SI1319668T1 - Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril - Google Patents

Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Info

Publication number
SI1319668T1
SI1319668T1 SI200330008T SI200330008T SI1319668T1 SI 1319668 T1 SI1319668 T1 SI 1319668T1 SI 200330008 T SI200330008 T SI 200330008T SI 200330008 T SI200330008 T SI 200330008T SI 1319668 T1 SI1319668 T1 SI 1319668T1
Authority
SI
Slovenia
Prior art keywords
synthesis
perindopril
alanyl
octahydro
indole
Prior art date
Application number
SI200330008T
Other languages
English (en)
Slovenian (sl)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1319668T1 publication Critical patent/SI1319668T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200330008T 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril SI1319668T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290606A EP1319668B1 (de) 2003-03-12 2003-03-12 Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril

Publications (1)

Publication Number Publication Date
SI1319668T1 true SI1319668T1 (en) 2005-02-28

Family

ID=8185878

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200330008T SI1319668T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
SI200330007T SI1323729T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200330007T SI1323729T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1319668B1 (de)
AR (1) AR043568A1 (de)
AT (1) ATE280775T1 (de)
DE (1) DE60300106T2 (de)
DK (1) DK1319668T3 (de)
ES (1) ES2231759T3 (de)
MY (1) MY135358A (de)
PT (1) PT1319668E (de)
SI (2) SI1319668T1 (de)
WO (1) WO2004082357A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2271497T3 (es) * 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1371659T3 (da) * 2003-08-29 2005-11-21 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
SI1380590T1 (sl) 2003-08-29 2006-12-31 Servier Lab Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
ATE310012T1 (de) 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
SI1323729T1 (en) 2005-02-28
EP1319668A1 (de) 2003-06-18
PT1319668E (pt) 2005-02-28
DE60300106D1 (de) 2004-12-02
AR043568A1 (es) 2005-08-03
ES2231759T3 (es) 2005-05-16
EP1319668B1 (de) 2004-10-27
WO2004082357A3 (fr) 2004-10-28
MY135358A (en) 2008-03-31
WO2004082357A2 (fr) 2004-09-30
ATE280775T1 (de) 2004-11-15
DE60300106T2 (de) 2005-10-13
DK1319668T3 (da) 2005-02-14

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