SK20694A3 - Recombinate sequence of dna - Google Patents

Recombinate sequence of dna Download PDF

Info

Publication number: SK20694A3
Authority: SK; Slovakia
Prior art keywords: sequence; region; recombinant; gene; equivalent
Prior art date: 1993-02-24

Application number

SK206-94A

Other languages

English (en)

Slovak (sk)

Inventor

Laurence Godiard

Yves Marco

Dominique Pontier

Dominique Roby

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-24

Filing date

1994-02-22

Publication date

1995-05-10

1994-02-22 Application filed by Sandoz Ag filed Critical Sandoz Ag

1995-05-10 Publication of SK20694A3 publication Critical patent/SK20694A3/sk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8205—Agrobacterium mediated transformation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8237—Externally regulated expression systems
- C12N15/8239—Externally regulated expression systems pathogen inducible
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Botany (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

SK206-94A 1993-02-24 1994-02-22 Recombinate sequence of dna SK20694A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93102887		1993-02-24

Publications (1)

Publication Number	Publication Date
SK20694A3 true SK20694A3 (en)	1995-05-10

Family

ID=8212635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK206-94A SK20694A3 (en)	1993-02-24	1994-02-22	Recombinate sequence of dna

Country Status (12)

Country	Link
US (2)	US5550228A (pl)
EP (1)	EP0612848A3 (pl)
JP (1)	JPH06319558A (pl)
KR (1)	KR940019860A (pl)
AU (1)	AU682674B2 (pl)
CA (1)	CA2116202A1 (pl)
CZ (1)	CZ40494A3 (pl)
HU (1)	HUT69614A (pl)
IL (1)	IL108728A0 (pl)
PL (1)	PL177329B1 (pl)
SK (1)	SK20694A3 (pl)
ZA (1)	ZA941281B (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1103616A3 (en)	1989-02-24	2001-06-27	Monsanto Company	Synthetic plant genes and method for preparation
WO1994001546A1 (en)	1992-07-01	1994-01-20	Cornell Research Foundation, Inc.	Elicitor of the hypersensitive response in plants
US5708139A (en) *	1993-05-17	1998-01-13	Cornell Research Foundation, Inc.	Pseudomonas syringae pv syringae hrpZ gene
US5981843A (en)	1995-05-18	1999-11-09	Board Of Trustee Of The University Of Kentucky	Elicitin-mediated plant resistance
US5850015A (en) *	1995-06-07	1998-12-15	Cornell Research Foundation, Inc.	Hypersensitive response elicitor from Erwinia chrysanthemi
JP3961023B2 (ja) *	1995-06-07	2007-08-15	コーネル・リサーチ・ファンデーション・インコーポレイテッド	植物における過敏応答誘導耐性
AR008231A1 (es) *	1996-06-13	1999-12-29	Univ Michigan State	Una secuencia de acido nucleico aislada, un vector que la comprende, una celula de planta transgenica, una semilla de dicha planta y un metodo paradisminuir la transcripcion de una secuencia de adn en una planta transgenica
US6235974B1 (en) *	1996-12-05	2001-05-22	Cornell Research Foundation, Inc.	Hypersensitive response induced resistance in plants by seed treatment with a hypersensitive response elicitor
US6277814B1 (en)	1997-01-27	2001-08-21	Cornell Research Foundation, Inc.	Enhancement of growth in plants
US6998515B1 (en)	1997-01-27	2006-02-14	Cornell Research Foundation, Inc.	Use of a nucleic acid encoding a hypersensitive response elicitor polypeptide to enhance growth in plants
US5977060A (en) *	1997-02-28	1999-11-02	Cornell Research Foundation, Inc.	Insect control with a hypersensitive response elicitor
BR9809699A (pt)	1997-05-30	2000-07-11	Cornell Res Foundation Inc	Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel de erwinia, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, processos para conferir resistência a doença e intensificar crescimento de plantas e para controlar insetos para plantas
US6262018B1 (en)	1997-08-06	2001-07-17	Cornell Research Foundation, Inc.	Hypersensitive response elicitor from Erwinia amylovora and its use
US6228644B1 (en)	1997-08-06	2001-05-08	Cornell Research Foundation, Inc.	Hypersensitive response elicitor from Erwinia amylovora, its use, and encoding gene
US6172184B1 (en)	1997-08-06	2001-01-09	Cornell Research Foundation, Inc.	Hypersensitive response elicitor from Pseudomonas syringae and its use
US6333302B1 (en)	1997-09-03	2001-12-25	Cornell Research Foundation, Inc.	Use of hypersensitive response elicitor protein or polypeptide from Clavibacter michiganensis for disease resistance, growth enhancement and insect control
WO2000002996A2 (en)	1998-07-10	2000-01-20	Cornell Research Foundation, Inc.	Recombinant constructs and systems for secretion of proteins via type iii secretion systems
US6087558A (en) *	1998-07-22	2000-07-11	Prodigene, Inc.	Commercial production of proteases in plants
EP0987331A1 (en) *	1998-09-01	2000-03-22	Hoechst Schering AgrEvo GmbH	Plant pathogenicity control by use of a pathogen inducible expression of deac gene
US6858707B1 (en)	1998-10-05	2005-02-22	Eden Bioscience Corporation	Hypersensitive response elicitor fragments which are active but do not elicit a hypersensitive response
US6960705B2 (en)	1998-10-05	2005-11-01	Eden Bioscience Corporation	Nucleic acid encoding a hypersensitive response elicitor from Xanthomonas campestris
US6624139B1 (en)	1998-11-05	2003-09-23	Eden Bioscience Corporation	Hypersensitive response elicitor-induced stress resistance
US6018038A (en) *	1999-01-04	2000-01-25	Korea Kumho Petrochemical Co., Ltd.	Incompatible plant and pathogen interaction related gene
US6734401B2 (en) *	2000-06-28	2004-05-11	3M Innovative Properties Company	Enhanced sample processing devices, systems and methods
US20080152546A1 (en) *	2006-12-22	2008-06-26	3M Innovative Properties Company	Enhanced sample processing devices, systems and methods
WO2008080049A2 (en) *	2006-12-22	2008-07-03	3M Innovative Properties Company	Thermal transfer methods and structures for microfluidic systems
BR112013029181B1 (pt)	2011-05-18	2020-11-03	Focus Diagnostics, Inc.	método e sistema para o processamento de dispositivos de processamento de amostras

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8800725A (nl) *	1988-03-23	1989-10-16	Mogen International N V En Rij	Recombinant dna; getransformeerde microorganismen, plantecellen en planten; werkwijze voor het produceren van een polypeptide of eiwit m.b.v. planten of plantecellen; werkwijze voor het produceren van planten met virusresistentie.
US5312912A (en) *	1989-06-13	1994-05-17	Hadwiger Lee A	Procedures and regulatory DNA sequences for genetically engineering disease resistance and other inducible traits in plants
JP2500321B2 (ja) *	1990-04-06	1996-05-29	農林水産省農業生物資源研究所長	新規なｄｎａ鎖

1994
- 1994-02-21 EP EP94810104A patent/EP0612848A3/xx not_active Withdrawn
- 1994-02-22 PL PL94302320A patent/PL177329B1/pl unknown
- 1994-02-22 AU AU56311/94A patent/AU682674B2/en not_active Ceased
- 1994-02-22 KR KR1019940003100A patent/KR940019860A/ko not_active Abandoned
- 1994-02-22 SK SK206-94A patent/SK20694A3/sk unknown
- 1994-02-22 CA CA002116202A patent/CA2116202A1/en not_active Abandoned
- 1994-02-22 IL IL10872894A patent/IL108728A0/xx unknown
- 1994-02-22 CZ CZ94404A patent/CZ40494A3/cs unknown
- 1994-02-23 HU HU9400527A patent/HUT69614A/hu unknown
- 1994-02-23 US US08/202,054 patent/US5550228A/en not_active Expired - Fee Related
- 1994-02-23 JP JP6025205A patent/JPH06319558A/ja active Pending
- 1994-02-24 ZA ZA941281A patent/ZA941281B/xx unknown
1995
- 1995-05-18 US US08/446,923 patent/US5552527A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL108728A0 (en)	1994-05-30
PL177329B1 (pl)	1999-10-29
AU5631194A (en)	1994-09-01
EP0612848A2 (en)	1994-08-31
HU9400527D0 (en)	1994-05-30
AU682674B2 (en)	1997-10-16
JPH06319558A (ja)	1994-11-22
US5552527A (en)	1996-09-03
KR940019860A (ko)	1994-09-15
HUT69614A (en)	1995-09-28
PL302320A1 (en)	1994-09-05
EP0612848A3 (fr)	1995-05-24
ZA941281B (en)	1995-08-24
CA2116202A1 (en)	1994-08-25
CZ40494A3 (en)	1995-07-12
US5550228A (en)	1996-08-27

Publication	Publication Date	Title
RU2130491C1 (ru)	1999-05-20	Фрагмент днк (варианты), слитый фрагмент днк для экспрессии в растениях и способ получения трансгенного растения и его потомков
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Clarke et al.	1994	Wound-induced and developmental activation of a poplar tree chitinase gene promoter in transgenic tobacco
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CA2184741A1 (en)	1995-09-14	Processes for inhibiting and for inducing flower formation in plants
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WO1997041237A1 (en)	1997-11-06	Fungus resistant transgenic plants
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