SK1572003A3 - Use of metal complexes containing perfluoroalkyl as contrast agents in MR-imaging for the representation of plaques, tumours and necroses - Google Patents

Use of metal complexes containing perfluoroalkyl as contrast agents in MR-imaging for the representation of plaques, tumours and necroses Download PDF

Info

Publication number: SK1572003A3
Authority: SK; Slovakia
Prior art keywords: formula; groups; mmol; complex; group
Prior art date: 2000-08-11

Application number

SK157-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Johannes Platzek

Peter Mareski

Ulrich Niedballa

Bernd Raduchel

Hanns-Joachim Weinmann

Bernd Misselwitz

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-11

Filing date

2001-07-23

Publication date

2003-10-07

2000-08-11 Priority claimed from DE10040380A external-priority patent/DE10040380B4/de

2001-07-23 Application filed by Schering Ag filed Critical Schering Ag

2003-10-07 Publication of SK1572003A3 publication Critical patent/SK1572003A3/sk

Links

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239000002184 metal Substances 0.000 title claims abstract description 42
238000003384 imaging method Methods 0.000 title claims abstract description 38
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239000002872 contrast media Substances 0.000 title claims abstract description 23
206010028980 Neoplasm Diseases 0.000 title claims description 19
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239000000693 micelle Substances 0.000 claims abstract description 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Radiology & Medical Imaging (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Dispersion Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK157-2003A 2000-08-11 2001-07-23 Use of metal complexes containing perfluoroalkyl as contrast agents in MR-imaging for the representation of plaques, tumours and necroses SK1572003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10040380A DE10040380B4 (de)	2000-08-11	2000-08-11	Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
PCT/EP2001/008498 WO2002013874A2 (de)	2000-08-11	2001-07-23	Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel im mr-imaging zur darstellung von plaques, tumoren und nekrosen

Publications (1)

Publication Number	Publication Date
SK1572003A3 true SK1572003A3 (en)	2003-10-07

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ID=7652860

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Application Number	Title	Priority Date	Filing Date
SK157-2003A SK1572003A3 (en)	2000-08-11	2001-07-23	Use of metal complexes containing perfluoroalkyl as contrast agents in MR-imaging for the representation of plaques, tumours and necroses

Country Status (26)

Country	Link
EP (1)	EP1307236A2 (pl)
JP (1)	JP2004506025A (pl)
KR (1)	KR20030022387A (pl)
CN (1)	CN1469757A (pl)
AR (1)	AR034139A1 (pl)
AU (2)	AU2001277549B2 (pl)
BG (1)	BG107542A (pl)
BR (1)	BR0113188A (pl)
CA (1)	CA2419223A1 (pl)
CZ (1)	CZ2003392A3 (pl)
DE (1)	DE10066210B4 (pl)
EE (1)	EE200300061A (pl)
HR (1)	HRP20030173A2 (pl)
HU (1)	HUP0300736A3 (pl)
IL (1)	IL154385A0 (pl)
MX (1)	MXPA03001287A (pl)
NO (1)	NO20030604L (pl)
NZ (1)	NZ523932A (pl)
PL (1)	PL365596A1 (pl)
RU (1)	RU2290206C2 (pl)
SK (1)	SK1572003A3 (pl)
TW (1)	TWI296931B (pl)
UA (1)	UA82642C2 (pl)
WO (1)	WO2002013874A2 (pl)
YU (1)	YU10603A (pl)
ZA (1)	ZA200301949B (pl)

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DE102005008309A1 (de) *	2005-02-17	2006-08-24	Schering Ag	Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) *	2006-05-09	2007-11-15	Bayer Schering Pharma Ag	Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) *	2006-09-19	2011-02-15	Fujifilm Corporation	Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) *	2006-10-18	2008-04-24	Bayer Schering Pharma Aktiengesellschaft	Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) *	2007-03-29	2008-10-02	Heinrich-Heine-Universität Düsseldorf	Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) *	2010-03-11	2011-09-29	Noguchi Institute	フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en)	2014-03-26	2018-05-22	Chevron U.S.A. Inc.	Multicarboxylate compositions and method of making the same
EP3101012A1 (en)	2015-06-04	2016-12-07	Bayer Pharma Aktiengesellschaft	New gadolinium chelate compounds for use in magnetic resonance imaging
EP3514137A4 (en) *	2016-09-14	2020-10-07	Daikin Industries, Ltd.	COMPOUND CONTAINING BRANCHED FLUORINE
ES2814555T3 (es)	2016-11-28	2021-03-29	Bayer Pharma AG	Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
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CN109867635A (zh) *	2019-02-14	2019-06-11	华东师范大学	一种t1型胶束磁共振成像造影剂及其制备方法

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2000
- 2000-08-11 DE DE10066210A patent/DE10066210B4/de not_active Expired - Fee Related
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- 2001-07-23 MX MXPA03001287A patent/MXPA03001287A/es active IP Right Grant
- 2001-07-23 CA CA002419223A patent/CA2419223A1/en not_active Abandoned
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- 2001-07-23 AU AU2001277549A patent/AU2001277549B2/en not_active Ceased
- 2001-07-23 CN CNA018172717A patent/CN1469757A/zh active Pending
- 2001-07-23 KR KR10-2003-7002023A patent/KR20030022387A/ko not_active Abandoned
- 2001-07-23 HR HR20030173A patent/HRP20030173A2/hr not_active Application Discontinuation
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- 2001-07-23 AU AU7754901A patent/AU7754901A/xx active Pending
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- 2001-07-23 CZ CZ2003392A patent/CZ2003392A3/cs unknown
- 2001-07-23 YU YU10603A patent/YU10603A/sh unknown
- 2001-07-23 HU HU0300736A patent/HUP0300736A3/hu unknown
- 2001-07-23 SK SK157-2003A patent/SK1572003A3/sk not_active Application Discontinuation
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Also Published As

Publication number	Publication date
UA82642C2 (uk)	2008-05-12
NZ523932A (en)	2007-07-27
NO20030604D0 (no)	2003-02-07
HUP0300736A2 (hu)	2003-09-29
YU10603A (sh)	2006-05-25
DE10066210B4 (de)	2008-02-28
AU7754901A (en)	2002-02-25
HRP20030173A2 (en)	2005-04-30
AR034139A1 (es)	2004-02-04
KR20030022387A (ko)	2003-03-15
AU2001277549B2 (en)	2007-02-08
BG107542A (bg)	2003-09-30
HUP0300736A3 (en)	2010-01-28
ZA200301949B (en)	2004-12-14
BR0113188A (pt)	2003-06-24
TWI296931B (en)	2008-05-21
WO2002013874A2 (de)	2002-02-21
JP2004506025A (ja)	2004-02-26
IL154385A0 (en)	2003-09-17
WO2002013874A8 (de)	2002-06-13
CA2419223A1 (en)	2003-02-11
RU2290206C2 (ru)	2006-12-27
EE200300061A (et)	2004-12-15
EP1307236A2 (de)	2003-05-07
CZ2003392A3 (cs)	2003-09-17
MXPA03001287A (es)	2003-10-06
PL365596A1 (pl)	2005-01-10
NO20030604L (no)	2003-04-11
CN1469757A (zh)	2004-01-21

Legal Events

Date	Code	Title	Description
2011-01-04	FC9A	Refused patent application

Publication	Publication Date	Title
SK1572003A3 (en)	2003-10-07	Use of metal complexes containing perfluoroalkyl as contrast agents in MR-imaging for the representation of plaques, tumours and necroses
AU2001289729B2 (en)	2006-11-16	Perfluoroalkyl-containing complexes comprising sugar residues, method for producing the same and use thereof
US6818203B2 (en)	2004-11-16	Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
US20090297454A1 (en)	2009-12-03	Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use
KR101451446B1 (ko)	2014-10-16	퍼플루오르화 ｐｅｇ기를 갖는 금속 킬레이트, 그의 제조 방법, 및 그의 용도
US6641797B2 (en)	2003-11-04	Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
ZA200301947B (en)	2004-06-25	Complexes containing perfluoroalkyl with polar radicals, method for the production and use thereof.
JP2009501174A (ja)	2009-01-15	ペルフルオロアルキル含有錯体、製造方法およびその使用
DE10040380A1 (de)	2002-02-28	Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques, Tumoren und Nekrosen