SG96294G - 1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof - Google Patents

1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

Info

Publication number: SG96294G
Authority: SG; Singapore
Prior art keywords: group; alkyl; halogen atoms; alkoxy; oxa
Prior art date: 1989-08-10

Application number

SG96294A

Other languages

English (en)

Inventor

Edit Toth

Jozsef Torley

Laszlo Dr Szporny

Bela Kiss

Egon Dr Karpati

Eva Dr Palosi

Dora Dr Groo

Istvan Dr Laszlovszky

Zsolt Dr Szombathelyi

Adam Dr Sarkadi

Aniko Gere

Katalin Csomor

Mihaly Dr Bodo

Judit Dr Laszy

Zsolt Szentirmay

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1994-07-16

Publication date

1994-10-28

1989-08-10 Priority to HU894095A priority Critical patent/HU204530B/hu

1990-08-09 Priority to EP90308784A priority patent/EP0414421B1/de

1990-08-09 Priority to KR1019900012256A priority patent/KR940006635B1/ko

1990-08-09 Priority to NZ234848A priority patent/NZ234848A/en

1990-08-09 Priority to NO903512A priority patent/NO177962C/no

1990-08-09 Priority to IE288490A priority patent/IE64911B1/en

1990-08-09 Priority to SI9011538A priority patent/SI9011538A/sl

1990-08-09 Priority to ES90308784T priority patent/ES2052180T3/es

1990-08-09 Priority to JP2209358A priority patent/JPH0749431B2/ja

1990-08-09 Priority to DE69007904T priority patent/DE69007904T2/de

1990-08-09 Priority to AU60807/90A priority patent/AU622039B2/en

1990-08-09 Priority to AT90308784T priority patent/ATE103920T1/de

1990-08-09 Priority to DK90308784.9T priority patent/DK0414421T3/da

1990-08-09 Priority to DD90343361A priority patent/DD299429A5/de

1990-08-09 Priority to ZA906302A priority patent/ZA906302B/xx

1990-08-09 Priority to IL9532090A priority patent/IL95320A/en

1990-08-10 Priority to PL90291701A priority patent/PL163431B1/pl

1990-08-10 Priority to FI903972A priority patent/FI93455C/fi

1990-08-10 Priority to PL90286440A priority patent/PL163370B1/pl

1990-08-10 Priority to PL90291702A priority patent/PL163593B1/pl

1990-08-10 Priority to US07/566,275 priority patent/US5118687A/en

1992-10-01 Priority to HRP-1538/90A priority patent/HRP920778A2/hr

1993-12-02 Priority to BG098261A priority patent/BG60436B2/bg

1994-07-16 Priority to SG96294A priority patent/SG96294G/en

1994-07-16 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1994-10-12 Priority to HU94P/P00036P priority patent/HU210072A9/hu

1994-10-28 Publication of SG96294G publication Critical patent/SG96294G/en

1994-12-22 Priority to HK145994A priority patent/HK145994A/en

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
SEUNTAIZLCAWDW-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decan-2-one Chemical class O1C(=O)CCC11CCNCC1 SEUNTAIZLCAWDW-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000496 anti-anoxic effect Effects 0.000 abstract 1
230000000141 anti-hypoxic effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000006931 brain damage Effects 0.000 abstract 1
231100000874 brain damage Toxicity 0.000 abstract 1
208000029028 brain injury Diseases 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
DIOQZVSQGTUSAI-NJFSPNSNSA-N decane Chemical class CCCCCCCCC[14CH3] DIOQZVSQGTUSAI-NJFSPNSNSA-N 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)

SG96294A 1989-08-10 1994-07-16 1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof SG96294G (en)

Priority Applications (26)

Application Number	Priority Date	Filing Date	Title
HU894095A HU204530B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
DD90343361A DD299429A5 (de)	1989-08-10	1990-08-09	Neue 1-oxa-2-oxo-8-aza-spiro[4,5]dekan-derivate und verfahren zur herstellung dieser verbindungen
NZ234848A NZ234848A (en)	1989-08-10	1990-08-09	1-oxa-2-oxo-3-(oxa or aza)-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions
NO903512A NO177962C (no)	1989-08-10	1990-08-09	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-oxa-2-oxo-8-azaspiro[4,5Ådecan-derivater
IE288490A IE64911B1 (en)	1989-08-10	1990-08-09	1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives processes for their preparation and pharmaceutical compositions thereof
SI9011538A SI9011538A (sl)	1989-08-10	1990-08-09	Novi 1-oksa-2-okso-8-azaspiro/4,5/dekanski derivati, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo
ES90308784T ES2052180T3 (es)	1989-08-10	1990-08-09	Derivados de 1-oxa-2-oxo-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos.
KR1019900012256A KR940006635B1 (ko)	1989-08-10	1990-08-09	1-옥사-2-옥소-8-아자스피로[4,5]데칸 유도체와 그들을 포함하는 약제학적 조성물 및 그 제조방법
DE69007904T DE69007904T2 (de)	1989-08-10	1990-08-09	1-Oxa-2-oxo-8-azaspiro[4,5]decan-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen daraus.
AU60807/90A AU622039B2 (en)	1989-08-10	1990-08-09	Novel 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives, pharmaceutical compositions containing them and process for preparing the same
AT90308784T ATE103920T1 (de)	1989-08-10	1990-08-09	1-oxa-2-oxo-8-azaspiro(4,5>decan-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen daraus.
IL9532090A IL95320A (en)	1989-08-10	1990-08-09	4-Transformed History of 8-Phenylalkyl-1-Oxa-2 Oxo-8-Azaspiri [4,5] Decan, Preparation and Pharmaceutical Preparations Containing Them
ZA906302A ZA906302B (en)	1989-08-10	1990-08-09	Novel 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives,pharmaceutical compositions containing them and process for preparing same
EP90308784A EP0414421B1 (de)	1989-08-10	1990-08-09	1-Oxa-2-oxo-8-azaspiro[4,5]decan-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen daraus
DK90308784.9T DK0414421T3 (da)	1989-08-10	1990-08-09	1-Oxa-2-oxo-8-azaspiro(4,5)decan-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske præparater med indhold deraf
JP2209358A JPH0749431B2 (ja)	1989-08-10	1990-08-09	１―オキサ―２―オキソ―アザスピロ〔４，５〕デカン誘導体
FI903972A FI93455C (fi)	1989-08-10	1990-08-10	Menetelmä uusien terapeuttisesti käyttökelpoisten 1-oksa-2-okso-8-atsaspiro/4,5/dekaanijohdannaisten valmistamiseksi
PL90286440A PL163370B1 (pl)	1989-08-10	1990-08-10	Sposób wytwarzania nowych pochodnych 1-oksa-2-okso-8-azaspiro-[4. 5] dekanu PL PL
PL90291702A PL163593B1 (en)	1989-08-10	1990-08-10	Method of obtaining novel derivatives of 1-oxa-2-oxo-8-azaspiro [4,5] decane
PL90291701A PL163431B1 (pl)	1989-08-10	1990-08-10	Sposób wytwarzania nowych pochodnych 1-oksa-2-okso-8-azaspiro[4.5]dekanu PL PL
US07/566,275 US5118687A (en)	1989-08-10	1990-08-10	1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives, pharmaceutical compositions containing them and process for preparing same
HRP-1538/90A HRP920778A2 (en)	1989-08-10	1992-10-01	Novel 1-oxa-2-oxo-8-azaspiro74,5/ decane derivatives, pharmaceutical preparations containing them and process for the preparation thereof
BG098261A BG60436B2 (bg)	1989-08-10	1993-12-02	1-окса-2-оксо-8-азаспиро(4,5)декани,фармацевтични състави, които ги съдържат,и метод за получаването им
SG96294A SG96294G (en)	1989-08-10	1994-07-16	1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
HU94P/P00036P HU210072A9 (en)	1989-08-10	1994-10-12	Novel 1-oxa-2-oxo-8-azaspiro/4,5/decane derivatives, pharmaceutical compositions containing them and process for preparing same
HK145994A HK145994A (en)	1989-08-10	1994-12-22	1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU894095A HU204530B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
SG96294A SG96294G (en)	1989-08-10	1994-07-16	1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

Publications (1)

Publication Number	Publication Date
SG96294G true SG96294G (en)	1994-10-28

Family

ID=26317733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG96294A SG96294G (en)	1989-08-10	1994-07-16	1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

Country Status (23)

Country	Link
US (1)	US5118687A (de)
EP (1)	EP0414421B1 (de)
JP (1)	JPH0749431B2 (de)
KR (1)	KR940006635B1 (de)
AT (1)	ATE103920T1 (de)
AU (1)	AU622039B2 (de)
BG (1)	BG60436B2 (de)
DD (1)	DD299429A5 (de)
DE (1)	DE69007904T2 (de)
DK (1)	DK0414421T3 (de)
ES (1)	ES2052180T3 (de)
FI (1)	FI93455C (de)
HK (1)	HK145994A (de)
HR (1)	HRP920778A2 (de)
HU (2)	HU204530B (de)
IE (1)	IE64911B1 (de)
IL (1)	IL95320A (de)
NO (1)	NO177962C (de)
NZ (1)	NZ234848A (de)
PL (3)	PL163370B1 (de)
SG (1)	SG96294G (de)
SI (1)	SI9011538A (de)
ZA (1)	ZA906302B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
DK1223990T3 (da) *	1999-10-15	2004-11-29	Inst Genetics Llc	Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
RU2257202C2 (ru) *	2000-12-01	2005-07-27	Соболев Дмитрий Владимирович	Натриевая соль поли(парадигидрокси- парафенилен)тиосульфокислоты в качестве регулятора метаболизма клеток и антигипоксанта, фармацевтическая композиция на ее основе
KR20020091462A (ko) *	2001-05-30	2002-12-06	삼성광주전자 주식회사	원료 굳음 방지기능을 갖는 자동판매기 및 그 제어방법
GB201416346D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR96352E (fr) *	1967-12-29	1972-06-16	Science Union & Cie	Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation.
BE790675A (fr) *	1971-10-29	1973-04-27	Science Union & Cie	Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
EP0189370A3 (de) *	1985-01-16	1988-01-27	Sandoz Ag	Spiro-dioxolane, -dithiolane und -oxothiolane
KR940003491B1 (ko) *	1989-08-10	1994-04-23	리히터 게데온 베기에스제티 기아르 알.티	4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

1989
- 1989-08-10 HU HU894095A patent/HU204530B/hu not_active IP Right Cessation
1990
- 1990-08-09 IL IL9532090A patent/IL95320A/en not_active IP Right Cessation
- 1990-08-09 ES ES90308784T patent/ES2052180T3/es not_active Expired - Lifetime
- 1990-08-09 SI SI9011538A patent/SI9011538A/sl unknown
- 1990-08-09 NO NO903512A patent/NO177962C/no unknown
- 1990-08-09 IE IE288490A patent/IE64911B1/en not_active IP Right Cessation
- 1990-08-09 DD DD90343361A patent/DD299429A5/de not_active IP Right Cessation
- 1990-08-09 AT AT90308784T patent/ATE103920T1/de not_active IP Right Cessation
- 1990-08-09 AU AU60807/90A patent/AU622039B2/en not_active Ceased
- 1990-08-09 JP JP2209358A patent/JPH0749431B2/ja not_active Expired - Lifetime
- 1990-08-09 DE DE69007904T patent/DE69007904T2/de not_active Expired - Fee Related
- 1990-08-09 KR KR1019900012256A patent/KR940006635B1/ko not_active Expired - Fee Related
- 1990-08-09 DK DK90308784.9T patent/DK0414421T3/da active
- 1990-08-09 ZA ZA906302A patent/ZA906302B/xx unknown
- 1990-08-09 EP EP90308784A patent/EP0414421B1/de not_active Expired - Lifetime
- 1990-08-09 NZ NZ234848A patent/NZ234848A/en unknown
- 1990-08-10 PL PL90286440A patent/PL163370B1/pl unknown
- 1990-08-10 PL PL90291701A patent/PL163431B1/pl unknown
- 1990-08-10 PL PL90291702A patent/PL163593B1/pl unknown
- 1990-08-10 US US07/566,275 patent/US5118687A/en not_active Expired - Fee Related
- 1990-08-10 FI FI903972A patent/FI93455C/fi not_active IP Right Cessation
1992
- 1992-10-01 HR HRP-1538/90A patent/HRP920778A2/hr not_active Application Discontinuation
1993
- 1993-12-02 BG BG098261A patent/BG60436B2/bg unknown
1994
- 1994-07-16 SG SG96294A patent/SG96294G/en unknown
- 1994-10-12 HU HU94P/P00036P patent/HU210072A9/hu unknown
- 1994-12-22 HK HK145994A patent/HK145994A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU622039B2 (en)	1992-03-26
FI93455C (fi)	1995-04-10
HU204530B (en)	1992-01-28
ATE103920T1 (de)	1994-04-15
PL291701A1 (en)	1992-05-04
DK0414421T3 (da)	1994-05-16
EP0414421A2 (de)	1991-02-27
SI9011538A (sl)	1998-08-31
BG60436B2 (bg)	1995-03-31
KR910004632A (ko)	1991-03-29
PL163593B1 (en)	1994-04-29
FI93455B (fi)	1994-12-30
IL95320A (en)	1994-01-25
PL286440A1 (en)	1992-01-27
FI903972A0 (fi)	1990-08-10
EP0414421A3 (en)	1991-07-24
IE902884A1 (en)	1991-02-27
HK145994A (en)	1994-12-30
HUT55786A (en)	1991-06-28
NO177962C (no)	1995-12-27
DE69007904T2 (de)	1994-07-21
ES2052180T3 (es)	1994-07-01
PL163431B1 (pl)	1994-03-31
NO177962B (no)	1995-09-18
NO903512D0 (no)	1990-08-09
NO903512L (no)	1991-02-11
DD299429A5 (de)	1992-04-16
US5118687A (en)	1992-06-02
HU210072A9 (en)	1995-02-28
HRP920778A2 (en)	1998-02-28
JPH0749431B2 (ja)	1995-05-31
JPH0377884A (ja)	1991-04-03
EP0414421B1 (de)	1994-04-06
AU6080790A (en)	1991-02-14
KR940006635B1 (ko)	1994-07-23
NZ234848A (en)	1992-03-26
DE69007904D1 (de)	1994-05-11
IE64911B1 (en)	1995-09-20
ZA906302B (en)	1991-06-26
IL95320A0 (en)	1991-06-30
PL291702A1 (en)	1992-05-04
PL163370B1 (pl)	1994-03-31

Publication	Publication Date	Title
DE3873612D1 (de)	1992-09-17	Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IL95321A0 (en)	1991-06-30	2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
ATE63746T1 (de)	1991-06-15	Thiophenderivat und verfahren zur herstellung.
SG96294G (en)	1994-10-28	1-oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
HU900840D0 (en)	1990-04-28	Process for preparation of aralkyl-amine-derivatives and compositions containing them
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