ATE253078T1 - Analoge des parathormons zur behandlung der osteoporose - Google Patents

Analoge des parathormons zur behandlung der osteoporose

Info

Publication number
ATE253078T1
ATE253078T1 AT97933603T AT97933603T ATE253078T1 AT E253078 T1 ATE253078 T1 AT E253078T1 AT 97933603 T AT97933603 T AT 97933603T AT 97933603 T AT97933603 T AT 97933603T AT E253078 T1 ATE253078 T1 AT E253078T1
Authority
AT
Austria
Prior art keywords
analogues
lys
activities
rat
increased
Prior art date
Application number
AT97933603T
Other languages
English (en)
Inventor
Jean-Rene Barbier
Paul Morley
Witold Neugebauer
James Whitfield
Gordon E Willick
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/691,647 external-priority patent/US5955425A/en
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of ATE253078T1 publication Critical patent/ATE253078T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement Of Radiation (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97933603T 1996-08-02 1997-08-01 Analoge des parathormons zur behandlung der osteoporose ATE253078T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/691,647 US5955425A (en) 1996-08-02 1996-08-02 Parathyroid hormone analogues for the treatment of osteoporosis
US4056097P 1997-03-14 1997-03-14
PCT/CA1997/000547 WO1998005683A1 (en) 1996-08-02 1997-08-01 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (1)

Publication Number Publication Date
ATE253078T1 true ATE253078T1 (de) 2003-11-15

Family

ID=26717175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97933603T ATE253078T1 (de) 1996-08-02 1997-08-01 Analoge des parathormons zur behandlung der osteoporose

Country Status (24)

Country Link
EP (1) EP0915911B1 (de)
JP (3) JP4122061B2 (de)
KR (1) KR100500859B1 (de)
CN (1) CN1176947C (de)
AT (1) ATE253078T1 (de)
AU (1) AU723728B2 (de)
BG (1) BG103128A (de)
BR (1) BR9711002B1 (de)
CA (1) CA2261564C (de)
CZ (1) CZ34799A3 (de)
DE (1) DE69725850T2 (de)
DK (1) DK0915911T3 (de)
EE (1) EE9900039A (de)
ES (1) ES2207740T3 (de)
FI (1) FI990126L (de)
GE (1) GEP20033095B (de)
IS (1) IS4962A (de)
LV (1) LV12293B (de)
NZ (1) NZ333809A (de)
PT (1) PT915911E (de)
RU (1) RU2203286C2 (de)
SI (1) SI9720057A (de)
SK (1) SK287397B6 (de)
WO (1) WO1998005683A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0003349A3 (en) * 1997-05-14 2001-12-28 Aventis Pharmaceuticals Inc Co Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
WO2000031266A1 (en) * 1998-11-25 2000-06-02 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
AU777634B2 (en) * 1999-07-28 2004-10-28 Kazuhiro Aoki Methods of inhibiting osteoclastogenesis
US6316410B1 (en) * 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
KR20040030120A (ko) * 2001-08-17 2004-04-08 노파르티스 아게 부갑상선 호르몬 단편의 경구 전달제로서의 5-ｃｎａｃ
EP1531855A4 (de) 2002-01-10 2009-07-22 Osteotrophin Llc Behandlung von knochenerkrankungen mit skelettalen anabolika
CA2511966A1 (en) * 2002-11-01 2004-07-22 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
CN100508957C (zh) * 2003-01-21 2009-07-08 尤尼金实验室股份有限公司 肽经口输递的改进
AU2006343306A1 (en) * 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
CA2659846A1 (en) * 2006-07-31 2008-02-07 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
BRPI0719885B8 (pt) 2006-10-13 2021-05-25 Lilly Co Eli peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
CN104072606B (zh) 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
MX358161B (es) * 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
US11219697B2 (en) 2017-07-15 2022-01-11 The Regents Of The University Of California Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration
US12404393B2 (en) 2018-09-26 2025-09-02 Borealis Ag Propylene copolymer composition with excellent optical and mechanical properties
CN113549144A (zh) * 2021-06-30 2021-10-26 华南理工大学 一种特立帕肽hPTH(1-34)的生产和纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis

Also Published As

Publication number Publication date
LV12293A (lv) 1999-06-20
PT915911E (pt) 2004-03-31
GEP20033095B (en) 2003-10-27
ES2207740T3 (es) 2004-06-01
CN1176947C (zh) 2004-11-24
FI990126A0 (fi) 1999-01-22
WO1998005683A1 (en) 1998-02-12
SI9720057A (sl) 1999-12-31
CZ34799A3 (cs) 1999-07-14
BG103128A (bg) 2000-05-31
DE69725850T2 (de) 2004-08-19
IS4962A (is) 1999-01-29
AU723728B2 (en) 2000-09-07
FI990126A7 (fi) 1999-03-31
RU2203286C2 (ru) 2003-04-27
LV12293B (en) 2000-11-20
NZ333809A (en) 2000-07-28
CN1231676A (zh) 1999-10-13
KR20000029783A (ko) 2000-05-25
JP2009057386A (ja) 2009-03-19
SK287397B6 (sk) 2010-08-09
JP2001500845A (ja) 2001-01-23
BR9711002A (pt) 2002-01-15
JP4224111B2 (ja) 2009-02-12
KR100500859B1 (ko) 2005-07-14
CA2261564A1 (en) 1998-02-12
DK0915911T3 (da) 2004-03-08
FI990126L (fi) 1999-03-31
AU3690597A (en) 1998-02-25
EE9900039A (et) 1999-08-16
DE69725850D1 (de) 2003-12-04
SK13299A3 (en) 1999-10-08
CA2261564C (en) 2007-10-30
EP0915911B1 (de) 2003-10-29
EP0915911A1 (de) 1999-05-19
JP4122061B2 (ja) 2008-07-23
BR9711002B1 (pt) 2011-09-06
JP2007254480A (ja) 2007-10-04

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