SK282905B6 - Spôsob prípravy vodného farmaceutického prípravku - Google Patents

Spôsob prípravy vodného farmaceutického prípravku Download PDF

Info

Publication number: SK282905B6
Authority: SK; Slovakia
Prior art keywords: batches; water; amount; aqueous; pharmaceutical composition
Prior art date: 1997-02-20

Application number

SK1111-99A

Other languages

English (en)

Slovak (sk)

Other versions

SK111199A3 (en

Inventor

Giovanni Cavallo

Leonardo Marchitto

Original Assignee

Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-20

Filing date

1998-02-12

Publication date

2003-01-09

1998-02-12 Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.

2000-06-12 Publication of SK111199A3 publication Critical patent/SK111199A3/sk

2003-01-09 Publication of SK282905B6 publication Critical patent/SK282905B6/sk

Links

XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 18
239000004480 active ingredient Substances 0.000 title abstract description 7
239000008194 pharmaceutical composition Substances 0.000 title abstract description 7
239000002502 liposome Substances 0.000 claims abstract description 33
239000013543 active substance Substances 0.000 claims abstract description 15
239000011148 porous material Substances 0.000 claims abstract description 11
150000002632 lipids Chemical class 0.000 claims abstract description 8
239000012528 membrane Substances 0.000 claims abstract description 6
239000006185 dispersion Substances 0.000 claims abstract description 5
239000008346 aqueous phase Substances 0.000 claims abstract description 4
238000000034 method Methods 0.000 claims description 24
238000002360 preparation method Methods 0.000 claims description 14
239000000725 suspension Substances 0.000 claims description 14
239000012071 phase Substances 0.000 claims description 11
239000000825 pharmaceutical preparation Substances 0.000 claims 1
150000003904 phospholipids Chemical class 0.000 description 24
238000001125 extrusion Methods 0.000 description 17
239000000203 mixture Substances 0.000 description 15
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 14
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 14
229960003987 melatonin Drugs 0.000 description 14
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
229940079593 drug Drugs 0.000 description 12
239000003814 drug Substances 0.000 description 12
238000009472 formulation Methods 0.000 description 11
238000004128 high performance liquid chromatography Methods 0.000 description 9
229930105110 Cyclosporin A Natural products 0.000 description 7
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 7
108010036949 Cyclosporine Proteins 0.000 description 7
229960001265 ciclosporin Drugs 0.000 description 7
239000007789 gas Substances 0.000 description 7
239000007788 liquid Substances 0.000 description 7
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 7
239000011780 sodium chloride Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
238000004220 aggregation Methods 0.000 description 6
230000002776 aggregation Effects 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 6
238000001816 cooling Methods 0.000 description 6
239000001307 helium Substances 0.000 description 6
229910052734 helium Inorganic materials 0.000 description 6
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 6
229910052757 nitrogen Inorganic materials 0.000 description 6
238000010438 heat treatment Methods 0.000 description 5
WDRYRZXSPDWGEB-UHFFFAOYSA-N lonidamine Chemical compound C12=CC=CC=C2C(C(=O)O)=NN1CC1=CC=C(Cl)C=C1Cl WDRYRZXSPDWGEB-UHFFFAOYSA-N 0.000 description 5
229960003538 lonidamine Drugs 0.000 description 5
229920000515 polycarbonate Polymers 0.000 description 5
239000004417 polycarbonate Substances 0.000 description 5
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
150000003626 triacylglycerols Chemical class 0.000 description 4
RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 description 3
MTHORRSSURHQPZ-UHFFFAOYSA-N 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid Chemical compound C12=CC=CC=C2C(COC(C)(C)C(O)=O)=NN1CC1=CC=CC=C1 MTHORRSSURHQPZ-UHFFFAOYSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
239000011627 DL-alpha-tocopherol Substances 0.000 description 3
235000001815 DL-alpha-tocopherol Nutrition 0.000 description 3
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 3
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
229950009949 bindarit Drugs 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
235000021588 free fatty acids Nutrition 0.000 description 3
238000007710 freezing Methods 0.000 description 3
230000008014 freezing Effects 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
150000008104 phosphatidylethanolamines Chemical class 0.000 description 3
238000012360 testing method Methods 0.000 description 3
229960000984 tocofersolan Drugs 0.000 description 3
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
239000003570 air Substances 0.000 description 2
229910052786 argon Inorganic materials 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
230000000887 hydrating effect Effects 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
238000011160 research Methods 0.000 description 2
238000010257 thawing Methods 0.000 description 2
238000002604 ultrasonography Methods 0.000 description 2
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
229930012538 Paclitaxel Natural products 0.000 description 1
239000013011 aqueous formulation Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
238000001514 detection method Methods 0.000 description 1
-1 diglycerides Chemical class 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
229940088679 drug related substance Drugs 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
230000004927 fusion Effects 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
150000002327 glycerophospholipids Chemical class 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
229960001592 paclitaxel Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
238000012805 post-processing Methods 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
150000003408 sphingolipids Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK1111-99A 1997-02-20 1998-02-12 Spôsob prípravy vodného farmaceutického prípravku SK282905B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI000363A IT1289939B1 (it)	1997-02-20	1997-02-20	Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua
PCT/EP1998/000816 WO1998036735A1 (en)	1997-02-20	1998-02-12	Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water

Publications (2)

Publication Number	Publication Date
SK111199A3 SK111199A3 (en)	2000-06-12
SK282905B6 true SK282905B6 (sk)	2003-01-09

Family

ID=11376099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1111-99A SK282905B6 (sk)	1997-02-20	1998-02-12	Spôsob prípravy vodného farmaceutického prípravku

Country Status (26)

Country	Link
US (1)	US6337087B1 (de)
EP (1)	EP0973505B1 (de)
JP (1)	JP4299369B2 (de)
KR (1)	KR100515249B1 (de)
CN (1)	CN1135969C (de)
AR (1)	AR011682A1 (de)
AT (1)	ATE257374T1 (de)
AU (1)	AU740619B2 (de)
BG (1)	BG64367B1 (de)
CA (1)	CA2285985C (de)
CZ (1)	CZ296700B6 (de)
DE (1)	DE69821001T2 (de)
DK (1)	DK0973505T3 (de)
EA (1)	EA002281B1 (de)
ES (1)	ES2213894T3 (de)
GE (1)	GEP20022751B (de)
HU (1)	HU225594B1 (de)
IL (2)	IL131354A0 (de)
IT (1)	IT1289939B1 (de)
PL (1)	PL190987B1 (de)
PT (1)	PT973505E (de)
SK (1)	SK282905B6 (de)
TR (1)	TR199901987T2 (de)
UA (1)	UA63939C2 (de)
WO (1)	WO1998036735A1 (de)
ZA (1)	ZA981354B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9804192D0 (sv) *	1998-12-03	1998-12-03	Scotia Lipidteknik Ab	New formulation
US6075045A (en) *	1999-04-28	2000-06-13	Ajinomoto Co., Inc.	Method of treating paralysis of the extremities caused by cerebral infarction
JP4894119B2 (ja) *	2001-09-26	2012-03-14	日油株式会社	脂肪酸含有リポソーム分散液
US20040115226A1 (en) *	2002-12-12	2004-06-17	Wenji Li	Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
JP2006516571A (ja) *	2003-01-17	2006-07-06	スレッシュオールドファーマシューティカルズ，インコーポレイテッド	良性前立腺増殖症の処置
US20050238675A1 (en) *	2004-04-26	2005-10-27	Wenjie Li	Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US8999292B2 (en)	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
CN117695226A (zh) *	2018-12-11	2024-03-15	迪斯拉普申实验室公司	用于递送治疗剂的组合物及其使用方法和制备方法
CN111759807B (zh) *	2019-04-01	2021-06-01	上海谷森医药有限公司	一种环孢素脂质体及其制备方法
WO2020261158A1 (en)	2019-06-25	2020-12-30	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1264668A (en) *	1984-06-20	1990-01-23	Pieter R. Cullis	Extrusion techniques for producing liposomes
DE4038075C1 (en) *	1990-11-29	1992-03-19	B. Braun Melsungen Ag, 3508 Melsungen, De	Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
IT1254995B (it) *	1992-06-24	1995-10-11		Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
AT396755B (de) *	1992-07-09	1993-11-25	Oesko Gmbh	Verfahren zum reinigen eines rauchgasstromes mit hilfe einer waschflüssigkeit
FR2716110B1 (fr) *	1994-02-16	1996-04-05	Roussel Uclaf	Compositions cosmétiques ou pharmaceutiques comprenant des liposomes.
DE4430593C2 (de) *	1994-08-20	1999-01-14	Max Delbrueck Centrum	Verfahren zur Herstellung von Liposomal verkapseltem Taxol
AU6047996A (en) *	1995-06-07	1996-12-30	Nexstar Pharmaceuticals, Inc.	Liposomal cyclosporin formulations as agents for immunosuppr ession and multiple drug resistant indications

1997
- 1997-02-20 IT IT97MI000363A patent/IT1289939B1/it active IP Right Grant
1998
- 1998-02-12 SK SK1111-99A patent/SK282905B6/sk not_active IP Right Cessation
- 1998-02-12 CZ CZ0292699A patent/CZ296700B6/cs not_active IP Right Cessation
- 1998-02-12 DE DE69821001T patent/DE69821001T2/de not_active Expired - Lifetime
- 1998-02-12 KR KR10-1999-7007539A patent/KR100515249B1/ko not_active Expired - Fee Related
- 1998-02-12 PL PL335208A patent/PL190987B1/pl unknown
- 1998-02-12 HU HU0000910A patent/HU225594B1/hu not_active IP Right Cessation
- 1998-02-12 WO PCT/EP1998/000816 patent/WO1998036735A1/en not_active Ceased
- 1998-02-12 TR TR1999/01987T patent/TR199901987T2/xx unknown
- 1998-02-12 IL IL13135498A patent/IL131354A0/xx unknown
- 1998-02-12 JP JP53622798A patent/JP4299369B2/ja not_active Expired - Fee Related
- 1998-02-12 GE GEAP19984992A patent/GEP20022751B/en unknown
- 1998-02-12 EP EP98909460A patent/EP0973505B1/de not_active Expired - Lifetime
- 1998-02-12 AU AU63987/98A patent/AU740619B2/en not_active Ceased
- 1998-02-12 US US09/367,699 patent/US6337087B1/en not_active Expired - Lifetime
- 1998-02-12 AT AT98909460T patent/ATE257374T1/de active
- 1998-02-12 CN CNB98802733XA patent/CN1135969C/zh not_active Expired - Fee Related
- 1998-02-12 PT PT98909460T patent/PT973505E/pt unknown
- 1998-02-12 DK DK98909460T patent/DK0973505T3/da active
- 1998-02-12 CA CA002285985A patent/CA2285985C/en not_active Expired - Fee Related
- 1998-02-12 EA EA199900750A patent/EA002281B1/ru not_active IP Right Cessation
- 1998-02-12 ES ES98909460T patent/ES2213894T3/es not_active Expired - Lifetime
- 1998-02-18 ZA ZA981354A patent/ZA981354B/xx unknown
- 1998-02-20 AR ARP980100755A patent/AR011682A1/es active IP Right Grant
- 1998-12-02 UA UA99095151A patent/UA63939C2/uk unknown
1999
- 1999-08-11 IL IL131354A patent/IL131354A/en not_active IP Right Cessation
- 1999-09-16 BG BG103739A patent/BG64367B1/bg unknown

Also Published As

Publication number	Publication date
EA002281B1 (ru)	2002-02-28
AR011682A1 (es)	2000-08-30
CN1135969C (zh)	2004-01-28
DE69821001D1 (de)	2004-02-12
PL190987B1 (pl)	2006-02-28
PT973505E (pt)	2004-05-31
IL131354A (en)	2010-06-30
DE69821001T2 (de)	2004-11-11
ZA981354B (en)	1998-08-17
ATE257374T1 (de)	2004-01-15
PL335208A1 (en)	2000-04-10
EA199900750A1 (ru)	2000-04-24
HUP0000910A2 (hu)	2000-10-28
HU225594B1 (en)	2007-05-02
CZ292699A3 (cs)	2000-01-12
UA63939C2 (uk)	2004-02-16
JP2001519775A (ja)	2001-10-23
BG103739A (en)	2000-06-30
KR100515249B1 (ko)	2005-09-16
CA2285985C (en)	2008-01-29
IL131354A0 (en)	2001-01-28
HUP0000910A3 (en)	2000-11-28
BG64367B1 (bg)	2004-12-30
EP0973505A1 (de)	2000-01-26
EP0973505B1 (de)	2004-01-07
DK0973505T3 (da)	2004-05-03
KR20000075480A (ko)	2000-12-15
JP4299369B2 (ja)	2009-07-22
ES2213894T3 (es)	2004-09-01
ITMI970363A1 (it)	1998-08-20
TR199901987T2 (xx)	1999-11-22
SK111199A3 (en)	2000-06-12
AU740619B2 (en)	2001-11-08
US6337087B1 (en)	2002-01-08
AU6398798A (en)	1998-09-09
WO1998036735A1 (en)	1998-08-27
GEP20022751B (en)	2002-08-26
CZ296700B6 (cs)	2006-05-17
CN1255057A (zh)	2000-05-31
IT1289939B1 (it)	1998-10-19
CA2285985A1 (en)	1998-08-27

Legal Events

Date	Code	Title	Description
2017-11-03	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20170212

Publication	Publication Date	Title
US5616334A (en)	1997-04-01	Low toxicity drug-lipid systems
EP2394640A1 (de)	2011-12-14	Verbesserte liposomale Formulierungen von lipophilen Verbindungen
HK1007497B (en)	1999-04-16	Accumulations of amino acids and peptides into liposomes
HK1007497A1 (en)	1999-04-16	Accumulations of amino acids and peptides into liposomes
EP0282405B2 (de)	1998-07-22	Arzneistoff-Lipid-Systeme mit geringer Toxizität
DE4216644B4 (de)	2006-01-12	Liposomen enthaltende Arzneimittel
ITMI20090350A1 (it)	2010-09-11	Glicerosomi e loro impiego in preparazioni farmaceutiche e cosmetiche per uso topico
PL190628B1 (pl)	2005-12-30	Liofilizowana kompozycja zawierająca trehalozę i lipidowe liposomy i sposób liofilizacji kompozycjizawierającej trehalozę i lipidowe liposomy
SK282905B6 (sk)	2003-01-09	Spôsob prípravy vodného farmaceutického prípravku
US20090324709A1 (en)	2009-12-31	Liposomal formulations
JPH04505616A (ja)	1992-10-01	プロトン勾配によるリポソームへの薬剤の蓄積
EP0478727B1 (de)	1996-08-21	Verfahren zur herstellung von wirkstoffhaltigen wässrigen liposomensuspensionen
US20050129750A1 (en)	2005-06-16	Process for producing liposome suspension and product containing liposome suspension produced thereby
CA2279259A1 (en)	1998-08-06	Pain reducing parenteral liposome formulation
WO1989003689A1 (en)	1989-05-05	Tocopherol-based pharmaceutical systems
JPH10316555A (ja)	1998-12-02	高分子化合物を含有するリポソーム外用剤
EP2255790B1 (de)	2017-12-06	Liposomzusammensetzung enthaltend Naproxen und herstellungsverfahren dafür
US20020119170A1 (en)	2002-08-29	Low toxicity drug-lipid systems
MXPA99007683A (en)	2000-06-01	Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water