SK281433B6 - 5-heterocyklo-1,5-benzodiazepínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

5-heterocyklo-1,5-benzodiazepínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK281433B6
SK281433B6 SK1300-96A SK130096A SK281433B6 SK 281433 B6 SK281433 B6 SK 281433B6 SK 130096 A SK130096 A SK 130096A SK 281433 B6 SK281433 B6 SK 281433B6
Authority
SK
Slovakia
Prior art keywords
alkyl
formula
group
carbon atoms
solution
Prior art date
Application number
SK1300-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK130096A3 (en
Inventor
Christopher Joseph Aquino
Elizabeth Ellen Sugg
Jerzy Ryszard Szewczyk
Original Assignee
Glaxo Wellcome Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9407433A external-priority patent/GB9407433D0/en
Priority claimed from GB9420783A external-priority patent/GB9420783D0/en
Application filed by Glaxo Wellcome Inc. filed Critical Glaxo Wellcome Inc.
Publication of SK130096A3 publication Critical patent/SK130096A3/sk
Publication of SK281433B6 publication Critical patent/SK281433B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SK1300-96A 1994-04-14 1995-04-12 5-heterocyklo-1,5-benzodiazepínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie SK281433B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9407433A GB9407433D0 (en) 1994-04-14 1994-04-14 Heterocyclic derivatives
GB9420783A GB9420783D0 (en) 1994-10-14 1994-10-14 Heterocyclic derivatives
PCT/US1995/004163 WO1995028419A1 (en) 1994-04-14 1995-04-12 Cck or gastrin modulating 5-heterocyclic-1,5-benzodiazepines

Publications (2)

Publication Number Publication Date
SK130096A3 SK130096A3 (en) 1997-08-06
SK281433B6 true SK281433B6 (sk) 2001-03-12

Family

ID=26304703

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1300-96A SK281433B6 (sk) 1994-04-14 1995-04-12 5-heterocyklo-1,5-benzodiazepínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (25)

Country Link
EP (1) EP0756602B1 (de)
JP (1) JPH09511223A (de)
KR (1) KR970702274A (de)
CN (1) CN1176646A (de)
AT (1) ATE181737T1 (de)
AU (1) AU697349B2 (de)
BR (1) BR9507381A (de)
CA (1) CA2186900A1 (de)
CZ (1) CZ286764B6 (de)
DE (1) DE69510545T2 (de)
DK (1) DK0756602T3 (de)
ES (1) ES2135722T3 (de)
FI (1) FI964045A7 (de)
GR (1) GR3031335T3 (de)
HU (1) HUT76135A (de)
IL (1) IL113365A (de)
IS (1) IS4367A (de)
MX (1) MX9604765A (de)
NO (1) NO964348L (de)
NZ (1) NZ283929A (de)
PL (1) PL180026B1 (de)
RU (1) RU2152939C1 (de)
SK (1) SK281433B6 (de)
TW (1) TW369529B (de)
WO (1) WO1995028419A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
JP3999819B2 (ja) * 1996-12-10 2007-10-31 ゼリア新薬工業株式会社 １，５―ベンゾジアセピン誘導体
US7910548B2 (en) * 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
EP1123928A4 (de) * 1998-10-20 2005-02-16 Takeda Pharmaceutical 1,5-benzodiazepin-verbindungen, verfahren zu ihrer herstellung und eine medizin
JP4535350B2 (ja) * 1998-11-17 2010-09-01 クミアイ化学工業株式会社 ピリミジニルベンズイミダゾール誘導体及び農園芸用殺菌剤
ATE402700T1 (de) * 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
GEP20094723B (en) 2004-05-25 2009-07-10 Pfizer Prod Inc Tetraazabenzo [e] azulene derivatives and analogs thereof
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
WO2013105608A1 (ja) 2012-01-13 2013-07-18 日本ケミファ株式会社 Ｐ２ｘ４受容体拮抗剤
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
LT3552017T (lt) 2016-12-09 2022-05-10 Denali Therapeutics Inc. Junginiai, naudotini kaip ripk1 inhibitoriai
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
MX2022010548A (es) 2020-02-28 2022-09-23 Kallyope Inc Agonistas de gpr40.
EP4463229A1 (de) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Kristalline formen von (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b! [l,4)oxazepin-3-yl)-4h-1,2,4-triazol-3-carboxamid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin

Also Published As

Publication number Publication date
ATE181737T1 (de) 1999-07-15
CN1176646A (zh) 1998-03-18
EP0756602A1 (de) 1997-02-05
KR970702274A (ko) 1997-05-13
NO964348D0 (no) 1996-10-11
HUT76135A (en) 1997-06-30
PL316870A1 (en) 1997-02-17
CA2186900A1 (en) 1995-10-26
HU9602835D0 (en) 1996-12-30
SK130096A3 (en) 1997-08-06
GR3031335T3 (en) 1999-12-31
DK0756602T3 (da) 2000-01-31
MX9604765A (es) 1998-05-31
RU2152939C1 (ru) 2000-07-20
AU697349B2 (en) 1998-10-01
NO964348L (no) 1996-12-02
IL113365A0 (en) 1995-07-31
FI964045L (fi) 1996-10-09
FI964045A0 (fi) 1996-10-09
NZ283929A (en) 1998-02-26
TW369529B (en) 1999-09-11
BR9507381A (pt) 1997-09-23
DE69510545D1 (de) 1999-08-05
CZ286764B6 (en) 2000-06-14
FI964045A7 (fi) 1996-10-09
CZ297296A3 (en) 1997-09-17
IL113365A (en) 1999-11-30
AU2239095A (en) 1995-11-10
WO1995028419A1 (en) 1995-10-26
PL180026B1 (pl) 2000-12-29
DE69510545T2 (de) 2000-01-13
ES2135722T3 (es) 1999-11-01
IS4367A (is) 1996-09-30
EP0756602B1 (de) 1999-06-30
JPH09511223A (ja) 1997-11-11

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