SK164897A3 - Methods and compositions for preparing soft gelatin capsules having shells resistant to permeation by fill materials - Google Patents

Methods and compositions for preparing soft gelatin capsules having shells resistant to permeation by fill materials Download PDF

Info

Publication number: SK164897A3
Authority: SK; Slovakia
Prior art keywords: gelatin; layer; barrier layer; outer layer; capsule
Prior art date: 1995-06-07

Application number

SK1648-97A

Other languages

English (en)

Slovak (sk)

Inventor

Mani R Sundararajan

Elizabeth Youngblood

Gilbert T Rodrigues

David J Walker

Peter Beke

Norman S Stroud

Original Assignee

Scherer Corp R P

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-06

Publication date

1998-12-02

1996-06-06 Application filed by Scherer Corp R P filed Critical Scherer Corp R P

1998-12-02 Publication of SK164897A3 publication Critical patent/SK164897A3/sk

Links

239000000463 material Substances 0.000 title claims abstract description 101
239000007903 gelatin capsule Substances 0.000 title claims abstract description 61
239000000203 mixture Substances 0.000 title claims description 31
238000000034 method Methods 0.000 title claims description 23
229920000159 gelatin Polymers 0.000 claims abstract description 79
235000019322 gelatine Nutrition 0.000 claims abstract description 79
108010010803 Gelatin Proteins 0.000 claims abstract description 72
239000008273 gelatin Substances 0.000 claims abstract description 72
235000011852 gelatine desserts Nutrition 0.000 claims abstract description 72
239000002775 capsule Substances 0.000 claims abstract description 29
230000004888 barrier function Effects 0.000 claims description 78
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
239000000945 filler Substances 0.000 claims description 32
-1 polyethylene copolymer Polymers 0.000 claims description 25
230000002209 hydrophobic effect Effects 0.000 claims description 23
238000013508 migration Methods 0.000 claims description 18
230000005012 migration Effects 0.000 claims description 18
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
239000004200 microcrystalline wax Substances 0.000 claims description 11
235000019808 microcrystalline wax Nutrition 0.000 claims description 11
150000001298 alcohols Chemical class 0.000 claims description 9
239000002131 composite material Substances 0.000 claims description 9
150000002148 esters Chemical class 0.000 claims description 8
239000004698 Polyethylene Substances 0.000 claims description 7
238000005538 encapsulation Methods 0.000 claims description 7
229930195733 hydrocarbon Natural products 0.000 claims description 7
150000002430 hydrocarbons Chemical class 0.000 claims description 7
238000012856 packing Methods 0.000 claims description 7
229920000573 polyethylene Polymers 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 6
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 6
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 6
229920001223 polyethylene glycol Polymers 0.000 claims description 6
239000004034 viscosity adjusting agent Substances 0.000 claims description 6
239000001993 wax Substances 0.000 claims description 6
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 5
229920006242 ethylene acrylic acid copolymer Polymers 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
239000012188 paraffin wax Substances 0.000 claims description 5
229920005638 polyethylene monopolymer Polymers 0.000 claims description 5
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 4
239000002202 Polyethylene glycol Substances 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
238000000465 moulding Methods 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 3
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 3
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
239000000178 monomer Substances 0.000 claims description 3
238000006116 polymerization reaction Methods 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
239000000126 substance Substances 0.000 claims description 3
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
239000005977 Ethylene Substances 0.000 claims description 2
150000007513 acids Chemical class 0.000 claims description 2
238000007789 sealing Methods 0.000 claims description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 claims 4
OVGRCEFMXPHEBL-UHFFFAOYSA-N 1-ethenoxypropane Chemical compound CCCOC=C OVGRCEFMXPHEBL-UHFFFAOYSA-N 0.000 claims 2
239000004215 Carbon black (E152) Substances 0.000 claims 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
IAQRGUVFOMOMEM-UHFFFAOYSA-N but-2-ene Chemical group CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 claims 2
150000004668 long chain fatty acids Chemical class 0.000 claims 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
230000015572 biosynthetic process Effects 0.000 claims 1
KVIPHDKUOLVVQN-UHFFFAOYSA-N ethene;hydrate Chemical compound O.C=C KVIPHDKUOLVVQN-UHFFFAOYSA-N 0.000 claims 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
239000011976 maleic acid Substances 0.000 claims 1
ARJOQCYCJMAIFR-UHFFFAOYSA-N prop-2-enoyl prop-2-enoate Chemical compound C=CC(=O)OC(=O)C=C ARJOQCYCJMAIFR-UHFFFAOYSA-N 0.000 claims 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
239000010410 layer Substances 0.000 description 111
239000007788 liquid Substances 0.000 description 15
239000011257 shell material Substances 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
239000001828 Gelatine Substances 0.000 description 7
239000007963 capsule composition Substances 0.000 description 7
238000001125 extrusion Methods 0.000 description 7
239000010408 film Substances 0.000 description 6
238000009472 formulation Methods 0.000 description 6
235000011187 glycerol Nutrition 0.000 description 6
235000019271 petrolatum Nutrition 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
229920001296 polysiloxane Polymers 0.000 description 4
239000000243 solution Substances 0.000 description 4
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
239000004166 Lanolin Substances 0.000 description 3
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
235000013871 bee wax Nutrition 0.000 description 3
239000012166 beeswax Substances 0.000 description 3
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 3
239000003925 fat Substances 0.000 description 3
235000019197 fats Nutrition 0.000 description 3
239000000499 gel Substances 0.000 description 3
235000019388 lanolin Nutrition 0.000 description 3
229940039717 lanolin Drugs 0.000 description 3
235000019809 paraffin wax Nutrition 0.000 description 3
239000004014 plasticizer Substances 0.000 description 3
238000012545 processing Methods 0.000 description 3
239000000758 substrate Substances 0.000 description 3
235000015112 vegetable and seed oil Nutrition 0.000 description 3
239000008158 vegetable oil Substances 0.000 description 3
229920001817 Agar Polymers 0.000 description 2
229920000856 Amylose Polymers 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
239000004264 Petrolatum Substances 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
230000002411 adverse Effects 0.000 description 2
239000008272 agar Substances 0.000 description 2
235000010419 agar Nutrition 0.000 description 2
239000012164 animal wax Substances 0.000 description 2
239000011247 coating layer Substances 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
239000006071 cream Substances 0.000 description 2
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 2
239000003814 drug Substances 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000010030 laminating Methods 0.000 description 2
239000011344 liquid material Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000002480 mineral oil Substances 0.000 description 2
239000012768 molten material Substances 0.000 description 2
229940066842 petrolatum Drugs 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
239000008213 purified water Substances 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
239000010409 thin film Substances 0.000 description 2
239000012178 vegetable wax Substances 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
241000252233 Cyprinus carpio Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241001553290 Euphorbia antisyphilitica Species 0.000 description 1
244000142061 Helianthus annuus ssp lenticularis Species 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
108010046377 Whey Proteins Proteins 0.000 description 1
102000007544 Whey Proteins Human genes 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
238000005266 casting Methods 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000032798 delamination Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229920001038 ethylene copolymer Polymers 0.000 description 1
229920006226 ethylene-acrylic acid Polymers 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
235000019534 high fructose corn syrup Nutrition 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000003317 industrial substance Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000011229 interlayer Substances 0.000 description 1
229940059904 light mineral oil Drugs 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
239000007764 o/w emulsion Substances 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
239000000047 product Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000002356 single layer Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
238000005507 spraying Methods 0.000 description 1
229940032094 squalane Drugs 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
235000021119 whey protein Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Laminated Bodies (AREA)
Manufacturing Of Micro-Capsules (AREA)
Artificial Filaments (AREA)
Materials For Medical Uses (AREA)

SK1648-97A 1995-06-07 1996-06-06 Methods and compositions for preparing soft gelatin capsules having shells resistant to permeation by fill materials SK164897A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47289595A	1995-06-07	1995-06-07
PCT/US1996/009145 WO1996040083A2 (fr)	1995-06-07	1996-06-06	Procedes et compositions pour preparer des gelules molles de gelatine presentant des enveloppes resistant a l'infiltration par des substances de remplissage

Publications (1)

Publication Number	Publication Date
SK164897A3 true SK164897A3 (en)	1998-12-02

Family

ID=23877340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1648-97A SK164897A3 (en)	1995-06-07	1996-06-06	Methods and compositions for preparing soft gelatin capsules having shells resistant to permeation by fill materials

Country Status (14)

Country	Link
EP (1)	EP0837675A2 (fr)
JP (1)	JPH11506785A (fr)
KR (1)	KR19990022443A (fr)
CN (1)	CN1186429A (fr)
AU (1)	AU6154696A (fr)
BR (1)	BR9608608A (fr)
CA (1)	CA2222120A1 (fr)
CZ (1)	CZ381897A3 (fr)
HU (1)	HUP9900858A2 (fr)
IL (1)	IL122422A0 (fr)
NZ (1)	NZ310708A (fr)
PL (1)	PL323790A1 (fr)
SK (1)	SK164897A3 (fr)
WO (1)	WO1996040083A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6333047B1 (en)	1997-05-09	2001-12-25	Daiichi Kasei Co., Ltd.	Molded capsule superior in strength and stability and method for preparing same
JP3188649B2 (ja) *	1997-05-09	2001-07-16	株式会社第一化成	カプセル
DE59812488D1 (de) *	1997-07-09	2005-02-17	Swiss Caps Rechte & Lizenzen	Verfahren und vorrichtung zum herstellen einer mehrschichtigen, physiologisch verträglichen darreichungsform
GB2398499B (en) *	2000-02-16	2004-11-24	Bioprogress Technology Ltd	Two layer capsules
CN1111419C (zh) *	2000-07-05	2003-06-18	宋令春	一种治疗心脑血管中风和中风先兆症状的药物及其制备方法
EP1498117A1 (fr) *	2003-07-15	2005-01-19	Pfizer GmbH Arzneimittelwerk Gödecke	Capsule en gélatine ou composition de capsules contenant de la gélatine à stabilité améliorée, procédé de préparation de capsules et procédé pour améliorer la stabilité de capsules en gélatine
NL2000247C2 (nl) *	2006-09-25	2008-03-26	Drie Mollen Holding B V	Vloeistofhoudende capsule.
CN101596174B (zh) *	2009-07-13	2011-04-06	北京航洋胶囊技术有限公司	一种软胶囊及其制备方法
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CN103550065B (zh) *	2013-10-26	2015-01-28	中山市凯博思淀粉材料科技有限公司	一种复合挤出法生产淀粉基软胶囊的方法
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CN107361392B (zh) *	2017-07-26	2019-10-25	云南芯韵科技开发有限公司	一种三层含水胶囊及其制备方法
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KR102874336B1 (ko) *	2024-03-06	2025-10-29	이상수	캡슐형 치약, 그 제조방법 및 제조장치
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1996
- 1996-06-06 EP EP96919128A patent/EP0837675A2/fr not_active Withdrawn
- 1996-06-06 PL PL96323790A patent/PL323790A1/xx unknown
- 1996-06-06 CN CN96194414A patent/CN1186429A/zh active Pending
- 1996-06-06 SK SK1648-97A patent/SK164897A3/sk unknown
- 1996-06-06 BR BR9608608-4A patent/BR9608608A/pt not_active Application Discontinuation
- 1996-06-06 JP JP9501535A patent/JPH11506785A/ja active Pending
- 1996-06-06 NZ NZ310708A patent/NZ310708A/xx unknown
- 1996-06-06 IL IL12242296A patent/IL122422A0/xx unknown
- 1996-06-06 WO PCT/US1996/009145 patent/WO1996040083A2/fr not_active Ceased
- 1996-06-06 CZ CZ973818A patent/CZ381897A3/cs unknown
- 1996-06-06 AU AU61546/96A patent/AU6154696A/en not_active Abandoned
- 1996-06-06 HU HU9900858A patent/HUP9900858A2/hu unknown
- 1996-06-06 CA CA002222120A patent/CA2222120A1/fr not_active Abandoned
- 1996-06-06 KR KR1019970708924A patent/KR19990022443A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
KR19990022443A (ko)	1999-03-25
NZ310708A (en)	1999-11-29
HUP9900858A2 (hu)	1999-08-30
EP0837675A2 (fr)	1998-04-29
IL122422A0 (en)	1998-06-15
CN1186429A (zh)	1998-07-01
MX9709198A (es)	1998-03-31
WO1996040083A3 (fr)	1997-02-06
AU6154696A (en)	1996-12-30
CZ381897A3 (cs)	1998-05-13
JPH11506785A (ja)	1999-06-15
CA2222120A1 (fr)	1996-12-19
BR9608608A (pt)	1999-12-07
PL323790A1 (en)	1998-04-27
WO1996040083A2 (fr)	1996-12-19

Publication	Publication Date	Title
CZ381897A3 (cs)	1998-05-13	Směs pro výrobu měkkých želatinových kapslí a způsoby její výroby
DE3509410C2 (de)	1997-03-20	Abgabesystem zur Freisetzung einer Wirkstofformulierung
US4844906A (en)	1989-07-04	Tamper evident pharmaceutical capsule
JP2662253B2 (ja)	1997-10-08	生物活性剤の制御された放出のための逆相形態を有するポリマーブレンド
FI102515B (fi)	1998-12-31	Asymmetrisiä kalvoja käsittävä väline, joka pystyy kontrolloidusti vap auttamaan aktiivista ainetta sekä menetelmiä välineiden valmistamiseks i
FI97686B (fi)	1996-10-31	Menetelmä helmien valmistamiseksi tarkoituksena tuottaa hallitusti vapauttavia tuotteita
KR100240528B1 (ko)	2000-02-01	이음매가 없는 캡슐 및 그의 제조방법
US5614217A (en)	1997-03-25	Capsule shell formulation to produce brittle capsules
US5698220A (en)	1997-12-16	Asymmetric membranes in delivery devices
DE3626362C2 (de)	1996-09-19	Abgabevorrichtung zur Freisetzung eines Wirkstoffes an Wiederkäuer
CZ148396A3 (en)	1996-10-16	Preparation intended for controllable release of active compounds and the use thereof
OA10130A (en)	1996-12-18	Beads having a core coated with an antifungal and a polymer
KR910014110A (ko)	1991-08-31	이중 예비피복된 캡슐-유사형 약제
BRPI0618175A2 (pt)	2011-08-16	tecnologia para revestimento de múltiplas camadas para o mascaramento de sabor
CA2165415A1 (fr)	1994-12-19	Capsules de gelatine molles
FI86373C (fi)	1992-08-25	Belaeggning foer en farmaceutiskt tablett med foerdroejd effekt och foerfarande foer framstaellning av en tablett.
CA2000932C (fr)	1999-12-28	Forme pharmaceutique orale multiparticulaire a liberation controlee
EP1667652B1 (fr)	2007-05-30	Forme posologique amelioree a liberation controlee comprenant un moteur attache
CA2350943C (fr)	2006-06-20	Procede de fabrication de capsules remplies de liquide
US4973480A (en)	1990-11-27	Tamper evident pharmaceutical capsule
JPH01232963A (ja)	1989-09-18	重層軟カプセルの製造方法
MXPA97009198A (en)	1998-10-15	Methods and compositions for preparing soft degelatine capsules that have resistant coverings to permeation by rell materials
GB2049469A (en)	1980-12-31	Process for making an osmotically driven active agent dispenser
JPH08511226A (ja)	1996-11-26	農薬を密封する水溶性バッグ
ZA200500834B (en)	2006-04-26	Oral dosage form comprising a liquid active agent formulation and controlling release thereof by an expandable osmotic composition