DK1483251T3 - C3-cyano-epothilon-derivater - Google Patents
C3-cyano-epothilon-derivaterInfo
- Publication number
- DK1483251T3 DK1483251T3 DK03714096.9T DK03714096T DK1483251T3 DK 1483251 T3 DK1483251 T3 DK 1483251T3 DK 03714096 T DK03714096 T DK 03714096T DK 1483251 T3 DK1483251 T3 DK 1483251T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyano
- epothilone derivatives
- cancer
- treatment
- proliferative diseases
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Lubricants (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36344102P | 2002-03-12 | 2002-03-12 | |
| PCT/US2003/007584 WO2003078411A1 (en) | 2002-03-12 | 2003-03-11 | C3-cyano epothilone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1483251T3 true DK1483251T3 (da) | 2010-04-12 |
Family
ID=28041767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03714096.9T DK1483251T3 (da) | 2002-03-12 | 2003-03-11 | C3-cyano-epothilon-derivater |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6719540B2 (da) |
| EP (1) | EP1483251B1 (da) |
| AT (1) | ATE452896T1 (da) |
| AU (1) | AU2003218110A1 (da) |
| CY (1) | CY1109906T1 (da) |
| DE (1) | DE60330651D1 (da) |
| DK (1) | DK1483251T3 (da) |
| ES (1) | ES2337134T3 (da) |
| PT (1) | PT1483251E (da) |
| SI (1) | SI1483251T1 (da) |
| WO (1) | WO2003078411A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2003077903A1 (en) | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE10355223A1 (de) * | 2003-11-26 | 2005-06-30 | Institut für Pflanzenbiochemie (IPB) | Neue Makrocyclen zur Behandlung von Krebserkrankungen |
| GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| MX2007005763A (es) * | 2004-11-18 | 2007-07-20 | Squibb Bristol Myers Co | Perla recubierta enterica que comprende ixabepilona, y preparacion y administracion de la misma. |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
| JP2009532035A (ja) | 2006-03-31 | 2009-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | 微小管安定化剤に対する感受性を決定するためのバイオマーカーおよび方法 |
| US8008256B2 (en) | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| NZ588555A (en) * | 2008-04-24 | 2012-06-29 | Bristol Myers Squibb Co | Use of epothilone d in treating tau-associated diseases including alzheimer's disease |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| CN103037903A (zh) | 2010-05-18 | 2013-04-10 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
| US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
| WO2015107534A1 (en) * | 2013-11-04 | 2015-07-23 | Emcure Pharmaceuticals Limited | Lyophilized formulation of treosulfan |
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| US4272525A (en) | 1978-10-23 | 1981-06-09 | Schering Corporation | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| US5217960A (en) | 1991-05-03 | 1993-06-08 | Abbott Laboratories | Erythromycin derivatives |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| TW226373B (da) | 1992-07-15 | 1994-07-11 | Pfizer | |
| US5677287A (en) | 1993-03-18 | 1997-10-14 | Pfizer Inc. | Antibacterial 16-membered ring macrolides containing olefins at C-20 |
| EP0708770B1 (en) | 1993-07-15 | 1997-04-16 | Pfizer Inc. | Amide derivatives of 16-membered ring antibiotic macrolides |
| EP0639644A1 (de) | 1993-08-16 | 1995-02-22 | Ciba-Geigy Ag | Neue Makrolide und ihre Verwendung |
| AU3121095A (en) | 1994-09-22 | 1996-04-09 | Pfizer Inc. | Antibiotic macrolides |
| IL117200A0 (en) | 1995-02-21 | 1996-06-18 | Schering Ag | Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| ATE218556T1 (de) | 1995-11-17 | 2002-06-15 | Biotechnolog Forschung Gmbh | Epothilon-derivate und deren herstellung |
| EP0778283A3 (en) | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotic macrolides |
| DE19613933A1 (de) | 1996-04-06 | 1997-10-09 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US6174434B1 (en) | 1996-04-26 | 2001-01-16 | The Lenox Institute Of Water Technology, Inc. | Three zone dissolved air floatation clarifier with fixed lamellae and improved paddle-and-ramp sludge removal system |
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| AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
| JP4274583B2 (ja) | 1996-11-18 | 2009-06-10 | ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） | エポチロンｃ，ｄ，ｅ及びｆ、製造と薬剤 |
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| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| EP1201666A3 (de) | 1997-02-25 | 2003-03-05 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Seitenkettenmodifizierte Epothilone |
| EP0975622B1 (de) | 1997-04-18 | 2002-10-09 | Studiengesellschaft Kohle mbH | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
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| CA2299608A1 (en) | 1997-08-09 | 1999-02-18 | Schering Aktiengesellschaft | New epothilone derivatives, method for producing same and their pharmaceutical use |
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| US6320045B1 (en) | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| US6090601A (en) | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
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| US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| US6380395B1 (en) | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
| DE19820599A1 (de) | 1998-05-08 | 1999-11-11 | Biotechnolog Forschung Gmbh | Epothilonderivate, Verfahren zu deren Herstellung und deren Verwendung |
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| EP1087951B9 (en) | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| DE19826988A1 (de) | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| NZ508326A (en) | 1998-06-18 | 2003-10-31 | Novartis Ag | A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B |
| US6121029A (en) | 1998-06-18 | 2000-09-19 | Novartis Ag | Genes for the biosynthesis of epothilones |
| WO1999067253A2 (en) | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethyl epothilones |
| WO2000001701A1 (en) | 1998-07-02 | 2000-01-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
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| DE19848306A1 (de) | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
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| KR100851418B1 (ko) | 1998-11-20 | 2008-08-08 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
| AU2795000A (en) | 1998-12-22 | 2000-07-12 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
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| NZ513268A (en) | 1999-02-18 | 2004-05-28 | Schering Ag | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
| DE19908763A1 (de) | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
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| WO2000050423A1 (en) | 1999-02-22 | 2000-08-31 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) | C-21 modified epothilones |
| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| CA2368658A1 (en) | 1999-03-29 | 2000-10-05 | Soong-Hoon Kim | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6291684B1 (en) | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6395710B1 (en) | 1999-04-16 | 2002-05-28 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| PE20010116A1 (es) | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
| US6268488B1 (en) | 1999-05-25 | 2001-07-31 | Barbas, Iii Carlos F. | Prodrug activation using catalytic antibodies |
| JP2003505459A (ja) | 1999-07-22 | 2003-02-12 | シエーリング アクチエンゲゼルシャフト | エポチロンｂおよび誘導体製造のための方法、ならびにこの方法のための中間製品 |
| HUP9902628A3 (en) | 1999-08-02 | 2001-07-30 | Ivax Gyogyszerki Kft | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
| CA2425620A1 (en) | 1999-10-08 | 2001-04-19 | The Scripps Research Institute | 13-alkyl epothilone derivatives |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
-
2003
- 2003-03-11 DK DK03714096.9T patent/DK1483251T3/da active
- 2003-03-11 WO PCT/US2003/007584 patent/WO2003078411A1/en not_active Ceased
- 2003-03-11 ES ES03714096T patent/ES2337134T3/es not_active Expired - Lifetime
- 2003-03-11 US US10/386,072 patent/US6719540B2/en not_active Expired - Lifetime
- 2003-03-11 EP EP03714096A patent/EP1483251B1/en not_active Expired - Lifetime
- 2003-03-11 AU AU2003218110A patent/AU2003218110A1/en not_active Abandoned
- 2003-03-11 DE DE60330651T patent/DE60330651D1/de not_active Expired - Lifetime
- 2003-03-11 AT AT03714096T patent/ATE452896T1/de not_active IP Right Cessation
- 2003-03-11 PT PT03714096T patent/PT1483251E/pt unknown
- 2003-03-11 SI SI200331741T patent/SI1483251T1/sl unknown
-
2010
- 2010-03-19 CY CY20101100251T patent/CY1109906T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1109906T1 (el) | 2014-09-10 |
| US6719540B2 (en) | 2004-04-13 |
| PT1483251E (pt) | 2010-02-26 |
| WO2003078411A1 (en) | 2003-09-25 |
| EP1483251A4 (en) | 2006-02-08 |
| EP1483251A1 (en) | 2004-12-08 |
| AU2003218110A1 (en) | 2003-09-29 |
| ES2337134T3 (es) | 2010-04-21 |
| ATE452896T1 (de) | 2010-01-15 |
| SI1483251T1 (sl) | 2010-03-31 |
| DE60330651D1 (en) | 2010-02-04 |
| US20030191089A1 (en) | 2003-10-09 |
| EP1483251B1 (en) | 2009-12-23 |
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