SK151296A3 - Process for detecting evanescently excited luminescence - Google Patents

Process for detecting evanescently excited luminescence Download PDF

Info

Publication number: SK151296A3
Authority: SK; Slovakia
Prior art keywords: waveguide; luminescence; sensor base; coupling; optical sensor
Prior art date: 1994-05-27

Application number

SK1512-96A

Other languages

English (en)

Slovak (sk)

Inventor

Burkhard Danielzik

Gert L Duveneck

Martin Heming

Dieter Neuschafer

Johannes Segner

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-27

Filing date

1995-05-17

Publication date

1997-07-09

1995-05-17 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1997-07-09 Publication of SK151296A3 publication Critical patent/SK151296A3/sk

Links

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Classifications

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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide

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Chemical & Material Sciences (AREA)
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Health & Medical Sciences (AREA)
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Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
Manufacture, Treatment Of Glass Fibers (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)

SK1512-96A 1994-05-27 1995-05-17 Process for detecting evanescently excited luminescence SK151296A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH164394		1994-05-27
PCT/IB1995/000368 WO1995033198A1 (fr)	1994-05-27	1995-05-17	Procede permettant de detecter une luminescence a excitation evanescente

Publications (1)

Publication Number	Publication Date
SK151296A3 true SK151296A3 (en)	1997-07-09

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ID=4215258

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Application Number	Title	Priority Date	Filing Date
SK1513-96A SK151396A3 (en)	1994-05-27	1995-05-17	Process for detecting evanescently excited luminescence
SK1512-96A SK151296A3 (en)	1994-05-27	1995-05-17	Process for detecting evanescently excited luminescence

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Application Number	Title	Priority Date	Filing Date
SK1513-96A SK151396A3 (en)	1994-05-27	1995-05-17	Process for detecting evanescently excited luminescence

Country Status (21)

Country	Link
US (2)	US5822472A (fr)
EP (2)	EP0760944B1 (fr)
JP (3)	JP3645907B2 (fr)
KR (1)	KR970703527A (fr)
CN (2)	CN1149336A (fr)
AT (2)	ATE172300T1 (fr)
AU (2)	AU689604B2 (fr)
CA (2)	CA2190362A1 (fr)
CZ (2)	CZ347196A3 (fr)
DE (2)	DE69526438T2 (fr)
DK (1)	DK0760944T3 (fr)
ES (1)	ES2174948T3 (fr)
FI (2)	FI964664A7 (fr)
HU (2)	HUT76406A (fr)
IL (2)	IL113849A0 (fr)
MX (1)	MXPA96005828A (fr)
PL (2)	PL317379A1 (fr)
SK (2)	SK151396A3 (fr)
TW (2)	TW295624B (fr)
WO (2)	WO1995033198A1 (fr)
ZA (2)	ZA954327B (fr)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69526438T2 (de) *	1994-05-27	2002-10-31	Novartis Ag, Basel	Verfahren zum nachweis abklingend angeregter lumineszenz
US5814565A (en) *	1995-02-23	1998-09-29	University Of Utah Research Foundation	Integrated optic waveguide immunosensor
TW302435B (fr) *	1995-05-12	1997-04-11	Ciba Geigy Ag
GB9602542D0 (en) *	1996-02-08	1996-04-10	Fisons Plc	Analytical device
US6211954B1 (en)	1996-03-30	2001-04-03	Novartis Ag	Integrated optical luminescence sensor
JPH102860A (ja) *	1996-06-17	1998-01-06	Olympus Optical Co Ltd	微小物質検鏡装置
US6395558B1 (en)	1996-08-29	2002-05-28	Zeptosens Ag	Optical chemical/biochemical sensor
EP0843173A1 (fr)	1996-11-18	1998-05-20	Novartis AG	Cellule à circulation de fluide et appareil pour produire une radiation par excitation evanescente
DE59712460D1 (de)	1996-11-18	2005-12-01	Novartis Ag	Messvorrichtung mit einem planaren optischen wellenleiter
EP1012580B1 (fr) *	1997-09-10	2004-06-23	Artificial Sensing Instruments ASI AG	Capteur optique et procede optique de caracterisation d'une substance chimique et/ou biochimique
JP4662623B2 (ja) *	1998-02-05	2011-03-30	ノバルティスアーゲー	ルミネッセンスを測定する方法及び装置
EP2112501A1 (fr)	1998-02-05	2009-10-28	Novartis Ag	Procédé et dispositif destinés à la mesure de la luminescence
US6758337B2 (en) *	1999-03-02	2004-07-06	Meadwestvaco Packaging Systems, Llc	Beverage carton with strap type carrying handle
EP0957354A3 (fr) *	1998-03-20	2000-03-22	IA Inc.	Procédé et dispositif de mesure de la fixation de molécules biologiques
DE19815109A1 (de) *	1998-04-03	1999-10-07	Bodenseewerk Perkin Elmer Co	Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
FR2778986B1 (fr) *	1998-05-22	2000-07-21	Suisse Electronique Microtech	Capteur optique utilisant une reaction immunologique et un marqueur fluorescent
WO2000005582A2 (fr) *	1998-07-21	2000-02-03	Burstein Laboratories, Inc.	Dispositifs de dosage utilisant des disques optiques et methodes correspondantes
US6320991B1 (en)	1998-10-16	2001-11-20	Imation Corp.	Optical sensor having dielectric film stack
US6245518B1 (en) *	1998-12-11	2001-06-12	Hyseq, Inc.	Polynucleotide arrays and methods of making and using the same
DE69933193T2 (de) *	1999-02-25	2007-08-02	C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A.	Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
US6192168B1 (en) *	1999-04-09	2001-02-20	The United States Of America As Represented By The Secretary Of The Navy	Reflectively coated optical waveguide and fluidics cell integration
US6137117A (en) *	1999-06-21	2000-10-24	The United States Of America As Represented By The Secretary Of The Navy	Integrating multi-waveguide sensor
AU5760500A (en) *	1999-06-23	2001-01-09	Patrick Toomey	Water detection and source identification methods for structures using electromagnetic radiation spectroscopy
ES2273704T3 (es)	1999-07-05	2007-05-16	Novartis Ag	Procedimiento para utilizar un plataforma de deteccion.
US6771376B2 (en)	1999-07-05	2004-08-03	Novartis Ag	Sensor platform, apparatus incorporating the platform, and process using the platform
EP1274986B1 (fr)	1999-08-13	2011-07-13	Bayer Technology Services GmbH	Dispositif et procede de determination de plusieurs substances a analyser
US6667179B1 (en) *	1999-10-28	2003-12-23	The Board Of Trustees Of The University Of Illinois	Semiconductor luminescence quenchers for detecting proximal molecular binding events
US7167615B1 (en)	1999-11-05	2007-01-23	Board Of Regents, The University Of Texas System	Resonant waveguide-grating filters and sensors and methods for making and using same
FR2801977B1 (fr) *	1999-12-02	2002-05-17	Commissariat Energie Atomique	Amplification d'un signal de fluorescence emis par un echantillon surfacique
ATE267047T1 (de)	1999-12-17	2004-06-15	Zeptosens Ag	Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
US6510263B1 (en) *	2000-01-27	2003-01-21	Unaxis Balzers Aktiengesellschaft	Waveguide plate and process for its production and microtitre plate
WO2001079821A1 (fr) *	2000-04-14	2001-10-25	Zeptosens Ag	Structure reseau de guide d'onde destine a intensifier un champ d'excitation et son utilisation
JP2003532123A (ja)	2000-04-28	2003-10-28	エッジライトバイオサイエンシズインコーポレイテッド	マイクロアレーエバネッセント波蛍光検出装置
WO2001092870A2 (fr)	2000-06-02	2001-12-06	Zeptosens Ag	Kit et procede pour la detection d'une pluralite d'analytes
EP1311824A4 (fr) *	2000-06-25	2010-12-08	Affymetrix Inc	Substrats optiquement actifs
DE50115382D1 (de)	2000-08-09	2010-04-22	Artificial Sensing Instr Asi A	Wellenleitergitterstruktur und optische messanordnung
AU2001289853A1 (en) *	2000-09-04	2002-03-22	Zeptosens Ag	Multianalyte determination system and methods
WO2002020873A2 (fr) *	2000-09-05	2002-03-14	Zeptosens Ag	Procede de precipitation de couches simples ou multiples d'acides organophosphoriques et organophosphoniques et de leurs sels, et utilisation de ces composes
EP1356291B1 (fr) *	2000-12-06	2011-05-04	Ecole Polytechnique Fédérale de Lausanne (EPFL)	Procede de production d'un reactif bioanalytique, procede d'identification fonde sur l'utilisation du reactif bioanalytique et utilisation dudit procede
FR2818382B1 (fr) *	2000-12-20	2003-02-21	Commissariat Energie Atomique	Support pour determiner un analyte tel qu'une cible adn ou arn, comportant un filtre spectral selectif
DE10108483A1 (de) *	2001-02-22	2002-09-05	Bayer Ag	Phosphorhaltige Polymere für optischen Signalwandler
ES2392395T3 (es)	2001-03-01	2012-12-10	Sicpa Holding Sa	Detector mejorado de características de luminiscencia
EP1373875A2 (fr) *	2001-04-02	2004-01-02	Zeptosens AG	Structure optique d'excitation multiphoton et son utilisation
DE10133844B4 (de) *	2001-07-18	2006-08-17	Micronas Gmbh	Verfahren und Vorrichtung zur Detektion von Analyten
US6782013B2 (en) *	2001-07-25	2004-08-24	Jds Uniphase Corporation	Waveguide wavelength locker
US6671304B2 (en) *	2001-08-28	2003-12-30	The United States Of America As Represented By The Secretary Of The Navy	Amplitude-modulated laser for high-bandwidth communications systems
ATE528117T1 (de)	2001-08-30	2011-10-15	Bayer Technology Services Gmbh	Verfahren zur herstellung von abformkörpern, insbesondere optischen strukturen, und deren verwendung
US20030124599A1 (en) *	2001-11-14	2003-07-03	Shiping Chen	Biochemical analysis system with combinatorial chemistry applications
DE10158149A1 (de) *	2001-11-28	2003-06-18	Bayer Ag	Silangruppen enthaltende Polymere
US7179654B2 (en) *	2002-03-18	2007-02-20	Agilent Technologies, Inc.	Biochemical assay with programmable array detection
JP2003308714A (ja) *	2002-04-17	2003-10-31	Fuji Photo Film Co Ltd	導光フィルム
US20030232427A1 (en) *	2002-06-18	2003-12-18	Montagu Jean I.	Optically active substrates for examination of biological materials
US7154598B2 (en) *	2002-07-12	2006-12-26	Decision Biomarkers, Inc.	Excitation and imaging of fluorescent arrays
US7384742B2 (en) *	2002-08-16	2008-06-10	Decision Biomarkers, Inc.	Substrates for isolating reacting and microscopically analyzing materials
US7872804B2 (en)	2002-08-20	2011-01-18	Illumina, Inc.	Encoded particle having a grating with variations in the refractive index
US7508608B2 (en)	2004-11-17	2009-03-24	Illumina, Inc.	Lithographically fabricated holographic optical identification element
US7619819B2 (en)	2002-08-20	2009-11-17	Illumina, Inc.	Method and apparatus for drug product tracking using encoded optical identification elements
US7164533B2 (en)	2003-01-22	2007-01-16	Cyvera Corporation	Hybrid random bead/chip based microarray
US7900836B2 (en)	2002-08-20	2011-03-08	Illumina, Inc.	Optical reader system for substrates having an optically readable code
US7441703B2 (en)	2002-08-20	2008-10-28	Illumina, Inc.	Optical reader for diffraction grating-based encoded optical identification elements
EP1535241A1 (fr)	2002-08-20	2005-06-01	Cyvera Corporation	Element d'identification optique base sur un reseau de diffraction
US20060105337A1 (en) *	2002-08-30	2006-05-18	Brian Warner	Solid phase based nucleic acid assays combining high affinity and high specificity
AU2003258683A1 (en) *	2002-09-03	2004-03-29	Zeptosens Ag	Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners
JP2005537487A (ja)	2002-09-03	2005-12-08	ツェプトゼンス　アクチエンゲゼルシャフト	試料中において任意には分画された後の試料中において、固定化特異的結合パートナーとして測定される分析対象物を用いる分析プラットフォーム及び検出法
AU2003274979A1 (en)	2002-09-12	2004-04-30	Cyvera Corporation	Chemical synthesis using diffraction grating-based encoded optical elements
EP1540591A1 (fr)	2002-09-12	2005-06-15	Cyvera Corporation	Microparticules codees sur la base d'un reseau de diffraction pour experimentations multiplexees
US7092160B2 (en)	2002-09-12	2006-08-15	Illumina, Inc.	Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en)	2002-09-12	2010-10-07	Putnam Martin A	Method and apparatus for aligning microbeads in order to interrogate the same
AU2003267192A1 (en)	2002-09-12	2004-04-30	Cyvera Corporation	Method and apparatus for aligning elongated microbeads in order to interrogate the same
CA2499037A1 (fr)	2002-09-12	2004-03-25	Cyvera Corporation	Procede et appareil d'etiquetage utilisant des elements d'identification optique codes a reseau de diffraction
DE10245435B4 (de) *	2002-09-27	2006-03-16	Micronas Gmbh	Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
US7027163B2 (en) *	2003-01-24	2006-04-11	General Dynamics Advanced Information Systems, Inc.	Grating sensor
US7445938B2 (en) *	2003-01-24	2008-11-04	General Dynamics Advanced Information Systems, Inc.	System and method for detecting presence of analytes using gratings
US7545494B2 (en)	2003-07-23	2009-06-09	Bayer Technology Services Gmbh	Analytical system and method for analyzing nonlinear optical signals
DE10353694A1 (de) *	2003-11-18	2005-06-30	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Mikroskopievorrichtung
GB0327755D0 (en) *	2003-12-01	2003-12-31	Elliott Stephen R	Optical-sensor chip
JP4480130B2 (ja) *	2003-12-16	2010-06-16	キヤノン株式会社	光学分析装置
US7433123B2 (en)	2004-02-19	2008-10-07	Illumina, Inc.	Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
CA2559803A1 (fr) *	2004-03-03	2005-10-13	Bayer Technology Services Gmbh	Plate-forme analytique et procede de generation de profils d'expression proteinique de populations de cellules
US7080839B2 (en) *	2004-06-29	2006-07-25	Michael Shackleford	Blackjack variations
JP5296377B2 (ja)	2004-07-02	2013-09-25	バイエル・ヘルスケア・エルエルシー	流体試料中の検体の判定を行うために使用される光導体検査センサ、およびその製作方法
ES2292273B1 (es) *	2004-07-13	2009-02-16	Fabrica Nacional De Moneda Y Timbre - Real Casa De La Moneda	Pigmentos luminiscentes utilizados en documentos de seguridad y procedimiento de deteccion de los mismos.
US7678567B2 (en) *	2004-07-26	2010-03-16	Kabushiki Kaisha Toshiba	Optical biosensor
EP1621869B1 (fr) *	2004-07-26	2015-08-19	Kabushiki Kaisha Toshiba	Biocapteur optique
CN101696937B (zh) *	2004-07-30	2012-07-04	株式会社东芝	光学式生物传感器
CN100449313C (zh) *	2004-07-30	2009-01-07	株式会社东芝	光学式生物传感器
WO2006055735A2 (fr)	2004-11-16	2006-05-26	Illumina, Inc	Scanner dote d'un modulateur spatial de lumiere
EP1869615B1 (fr)	2004-11-16	2010-03-03	Illumina, Inc.	Procedes de diffusion optique de fourier permettant d'encoder des microbilles et procede et appareil correspondants
US7403284B2 (en) *	2004-12-16	2008-07-22	Andevices, Inc.	Integrated optics based high-resolution spectrophotometer
JP2005099054A (ja) *	2004-12-27	2005-04-14	Olympus Corp	微小物質の蛍光測定装置
US7327908B1 (en) *	2005-03-07	2008-02-05	Lightsmyth Technologies Inc.	Integrated optical sensor incorporating sets of diffractive elements
GB0507835D0 (en) *	2005-04-18	2005-05-25	Solexa Ltd	Method and device for nucleic acid sequencing using a planar wave guide
ES2525324T3 (es)	2005-04-26	2014-12-22	Bayer Intellectual Property Gmbh	Nuevo aparato y procedimiento de recubrimiento de sustratos portadores para la detección de analitos mediante un procedimiento de detección por afinidad
US7136005B1 (en) *	2005-05-05	2006-11-14	Analog Devices, Inc.	Accurate low noise analog to digital converter system
JP5383190B2 (ja) *	2005-08-08	2014-01-08	コーニングインコーポレイテッド	Ｃｃｄ検出器の読み出し速度を増加させる方法
WO2007043005A1 (fr)	2005-10-12	2007-04-19	Koninklijke Philips Electronics N. V.	Capteur optique de guide d'ondes constitue integralement de polymere
EP1941276A1 (fr)	2005-10-29	2008-07-09	Bayer Technology Services GmbH	Procédé pour la détermination d une ou plusieurs substances à analyser dans des échantillons de composition complexe d'origine biologique et son application
US7623624B2 (en)	2005-11-22	2009-11-24	Illumina, Inc.	Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
DE102005062785A1 (de) *	2005-12-28	2007-07-05	Robert Bosch Gmbh	Regensensor, insbesondere für ein Kraftfahrzeug, und Verfahren zur Herstellung des Regensensors
US20070196863A1 (en) *	2006-02-17	2007-08-23	Hanson Technologies, Inc.	Prion protein detection
US7951583B2 (en)	2006-03-10	2011-05-31	Plc Diagnostics, Inc.	Optical scanning system
US8288157B2 (en)	2007-09-12	2012-10-16	Plc Diagnostics, Inc.	Waveguide-based optical scanning systems
US8675199B2 (en)	2006-03-10	2014-03-18	Plc Diagnostics, Inc.	Waveguide-based detection system with scanning light source
US9423397B2 (en)	2006-03-10	2016-08-23	Indx Lifecare, Inc.	Waveguide-based detection system with scanning light source
US9976192B2 (en)	2006-03-10	2018-05-22	Ldip, Llc	Waveguide-based detection system with scanning light source
US9528939B2 (en)	2006-03-10	2016-12-27	Indx Lifecare, Inc.	Waveguide-based optical scanning systems
SE529711C2 (sv) *	2006-03-22	2007-11-06	Aamic Ab	Fluorescensläsare
US7830575B2 (en)	2006-04-10	2010-11-09	Illumina, Inc.	Optical scanner with improved scan time
WO2007127564A2 (fr)	2006-04-26	2007-11-08	Siemens Medical Solutions Diagnostics Gmbh	Dosage d'acides nucléiques sur phase solide combinant une capture et une détection à haute affinité par hybridation spécifique
US20080101744A1 (en) *	2006-10-31	2008-05-01	Honeywell International Inc.	Optical Waveguide Sensor Devices and Methods For Making and Using Them
US20100093107A1 (en) *	2006-12-14	2010-04-15	University Of Massachusetts	Polymer-protein substrates for immunosorbent fluorescence assays
US9475051B2 (en)	2007-02-27	2016-10-25	Sony Corporation	Nucleic acid amplifier
JP4458133B2 (ja) *	2007-02-27	2010-04-28	ソニー株式会社	核酸増幅装置
US20090325211A1 (en) *	2007-10-06	2009-12-31	Ye Fang	System and method for dual-detection of a cellular response
AT506177B1 (de) *	2008-03-26	2009-07-15	Univ Graz Tech	Optischer sensor
EP2110694B1 (fr)	2008-04-18	2013-08-14	Sony DADC Austria AG	Procédé de fabrication d'un guide d'onde optique, guide d'onde optique, et agencement de capteur
DE102008019928A1 (de)	2008-04-21	2009-12-31	Siemens Healthcare Diagnostics Gmbh	Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
GB2461026B (en)	2008-06-16	2011-03-09	Plc Diagnostics Inc	System and method for nucleic acids sequencing by phased synthesis
US9212995B2 (en)	2009-03-02	2015-12-15	Mbio Diagnostics, Inc.	System and method for detecting multiple molecules in one assay
US8300993B2 (en) *	2009-03-02	2012-10-30	Mbio Diagnostics, Inc.	Waveguide with integrated lens
US8331751B2 (en) *	2009-03-02	2012-12-11	mBio Diagnositcs, Inc.	Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en)	2009-03-02	2017-05-23	Mbio Diagnostics, Inc.	Planar waveguide based cartridges and associated methods for detecting target analyte
AU2010234063A1 (en)	2009-04-09	2011-11-03	Bayer Intellectual Property Gmbh	Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
DE102009016712A1 (de)	2009-04-09	2010-10-14	Bayer Technology Services Gmbh	Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
US8154716B2 (en) *	2009-09-04	2012-04-10	Octrolix Bv	Waveguide-based sensor
DE102010019095B4 (de) *	2010-04-30	2016-12-08	Deutsches Zentrum für Luft- und Raumfahrt e.V.	Verfahren und Vorrichtung zur Fluoreszenzlebensdauermessung
TW201217783A (en)	2010-09-15	2012-05-01	Mbio Diagnostics Inc	System and method for detecting multiple molecules in one assay
CN103597335B (zh) *	2011-07-13	2015-12-09	英派尔科技开发有限公司	利用具有可刷新表面的表面等离子体监测分析物的方法和系统
US9989525B2 (en) *	2013-03-15	2018-06-05	Axela Inc.	Diffraction based biosensor containing two diffractive gratings
US20150077756A1 (en) *	2013-06-13	2015-03-19	Lumense, Inc.	System and method for continuous real-time monitoring of water at contaminated sites
JP6573899B2 (ja)	2013-11-17	2019-09-11	クアンタム−エスアイインコーポレイテッドＱｕａｎｔｕｍ−ＳｉＩｎｃｏｒｐｏｒａｔｅｄ	分子をプローブし、検出し、及び分析するための、外部光源を備えた集積デバイス
US10018566B2 (en)	2014-02-28	2018-07-10	Ldip, Llc	Partially encapsulated waveguide based sensing chips, systems and methods of use
US9702813B2 (en) *	2014-07-23	2017-07-11	Infineon Technologies Ag	Sensing systems and methods using a coupling structure
CN112903639B (zh)	2014-08-08	2022-09-13	宽腾矽公司	用于对分子进行探测、检测和分析的带外部光源的集成装置
US10174363B2 (en)	2015-05-20	2019-01-08	Quantum-Si Incorporated	Methods for nucleic acid sequencing
WO2016023010A1 (fr)	2014-08-08	2016-02-11	Quantum-Si Incorporated	Système optique et puce d'analyse pour sonder, détecter, et analyser des molécules
EP3194935B1 (fr)	2014-08-08	2018-10-31	Quantum-si Incorporated	Dispositif intégré de compartimentation temporelle de photons reçus
WO2016138427A1 (fr)	2015-02-27	2016-09-01	Indx Lifecare, Inc.	Système de détection à guide d'ondes à source de lumière à balayage
US10605730B2 (en)	2015-05-20	2020-03-31	Quantum-Si Incorporated	Optical sources for fluorescent lifetime analysis
US10246742B2 (en)	2015-05-20	2019-04-02	Quantum-Si Incorporated	Pulsed laser and bioanalytic system
US11466316B2 (en)	2015-05-20	2022-10-11	Quantum-Si Incorporated	Pulsed laser and bioanalytic system
TW202139919A (zh)	2016-02-17	2021-11-01	美商太斯萊特健康股份有限公司	用於生命期成像及偵測應用之感測器及裝置
CA3047133A1 (fr)	2016-12-16	2018-06-21	Quantum-Si Incorporated	Module laser compact a verrouillage de mode
CN116466494A (zh)	2016-12-16	2023-07-21	宽腾矽公司	紧密的光束整形及操纵总成
US10845308B2 (en)	2016-12-22	2020-11-24	Quantum-Si Incorporated	Integrated photodetector with direct binning pixel
BR112020000826A2 (pt)	2017-07-24	2020-07-21	Quantum-Si Incorporated	instrumento bio-optoeletrônico maciçamente paralelo portátil
TWI653449B (zh) *	2018-01-31	2019-03-11	國立交通大學	光子晶體與磁珠結合的螢光免疫檢測裝置和方法
DE102018202591A1 (de) *	2018-02-21	2019-08-22	Robert Bosch Gmbh	Optisches System sowie ein Verfahren zur Herstellung eines optischen Systems
CA3067154A1 (fr)	2018-03-29	2019-10-03	Illumina, Inc.	Eclairage pour imagerie par fluorescence a l'aide d'une lentille d'objectif
KR20210021018A (ko)	2018-06-15	2021-02-24	퀀텀-에스아이 인코포레이티드	펄스형 광학 소스들을 갖는 고급 분석 기기들을 위한 데이터 취득 제어
AU2019288394B2 (en)	2018-06-22	2025-01-30	Quantum-Si Incorporated	Integrated photodetector with charge storage bin of varied detection time
US11255790B2 (en)	2019-01-08	2022-02-22	Boe Technology Group Co., Ltd.	Fluid detection panel with filter structure and fluid detection device with filter structure
CN109632660B (zh) *	2019-01-17	2022-04-05	京东方科技集团股份有限公司	流体检测面板
CA3142922A1 (fr)	2019-06-14	2020-12-17	Quantum-Si Incorporated	Coupleur de reseau tranche a sensibilite d'alignement de faisceau accrue
NL2023679B1 (en) *	2019-08-09	2021-04-13	Illumina Inc	System and method for patterning flow cell substrates
KR20220137027A (ko)	2020-01-14	2022-10-11	퀀텀-에스아이 인코포레이티드	진폭 변조 레이저
DE102021133357A1 (de)	2021-12-15	2023-06-15	Endress+Hauser Conducta Gmbh+Co. Kg	Sensorelement, Sensorsystem und Verfahren zum Herstellen des Sensorelements
TWI796944B (zh) *	2022-01-28	2023-03-21	國立中山大學	螢光增強基板及螢光檢測裝置
KR102935909B1 (ko) *	2023-07-27	2026-03-09	한국광기술원	라이다 장치 내 윈도우에 코팅되는 무반사 코팅층 및 그의 코팅방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4582809A (en) *	1982-06-14	1986-04-15	Myron J. Block	Apparatus including optical fiber for fluorescence immunoassay
DE3680999D1 (de) *	1985-05-29	1991-09-26	Artificial Sensing Instr Asi A	Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahlaenderungen in messubstanzen.
WO1989007756A1 (fr) *	1988-02-14	1989-08-24	Walter Lukosz	Procede optique integre d'interference
GB8807486D0 (en) *	1988-03-29	1988-05-05	Ares Serono Res & Dev Ltd	Waveguide sensor
GB8827853D0 (en) *	1988-11-29	1988-12-29	Ares Serono Res & Dev Ltd	Sensor for optical assay
US5082629A (en) *	1989-12-29	1992-01-21	The Board Of The University Of Washington	Thin-film spectroscopic sensor
JPH05504626A (ja) *	1990-03-02	1993-07-15	ファイソンズ　ピーエルシー	化学又は生化学試験に用いる試料セル
DE69128123T2 (de) *	1990-08-31	1998-03-05	Texas Instruments Inc	Verfahren zum Herstellen selbst-ausrichtender bipolarer Transistoren mit Heteroübergang
DE4228853C2 (de) *	1991-09-18	1993-10-21	Schott Glaswerke	Optischer Wellenleiter mit einem planaren oder nur geringfügig gewölbten Substrat und Verfahren zu dessen Herstellung sowie Verwendung eines solchen
US5294799A (en) *	1993-02-01	1994-03-15	Aslund Nils R D	Apparatus for quantitative imaging of multiple fluorophores
US5418371A (en) *	1993-02-01	1995-05-23	Aslund; Nils R. D.	Apparatus for quantitative imaging of multiple fluorophores using dual detectors
DE69526438T2 (de) *	1994-05-27	2002-10-31	Novartis Ag, Basel	Verfahren zum nachweis abklingend angeregter lumineszenz

1995
- 1995-05-17 DE DE69526438T patent/DE69526438T2/de not_active Expired - Lifetime
- 1995-05-17 PL PL95317379A patent/PL317379A1/xx unknown
- 1995-05-17 AU AU27346/95A patent/AU689604B2/en not_active Expired - Fee Related
- 1995-05-17 CN CN95193305A patent/CN1149336A/zh active Pending
- 1995-05-17 HU HU9603261A patent/HUT76406A/hu unknown
- 1995-05-17 CA CA002190362A patent/CA2190362A1/fr not_active Abandoned
- 1995-05-17 EP EP95922453A patent/EP0760944B1/fr not_active Expired - Lifetime
- 1995-05-17 DE DE69505370T patent/DE69505370T2/de not_active Expired - Lifetime
- 1995-05-17 SK SK1513-96A patent/SK151396A3/sk unknown
- 1995-05-17 AU AU23179/95A patent/AU2317995A/en not_active Abandoned
- 1995-05-17 SK SK1512-96A patent/SK151296A3/sk unknown
- 1995-05-17 JP JP50059796A patent/JP3645907B2/ja not_active Expired - Lifetime
- 1995-05-17 WO PCT/IB1995/000368 patent/WO1995033198A1/fr not_active Ceased
- 1995-05-17 DK DK95922453T patent/DK0760944T3/da active
- 1995-05-17 JP JP8500226A patent/JPH10501616A/ja active Pending
- 1995-05-17 AT AT95916823T patent/ATE172300T1/de not_active IP Right Cessation
- 1995-05-17 CA CA002190643A patent/CA2190643A1/fr not_active Abandoned
- 1995-05-17 KR KR1019960706871A patent/KR970703527A/ko not_active Withdrawn
- 1995-05-17 EP EP95916823A patent/EP0759159B1/fr not_active Expired - Lifetime
- 1995-05-17 US US08/737,846 patent/US5822472A/en not_active Expired - Lifetime
- 1995-05-17 CN CN95193304A patent/CN1149335A/zh active Pending
- 1995-05-17 MX MXPA96005828A patent/MXPA96005828A/es unknown
- 1995-05-17 AT AT95922453T patent/ATE216491T1/de active
- 1995-05-17 ES ES95922453T patent/ES2174948T3/es not_active Expired - Lifetime
- 1995-05-17 PL PL95317402A patent/PL317402A1/xx unknown
- 1995-05-17 WO PCT/EP1995/001845 patent/WO1995033197A1/fr not_active Ceased
- 1995-05-17 US US08/737,845 patent/US5959292A/en not_active Expired - Lifetime
- 1995-05-17 HU HU9603260A patent/HUT76407A/hu unknown
- 1995-05-17 CZ CZ963471A patent/CZ347196A3/cs unknown
- 1995-05-17 CZ CZ963472A patent/CZ347296A3/cs unknown
- 1995-05-25 IL IL11384995A patent/IL113849A0/xx unknown
- 1995-05-25 IL IL11385495A patent/IL113854A0/xx unknown
- 1995-05-26 ZA ZA954327A patent/ZA954327B/xx unknown
- 1995-05-26 ZA ZA954325A patent/ZA954325B/xx unknown
- 1995-06-28 TW TW084106623A patent/TW295624B/zh active
- 1995-06-28 TW TW084106622A patent/TW278135B/zh active
1996
- 1996-11-22 FI FI964664A patent/FI964664A7/fi not_active Application Discontinuation
- 1996-11-25 FI FI964684A patent/FI964684A7/fi not_active Application Discontinuation
2005
- 2005-05-31 JP JP2005159644A patent/JP2005326426A/ja active Pending

Also Published As

Publication number	Publication date
HUT76407A (en)	1997-08-28
DE69526438D1 (de)	2002-05-23
AU2317995A (en)	1995-12-21
CN1149336A (zh)	1997-05-07
ZA954327B (en)	1995-11-27
TW295624B (fr)	1997-01-11
CZ347196A3 (en)	1997-06-11
HU9603261D0 (en)	1997-01-28
CA2190643A1 (fr)	1995-12-07
TW278135B (fr)	1996-06-11
ATE172300T1 (de)	1998-10-15
DE69526438T2 (de)	2002-10-31
PL317379A1 (en)	1997-04-01
HUT76406A (en)	1997-08-28
JP2005326426A (ja)	2005-11-24
CA2190362A1 (fr)	1995-12-07
SK151396A3 (en)	1997-07-09
PL317402A1 (en)	1997-04-14
EP0759159B1 (fr)	1998-10-14
WO1995033198A1 (fr)	1995-12-07
ES2174948T3 (es)	2002-11-16
FI964684A7 (fi)	1997-01-27
US5959292A (en)	1999-09-28
FI964664A7 (fi)	1997-01-24
KR970703527A (ko)	1997-07-03
CZ347296A3 (en)	1997-03-12
JP3645907B2 (ja)	2005-05-11
JPH10501616A (ja)	1998-02-10
ATE216491T1 (de)	2002-05-15
JPH10501617A (ja)	1998-02-10
CN1149335A (zh)	1997-05-07
DE69505370D1 (de)	1998-11-19
HU9603260D0 (en)	1997-01-28
DK0760944T3 (da)	2002-08-05
WO1995033197A1 (fr)	1995-12-07
EP0759159A1 (fr)	1997-02-26
ZA954325B (en)	1995-11-27
MXPA96005828A (es)	2005-07-15
DE69505370T2 (de)	1999-04-01
FI964664A0 (fi)	1996-11-22
EP0760944B1 (fr)	2002-04-17
IL113849A0 (en)	1995-08-31
IL113854A0 (en)	1995-08-31
FI964684A0 (fi)	1996-11-25
AU2734695A (en)	1995-12-21
US5822472A (en)	1998-10-13
EP0760944A1 (fr)	1997-03-12
AU689604B2 (en)	1998-04-02

Publication	Publication Date	Title
EP0759159B1 (fr)	1998-10-14	Procede et capteur permettant de detecter une luminescence a excitation evanescente
US6395558B1 (en)	2002-05-28	Optical chemical/biochemical sensor
US6483096B1 (en)	2002-11-19	Integrated-optical chemical and biochemical sensor
US5830766A (en)	1998-11-03	Enhanced signal-to-noise ratio and sensitivity optical immunoassay
US7558446B2 (en)	2009-07-07	All polymer optical waveguide sensor
US20100055666A1 (en)	2010-03-04	Biosensor with evanescent waveguide and integrated sensor
KR19990014709A (ko)	1999-02-25	센서 플랫폼 및 감쇠 여기된 발광을 이용한 복수 분석물의병렬 검출 방법
EP0382832B1 (fr)	1994-03-23	Methode d'analyse d'un ligand dans un echantillon
Ives et al.	1987	Total internal reflection fluorescence surface sensors
Neuschaefer et al.	1996	Planar waveguides as efficient transducers for bioaffinity sensors
McAtamney	1999	Development of evanescent wave based sensor platforms for use in immunosensing