SK287496B6 - Polypeptid z H. medicinalis, spôsob jeho prípravy a použitie, farmaceutický prostriedok, polynukleotid, expresný vektor, hostiteľská bunka, protilátka a jej použitie - Google Patents

Polypeptid z H. medicinalis, spôsob jeho prípravy a použitie, farmaceutický prostriedok, polynukleotid, expresný vektor, hostiteľská bunka, protilátka a jej použitie Download PDF

Info

Publication number: SK287496B6
Authority: SK; Slovakia
Prior art keywords: polypeptide; saratin; protein; seq; sequence
Prior art date: 1999-03-18

Application number

SK1290-2001A

Other languages

English (en)

Slovak (sk)

Other versions

SK12902001A3 (sk

Inventor

Wolfgang Strittmatter

Detlef G�Ssow

Uwe Hofmann

J�Rgen Hemberger

Zisi Fotev

Bernhard Scheuble

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-18

Filing date

2000-03-10

Publication date

2010-12-07

2000-03-10 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2002-03-05 Publication of SK12902001A3 publication Critical patent/SK12902001A3/sk

2010-12-07 Publication of SK287496B6 publication Critical patent/SK287496B6/sk

Links

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235000019198 oils Nutrition 0.000 description 1
239000002674 ointment Substances 0.000 description 1
101150040063 orf gene Proteins 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
230000009054 pathological process Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
101150040383 pel2 gene Proteins 0.000 description 1
101150050446 pelB gene Proteins 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
239000002644 phorbol ester Substances 0.000 description 1
230000006461 physiological response Effects 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
229940127126 plasminogen activator Drugs 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000000106 platelet aggregation inhibitor Substances 0.000 description 1
210000004623 platelet-rich plasma Anatomy 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
229910000343 potassium bisulfate Inorganic materials 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
238000002331 protein detection Methods 0.000 description 1
238000000164 protein isolation Methods 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
239000013014 purified material Substances 0.000 description 1
230000010410 reperfusion Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000004044 response Effects 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
238000004366 reverse phase liquid chromatography Methods 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
150000003870 salicylic acids Chemical class 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
230000002784 sclerotic effect Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000003998 snake venom Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000008685 targeting Effects 0.000 description 1
239000003868 thrombin inhibitor Substances 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
238000011830 transgenic mouse model Methods 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000017105 transposition Effects 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
150000003628 tricarboxylic acids Chemical class 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000004304 visual acuity Effects 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SK1290-2001A 1999-03-18 2000-03-10 Polypeptid z H. medicinalis, spôsob jeho prípravy a použitie, farmaceutický prostriedok, polynukleotid, expresný vektor, hostiteľská bunka, protilátka a jej použitie SK287496B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99105530		1999-03-18
EP99109503		1999-05-12
PCT/EP2000/002117 WO2000056885A1 (fr)	1999-03-18	2000-03-10	Proteine permettant de bloquer l'adhesion des plaquettes

Publications (2)

Publication Number	Publication Date
SK12902001A3 SK12902001A3 (sk)	2002-03-05
SK287496B6 true SK287496B6 (sk)	2010-12-07

Family

ID=26152935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1290-2001A SK287496B6 (sk)	1999-03-18	2000-03-10	Polypeptid z H. medicinalis, spôsob jeho prípravy a použitie, farmaceutický prostriedok, polynukleotid, expresný vektor, hostiteľská bunka, protilátka a jej použitie

Country Status (27)

Country	Link
US (3)	US6774107B1 (fr)
EP (1)	EP1161530B1 (fr)
JP (1)	JP4805461B2 (fr)
KR (1)	KR100788219B1 (fr)
CN (1)	CN1185344C (fr)
AR (1)	AR023099A1 (fr)
AT (1)	ATE295883T1 (fr)
AU (1)	AU767172B2 (fr)
BR (1)	BR0009074A (fr)
CA (1)	CA2367457C (fr)
CO (1)	CO5241328A1 (fr)
CZ (1)	CZ301524B6 (fr)
DE (1)	DE60020220T2 (fr)
DK (1)	DK1161530T3 (fr)
ES (1)	ES2240067T3 (fr)
HK (1)	HK1045330B (fr)
HU (1)	HU228068B1 (fr)
MX (1)	MXPA01009363A (fr)
MY (1)	MY123371A (fr)
NO (1)	NO330769B1 (fr)
PL (1)	PL200384B1 (fr)
PT (1)	PT1161530E (fr)
RU (1)	RU2292351C2 (fr)
SI (1)	SI1161530T1 (fr)
SK (1)	SK287496B6 (fr)
TR (1)	TR200102729T2 (fr)
WO (1)	WO2000056885A1 (fr)

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DE102012016127A1 (de)	2011-08-31	2013-02-28	Daniel Elias	Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels

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US8017634B2 (en)	2003-12-29	2011-09-13	President And Fellows Of Harvard College	Compositions for treating obesity and insulin resistance disorders
KR101340580B1 (ko) *	2004-10-12	2013-12-11	보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티	플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성
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CA2623565A1 (fr) *	2005-09-28	2007-04-05	Biovascular, Inc.	Methodes et compositions servant a bloquer l'adherence plaquettaire et cellulaire, la migration cellulaire et l'inflammation
US20080015145A1 (en)	2006-07-11	2008-01-17	Maria Gyongyossy-Issa	Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2460915B (en)	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
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WO2012003461A2 (fr)	2010-07-02	2012-01-05	Draths Corporation	Synthases de phloroglucinol et leurs procédés de fabrication et d'utilisation
WO2012006244A1 (fr)	2010-07-06	2012-01-12	Draths Corporation	Procédé pour produire du phloroglucinol et du dihydrophloroglucinol
WO2012006245A1 (fr)	2010-07-06	2012-01-12	Draths Corporation	Phloroglucinol réductase et ses procédés de fabrication et d'utilisation
WO2012024650A2 (fr)	2010-08-19	2012-02-23	Abbott Laboratories	Anticorps anti-ngf et leur utilisation
US8790651B2 (en)	2011-07-21	2014-07-29	Zoetis Llc	Interleukin-31 monoclonal antibody
JP6629069B2 (ja)	2012-06-06	2020-01-15	ゾエティス・エルエルシー	イヌ化抗ｎｇｆ抗体およびその方法
CN104854128A (zh)	2012-07-19	2015-08-19	硕腾有限责任公司	牛流感病毒组合物
AU2013295770A1 (en)	2012-07-27	2015-01-29	Zoetis Services Llc	Tick toxin compositions
WO2018035199A1 (fr)	2016-08-17	2018-02-22	Pharmaq As	Vaccin contre le pou du poisson
BR102017005783A2 (pt) *	2017-03-21	2018-10-02	Fund Butantan	processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
MX2020009526A (es)	2018-03-12	2020-10-28	Zoetis Services Llc	Anticuerpos anti-ngf y metodos de estos.
WO2019178601A1 (fr)	2018-03-16	2019-09-19	Zoetis Services Llc	Vaccins peptidiques contre l'interleukine-31
KR20250026872A (ko)	2018-03-16	2025-02-25	조에티스 서비시즈 엘엘씨	수의학적 용도를 위한 인터류킨-31 단클론성 항체
JP7438135B2 (ja)	2018-05-09	2024-02-26	アイオーニスファーマシューティカルズ，インコーポレーテッド	Ｆｘｉの発現を低下させるための化合物及び方法
BR112022004488A2 (pt)	2019-09-11	2022-05-31	Zoetis Services Llc	Herpesvírus recombinante de vetores de peru que expressam antígenos de patógenos aviários e seus usos
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MY128992A (en) *	2000-08-25	2007-03-30	Merck Patent Gmbh	Saratin for inhibiting platelet adhesion to collagen

2000
- 2000-03-10 PL PL350147A patent/PL200384B1/pl not_active IP Right Cessation
- 2000-03-10 AU AU31662/00A patent/AU767172B2/en not_active Ceased
- 2000-03-10 ES ES00909351T patent/ES2240067T3/es not_active Expired - Lifetime
- 2000-03-10 EP EP00909351A patent/EP1161530B1/fr not_active Expired - Lifetime
- 2000-03-10 HK HK02106777.4A patent/HK1045330B/zh not_active IP Right Cessation
- 2000-03-10 WO PCT/EP2000/002117 patent/WO2000056885A1/fr not_active Ceased
- 2000-03-10 DE DE60020220T patent/DE60020220T2/de not_active Expired - Lifetime
- 2000-03-10 KR KR1020017011881A patent/KR100788219B1/ko not_active Expired - Fee Related
- 2000-03-10 MX MXPA01009363A patent/MXPA01009363A/es active IP Right Grant
- 2000-03-10 JP JP2000606744A patent/JP4805461B2/ja not_active Expired - Fee Related
- 2000-03-10 BR BR0009074-3A patent/BR0009074A/pt not_active IP Right Cessation
- 2000-03-10 DK DK00909351T patent/DK1161530T3/da active
- 2000-03-10 AT AT00909351T patent/ATE295883T1/de active
- 2000-03-10 TR TR2001/02729T patent/TR200102729T2/xx unknown
- 2000-03-10 SI SI200030723T patent/SI1161530T1/xx unknown
- 2000-03-10 PT PT00909351T patent/PT1161530E/pt unknown
- 2000-03-10 CZ CZ20013341A patent/CZ301524B6/cs not_active IP Right Cessation
- 2000-03-10 HU HU0200353A patent/HU228068B1/hu not_active IP Right Cessation
- 2000-03-10 CN CNB008052115A patent/CN1185344C/zh not_active Expired - Fee Related
- 2000-03-10 RU RU2001126921/13A patent/RU2292351C2/ru not_active IP Right Cessation
- 2000-03-10 US US09/936,737 patent/US6774107B1/en not_active Expired - Fee Related
- 2000-03-10 CA CA2367457A patent/CA2367457C/fr not_active Expired - Fee Related
- 2000-03-10 SK SK1290-2001A patent/SK287496B6/sk not_active IP Right Cessation
- 2000-03-14 MY MYPI20000991A patent/MY123371A/en unknown
- 2000-03-17 AR ARP000101192A patent/AR023099A1/es active IP Right Grant
- 2000-03-17 CO CO00019687A patent/CO5241328A1/es not_active Application Discontinuation
2001
- 2001-09-17 NO NO20014506A patent/NO330769B1/no not_active IP Right Cessation
2004
- 2004-05-17 US US10/846,668 patent/US6962801B2/en not_active Expired - Fee Related
2005
- 2005-06-16 US US11/153,433 patent/US7090986B2/en not_active Expired - Fee Related

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102012016127A1 (de)	2011-08-31	2013-02-28	Daniel Elias	Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
DE202012012998U1 (de)	2011-08-31	2014-06-13	Daniel Elias	Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels

Also Published As

Publication number	Publication date
ATE295883T1 (de)	2005-06-15
PL350147A1 (en)	2002-11-04
BR0009074A (pt)	2002-01-02
AR023099A1 (es)	2002-09-04
CA2367457A1 (fr)	2000-09-28
US6774107B1 (en)	2004-08-10
RU2292351C2 (ru)	2007-01-27
PL200384B1 (pl)	2008-12-31
NO20014506D0 (no)	2001-09-17
EP1161530A1 (fr)	2001-12-12
CZ301524B6 (cs)	2010-03-31
CO5241328A1 (es)	2003-01-31
AU3166200A (en)	2000-10-09
HK1045330A1 (en)	2002-11-22
CZ20013341A3 (cs)	2002-01-16
US20060094079A1 (en)	2006-05-04
MY123371A (en)	2006-05-31
MXPA01009363A (es)	2002-06-04
WO2000056885A1 (fr)	2000-09-28
AU767172B2 (en)	2003-11-06
ES2240067T3 (es)	2005-10-16
US20050065084A1 (en)	2005-03-24
PT1161530E (pt)	2005-09-30
SI1161530T1 (en)	2005-10-31
NO20014506L (no)	2001-11-16
KR20020008131A (ko)	2002-01-29
JP4805461B2 (ja)	2011-11-02
DK1161530T3 (da)	2005-08-08
HUP0200353A2 (hu)	2002-05-29
JP2002539788A (ja)	2002-11-26
DE60020220D1 (de)	2005-06-23
CA2367457C (fr)	2010-09-21
CN1344318A (zh)	2002-04-10
HK1045330B (zh)	2005-09-09
KR100788219B1 (ko)	2007-12-26
SK12902001A3 (sk)	2002-03-05
NO330769B1 (no)	2011-07-11
US7090986B2 (en)	2006-08-15
DE60020220T2 (de)	2006-05-24
CN1185344C (zh)	2005-01-19
EP1161530B1 (fr)	2005-05-18
HUP0200353A3 (en)	2003-12-29
TR200102729T2 (tr)	2002-04-22
US6962801B2 (en)	2005-11-08
HU228068B1 (en)	2012-09-28

Legal Events

Date	Code	Title	Description
2014-12-04	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20140310

Publication	Publication Date	Title
SK12902001A3 (sk)	2002-03-05	Proteín na blokovanie adhézie doštičiek
US5928939A (en)	1999-07-27	Vascular endothelial growth factor-b and dna coding therefor
IE914184A1 (en)	1992-06-03	Novel polypeptides for promoting cell attachment
JP2011097948A (ja)	2011-05-19	組換え血小板コラーゲン受容体糖タンパク質ｖｉおよびその薬学的使用
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