SK130194A3 - Protein complexes with the efficiency of factor viii:c and process for their production - Google Patents

Protein complexes with the efficiency of factor viii:c and process for their production Download PDF

Info

Publication number
SK130194A3
SK130194A3 SK1301-94A SK130194A SK130194A3 SK 130194 A3 SK130194 A3 SK 130194A3 SK 130194 A SK130194 A SK 130194A SK 130194 A3 SK130194 A3 SK 130194A3
Authority
SK
Slovakia
Prior art keywords
factor viii
psvf8
polypeptide
region
human factor
Prior art date
Application number
SK1301-94A
Other languages
English (en)
Slovak (sk)
Inventor
Barbara Chapman
Rae L Burke
Mirella E Rasmussen
Jan M Mikkelsen
Original Assignee
Chiron Corp
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Novo Nordisk As filed Critical Chiron Corp
Publication of SK130194A3 publication Critical patent/SK130194A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK1301-94A 1989-11-17 1994-10-26 Protein complexes with the efficiency of factor viii:c and process for their production SK130194A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43863989A 1989-11-17 1989-11-17

Publications (1)

Publication Number Publication Date
SK130194A3 true SK130194A3 (en) 1997-06-04

Family

ID=23741420

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1301-94A SK130194A3 (en) 1989-11-17 1994-10-26 Protein complexes with the efficiency of factor viii:c and process for their production

Country Status (22)

Country Link
EP (2) EP0500734B1 (de)
JP (3) JP2865861B2 (de)
KR (2) KR960701899A (de)
AT (1) ATE163194T1 (de)
AU (1) AU656311B2 (de)
CA (2) CA2135744A1 (de)
DE (1) DE69032043T2 (de)
DK (1) DK0500734T3 (de)
ES (1) ES2112255T3 (de)
FI (2) FI944903A7 (de)
GR (1) GR3026176T3 (de)
HU (2) HUT70457A (de)
IE (1) IE904140A1 (de)
IL (2) IL96368A0 (de)
NO (2) NO921946L (de)
NZ (1) NZ236094A (de)
PL (1) PL167083B1 (de)
PT (1) PT95923B (de)
SK (1) SK130194A3 (de)
WO (1) WO1991007490A1 (de)
YU (2) YU218690A (de)
ZA (1) ZA909167B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
KR100234828B1 (ko) * 1995-10-16 1999-12-15 카나가와 치히로 액정조성물 및 이를 함유하는 액정표시소자
PT1754718E (pt) 1996-04-24 2011-07-13 Univ Michigan Factor viii resistente à inactivação
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
KR100581574B1 (ko) * 2000-03-22 2006-05-22 옥타게네 게엠베하 인간 세포주 내 재조합 혈액 응고 인자의 제조
CN1856576B (zh) 2003-09-30 2011-05-04 宾夕法尼亚州立大学托管会 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
EP1707634A1 (de) 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
WO2006110689A2 (en) 2005-04-07 2006-10-19 The Trustees Of The University Of Pennsylvania Method of increasing the function of an aav vector
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
US20130023033A1 (en) 2010-03-29 2013-01-24 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
DK2675902T3 (da) 2011-02-17 2019-06-03 Univ Pennsylvania Sammensætninger og fremgangsmåder til at ændre vævsspecificitet og forbedre aav9-medieret genoverførsel
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
CN115074366A (zh) 2015-04-16 2022-09-20 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
JP2023537070A (ja) 2020-08-07 2023-08-30 アミカス セラピューティックス インコーポレイテッド 小胞を標的とするタンパク質及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652530A (en) 1967-08-28 1972-03-28 American Nat Red Cross Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en) 1970-05-01 1971-12-28 Baxter Laboratories Inc Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US4069216A (en) 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
WO1985001961A1 (en) * 1983-10-28 1985-05-09 Genetics Institute Production of factor viii and related products
ATE72838T1 (de) * 1985-04-12 1992-03-15 Genetics Inst Neue prokoagulierungsproteine.
FI98829C (fi) 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
AU588965B2 (en) * 1986-02-06 1989-09-28 Alcatel Australia Limited Telephone hook-switch

Also Published As

Publication number Publication date
EP0670332A2 (de) 1995-09-06
DK0500734T3 (da) 1998-03-30
NO921946D0 (no) 1992-05-15
FI922204A0 (fi) 1992-05-14
CA2068728A1 (en) 1991-05-18
FI922204A7 (fi) 1992-05-14
JP2771129B2 (ja) 1998-07-02
JP2865861B2 (ja) 1999-03-08
FI944903A0 (fi) 1994-10-19
NO943949D0 (no) 1994-10-18
YU218690A (sh) 1993-05-28
KR960701899A (ko) 1996-03-28
CA2135744A1 (en) 1991-05-18
JPH0856656A (ja) 1996-03-05
DE69032043T2 (de) 1998-06-04
PL167083B1 (pl) 1995-07-31
FI944903L (fi) 1994-10-19
EP0670332A3 (de) 1995-10-25
GR3026176T3 (en) 1998-05-29
HU9500546D0 (en) 1995-04-28
YU78194A (sh) 1997-05-28
HU9201629D0 (en) 1992-08-28
ES2112255T3 (es) 1998-04-01
PT95923A (pt) 1991-09-13
NO921946L (no) 1992-07-13
NZ236094A (en) 1993-04-28
DE69032043D1 (de) 1998-03-19
ATE163194T1 (de) 1998-02-15
EP0500734A1 (de) 1992-09-02
AU6752590A (en) 1991-06-13
IL111304A0 (en) 1994-12-29
IE904140A1 (en) 1991-05-22
AU656311B2 (en) 1995-02-02
JPH11130800A (ja) 1999-05-18
PT95923B (pt) 1998-04-30
HUT64591A (en) 1994-01-28
HUT70457A (en) 1995-10-30
ZA909167B (en) 1993-10-15
IL96368A0 (en) 1991-08-16
NO943949L (no) 1992-07-13
FI944903A7 (fi) 1994-10-19
JPH05502025A (ja) 1993-04-15
PL287807A1 (en) 1991-09-23
KR927003812A (ko) 1992-12-18
EP0500734B1 (de) 1998-02-11
WO1991007490A1 (en) 1991-05-30
FI922204L (fi) 1992-05-14

Similar Documents

Publication Publication Date Title
SK130194A3 (en) Protein complexes with the efficiency of factor viii:c and process for their production
US5789203A (en) Protein complexes having factor VIII:C activity and production thereof
US6060447A (en) Protein complexes having Factor VIII:C activity and production thereof
AU610059B2 (en) Method of producing a recombinant protein complex having human factor VIII:C activity
AU601358B2 (en) Preparation of functional human factor V111
AU609829B2 (en) A factor viii:c-like molecule with coagulating activity
EP0786474B1 (de) Rekombinanter Abkömmling des menschlichen Faktors VIII
US5618789A (en) Functional human factor VIII
CA2161651A1 (en) Erythropoietin analog compositions and methods
HU213300B (en) Process for producing novel proteins with factor viii activity and pharmaceutical preparations containing them
JPH0655144B2 (ja) エリトロポエチンをコードするｄｎａ配列、組換えｄｎａベクター及び形質転換体
AU615634B2 (en) Expression of biologically active factor XIII
US20060122376A1 (en) Protein complexes having factor VIII:C activity and production thereof
JP2872255B2 (ja) ファクター▲ｖｉｉｉ▼の高収量生産法