SK1962003A3 - Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain - Google Patents

Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain Download PDF

Info

Publication number: SK1962003A3
Authority: SK; Slovakia
Prior art keywords: enantiomer; formula; enantiomers; substantially free; enantiomeric mixture
Prior art date: 2000-07-21

Application number

SK196-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Ellen E Codd

Richard P Shank

Katherine E Rogers

Carlos R Plata-Salaman

Boyu Zhao

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2001-07-16

Publication date

2004-08-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22820176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK1962003(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-07-16 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-08-03 Publication of SK1962003A3 publication Critical patent/SK1962003A3/sk

Links

208000002193 Pain Diseases 0.000 title claims abstract description 47
208000004296 neuralgia Diseases 0.000 title claims abstract description 38
208000021722 neuropathic pain Diseases 0.000 title claims abstract description 37
208000019695 Migraine disease Diseases 0.000 title claims abstract description 29
206010027599 migraine Diseases 0.000 title claims abstract description 24
208000018912 cluster headache syndrome Diseases 0.000 title claims abstract description 23
208000006561 Cluster Headache Diseases 0.000 title abstract 2
150000004657 carbamic acid derivatives Chemical class 0.000 title description 5
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 67
239000000203 mixture Substances 0.000 claims abstract description 63
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 26
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 21
239000001257 hydrogen Substances 0.000 claims abstract description 21
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 16
125000001424 substituent group Chemical group 0.000 claims abstract description 14
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 12
229910052736 halogen Inorganic materials 0.000 claims abstract description 11
150000002367 halogens Chemical group 0.000 claims abstract description 11
229910052801 chlorine Inorganic materials 0.000 claims abstract description 9
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 9
229910052740 iodine Inorganic materials 0.000 claims abstract description 9
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 9
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 7
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 6
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 6
229910052731 fluorine Inorganic materials 0.000 claims abstract description 6
125000005843 halogen group Chemical group 0.000 claims abstract description 6
239000000460 chlorine Substances 0.000 claims abstract description 5
150000002431 hydrogen Chemical group 0.000 claims abstract description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 3
229910052794 bromium Inorganic materials 0.000 claims abstract description 3
239000011737 fluorine Substances 0.000 claims abstract description 3
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 44
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239000003814 drug Substances 0.000 claims description 19
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125000000217 alkyl group Chemical group 0.000 claims description 11
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
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KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
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206010016059 Facial pain Diseases 0.000 description 1
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206010021118 Hypotonia Diseases 0.000 description 1
PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
206010061296 Motor dysfunction Diseases 0.000 description 1
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235000019483 Peanut oil Nutrition 0.000 description 1
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QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
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VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
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RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical compound CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK196-2003A 2000-07-21 2001-07-16 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain SK1962003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21965700P	2000-07-21	2000-07-21
PCT/US2001/022322 WO2002007822A2 (en)	2000-07-21	2001-07-16	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain

Publications (1)

Publication Number	Publication Date
SK1962003A3 true SK1962003A3 (en)	2004-08-03

Family

ID=22820176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK196-2003A SK1962003A3 (en)	2000-07-21	2001-07-16	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain

Country Status (28)

Country	Link
US (4)	US20020107283A1 (de)
EP (1)	EP1305082B1 (de)
JP (1)	JP5271473B2 (de)
KR (1)	KR100792814B1 (de)
CN (1)	CN1250213C (de)
AT (1)	ATE267629T1 (de)
AU (2)	AU7349301A (de)
BG (1)	BG107529A (de)
BR (1)	BR0112713A (de)
CA (1)	CA2416819C (de)
CZ (1)	CZ2003445A3 (de)
DE (1)	DE60103546T2 (de)
DK (1)	DK1305082T3 (de)
EA (1)	EA005648B1 (de)
ES (1)	ES2221651T3 (de)
HU (1)	HUP0302940A3 (de)
IL (2)	IL154052A0 (de)
MX (1)	MXPA03000619A (de)
MY (1)	MY127317A (de)
NO (1)	NO330055B1 (de)
NZ (1)	NZ523851A (de)
PL (1)	PL365701A1 (de)
PT (1)	PT1305082E (de)
SK (1)	SK1962003A3 (de)
TR (1)	TR200401511T4 (de)
UA (1)	UA74195C2 (de)
WO (1)	WO2002007822A2 (de)
ZA (1)	ZA200301403B (de)

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PL368164A1 (en)	2001-07-16	2005-03-21	Ortho-Mcneil Pharmaceutical, Inc.	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
DK1406606T3 (da) *	2001-07-16	2007-03-05	Ortho Mcneil Pharm Inc	Carbamatforbindelser til forebyggelse eller behandling af neuropatisk smerte og smerte forbundet med klynge- og migrænehovedpine
US20040087642A1 (en) *	2002-10-24	2004-05-06	Zeldis Jerome B.	Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
WO2004054608A2 (en) *	2002-12-12	2004-07-01	Agennix Incorporated	Lactoferrin in the reduction of pain
WO2006047744A2 (en) *	2004-10-26	2006-05-04	Agennix Incorporated	Compositions of lactoferrin related peptides and uses thereof
EP1850841A1 (de) *	2005-01-20	2007-11-07	Janssen Pharmaceutica N.V.	Verfahren zur qt-intervall-steuerung
EP2476433A1 (de)	2006-03-30	2012-07-18	GlaxoSmithKline Biologicals S.A.	Immunogene Zusammensetzung
JP2010505952A (ja) *	2006-10-10	2010-02-25	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	（ｓ）−（＋）−２−（２−クロロフェニル）−２−ヒドロキシ−エチルカルバメートの新規結晶
US8609849B1 (en)	2010-11-30	2013-12-17	Fox Chase Chemical Diversity Center, Inc.	Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
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BR9810742A (pt) *	1997-06-05	2000-09-12	Sanofi Synthelabo	Derivados de 5-naftalen -1il-1,3-dioxana, preparação dos mesmos e aplicação em terapia
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2001
- 2001-07-16 AU AU7349301A patent/AU7349301A/xx active Pending
- 2001-07-16 BR BR0112713-6A patent/BR0112713A/pt not_active Application Discontinuation
- 2001-07-16 IL IL15405201A patent/IL154052A0/xx unknown
- 2001-07-16 PT PT01952773T patent/PT1305082E/pt unknown
- 2001-07-16 MX MXPA03000619A patent/MXPA03000619A/es active IP Right Grant
- 2001-07-16 WO PCT/US2001/022322 patent/WO2002007822A2/en not_active Ceased
- 2001-07-16 KR KR1020037000914A patent/KR100792814B1/ko not_active Expired - Lifetime
- 2001-07-16 CZ CZ2003445A patent/CZ2003445A3/cs unknown
- 2001-07-16 CN CNB01815798XA patent/CN1250213C/zh not_active Expired - Fee Related
- 2001-07-16 EP EP01952773A patent/EP1305082B1/de not_active Expired - Lifetime
- 2001-07-16 TR TR2004/01511T patent/TR200401511T4/xx unknown
- 2001-07-16 EA EA200300042A patent/EA005648B1/ru not_active IP Right Cessation
- 2001-07-16 ES ES01952773T patent/ES2221651T3/es not_active Expired - Lifetime
- 2001-07-16 DE DE60103546T patent/DE60103546T2/de not_active Expired - Lifetime
- 2001-07-16 JP JP2002513552A patent/JP5271473B2/ja not_active Expired - Lifetime
- 2001-07-16 PL PL01365701A patent/PL365701A1/xx not_active Application Discontinuation
- 2001-07-16 AU AU2001273493A patent/AU2001273493B2/en not_active Ceased
- 2001-07-16 UA UA2003010559A patent/UA74195C2/uk unknown
- 2001-07-16 DK DK01952773T patent/DK1305082T3/da active
- 2001-07-16 CA CA2416819A patent/CA2416819C/en not_active Expired - Fee Related
- 2001-07-16 HU HU0302940A patent/HUP0302940A3/hu unknown
- 2001-07-16 US US09/906,251 patent/US20020107283A1/en not_active Abandoned
- 2001-07-16 AT AT01952773T patent/ATE267629T1/de not_active IP Right Cessation
- 2001-07-16 NZ NZ523851A patent/NZ523851A/en unknown
- 2001-07-16 SK SK196-2003A patent/SK1962003A3/sk unknown
- 2001-07-20 MY MYPI20013443 patent/MY127317A/en unknown
2003
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- 2003-01-20 IL IL154052A patent/IL154052A/en unknown
- 2003-02-05 BG BG107529A patent/BG107529A/bg unknown
- 2003-02-20 ZA ZA200301403A patent/ZA200301403B/en unknown
2004
- 2004-06-15 US US10/868,633 patent/US20040266866A1/en not_active Abandoned
2005
- 2005-02-18 US US11/194,876 patent/US20060183795A1/en not_active Abandoned
2009
- 2009-07-20 US US12/505,765 patent/US20090281179A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2221651T3 (es)	2005-01-01
DE60103546D1 (de)	2004-07-01
US20060183795A1 (en)	2006-08-17
CN1250213C (zh)	2006-04-12
NZ523851A (en)	2004-09-24
IL154052A (en)	2008-07-08
JP5271473B2 (ja)	2013-08-21
MXPA03000619A (es)	2004-07-30
WO2002007822A2 (en)	2002-01-31
PT1305082E (pt)	2004-09-30
EA200300042A1 (ru)	2003-06-26
BR0112713A (pt)	2003-07-22
TR200401511T4 (tr)	2004-08-23
US20040266866A1 (en)	2004-12-30
DK1305082T3 (da)	2004-09-13
AU7349301A (en)	2002-02-05
CZ2003445A3 (cs)	2004-08-18
CA2416819A1 (en)	2002-01-31
ATE267629T1 (de)	2004-06-15
MY127317A (en)	2006-11-30
EA005648B1 (ru)	2005-04-28
KR100792814B1 (ko)	2008-01-14
KR20030022300A (ko)	2003-03-15
UA74195C2 (uk)	2005-11-15
IL154052A0 (en)	2003-07-31
EP1305082A2 (de)	2003-05-02
US20090281179A1 (en)	2009-11-12
HUP0302940A3 (en)	2012-02-28
CN1458853A (zh)	2003-11-26
JP2004504362A (ja)	2004-02-12
US20020107283A1 (en)	2002-08-08
HUP0302940A2 (hu)	2003-12-29
CA2416819C (en)	2011-03-22
PL365701A1 (en)	2005-01-10
BG107529A (bg)	2003-09-30
NO330055B1 (no)	2011-02-14
AU2001273493B2 (en)	2005-08-11
NO20030299D0 (no)	2003-01-20
EP1305082B1 (de)	2004-05-26
ZA200301403B (en)	2004-06-15
WO2002007822A3 (en)	2002-05-30
NO20030299L (no)	2003-03-12
DE60103546T2 (de)	2005-06-09

Legal Events

Date	Code	Title	Description
2011-11-04	FB9A	Suspension of patent application procedure

Publication	Publication Date	Title
US20090281179A1 (en)	2009-11-12	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache associated pain
AU2001273493A1 (en)	2002-05-02	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
EP1408954B1 (de)	2009-07-01	Carbamate verbindungen zur vorbeugung oder behandlung von neuropathischen schmerzen
AU2002354909B2 (en)	2006-10-05	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
AU2002322442B2 (en)	2007-06-07	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
AU2002354909A1 (en)	2003-05-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
AU2002322442A1 (en)	2003-05-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
ZA200401156B (en)	2005-06-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain.
HK1063435B (en)	2010-01-22	Carbamate compounds for use in preventing or treating neuropathic pain
HK1063288B (en)	2007-05-25	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
ZA200401155B (en)	2005-05-12	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain.