SK138197A3 - Bioprocess for production of dipeptide based compounds - Google Patents

Bioprocess for production of dipeptide based compounds Download PDF

Info

Publication number: SK138197A3
Authority: SK; Slovakia
Prior art keywords: pro; dipeptide; ala; peptide; expression
Prior art date: 1995-04-11

Application number

SK1381-97A

Other languages

English (en)

Slovak (sk)

Inventor

W Scott Borneman

Anil Goyal

Michael J Conder

Victor A Vinci

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-11

Filing date

1996-04-08

Publication date

1998-07-08

1996-04-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1998-07-08 Publication of SK138197A3 publication Critical patent/SK138197A3/sk

Links

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238000004519 manufacturing process Methods 0.000 title abstract description 6
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 67
238000000034 method Methods 0.000 claims abstract description 27
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 18
229920001184 polypeptide Polymers 0.000 claims abstract description 11
230000008569 process Effects 0.000 claims abstract description 8
WPWUFUBLGADILS-WDSKDSINSA-N Ala-Pro Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O WPWUFUBLGADILS-WDSKDSINSA-N 0.000 claims description 39
108010087924 alanylproline Proteins 0.000 claims description 39
AIXUQKMMBQJZCU-IUCAKERBSA-N Lys-Pro Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O AIXUQKMMBQJZCU-IUCAKERBSA-N 0.000 claims description 21
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Botany (AREA)
Toxicology (AREA)
Zoology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK1381-97A 1995-04-11 1996-04-08 Bioprocess for production of dipeptide based compounds SK138197A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41978795A	1995-04-11	1995-04-11
PCT/US1996/004794 WO1996032468A2 (en)	1995-04-11	1996-04-08	Bioprocess for production of dipeptide based compounds

Publications (1)

Publication Number	Publication Date
SK138197A3 true SK138197A3 (en)	1998-07-08

Family

ID=23663762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1381-97A SK138197A3 (en)	1995-04-11	1996-04-08	Bioprocess for production of dipeptide based compounds

Country Status (13)

Country	Link
US (1)	US6204008B1 (de)
EP (1)	EP0820465B1 (de)
CN (1)	CN1193998A (de)
AR (1)	AR001594A1 (de)
AT (1)	ATE247129T1 (de)
AU (1)	AU5445596A (de)
BR (1)	BR9608278A (de)
CZ (1)	CZ321497A3 (de)
DE (1)	DE69629460T2 (de)
EA (1)	EA000736B1 (de)
ES (1)	ES2203690T3 (de)
SK (1)	SK138197A3 (de)
WO (1)	WO1996032468A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7366892B2 (en) *	2003-01-28	2008-04-29	Cellport Systems, Inc.	Secure telematics
CN100420746C (zh) *	2005-06-24	2008-09-24	北京化工大学	重组降压肽的设计与发酵生产
GB0608368D0 (en) *	2006-04-28	2006-06-07	Isis Innovation	Process for making Oligopeptides
WO2014159247A1 (en) *	2013-03-14	2014-10-02	University Of Florida Research Foundation, Inc.	Di-amino acid repeat-containing proteins associated with als
US10509045B2 (en)	2015-05-29	2019-12-17	University Of Florida Research Foundation, Incorporated	Methods for diagnosing Huntington's disease
US10940161B2 (en)	2016-04-04	2021-03-09	University Of Florida Research Foundation, Incorporated	Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
WO2018195110A1 (en)	2017-04-17	2018-10-25	University Of Florida Research Foundation, Incorporated	Regolation of ran translation by pkr and eif2a-p pathways
EP3688020A4 (de)	2017-09-25	2021-07-14	University of Florida Research Foundation, Incorporated	Immunoassays zum nachweis von ran-proteinen
AU2018342105B2 (en)	2017-09-26	2023-11-16	University Of Florida Research Foundation, Incorporated	Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders
WO2021055880A1 (en)	2019-09-20	2021-03-25	University Of Florida Researchfoundation, Incorporated	Detection of antibodies against ran proteins from serum and tissue lysates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL58849A (en)	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2068971B (en) *	1980-01-30	1983-06-08	Searle & Co	Recombinant dna techniques
EP0036258A3 (de) *	1980-03-14	1982-02-10	Cetus Corporation	Verfahren zur Herstellung von Aspartam
US4555502A (en)	1982-09-30	1985-11-26	Merck & Co., Inc.	Aminoacyl-containing dipeptide derivatives useful as antihypertensives
DD248961A1 (de) *	1984-05-22	1987-08-26	Akad Wissenschaften Ddr	Verfahren zur herstellung wundheilungsfoerdernder praeparationen
US5089406A (en)	1987-01-07	1992-02-18	Allied-Signal Inc.	Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
NL8700767A (nl)	1987-04-01	1988-11-01	Groningen Science Park	Dipeptidase, isolering daarvan uit melkzuurbacterien, antilichamen tegen het dipeptidase, gebruik van het dipeptidase en van de antilichamen daartegen.
JPH07108232B2 (ja) *	1990-10-09	1995-11-22	エム・ディ・リサーチ株式会社	ペプチド又は蛋白質の製造方法
DK0524906T3 (da) *	1991-07-24	2003-08-11	Novartis Ag	DNA-kodende for prolyl-endopeptidase samt dets anvendelse
ATE253639T1 (de)	1991-08-19	2003-11-15	Daiichi Suntory Pharma Co Ltd	Verfahren zur herstellung von peptiden
WO1994016082A1 (en) *	1992-12-30	1994-07-21	Communaute Economique Europeenne (Cee)	X-prolyl-dipeptidyl-aminopeptidase from lactobacillus delbrückii ssp. lactis, nucleic acids coding for the same and its use in fermented foodstuff preparation processes

1996
- 1996-04-08 AT AT96911630T patent/ATE247129T1/de not_active IP Right Cessation
- 1996-04-08 AU AU54455/96A patent/AU5445596A/en not_active Abandoned
- 1996-04-08 EP EP96911630A patent/EP0820465B1/de not_active Expired - Lifetime
- 1996-04-08 DE DE69629460T patent/DE69629460T2/de not_active Expired - Fee Related
- 1996-04-08 EA EA199700310A patent/EA000736B1/ru not_active IP Right Cessation
- 1996-04-08 CZ CZ973214A patent/CZ321497A3/cs unknown
- 1996-04-08 ES ES96911630T patent/ES2203690T3/es not_active Expired - Lifetime
- 1996-04-08 BR BR9608278-0A patent/BR9608278A/pt not_active Application Discontinuation
- 1996-04-08 CN CN96194302A patent/CN1193998A/zh active Pending
- 1996-04-08 WO PCT/US1996/004794 patent/WO1996032468A2/en not_active Ceased
- 1996-04-08 SK SK1381-97A patent/SK138197A3/sk unknown
- 1996-04-10 AR AR33611996A patent/AR001594A1/es unknown
- 1996-11-12 US US08/748,073 patent/US6204008B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1996032468A3 (en)	1996-11-28
BR9608278A (pt)	1999-10-13
CN1193998A (zh)	1998-09-23
DE69629460T2 (de)	2004-06-24
AU5445596A (en)	1996-10-30
WO1996032468A2 (en)	1996-10-17
US6204008B1 (en)	2001-03-20
EA199700310A1 (ru)	1998-04-30
EA000736B1 (ru)	2000-02-28
AR001594A1 (es)	1997-11-26
ATE247129T1 (de)	2003-08-15
ES2203690T3 (es)	2004-04-16
EP0820465B1 (de)	2003-08-13
CZ321497A3 (cs)	1998-06-17
EP0820465A2 (de)	1998-01-28
DE69629460D1 (de)	2003-09-18

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