SK287039B6 - Chimerický glykozylovaný proteín - sIL-6R/IL-6 a jeho analógy, DNA sekvencia, transformované cicavčie bunky obsahujúce DNA vektor, spôsob výroby chimerického proteínu, farmaceutický prostriedok s jeho obsahom a jeho použitie - Google Patents

Chimerický glykozylovaný proteín - sIL-6R/IL-6 a jeho analógy, DNA sekvencia, transformované cicavčie bunky obsahujúce DNA vektor, spôsob výroby chimerického proteínu, farmaceutický prostriedok s jeho obsahom a jeho použitie Download PDF

Info

Publication number: SK287039B6
Authority: SK; Slovakia
Prior art keywords: sil; protein; cells; chimeric; sequence
Prior art date: 1997-07-10

Application number

SK6-2000A

Other languages

English (en)

Slovak (sk)

Other versions

SK62000A3 (en

Inventor

Michel Revel

Judith Chebath

Tsvee Lapidot

Orit Kollet

Original Assignee

Yeda Research And Development Company Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-10

Filing date

1998-07-09

Publication date

2009-10-07

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26323470&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287039(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-07-10 Priority claimed from IL12128497A external-priority patent/IL121284A0/xx

1998-07-09 Application filed by Yeda Research And Development Company Limited filed Critical Yeda Research And Development Company Limited

2000-07-11 Publication of SK62000A3 publication Critical patent/SK62000A3/sk

2009-10-07 Publication of SK287039B6 publication Critical patent/SK287039B6/sk

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Classifications

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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

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General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
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Biochemistry (AREA)
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Biophysics (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
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Cell Biology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SK6-2000A 1997-07-10 1998-07-09 Chimerický glykozylovaný proteín - sIL-6R/IL-6 a jeho analógy, DNA sekvencia, transformované cicavčie bunky obsahujúce DNA vektor, spôsob výroby chimerického proteínu, farmaceutický prostriedok s jeho obsahom a jeho použitie SK287039B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IL12128497A IL121284A0 (en)	1997-07-10	1997-07-10	Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
IL12281897A IL122818A0 (en)	1997-07-10	1997-12-30	Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
PCT/IL1998/000321 WO1999002552A2 (en)	1997-07-10	1998-07-09	Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof

Publications (2)

Publication Number	Publication Date
SK62000A3 SK62000A3 (en)	2000-07-11
SK287039B6 true SK287039B6 (sk)	2009-10-07

Family

ID=26323470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK6-2000A SK287039B6 (sk)	1997-07-10	1998-07-09	Chimerický glykozylovaný proteín - sIL-6R/IL-6 a jeho analógy, DNA sekvencia, transformované cicavčie bunky obsahujúce DNA vektor, spôsob výroby chimerického proteínu, farmaceutický prostriedok s jeho obsahom a jeho použitie

Country Status (26)

Country	Link
US (2)	US7198781B1 (cs)
EP (1)	EP0991661B1 (cs)
JP (1)	JP4402288B2 (cs)
KR (1)	KR100505172B1 (cs)
CN (1)	CN1185348C (cs)
AR (1)	AR013201A1 (cs)
AT (1)	ATE342915T1 (cs)
AU (1)	AU758161B2 (cs)
BG (1)	BG64680B1 (cs)
BR (1)	BR9812096B1 (cs)
CA (1)	CA2295936C (cs)
CY (1)	CY1105895T1 (cs)
CZ (1)	CZ302488B6 (cs)
DE (1)	DE69836217T2 (cs)
DK (1)	DK0991661T3 (cs)
EA (1)	EA004793B1 (cs)
EE (1)	EE05519B1 (cs)
ES (1)	ES2271999T3 (cs)
HU (1)	HU225855B1 (cs)
IL (2)	IL122818A0 (cs)
NO (1)	NO327397B1 (cs)
NZ (1)	NZ502139A (cs)
PL (1)	PL199212B1 (cs)
PT (1)	PT991661E (cs)
SK (1)	SK287039B6 (cs)
WO (1)	WO1999002552A2 (cs)

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IL159558A0 (en) *	2003-12-24	2004-06-01	Applied Research Systems	Use of il-6 in liver injury
IL161673A0 (en)	2004-04-29	2004-09-27	Applied Research Systems	Compositions and methods for therapy of chemotherapy-induced neuropathy
IL161672A0 (en)	2004-04-29	2004-09-27	Yeda Res & Dev	Compositions and methods for therapy of chemotherapy-induced neuropathy
AU2012261726B2 (en) *	2005-08-29	2015-03-12	Technion Research & Development Foundation Ltd.	Media for Culturing Stem Cells
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EP1777294A1 (en) *	2005-10-20	2007-04-25	Institut National De La Sante Et De La Recherche Medicale (Inserm)	IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
JP2009543579A (ja) *	2006-07-19	2009-12-10	ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア	抗炎症反応のための標的としてのＷＳＸ−１／ｐ２８
DK3441459T3 (da) *	2006-08-02	2021-06-07	Technion Res & Dev Foundation	Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur
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NZ590667A (en) *	2008-07-02	2013-01-25	Emergent Product Dev Seattle	Tgf-b antagonist multi-target binding proteins
EP2387415A1 (en)	2009-01-16	2011-11-23	AGIRx Limited	Vaccine compositions
US9018010B2 (en)	2009-11-12	2015-04-28	Technion Research & Development Foundation Limited	Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
WO2011079308A2 (en)	2009-12-23	2011-06-30	Emergent Product Development Seattle, Llc	Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
JP6283223B2 (ja)	2010-09-07	2018-02-21	テクニオンリサーチアンドディベロップメントファウンデーションリミテッド	多能性幹細胞を培養するための新規な方法および培養培地
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1997
- 1997-12-30 IL IL12281897A patent/IL122818A0/xx unknown
1998
- 1998-07-09 JP JP2000502071A patent/JP4402288B2/ja not_active Expired - Fee Related
- 1998-07-09 DK DK98931006T patent/DK0991661T3/da active
- 1998-07-09 CA CA002295936A patent/CA2295936C/en not_active Expired - Fee Related
- 1998-07-09 AT AT98931006T patent/ATE342915T1/de active
- 1998-07-09 AU AU81271/98A patent/AU758161B2/en not_active Ceased
- 1998-07-09 DE DE69836217T patent/DE69836217T2/de not_active Expired - Lifetime
- 1998-07-09 PT PT98931006T patent/PT991661E/pt unknown
- 1998-07-09 WO PCT/IL1998/000321 patent/WO1999002552A2/en not_active Ceased
- 1998-07-09 CZ CZ20000075A patent/CZ302488B6/cs not_active IP Right Cessation
- 1998-07-09 ES ES98931006T patent/ES2271999T3/es not_active Expired - Lifetime
- 1998-07-09 NZ NZ502139A patent/NZ502139A/en not_active IP Right Cessation
- 1998-07-09 EA EA200000109A patent/EA004793B1/ru not_active IP Right Cessation
- 1998-07-09 CN CNB988089416A patent/CN1185348C/zh not_active Expired - Fee Related
- 1998-07-09 EP EP98931006A patent/EP0991661B1/en not_active Revoked
- 1998-07-09 US US09/462,416 patent/US7198781B1/en not_active Expired - Fee Related
- 1998-07-09 SK SK6-2000A patent/SK287039B6/sk not_active IP Right Cessation
- 1998-07-09 PL PL338002A patent/PL199212B1/pl unknown
- 1998-07-09 EE EEP200000012A patent/EE05519B1/xx not_active IP Right Cessation
- 1998-07-09 HU HU0002426A patent/HU225855B1/hu not_active IP Right Cessation
- 1998-07-09 BR BRPI9812096-4A patent/BR9812096B1/pt not_active IP Right Cessation
- 1998-07-09 KR KR10-2000-7000080A patent/KR100505172B1/ko not_active Expired - Fee Related
- 1998-07-10 AR ARP980103377A patent/AR013201A1/es active IP Right Grant
2000
- 2000-01-07 NO NO20000086A patent/NO327397B1/no not_active IP Right Cessation
- 2000-01-10 BG BG104070A patent/BG64680B1/bg unknown
- 2000-01-10 IL IL133972A patent/IL133972A/en not_active IP Right Cessation
2006
- 2006-12-29 CY CY20061101873T patent/CY1105895T1/el unknown
2007
- 2007-03-20 US US11/688,640 patent/US7374912B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL199212B1 (pl)	2008-08-29
DE69836217T2 (de)	2007-08-23
EP0991661A2 (en)	2000-04-12
BG64680B1 (bg)	2005-11-30
BG104070A (en)	2000-11-30
HU225855B1 (en)	2007-11-28
CY1105895T1 (el)	2011-02-02
DK0991661T3 (da)	2007-02-05
BR9812096B1 (pt)	2011-09-06
ES2271999T3 (es)	2007-04-16
ATE342915T1 (de)	2006-11-15
IL133972A (en)	2015-07-30
US7374912B2 (en)	2008-05-20
EA200000109A1 (ru)	2000-08-28
PL338002A1 (en)	2000-09-25
US20070172455A1 (en)	2007-07-26
HUP0002426A3 (en)	2003-01-28
EA004793B1 (ru)	2004-08-26
EP0991661B1 (en)	2006-10-18
HK1031895A1 (en)	2001-06-29
IL122818A0 (en)	1998-08-16
EE05519B1 (et)	2012-02-15
BR9812096A (pt)	2000-07-18
US7198781B1 (en)	2007-04-03
KR20010021522A (ko)	2001-03-15
DE69836217D1 (de)	2006-11-30
AU8127198A (en)	1999-02-08
WO1999002552A3 (en)	1999-04-01
CA2295936C (en)	2009-05-26
CZ302488B6 (cs)	2011-06-15
CN1269835A (zh)	2000-10-11
KR100505172B1 (ko)	2005-08-03
CZ200075A3 (cs)	2000-08-16
AU758161B2 (en)	2003-03-20
JP4402288B2 (ja)	2010-01-20
JP2001509371A (ja)	2001-07-24
SK62000A3 (en)	2000-07-11
CA2295936A1 (en)	1999-01-21
NO20000086D0 (no)	2000-01-07
HUP0002426A2 (hu)	2000-11-28
PT991661E (pt)	2007-01-31
WO1999002552A2 (en)	1999-01-21
NZ502139A (en)	2002-03-28
EE200000012A (et)	2000-08-15
AR013201A1 (es)	2000-12-13
NO20000086L (no)	2000-03-08
NO327397B1 (no)	2009-06-22
CN1185348C (zh)	2005-01-19

Legal Events

Date	Code	Title	Description
2017-04-03	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20160709

Publication	Publication Date	Title
JP4402288B2 (ja)	2010-01-20	キメラのインターロイキン−６可溶性受容体／リガンドタンパク質、その類似体およびその使用
FI116943B (fi)	2006-04-13	Menetelmä kasvainkuoliotekijän reseptoria sisältävien fuusioproteiinien valmistamiseksi ja niitä koodaava DNA ja vektori
ES2229264T3 (es)	2005-04-16	Receptor il-17.
JP3115318B2 (ja)	2000-12-04	Ｇｍ―ｃｓｆ及びｉｌ―３を含む融合タンパク質
JP3750819B2 (ja)	2006-03-01	Ｃ−ｋｉｔ受容体に対するリガンド及びその使用法
PT772624E (pt)	2001-03-30	Interleucina-15
MX2007014474A (es)	2008-02-07	Composiciones y metodos para inmunomodulacion en un organismo.
JP2010279365A (ja)	2010-12-16	修飾したヒト胸腺ストローマ細胞リンホポエチン
FI103987B (fi)	1999-10-29	Interleukiini-7
EP1148065B1 (en)	2008-01-02	Fusion proteins comprising two soluble gp130 molecules
NZ238659A (en)	1992-09-25	Mast cell growth factor, recombinant production and isolated sequences
NZ501831A (en)	2001-09-28	Trail binding protein (TRAIL-BP) showing significant homology to the extracellular domains of members of the tumour necrosis factor receptor (TNF-R) and is anchored to cell surface via glycosylphosphatidylinositol (GPI) linkage
MXPA00000364A (en)	2001-12-04	Chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
KR20000029998A (ko)	2000-05-25	발현벡터,세포,그리고혈소판조혈인자를제조하는방법
JP3689111B2 (ja)	2005-08-31	インターロイキン１５
MXPA97004173A (en)	1998-07-03	Designated citoquina lce