal Health Ltd Intermediates for the preparation of beta-lactam antibiotics
JPH0791291B2 (ja) * 1985-12-30 1995-10-04 イ−ライ・リリ−・アンド・カンパニ− １−カルバセフアロスポリン抗生物質

Also Published As

Publication number Publication date
JPH07300475A (ja) 1995-11-14
GR861858B (en) 1986-11-18
ES2000589A6 (es) 1988-03-01
SU1547709A3 (ru) 1990-02-28
HK3392A (en) 1992-01-17
AU586694B2 (en) 1989-07-20
AU6014986A (en) 1987-02-05
JPS6259277A (ja) 1987-03-14
IL79421A (en) 1991-06-10
CN86105247A (zh) 1987-02-04
HUT41407A (en) 1987-04-28
IE861901L (en) 1987-02-02
IE58998B1 (en) 1993-12-15
CN1015103B (zh) 1991-12-18
KR900001883B1 (ko) 1990-03-26
CA1305964C (fr) 1992-08-04
ZA865275B (en) 1988-02-24
EP0211540A1 (fr) 1987-02-25
JPH0762016B2 (ja) 1995-07-05
EP0211540B1 (fr) 1990-05-16
PT82990A (en) 1986-08-01
DK335786A (da) 1987-02-03
JP2529544B2 (ja) 1996-08-28
DE3671225D1 (de) 1990-06-21
CA1262356A (fr) 1989-10-17
PT82990B (pt) 1989-01-30
DK335786D0 (da) 1986-07-15
KR870002123A (ko) 1987-03-30
HU201932B (en) 1991-01-28
NZ216872A (en) 1989-10-27
US4673737A (en) 1987-06-16
ATE52779T1 (de) 1990-06-15
PH22722A (en) 1988-11-28

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