SK176998A3 - Nasal administration of desmopressin - Google Patents

Nasal administration of desmopressin Download PDF

Info

Publication number: SK176998A3
Authority: SK; Slovakia
Prior art keywords: desmopressin; volume; solution; composition; compound
Prior art date: 1996-06-20

Application number

SK1769-98A

Other languages

English (en)

Slovak (sk)

Inventor

Bengt Bengtsson

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-20

Filing date

1997-06-10

Publication date

1999-05-07

1997-06-10 Application filed by Ferring Bv filed Critical Ferring Bv

1999-05-07 Publication of SK176998A3 publication Critical patent/SK176998A3/sk

Links

108010000437 Deamino Arginine Vasopressin Proteins 0.000 title claims abstract description 70
229960004281 desmopressin Drugs 0.000 title claims abstract description 50
NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 title claims abstract description 49
FIEYHAAMDAPVCH-UHFFFAOYSA-N 2-methyl-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(C)=NC(=O)C2=C1 FIEYHAAMDAPVCH-UHFFFAOYSA-N 0.000 claims abstract description 20
229960002845 desmopressin acetate Drugs 0.000 claims abstract description 20
239000000203 mixture Substances 0.000 claims abstract description 19
150000003839 salts Chemical class 0.000 claims abstract description 19
208000008967 Enuresis Diseases 0.000 claims abstract description 12
239000007864 aqueous solution Substances 0.000 claims abstract description 12
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
230000002485 urinary effect Effects 0.000 claims abstract description 7
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims abstract description 6
201000010064 diabetes insipidus Diseases 0.000 claims abstract description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
230000036470 plasma concentration Effects 0.000 claims abstract description 6
208000005346 nocturnal enuresis Diseases 0.000 claims abstract 2
239000000243 solution Substances 0.000 claims description 20
150000001875 compounds Chemical class 0.000 claims description 12
238000000034 method Methods 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 10
108090000765 processed proteins & peptides Proteins 0.000 claims description 8
238000009472 formulation Methods 0.000 claims description 5
239000007922 nasal spray Substances 0.000 claims description 5
229940097496 nasal spray Drugs 0.000 claims description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
206010046543 Urinary incontinence Diseases 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 3
230000000422 nocturnal effect Effects 0.000 claims 1
206010021639 Incontinence Diseases 0.000 abstract description 2
239000011550 stock solution Substances 0.000 description 7
102000004196 processed proteins & peptides Human genes 0.000 description 6
239000007921 spray Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
-1 desmopressin salt Chemical class 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
208000021891 Micturition disease Diseases 0.000 description 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
108010004977 Vasopressins Proteins 0.000 description 1
102000002852 Vasopressins Human genes 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
239000003833 bile salt Substances 0.000 description 1
229940093761 bile salts Drugs 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
230000004682 mucosal barrier function Effects 0.000 description 1
210000002850 nasal mucosa Anatomy 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK1769-98A 1996-06-20 1997-06-10 Nasal administration of desmopressin SK176998A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/667,047 US5763398A (en)	1996-06-20	1996-06-20	Nasal administration of desmopressin
PCT/SE1997/001010 WO1997048379A1 (en)	1996-06-20	1997-06-10	Nasal administration of desmopressin

Publications (1)

Publication Number	Publication Date
SK176998A3 true SK176998A3 (en)	1999-05-07

Family

ID=24676595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1769-98A SK176998A3 (en)	1996-06-20	1997-06-10	Nasal administration of desmopressin

Country Status (24)

Country	Link
US (1)	US5763398A (cs)
EP (1)	EP0921786A1 (cs)
JP (1)	JP2000502358A (cs)
KR (1)	KR20000016781A (cs)
CN (1)	CN1233952A (cs)
AU (1)	AU707527B2 (cs)
BR (1)	BR9700797A (cs)
CA (1)	CA2258552A1 (cs)
CZ (1)	CZ420198A3 (cs)
EE (1)	EE9800453A (cs)
HU (1)	HUP9903541A3 (cs)
IL (1)	IL127572A (cs)
LT (1)	LT4621B (cs)
LV (1)	LV12230B (cs)
NO (1)	NO985936L (cs)
NZ (1)	NZ333124A (cs)
PL (1)	PL330902A1 (cs)
RO (1)	RO120170B1 (cs)
RU (1)	RU2173559C2 (cs)
SI (1)	SI9720040A (cs)
SK (1)	SK176998A3 (cs)
TR (1)	TR199802596T2 (cs)
UA (1)	UA49888C2 (cs)
WO (1)	WO1997048379A1 (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7153845B2 (en) *	1998-08-25	2006-12-26	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
US8765177B2 (en) *	1997-09-12	2014-07-01	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
JP2001233787A (ja) *	2000-02-04	2001-08-28	Patents Exploitation Co Bv	小・中サイズのペプチド含有薬学的組成物
EP1121935B1 (en) *	2000-02-04	2008-08-13	Patents Exploitation Company B.V.	Pharmaceutical composition containing a small or medium size peptide
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
GB0210397D0 (en)	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
US7094545B2 (en)	2003-04-30	2006-08-22	Ferring Bv	Pharmaceutical composition as solid dosage form and method for manufacturing thereof
ES2260563T3 (es) *	2003-11-13	2006-11-01	Ferring B.V.	Paquete de blister y forma farmaceutica solida para ello.
SE528446C2 (sv) *	2006-03-02	2006-11-14	Ferring Int Ct Sa	Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
KR20140143461A (ko)	2007-08-06	2014-12-16	알레간 인코포레이티드	데스모프레신 약물 전달을 위한 방법 및 장치
ES2319054B1 (es) *	2007-08-06	2010-02-12	Gp Pharm S.A.	Composicion farmaceutica oral de desmopresina.
US8986253B2 (en)	2008-01-25	2015-03-24	Tandem Diabetes Care, Inc.	Two chamber pumps and related methods
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
SI2712622T1 (sl) *	2008-05-21	2016-10-28	Ferring B.V.	Orodisperzibilni dezmopresin za povečanje začetnega obdobja spanja nemotenega z nokturijo
US8408421B2 (en)	2008-09-16	2013-04-02	Tandem Diabetes Care, Inc.	Flow regulating stopcocks and related methods
CA2737461A1 (en)	2008-09-19	2010-03-25	Tandem Diabetes Care, Inc.	Solute concentration measurement device and related methods
CA2747998C (en) *	2008-12-22	2016-05-31	Allergan, Inc.	Safe desmopressin administration
PT2442821T (pt)	2009-06-18	2017-09-29	Allergan Inc	Administração segura de desmopressina
EP2724739B1 (en)	2009-07-30	2015-07-01	Tandem Diabetes Care, Inc.	Portable infusion pump system
FR2954774B1 (fr) *	2009-10-30	2012-01-06	Michelin Soc Tech	Methode de preparation d'un melange maitre de caoutchouc naturel et de silice
US9180242B2 (en)	2012-05-17	2015-11-10	Tandem Diabetes Care, Inc.	Methods and devices for multiple fluid transfer
US9173998B2 (en)	2013-03-14	2015-11-03	Tandem Diabetes Care, Inc.	System and method for detecting occlusions in an infusion pump
RU2605311C1 (ru) *	2015-07-14	2016-12-20	Федеральное государственное бюджетное научное учреждение "Институт экспериментальной медицины" (ФГБНУ "ИЭМ")	Способ лечения болевого синдрома у больных с дегенеративно-дистрофическими заболеваниями позвоночника

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH495957A (de) *	1966-09-15	1970-09-15	Ceskoslovenska Akademie Ved	Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4271068A (en) *	1968-05-10	1981-06-02	Ciba-Geigy Corporation	Process for the manufacture of cystine-containing peptides
CH517705A (de) *	1969-12-16	1972-01-15	Ciba Geigy Ag	Verfahren zur Herstellung von Cystin-haltigen Peptiden
US3929758A (en) *	1974-09-12	1975-12-30	Armour Pharma	Cyclization of cysteine-containing peptides
US4033940A (en) *	1975-11-12	1977-07-05	Armour Pharmaceutical Company	Cyclization of peptides
US4093610A (en) *	1977-01-31	1978-06-06	American Home Products Corporation	Process for producing triglycyl-lysine vasopressin and intermediates therefor
US4216141A (en) *	1978-07-19	1980-08-05	The Salk Institute For Biological Studies	Method for cyclization of peptides
DE2923787A1 (de) *	1979-06-12	1980-12-18	Max Planck Gesellschaft	Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
IE56021B1 (en) *	1982-10-13	1991-03-27	Akzo Nv	Peptides
US5066716A (en) *	1988-12-13	1991-11-19	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
US5482931A (en) *	1993-06-29	1996-01-09	Ferring Ab	Stabilized pharmaceutical peptide compositions
US5500413A (en) *	1993-06-29	1996-03-19	Ferring Ab	Process for manufacture of 1-deamino-8-D-arginine vasopressin
RU2135204C1 (ru) *	1993-06-29	1999-08-27	Ферринг Б.В.	Составы для назального введения десмопрессина

1996
- 1996-06-20 US US08/667,047 patent/US5763398A/en not_active Expired - Fee Related
1997
- 1997-01-28 BR BR9700797A patent/BR9700797A/pt not_active Application Discontinuation
- 1997-06-10 HU HU9903541A patent/HUP9903541A3/hu unknown
- 1997-06-10 CN CN97195712A patent/CN1233952A/zh active Pending
- 1997-06-10 EE EE9800453A patent/EE9800453A/xx unknown
- 1997-06-10 RU RU99100320/14A patent/RU2173559C2/ru not_active IP Right Cessation
- 1997-06-10 RO RO98-01718A patent/RO120170B1/ro unknown
- 1997-06-10 AU AU32802/97A patent/AU707527B2/en not_active Ceased
- 1997-06-10 CZ CZ984201A patent/CZ420198A3/cs unknown
- 1997-06-10 SK SK1769-98A patent/SK176998A3/sk unknown
- 1997-06-10 EP EP97928577A patent/EP0921786A1/en not_active Withdrawn
- 1997-06-10 IL IL12757297A patent/IL127572A/xx not_active IP Right Cessation
- 1997-06-10 NZ NZ333124A patent/NZ333124A/xx unknown
- 1997-06-10 JP JP10502778A patent/JP2000502358A/ja active Pending
- 1997-06-10 SI SI9720040A patent/SI9720040A/sl not_active IP Right Cessation
- 1997-06-10 TR TR1998/02596T patent/TR199802596T2/xx unknown
- 1997-06-10 CA CA002258552A patent/CA2258552A1/en not_active Abandoned
- 1997-06-10 KR KR1019980710391A patent/KR20000016781A/ko not_active Ceased
- 1997-06-10 WO PCT/SE1997/001010 patent/WO1997048379A1/en not_active Ceased
- 1997-06-10 PL PL97330902A patent/PL330902A1/xx unknown
- 1997-10-06 UA UA98126542A patent/UA49888C2/uk unknown
1998
- 1998-12-08 LV LVP-98-275A patent/LV12230B/en unknown
- 1998-12-17 NO NO985936A patent/NO985936L/no not_active Application Discontinuation
- 1998-12-18 LT LT98-188A patent/LT4621B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP9903541A2 (hu)	2000-04-28
US5763398A (en)	1998-06-09
RO120170B1 (ro)	2005-10-28
LV12230A (lv)	1999-03-20
IL127572A (en)	2003-04-10
CA2258552A1 (en)	1997-12-24
TR199802596T2 (xx)	1999-03-22
HUP9903541A3 (en)	2000-10-30
NO985936D0 (no)	1998-12-17
AU707527B2 (en)	1999-07-15
PL330902A1 (en)	1999-06-07
WO1997048379A1 (en)	1997-12-24
SI9720040A (sl)	1999-08-31
LT98188A (en)	1999-11-25
CZ420198A3 (cs)	1999-04-14
NO985936L (no)	1999-02-16
CN1233952A (zh)	1999-11-03
JP2000502358A (ja)	2000-02-29
NZ333124A (en)	1999-05-28
UA49888C2 (uk)	2002-10-15
BR9700797A (pt)	1998-10-06
EP0921786A1 (en)	1999-06-16
RU2173559C2 (ru)	2001-09-20
LV12230B (en)	1999-06-20
LT4621B (lt)	2000-02-25
KR20000016781A (ko)	2000-03-25
IL127572A0 (en)	1999-10-28
AU3280297A (en)	1998-01-07
EE9800453A (et)	1999-08-16

Publication	Publication Date	Title
RU2173559C2 (ru)	2001-09-20	Назальное введение десмопрессина
EP0710122B1 (en)	2001-12-12	Stabilized pharmaceutical peptide compositions
EP0708657B1 (en)	2001-07-25	Compositions for nasal administration of desmopressin
AU2023202420A1 (en)	2023-05-11	Compositions, devices, and methods for the treatment of alcohol use disorder
CA2399505C (en)	2012-01-03	Nasal calcitonin formulations
MXPA97000440A (en)	1998-01-01	Pharmaceutical composition nasod administrable monodosis and method of application of such composic
US20070213272A1 (en)	2007-09-13	Transmucosal Administration Agent Containing Pth
IT9021264A1 (it)	1992-02-10	Composizioni farmaceutiche per la somministrazione intranasale di calcitonina
HK1000906B (en)	2002-03-08	Compositions for nasal administration of desmopressin