SK287397B6 - Analógy paratyroidného hormónu na liečenie osteoporózy - Google Patents

Analógy paratyroidného hormónu na liečenie osteoporózy Download PDF

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Publication number
SK287397B6
SK287397B6 SK132-99A SK13299A SK287397B6 SK 287397 B6 SK287397 B6 SK 287397B6 SK 13299 A SK13299 A SK 13299A SK 287397 B6 SK287397 B6 SK 287397B6
Authority
SK
Slovakia
Prior art keywords
hpth
leu
lys
glu
seq
Prior art date
Application number
SK132-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK13299A3 (en
Inventor
Jean-Ren Barbier
Paul Morley
Witold Neugebauer
Virginia Ross
James Whitfield
Gordon E. Willick
Original Assignee
National Research Council Of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/691,647 external-priority patent/US5955425A/en
Application filed by National Research Council Of Canada filed Critical National Research Council Of Canada
Publication of SK13299A3 publication Critical patent/SK13299A3/sk
Publication of SK287397B6 publication Critical patent/SK287397B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement Of Radiation (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK132-99A 1996-08-02 1997-08-01 Analógy paratyroidného hormónu na liečenie osteoporózy SK287397B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/691,647 US5955425A (en) 1996-08-02 1996-08-02 Parathyroid hormone analogues for the treatment of osteoporosis
US4056097P 1997-03-14 1997-03-14
PCT/CA1997/000547 WO1998005683A1 (en) 1996-08-02 1997-08-01 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (2)

Publication Number Publication Date
SK13299A3 SK13299A3 (en) 1999-10-08
SK287397B6 true SK287397B6 (sk) 2010-08-09

Family

ID=26717175

Family Applications (1)

Application Number Title Priority Date Filing Date
SK132-99A SK287397B6 (sk) 1996-08-02 1997-08-01 Analógy paratyroidného hormónu na liečenie osteoporózy

Country Status (24)

Country Link
EP (1) EP0915911B1 (is)
JP (3) JP4122061B2 (is)
KR (1) KR100500859B1 (is)
CN (1) CN1176947C (is)
AT (1) ATE253078T1 (is)
AU (1) AU723728B2 (is)
BG (1) BG103128A (is)
BR (1) BR9711002B1 (is)
CA (1) CA2261564C (is)
CZ (1) CZ34799A3 (is)
DE (1) DE69725850T2 (is)
DK (1) DK0915911T3 (is)
EE (1) EE9900039A (is)
ES (1) ES2207740T3 (is)
FI (1) FI990126L (is)
GE (1) GEP20033095B (is)
IS (1) IS4962A (is)
LV (1) LV12293B (is)
NZ (1) NZ333809A (is)
PT (1) PT915911E (is)
RU (1) RU2203286C2 (is)
SI (1) SI9720057A (is)
SK (1) SK287397B6 (is)
WO (1) WO1998005683A1 (is)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK151599A3 (en) * 1997-05-14 2000-09-12 Rhone Poulenc Rorer Pharma Peptide parathyroid hormone analogs
WO2000023594A1 (en) * 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
JP4486258B2 (ja) 1998-11-25 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション ヒト副甲状腺ホルモンの改変、調製および使用
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
AU777634B2 (en) * 1999-07-28 2004-10-28 Kazuhiro Aoki Methods of inhibiting osteoclastogenesis
US6316410B1 (en) * 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
WO2003009804A2 (en) 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
MXPA04001418A (es) * 2001-08-17 2004-05-27 Novartis Ag Acido n-(5-clorosalociloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides.
WO2003059291A2 (en) 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
AU2002359391A1 (en) * 2002-11-01 2004-07-29 Amgen, Inc. Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
CN100508957C (zh) * 2003-01-21 2009-07-08 尤尼金实验室股份有限公司 肽经口输递的改进
JP2009508820A (ja) * 2005-09-06 2009-03-05 ゼロス セラピューティクス， インコーポレイテッド 副甲状腺ホルモンアナログおよび使用法
JP2010501476A (ja) * 2006-07-31 2010-01-21 ゼロス セラピューティクス， インコーポレイテッド 副甲状腺ホルモン類似体およびその使用方法
BRPI0719885B8 (pt) 2006-10-13 2021-05-25 Lilly Co Eli peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
CN101784281B (zh) 2007-08-01 2014-07-02 总医院有限公司 确定g蛋白偶联受体激动剂的方法
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
EP3655104A4 (en) 2017-07-15 2021-03-17 The Regents of the University of California CATHEPSIN K OSTEOADSORBANT FLUOROGENIC SUBSTRATE FOR IMAGING OF OSTEOCLAST ACTIVITY AND MIGRATION
US12404393B2 (en) 2018-09-26 2025-09-02 Borealis Ag Propylene copolymer composition with excellent optical and mechanical properties
CN113549144A (zh) * 2021-06-30 2021-10-26 华南理工大学 一种特立帕肽hPTH(1-34)的生产和纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis

Also Published As

Publication number Publication date
NZ333809A (en) 2000-07-28
ATE253078T1 (de) 2003-11-15
LV12293B (en) 2000-11-20
JP2001500845A (ja) 2001-01-23
KR100500859B1 (ko) 2005-07-14
LV12293A (lv) 1999-06-20
JP4122061B2 (ja) 2008-07-23
CA2261564C (en) 2007-10-30
EP0915911B1 (en) 2003-10-29
KR20000029783A (ko) 2000-05-25
SK13299A3 (en) 1999-10-08
ES2207740T3 (es) 2004-06-01
JP4224111B2 (ja) 2009-02-12
AU3690597A (en) 1998-02-25
CN1176947C (zh) 2004-11-24
DE69725850T2 (de) 2004-08-19
PT915911E (pt) 2004-03-31
EE9900039A (et) 1999-08-16
BR9711002A (pt) 2002-01-15
BR9711002B1 (pt) 2011-09-06
AU723728B2 (en) 2000-09-07
BG103128A (bg) 2000-05-31
JP2009057386A (ja) 2009-03-19
CA2261564A1 (en) 1998-02-12
FI990126A0 (fi) 1999-01-22
EP0915911A1 (en) 1999-05-19
WO1998005683A1 (en) 1998-02-12
DE69725850D1 (de) 2003-12-04
CN1231676A (zh) 1999-10-13
FI990126A7 (fi) 1999-03-31
JP2007254480A (ja) 2007-10-04
CZ34799A3 (cs) 1999-07-14
IS4962A (is) 1999-01-29
SI9720057A (sl) 1999-12-31
FI990126L (fi) 1999-03-31
RU2203286C2 (ru) 2003-04-27
GEP20033095B (en) 2003-10-27
DK0915911T3 (da) 2004-03-08

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120801