ATE247129T1 - Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden - Google Patents

Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden

Info

Publication number
ATE247129T1
ATE247129T1 AT96911630T AT96911630T ATE247129T1 AT E247129 T1 ATE247129 T1 AT E247129T1 AT 96911630 T AT96911630 T AT 96911630T AT 96911630 T AT96911630 T AT 96911630T AT E247129 T1 ATE247129 T1 AT E247129T1
Authority
AT
Austria
Prior art keywords
dipeptids
biological process
compounds based
producing compounds
producing
Prior art date
Application number
AT96911630T
Other languages
English (en)
Inventor
W Scott Borneman
Anil Goyal
Michael J Conder
Victor A Vinci
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE247129T1 publication Critical patent/ATE247129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96911630T 1995-04-11 1996-04-08 Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden ATE247129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41978795A 1995-04-11 1995-04-11
PCT/US1996/004794 WO1996032468A2 (en) 1995-04-11 1996-04-08 Bioprocess for production of dipeptide based compounds

Publications (1)

Publication Number Publication Date
ATE247129T1 true ATE247129T1 (de) 2003-08-15

Family

ID=23663762

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911630T ATE247129T1 (de) 1995-04-11 1996-04-08 Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden

Country Status (13)

Country Link
US (1) US6204008B1 (de)
EP (1) EP0820465B1 (de)
CN (1) CN1193998A (de)
AR (1) AR001594A1 (de)
AT (1) ATE247129T1 (de)
AU (1) AU5445596A (de)
BR (1) BR9608278A (de)
CZ (1) CZ321497A3 (de)
DE (1) DE69629460T2 (de)
EA (1) EA000736B1 (de)
ES (1) ES2203690T3 (de)
SK (1) SK138197A3 (de)
WO (1) WO1996032468A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068424A2 (en) * 2003-01-28 2004-08-12 Cellport Systems, Inc. Secure telematics
CN100420746C (zh) * 2005-06-24 2008-09-24 北京化工大学 重组降压肽的设计与发酵生产
GB0608368D0 (en) 2006-04-28 2006-06-07 Isis Innovation Process for making Oligopeptides
US10295547B2 (en) 2013-03-14 2019-05-21 University Of Florida Research Foundation, Incorporated Use and treatment of di-amino acid repeat-containing proteins associated with ALS
US10509045B2 (en) 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
EP3440100A4 (de) 2016-04-04 2020-01-22 University of Florida Research Foundation, Incorporated Manipulation von eif3 zur modulierung von wiederholungsassoziierter nicht-atg(ran)-übersetzung
AU2018255293B2 (en) 2017-04-17 2024-03-07 University Of Florida Research Foundation, Incorporated Regulation of RAN translation by PKR and eIF2a-P pathways
US12504380B2 (en) 2017-09-25 2025-12-23 University Of Florida Research Foundation, Incorporated Immunoassays for detection of ran proteins
CA3076214A1 (en) 2017-09-26 2019-04-04 University Of Florida Research Foundation, Incorporated Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders
AU2020348916B2 (en) 2019-09-20 2025-12-18 University Of Florida Research Foundation, Incorporated Detection of antibodies against RAN proteins from serum and tissue lysates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2068971B (en) * 1980-01-30 1983-06-08 Searle & Co Recombinant dna techniques
EP0036258A3 (de) * 1980-03-14 1982-02-10 Cetus Corporation Verfahren zur Herstellung von Aspartam
US4555502A (en) 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
DD248961A1 (de) * 1984-05-22 1987-08-26 Akad Wissenschaften Ddr Verfahren zur herstellung wundheilungsfoerdernder praeparationen
US5089406A (en) 1987-01-07 1992-02-18 Allied-Signal Inc. Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
NL8700767A (nl) 1987-04-01 1988-11-01 Groningen Science Park Dipeptidase, isolering daarvan uit melkzuurbacterien, antilichamen tegen het dipeptidase, gebruik van het dipeptidase en van de antilichamen daartegen.
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
ATE237689T1 (de) * 1991-07-24 2003-05-15 Novartis Pharma Gmbh Dna kodierend für propylendopeptidase und dessen verwendung
ATE253639T1 (de) 1991-08-19 2003-11-15 Daiichi Suntory Pharma Co Ltd Verfahren zur herstellung von peptiden
WO1994016082A1 (en) * 1992-12-30 1994-07-21 Communaute Economique Europeenne (Cee) X-prolyl-dipeptidyl-aminopeptidase from lactobacillus delbrückii ssp. lactis, nucleic acids coding for the same and its use in fermented foodstuff preparation processes

Also Published As

Publication number Publication date
SK138197A3 (en) 1998-07-08
DE69629460D1 (de) 2003-09-18
EA199700310A1 (ru) 1998-04-30
AU5445596A (en) 1996-10-30
DE69629460T2 (de) 2004-06-24
EP0820465B1 (de) 2003-08-13
WO1996032468A2 (en) 1996-10-17
EP0820465A2 (de) 1998-01-28
BR9608278A (pt) 1999-10-13
US6204008B1 (en) 2001-03-20
AR001594A1 (es) 1997-11-26
EA000736B1 (ru) 2000-02-28
WO1996032468A3 (en) 1996-11-28
CZ321497A3 (cs) 1998-06-17
ES2203690T3 (es) 2004-04-16
CN1193998A (zh) 1998-09-23

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties