SK121699A3 - Stable solid preparation containing vitamin d3 and tricalcium phosphate - Google Patents

Stable solid preparation containing vitamin d3 and tricalcium phosphate Download PDF

Info

Publication number: SK121699A3
Authority: SK; Slovakia
Prior art keywords: vitamin; tricalcium phosphate; pharmaceutical composition; calcium; active form
Prior art date: 1997-03-12

Application number

SK1216-99A

Other languages

English (en)

Slovak (sk)

Inventor

Achim Schaffler

Claudia Wildner

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-12

Filing date

1998-03-04

Publication date

2000-01-18

1998-03-04 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2000-01-18 Publication of SK121699A3 publication Critical patent/SK121699A3/sk

Links

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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 30
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239000012188 paraffin wax Substances 0.000 description 1
RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229940088417 precipitated calcium carbonate Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
239000008213 purified water Substances 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229960003885 sodium benzoate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000013112 stability test Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
229940114926 stearate Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
BUNBVCKYYMRTNS-UHFFFAOYSA-N tachysterol Natural products C=1CCC2(C)C(C(C)CCC(C)C(C)C)CCC2C=1C=CC1=C(C)CCC(O)C1 BUNBVCKYYMRTNS-UHFFFAOYSA-N 0.000 description 1
229940033134 talc Drugs 0.000 description 1
229940035024 thioglycerol Drugs 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
235000013337 tricalcium citrate Nutrition 0.000 description 1
230000002792 vascular Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000003643 water by type Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Inorganic Chemistry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1216-99A 1997-03-12 1998-03-04 Stable solid preparation containing vitamin d3 and tricalcium phosphate SK121699A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19710054A DE19710054A1 (de)	1997-03-12	1997-03-12	Pharmazeutische Zubereitung
PCT/EP1998/001208 WO1998040085A1 (de)	1997-03-12	1998-03-04	Stabile, feste zubereitung enthaltend vitamin d3 und tricalciumphosphat

Publications (1)

Publication Number	Publication Date
SK121699A3 true SK121699A3 (en)	2000-01-18

Family

ID=7823015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1216-99A SK121699A3 (en)	1997-03-12	1998-03-04	Stable solid preparation containing vitamin d3 and tricalcium phosphate

Country Status (20)

Country	Link
EP (1)	EP0969849B1 (cs)
JP (1)	JP2001515486A (cs)
KR (1)	KR20000076042A (cs)
CN (1)	CN1249689A (cs)
AR (1)	AR010903A1 (cs)
AT (1)	ATE245425T1 (cs)
AU (1)	AU730675B2 (cs)
BR (1)	BR9808233A (cs)
CA (1)	CA2284183A1 (cs)
CZ (1)	CZ290991B6 (cs)
DE (2)	DE19710054A1 (cs)
DK (1)	DK0969849T3 (cs)
ES (1)	ES2201460T3 (cs)
HU (1)	HUP0002928A3 (cs)
NO (1)	NO994395D0 (cs)
PL (1)	PL335644A1 (cs)
PT (1)	PT969849E (cs)
SK (1)	SK121699A3 (cs)
WO (1)	WO1998040085A1 (cs)
ZA (1)	ZA982073B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9801821B2 (en)	2013-03-27	2017-10-31	Psm Healthcare Limited	Stabilized vitamin D formulations

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6479474B2 (en) *	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
CA2476679A1 (en) *	2002-02-20	2003-08-28	Teijin Limited	Vitamin d3 derivatives and remedies using the same
US7163933B2 (en)	2002-02-22	2007-01-16	Teijin Limited	Treating agent for Paget's disease of bone
EP1622630B1 (en) *	2003-05-07	2012-08-29	Osteologix A/S	Strontium combinations for the prophylaxis/treatment of cartilage and/or bone conditions
RU2268053C1 (ru) *	2004-05-05	2006-01-20	Григорий Николаевич Коныгин	Способ лечения гипокальциемий, остеопорозов, переломов
TR200900880A2 (tr)	2009-02-05	2010-08-23	Bi̇lgi̇ç Mahmut	Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
TR200900878A2 (tr)	2009-02-05	2010-08-23	Bi̇lgi̇ç Mahmut	Tek bir dozaj formunda kombine edilen farmasötik formülasyonlar
JP5817067B2 (ja) *	2010-06-24	2015-11-18	プライオンエス．エー．	安定化された活性化合物
EP3042649A1 (en) *	2015-01-09	2016-07-13	S.B.M. S.r.l.	A composition, comprising tricalcium phosphate and gelatin, for treating dyspepsia and related disorders
CN105982071A (zh) *	2015-02-05	2016-10-05	宁志伟	高剂量维生素d3口服制剂配方
CN104800166B (zh) *	2015-04-22	2017-11-10	青岛正大海尔制药有限公司	一种阿法骨化醇散剂及其制备方法
CN113350374B (zh) *	2021-06-23	2022-05-31	锦州医科大学	一种磷酸钙与维生素d复合微囊的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2525478B2 (ja) *	1989-03-01	1996-08-21	帝人株式会社	安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JP3147249B2 (ja) *	1992-03-11	2001-03-19	コベルコ建機株式会社	走行用ポンプ圧の制御装置
IL103224A (en) *	1992-09-18	1998-08-16	Teva Pharma	Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
US5548203A (en) *	1994-06-29	1996-08-20	Electric Power Research Institute, Inc.	Capacitor polarity-based var correction controller for resonant line conditions and large amplitude line harmonics
FR2724844B1 (fr) *	1994-09-23	1997-01-24	Innothera Lab Sa	Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
IL115241A (en) *	1994-09-26	2000-08-31	American Cyanamid Co	Calcium dietary supplement

1997
- 1997-03-12 DE DE19710054A patent/DE19710054A1/de not_active Withdrawn
1998
- 1998-03-04 PT PT98910722T patent/PT969849E/pt unknown
- 1998-03-04 AU AU64997/98A patent/AU730675B2/en not_active Ceased
- 1998-03-04 KR KR1019997008130A patent/KR20000076042A/ko not_active Withdrawn
- 1998-03-04 AT AT98910722T patent/ATE245425T1/de active
- 1998-03-04 BR BR9808233-7A patent/BR9808233A/pt not_active IP Right Cessation
- 1998-03-04 PL PL98335644A patent/PL335644A1/xx unknown
- 1998-03-04 CZ CZ19993221A patent/CZ290991B6/cs not_active IP Right Cessation
- 1998-03-04 HU HU0002928A patent/HUP0002928A3/hu unknown
- 1998-03-04 SK SK1216-99A patent/SK121699A3/sk unknown
- 1998-03-04 CA CA002284183A patent/CA2284183A1/en not_active Abandoned
- 1998-03-04 DE DE59809085T patent/DE59809085D1/de not_active Expired - Lifetime
- 1998-03-04 ES ES98910722T patent/ES2201460T3/es not_active Expired - Lifetime
- 1998-03-04 DK DK98910722T patent/DK0969849T3/da active
- 1998-03-04 EP EP98910722A patent/EP0969849B1/de not_active Expired - Lifetime
- 1998-03-04 JP JP53916598A patent/JP2001515486A/ja active Pending
- 1998-03-04 WO PCT/EP1998/001208 patent/WO1998040085A1/de not_active Ceased
- 1998-03-04 CN CN98803171A patent/CN1249689A/zh active Pending
- 1998-03-11 AR ARP980101087A patent/AR010903A1/es not_active Application Discontinuation
- 1998-03-11 ZA ZA982073A patent/ZA982073B/xx unknown
1999
- 1999-09-10 NO NO994395A patent/NO994395D0/no unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9801821B2 (en)	2013-03-27	2017-10-31	Psm Healthcare Limited	Stabilized vitamin D formulations

Also Published As

Publication number	Publication date
ZA982073B (en)	1998-09-16
KR20000076042A (ko)	2000-12-26
ES2201460T3 (es)	2004-03-16
DE19710054A1 (de)	1998-09-17
CN1249689A (zh)	2000-04-05
AU6499798A (en)	1998-09-29
NO994395L (no)	1999-09-10
PL335644A1 (en)	2000-05-08
CZ322199A3 (cs)	2000-01-12
DE59809085D1 (de)	2003-08-28
JP2001515486A (ja)	2001-09-18
ATE245425T1 (de)	2003-08-15
DK0969849T3 (da)	2003-11-03
WO1998040085A1 (de)	1998-09-17
HUP0002928A2 (hu)	2001-02-28
AU730675B2 (en)	2001-03-08
EP0969849A1 (de)	2000-01-12
BR9808233A (pt)	2000-05-16
AR010903A1 (es)	2000-07-12
EP0969849B1 (de)	2003-07-23
PT969849E (pt)	2003-12-31
CZ290991B6 (cs)	2002-11-13
HUP0002928A3 (en)	2001-04-28
NO994395D0 (no)	1999-09-10
CA2284183A1 (en)	1998-09-17

Publication	Publication Date	Title
KR100196209B1 (ko)	1999-06-15	안정화된 고형화학 조성물
US20140220151A1 (en)	2014-08-07	Stability in Vitamin and Mineral Supplements
SK121699A3 (en)	2000-01-18	Stable solid preparation containing vitamin d3 and tricalcium phosphate
HU220604B1 (hu)	2002-03-28	Szárazon formált, 4-amino-1-hidroxibutilidén-1,1-bisz-foszfonsavat, vagy sóit tartalmazó gyógyszerkészítmények
CZ336796A3 (en)	1997-06-11	Pharmaceutical preparation
US5292520A (en)	1994-03-08	Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer
JPH026409A (ja)	1990-01-10	ジホスホン酸誘導体経口医薬組成物
AU3932199A (en)	1999-12-06	Pharmaceutical preparation containing levothyroxine sodium
US5234696A (en)	1993-08-10	Method of producing tablets, tablets produced thereby, and method of treatment using same
CA2035841C (en)	1996-02-13	Storage-stable glucosamine sulphate oral dosage forms and methods for their manufacture
JP2002532429A (ja)	2002-10-02	薬学的処方物
CA2014377A1 (en)	1990-10-13	Composition
EP1651191B1 (en)	2008-11-12	Effervescent pharmaceutical compositions containing vitamin d, calcium and phospate and their therapeutic use
KR100741937B1 (ko)	2007-07-24	제제의 안정화 방법
SK11632003A3 (sk)	2004-04-06	Stabilný farmaceutický prípravok obsahujúci modifikáciu II torsemidu
MXPA99008344A (en)	2000-12-06	Stable solid preparation containing vitamin d3 and tricalcium phosphate
SK68597A3 (en)	1997-11-05	Kit for osteoporosis treatment cycle
IE912041A1 (en)	1991-12-18	Gemfibrozil formulations
EP2661262A1 (en)	2013-11-13	Improved bisphosphonate formulations
JPH09157174A (ja)	1997-06-17	カルシウム製剤
HK1026631A (en)	2000-12-22	Stable solid preparation containing vitamin d3 and tricalcium phosphate
JPWO1996028166A1 (ja)	1998-04-28	骨粗しょう症治療剤及び骨形成促進剤

SK121699A3 - Stable solid preparation containing vitamin d3 and tricalcium phosphate - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=7823015

Family Applications (1)

Country Status (20)

Cited By (1)

Families Citing this family (12)

Family Cites Families (6)

Cited By (1)

Also Published As

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